Olig2 (oligodendrocyte transcription factor 2)

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Gene: Olig2 (oligodendrocyte transcription factor 2) Ictidomys tridecemlineatus

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Symbol:

Olig2

Name:

oligodendrocyte transcription factor 2

RGD ID:

12555991

Description:

ENCODES a protein that exhibits DNA-binding transcription factor activity (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); E-box binding (inferred); INVOLVED IN myelination (ortholog); negative regulation of neuron differentiation (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autosomal dominant intellectual developmental disorder 7 (ortholog); Experimental Autoimmune Encephalomyelitis (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

oligodendrocyte lineage transcription factor 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	28,219,922 - 28,222,625 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	9,245,880 - 9,247,756 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	9,244,595 - 9,247,756 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis type 1 (ISO)

autosomal dominant intellectual developmental disorder 7 (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

Familial Platelet Disorder with Associated Myeloid Malignancy (ISO)

genetic disease (ISO)

HIV Encephalitis (ISO)

immunodeficiency 28 (ISO)

Neoplasm Metastasis (ISO)

Parkinson's disease 20 (ISO)

Spinal Cord Injuries (ISO)

status epilepticus (ISO)

toxocariasis (ISO)

ZTTK syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axon development (IEA)

myelination (IEA,ISO)

negative regulation of neuron differentiation (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

nervous system development (IEA,ISO)

neuron differentiation (IEA,ISO)

neuron fate commitment (IEA,ISO)

oligodendrocyte cell fate specification (IEA)

oligodendrocyte differentiation (IEA,ISO)

positive regulation of oligodendrocyte differentiation (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA)

regulation of DNA-templated transcription (IEA,ISO)

sensory organ development (IEA)

spinal cord motor neuron differentiation (IEA,ISO)

spinal cord oligodendrocyte cell differentiation (IEA,ISO)

spinal cord oligodendrocyte cell fate specification (IEA,ISO)

thalamus development (IEA,ISO)

Cellular Component

cytoplasm (IEA)

nucleus (IEA)

Molecular Function

DNA-binding transcription factor activity (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

E-box binding (IEA)

HMG box domain binding (IEA)

identical protein binding (IEA)

protein binding (ISO)

protein dimerization activity (IEA)

sequence-specific double-stranded DNA binding (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Olig2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	28,219,922 - 28,222,625 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	9,245,880 - 9,247,756 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	9,244,595 - 9,247,756 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OLIG2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	33,025,935 - 33,029,185 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	33,025,935 - 33,029,196 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	21	34,398,243 - 34,401,493 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	33,320,109 - 33,323,370 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	21	33,320,162 - 33,323,371	NCBI
Celera	21	19,583,840 - 19,587,101 (+)	NCBI		Celera
Cytogenetic Map	21	q22.11	NCBI
HuRef	21	19,809,438 - 19,812,730 (+)	NCBI		HuRef
CHM1_1	21	33,960,322 - 33,963,610 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	31,394,108 - 31,397,358 (+)	NCBI		T2T-CHM13v2.0

Olig2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	91,016,745 - 91,025,567 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	91,022,345 - 91,025,565 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	91,225,550 - 91,228,677 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	91,225,457 - 91,228,677 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	91,225,795 - 91,228,922 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	91,114,409 - 91,117,536 (+)	NCBI		MGSCv36	mm8
Celera	16	92,308,914 - 92,312,041 (+)	NCBI		Celera
Cytogenetic Map	16	C3.3	NCBI
cM Map	16	52.6	NCBI

Olig2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	43,961,585 - 43,964,961 (+)	NCBI		GRCr8
mRatBN7.2	11	30,475,510 - 30,478,886 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	30,475,398 - 30,480,152 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	39,162,510 - 39,165,873 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	31,833,948 - 31,837,317 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	31,008,354 - 31,011,714 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	31,389,514 - 31,392,890 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	31,389,514 - 31,392,890 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	34,998,542 - 35,001,918 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	31,205,416 - 31,208,792 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	31,244,022 - 31,245,269 (+)	NCBI
Celera	11	30,143,763 - 30,147,131 (+)	NCBI		Celera
Cytogenetic Map	11	q11	NCBI

