Gene: Hrg (histidine-rich glycoprotein) Rattus norvegicus
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Symbol:
Hrg
Name:
histidine-rich glycoprotein
RGD ID:
619808
Description:
Predicted to have several functions, including anion binding activity; heme binding activity; and serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of endothelial cell migration; and regulation of blood coagulation. Predicted to localize to cell surface; extracellular region; and lysosome. Human ortholog(s) of this gene implicated in thrombophilia due to HRG deficiency and thrombosis. Orthologous to human HRG (histidine rich glycoprotein); INTERACTS WITH (+)-schisandrin B; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
histidine-proline-rich glycoprotein; histidine-rich glycoprotein 1; HPRG; HRG1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
HRG (histidine rich glycoprotein) HGNC
Ensembl, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Hrg (histidine-rich glycoprotein) HGNC
Treefam, OrthoMCL, NCBI, OMA, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Hrg (histidine rich glycoprotein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
HRG (histidine rich glycoprotein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
HRG (histidine rich glycoprotein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Hrg (histidine rich glycoprotein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
HRG (histidine rich glycoprotein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
HRG (histidine rich glycoprotein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Hrg (histidine rich glycoprotein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
HRG (histidine rich glycoprotein)
Alliance
DIOPT (HGNC)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 11 81,621,274 - 81,639,938 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 11 81,621,283 - 81,639,952 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 11 84,718,226 - 84,736,651 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 11 80,248,578 - 80,264,179 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 11 80,306,169 - 80,321,768 (-) NCBI Celera 11 76,927,058 - 76,941,902 (-) NCBI Celera Cytogenetic Map 11 q23 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
3MC syndrome 1 ISO RGD:736906 8554872 ClinVar Annotator: match by term: 3MC syndrome 1 ClinVar PMID:28492532 3MC syndrome 1 ISO RGD:736906 8554872 ClinVar Annotator: match by term: Michels syndrome ClinVar PMID:28492532 , PMID:29407414 thrombophilia due to HRG deficiency ISO RGD:736906 8554872 ClinVar Annotator: match by term: THROMBOPHILIA DUE TO HISTIDINE-RICH GLYCOPROTEIN DEFICIENCY ClinVar PMID:29108964 thrombophilia due to HRG deficiency ISO RGD:736906 8554872 ClinVar Annotator: match by OMIM:613116 ClinVar PMID:9414276 thrombophilia due to HRG deficiency ISO RGD:736906 8554872 ClinVar Annotator: match by OMIM:613116 ClinVar PMID:11057869
Imported Annotations - CTD
Breast Neoplasms ISO RGD:736906 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19552798 Imported Annotations - OMIM
thrombophilia due to HRG deficiency ISO RGD:736906 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of HRG mRNA] CTD PMID:31150632 17alpha-ethynylestradiol decreases expression ISO RGD:736906 6480464 Ethinyl Estradiol results in decreased expression of HRG protein CTD PMID:7667832 17beta-estradiol decreases expression ISO RGD:736906 6480464 Estradiol results in decreased expression of HRG mRNA CTD PMID:20106945 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736906 6480464 [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HRG mRNA CTD PMID:26159488 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:736907 6480464 Tetrachlorodibenzodioxin results in decreased expression of HRG mRNA CTD PMID:28213091 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736907 6480464 Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HRG gene] CTD PMID:28213091 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of HRG mRNA CTD PMID:21346803 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of HRG mRNA CTD PMID:28522335 