Gene: OLIG2 (oligodendrocyte transcription factor 2) Homo sapiens
Symbol: OLIG2
Name: oligodendrocyte transcription factor 2
Description: This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basic domain, helix-loop-helix protein, class B, 1; BHLHB1; bHLHe19; class B basic helix-loop-helix protein 1; class E basic helix-loop-helix protein 19; human protein kinase C-binding protein RACK17; OLIGO2; oligodendrocyte lineage transcription factor 2; oligodendrocyte-specific bHLH transcription factor 2; PRKCBP2; protein kinase C binding protein 2; protein kinase C-binding protein 2; protein kinase C-binding protein RACK17; RACK17
Mus musculus (house mouse) : Olig2 (oligodendrocyte transcription factor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Olig2 (oligodendrocyte transcription factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Olig2 (oligodendrocyte transcription factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : OLIG2 (oligodendrocyte transcription factor 2)
Canis lupus familiaris (dog) : OLIG2 (oligodendrocyte transcription factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Olig2 (oligodendrocyte transcription factor 2)
Sus scrofa (pig) : OLIG2 (oligodendrocyte transcription factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382133,025,908 - 33,029,196 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372134,398,216 - 34,401,504 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362133,320,109 - 33,323,370 (+)NCBINCBI36hg18NCBI36
Build 342133,320,162 - 33,323,371NCBI
Celera2119,583,840 - 19,587,101 (+)NCBI
Cytogenetic Map21q22.11NCBI
HuRef2119,809,438 - 19,812,730 (+)NCBIHuRef
CHM1_12133,960,322 - 33,963,610 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on OLIG2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316088
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-04-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.