Olig2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	32,433,849 - 32,434,923 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	32,432,888 - 32,436,209 (+)	NCBI	ChiLan1.0	ChiLan1.0

OLIG2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	29,138,290 - 29,141,729 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	23,998,222 - 24,001,643 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	19,387,860 - 19,391,291 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	32,766,039 - 32,769,408 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

OLIG2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	27,674,112 - 27,677,521 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	27,674,107 - 27,676,822 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	27,667,931 - 27,670,007 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	27,878,129 - 27,880,215 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	27,878,117 - 27,880,829 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	27,745,936 - 27,748,017 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	27,755,719 - 27,757,790 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	28,259,002 - 28,261,083 (+)	NCBI		UU_Cfam_GSD_1.0

OLIG2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	196,599,822 - 196,600,793 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	196,596,838 - 196,602,197 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	206,661,824 - 206,663,897 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OLIG2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	59,151,151 - 59,161,253 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	59,152,487 - 59,153,458 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	1,690,456 - 1,693,867 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Olig2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	21,270,965 - 21,272,932 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624745	21,270,804 - 21,274,225 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005323527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000025966 ⟹ ENSSTOP00000022667

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936500	9,245,880 - 9,247,756 (-)	Ensembl

RefSeq Acc Id:

XM_005323527 ⟹ XP_005323584

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404971	28,219,922 - 28,222,625 (+)	NCBI
SpeTri2.0	NW_004936500	9,244,595 - 9,247,756 (-)	NCBI

Sequence:

show sequence

CGCCCGGAGCCAGGATCTCCACAGCAGCTTTTTGGAGCGAGCTCCTCAAATTGGATTCACACTC
TGAGGACCCAGTGAGAAAGGACCTCGCAAAAGCTGCGACTCTTCCCCGAGGCCATGGACTCGGA
CGCCAGCCTGGTGTCCAGCCGCCCGTCGTCGCCAGAGCCCGATGACCTTTTTCTGCCGGCCCGG
AGCAAGGGCAGTAGCGGCAGCGGCTTCACAGGCGGCACAGTGTCCTCGTCCACACCGAGCGACT
GCCCTCCAGAGCTGAGCGCCGAGCTGCGCGGAGCCATGGGCGCGGCGGGCGCGCACCCCGGGGA
CAAGCTGGGCGGCAGTGGCTTCAAGTCATCTTCGTCCAGCACTTCATCGTCCACGTCTTCAGCG
GCTACGTCGTCCACCAAGAAGGACAAGAAACAGATGACCGAGCCGGAGCTGCAGCAGCTGCGCC
TCAAGATCAACAGCCGCGAGCGCAAGCGCATGCACGACCTCAACATCGCCATGGACGGCCTGCG
CGAGGTCATGCCTTATGCGCACGGCCCGTCGGTGCGCAAGCTCTCCAAGATCGCCACGCTGCTC
CTGGCGCGCAACTACATCCTCATGCTTACCAACTCTTTGGAGGAGATGAAGCGACTGGTGAGCG
AGATCTACGGAGGCCACCACGCCGGTTTCCATCCGTCGGCCTGCGGCGGTCTGGCGCACTCTGC
ACCGCTGCCCGCGGCCACCGCTCACCCGGCGGCCGCCGCTCACGCAGCGCACCATCCGGCAGTG
CATCACCCCATTCTGCCTCCCGCCGCAGCCGCCGCAGCTGCCGCCGCCGCCGCCGCGGCGGTGT
CCAGCGCCTCTCTGCCGGGCTCCGGGCTGTCGTCTGTCGGCTCCATCCGGCCTCCGCATGGCTT
GCTCAAGTCTCCGTCAGCGGCCACGGCCGCCCCGCTCGGGGGCGGGGGAGGCGGCAGCGGAGGC
AGCGGTGGCTTCCAGCACTGGGGAGGCATGCCCTGCCCCTGCAGCATGTGCCAGGTGCCACCAC
CACACCACCATGTGTCGGCTATGGGCGCCGGCAGCCTGCCGCGCCTCACCTCCGACGCCAAGTG
AGCTGGTCGGTGCTGGAGCGTTCTGGAGAGCAGGGGGTGCCCAGAGGGTGCAGAGAAGCGAGGG
GACTGGCCGGCACTAGGGCTCGCAAGGAGGGGCTCAGGACCATGGGCTAGGGTGGGGAATGATT
GGGACTACAGCGCCCGGGAATGGAAGTAATGGGAACGCGCAGAGTCGGGAGTGAGGGGCGCTTG
ACTCCGGGACCTAGTTCGGCCCTCGGCTTTAAACTGCGCAGATCCGGTAGACACTACTTCATAA
AATGGCACCACCGTATGCGTCCTTCACTCGAATTCCTTCTCTCCACCCCGGGGGAAAGAATCTA
AAAACTGTTTCCCCAAGAGCCAAGGTTTAACTCCCAGATTGGACCCCGGCAGCACTTCGTGGGG
GGTCAGGGATTTTCCCTCCTTCCTCCTTTCACGGCTGGTAGGAGACTCTGGTGGGATCCTCACT
GCAGAAGCAACCGCTGGGCCTCACCCTCAAGGGTCGTCTCCAAGCCTGGGCCAGGGGCAATGAG
TTAGATGGAAGTTGGCGCTGGTACCCGAAGCACTTACGGTCATGTCTCGTCATGCCGGGTTTCC
ATATCTGGGTAAACCCACATCGTGTAAAAACTGTGGCCATTCCTGTCTCTCTTGTTGACTTGGG
GGTTTGTGGTTTTCTAATAAATCTGTGAATGTTCCTTTTTCAACAGTATGAGCAAGCTTTATAG
ACGCTCAGAATAGAACCACTTGTGGAGTGAAATAACCCAAACTGCCGATTTAGGGGGAGGCGGG
TGTTTTTTCGGTATTTTAAAATGAATACTAGCCCCCGCCCTCTCCATTCTTTCCGTCTTGAGCG
CGCGCGCGCACATACACACACACACACACACACACACACACACACACACACACACACACACACA
AAGTGATTTGGTTTCTTACCCGATTGGGAACAGTTATTTTGGTACCTGAGGGTTTGACAGAACT
GAAAGAAGATGCTGTGAATATAGCTTGAGTTATGGGGGCGGGGTTCTGTTAGTTGTTTAATAAT
TTCTTTCTGGAAGATGTAAATACACTATCAGTGATGAGGTAAGTGCAAGATGCTAAGCTGTTTG
CTCACGTGACTGCCAACCCCTCCGGAGTCTGAGCCGGCTTTCCTCTCTGTATCGGTTTCTTTTT
GCCACGGTTTTTTTTTTTAAACTCAAATGGCAAACTACTCCACGTGCTTCCTGCTCTGGTGCAA
ATCGCCGGGCGCTGGTTGCGTTGCAATATGGGCTTCAAATCCTCTGCCACATAACATCCCTCCT
CTGATA

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Protein Sequences


Protein RefSeqs	XP_005323584	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000022667.1
GenBank Protein	KAG3283889	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005323584 ⟸ XM_005323527

- UniProtKB:

I3NE70 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSGFTGGTVSSSTPSDCPPELSAELRGAMGAAGA
HPGDKLGGSGFKSSSSSTSSSTSSAATSSTKKDKKQMTEPELQQLRLKINSRERKRMHDLNIAM
DGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGL
AHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSSASLPGSGLSSVGSIRP
PHGLLKSPSAATAAPLGGGGGGSGGSGGFQHWGGMPCPCSMCQVPPPHHHVSAMGAGSLPRLTS
DAK

hide sequence

Ensembl Acc Id:

ENSSTOP00000022667 ⟸ ENSSTOT00000025966

Protein Domains

bHLH

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000020899	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000025966.2	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/TrEMBL
InterPro	bHLH_dom	UniProtKB/TrEMBL
	bHLH_transcription_factors	UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/TrEMBL
	Olig2	UniProtKB/TrEMBL
NCBI Gene	Olig2	ENTREZGENE
PANTHER	BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED	UniProtKB/TrEMBL
	PTHR19290:SF32	UniProtKB/TrEMBL
Pfam	HLH	UniProtKB/TrEMBL
PROSITE	BHLH	UniProtKB/TrEMBL
SMART	HLH	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47459	UniProtKB/TrEMBL
UniProt	I3NE70	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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