aflatoxin B1 affects expression ISO RGD:736906 6480464 Aflatoxin B1 affects the expression of HRG protein CTD PMID:20106945 aflatoxin B1 decreases expression ISO RGD:736906 6480464 Aflatoxin B1 results in decreased expression of HRG mRNA CTD PMID:27153756 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of HRG mRNA CTD PMID:16483693 arsane affects expression ISO RGD:736906 6480464 Arsenic affects the expression of HRG protein CTD PMID:24675094 arsenic atom affects expression ISO RGD:736906 6480464 Arsenic affects the expression of HRG protein CTD PMID:24675094 arsenous acid increases expression ISO RGD:736906 6480464 Arsenic Trioxide results in increased expression of HRG mRNA CTD PMID:27829220 benzo[a]pyrene increases methylation ISO RGD:736906 6480464 Benzo(a)pyrene results in increased methylation of HRG promoter CTD PMID:27901495 benzo[a]pyrene decreases expression ISO RGD:736906 6480464 Benzo(a)pyrene results in decreased expression of HRG mRNA CTD PMID:32234424 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of HRG mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:736907 6480464 bisphenol A results in increased expression of HRG mRNA CTD PMID:30245210 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of HRG mRNA CTD PMID:30903817 buta-1,3-diene decreases expression ISO RGD:736907 6480464 1, 3-butadiene results in decreased expression of HRG mRNA CTD PMID:29038090 cadmium atom affects binding ISO RGD:736906 6480464 HRG protein binds to Cadmium CTD PMID:23896426 cefaloridine decreases expression EXP 6480464 Cephaloridine results in decreased expression of HRG mRNA CTD PMID:18500788 clofibrate multiple interactions ISO RGD:736907 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of HRG mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HRG mRNA] CTD PMID:17585979 clofibrate decreases expression ISO RGD:736907 6480464 Clofibrate results in decreased expression of HRG mRNA CTD PMID:17585979 copper atom increases activity ISO RGD:736906 6480464 Copper results in increased activity of HRG protein CTD PMID:8690451 copper atom affects binding ISO RGD:736906 6480464 HRG protein binds to Copper CTD PMID:23896426 copper atom multiple interactions ISO RGD:736906 6480464 [NSC 689534 binds to Copper] which results in increased expression of HRG mRNA CTD PMID:20971185 copper atom decreases expression EXP 6480464 Copper results in decreased expression of HRG mRNA CTD PMID:22465980 copper(0) increases activity ISO RGD:736906 6480464 Copper results in increased activity of HRG protein CTD PMID:8690451 copper(0) affects binding ISO RGD:736906 6480464 HRG protein binds to Copper CTD PMID:23896426 copper(0) multiple interactions ISO RGD:736906 6480464 [NSC 689534 binds to Copper] which results in increased expression of HRG mRNA CTD PMID:20971185 copper(0) decreases expression EXP 6480464 Copper results in decreased expression of HRG mRNA CTD PMID:22465980 cyclosporin A decreases expression ISO RGD:736906 6480464 Cyclosporine results in decreased expression of HRG mRNA CTD PMID:20106945 , PMID:27989131 diarsenic trioxide increases expression ISO RGD:736906 6480464 Arsenic Trioxide results in increased expression of HRG mRNA CTD PMID:27829220 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of HRG mRNA CTD PMID:32289291 endosulfan multiple interactions ISO RGD:736906 6480464 [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HRG mRNA CTD PMID:26159488 furan increases methylation EXP 6480464 furan results in increased methylation of HRG gene CTD PMID:22079235 furan decreases expression EXP 6480464 furan results in decreased expression of HRG mRNA CTD PMID:26194646 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of HRG mRNA CTD PMID:22061828 graphite affects expression EXP 6480464 Graphite affects the expression of HRG mRNA CTD PMID:29933104 GW 4064 decreases expression ISO RGD:736907 6480464 GW 4064 results in decreased expression of HRG mRNA CTD PMID:26655953 heparin multiple interactions ISO RGD:736906 6480464 Heparin inhibits the reaction [Zinc results in increased activity of HRG protein] CTD PMID:8690451 irinotecan increases expression ISO RGD:736906 6480464 Irinotecan metabolite results in increased expression of HRG mRNA, Irinotecan results in increased expression of HRG mRNA CTD PMID:15956246 lead(0) affects binding ISO RGD:736906 6480464 HRG protein binds to Lead CTD PMID:23896426 lead(2+) affects binding ISO RGD:736906 6480464 HRG protein binds to Lead CTD PMID:23896426 lipopolysaccharide increases expression ISO RGD:736906 6480464 Lipopolysaccharides results in increased expression of HRG mRNA CTD PMID:26667767 lipopolysaccharide multiple interactions ISO RGD:736906 6480464 resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of HRG mRNA] CTD PMID:26667767 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of HRG mRNA CTD PMID:28943392 nickel atom affects binding ISO RGD:736906 6480464 HRG protein binds to Nickel CTD PMID:23896426 O-methyleugenol decreases expression ISO RGD:736906 6480464 methyleugenol results in decreased expression of HRG mRNA CTD PMID:32234424 olanzapine affects phosphorylation ISO RGD:736906 6480464 olanzapine affects the phosphorylation of HRG protein CTD PMID:25821032 ouabain affects expression ISO RGD:736906 6480464 Ouabain affects the expression of HRG protein CTD PMID:17268060 paracetamol multiple interactions ISO RGD:736907 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of HRG mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HRG mRNA] CTD PMID:17585979 paracetamol decreases expression ISO RGD:736906 6480464 Acetaminophen results in decreased expression of HRG mRNA CTD PMID:29067470 perfluorononanoic acid decreases expression ISO RGD:736906 6480464 perfluorononanoic acid results in decreased expression of HRG mRNA CTD PMID:32588087 pirinixic acid multiple interactions ISO RGD:736906 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HRG mRNA CTD PMID:19710929 pirinixic acid decreases expression ISO RGD:736907 6480464 pirinixic acid results in decreased expression of HRG mRNA CTD PMID:20813756 , PMID:23811191 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of HRG mRNA CTD PMID:16940010 pirinixic acid multiple interactions ISO RGD:736907 6480464 [pirinixic acid co-treated with PPARA] results in decreased expression of HRG mRNA CTD PMID:20813756 potassium dichromate increases expression ISO RGD:736907 6480464 Potassium Dichromate results in increased expression of HRG mRNA CTD PMID:23608068 pravastatin decreases expression ISO RGD:736907 6480464 Pravastatin results in decreased expression of HRG mRNA CTD PMID:27225895 pravastatin decreases expression EXP 6480464 Pravastatin results in decreased expression of HRG mRNA CTD PMID:27225895 resveratrol multiple interactions ISO RGD:736906 6480464 resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of HRG mRNA] CTD PMID:26667767 sodium arsenite decreases expression ISO RGD:736906 6480464 sodium arsenite results in decreased expression of HRG mRNA CTD PMID:29301061 tamoxifen decreases response to substance ISO RGD:736906 6480464 HRG protein results in decreased susceptibility to Tamoxifen CTD PMID:19552798 tauroursodeoxycholic acid decreases expression EXP 6480464 tauroursodeoxycholic acid results in decreased expression of HRG mRNA CTD PMID:15885361 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of HRG mRNA CTD PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of HRG mRNA] CTD PMID:31150632 thioacetamide multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of HRG mRNA CTD PMID:28943392 Triptolide increases expression EXP 6480464 triptolide results in increased expression of HRG protein CTD PMID:32519852 troglitazone decreases expression ISO RGD:736906 6480464 troglitazone results in decreased expression of HRG mRNA CTD PMID:25572481 ursodeoxycholic acid decreases expression EXP 6480464 Ursodeoxycholic Acid results in decreased expression of HRG mRNA CTD PMID:15885361 valproic acid decreases expression ISO RGD:736906 6480464 Valproic Acid results in decreased expression of HRG mRNA CTD PMID:29154799 valproic acid decreases methylation ISO RGD:736906 6480464 Valproic Acid results in decreased methylation of HRG gene CTD PMID:29154799 zaragozic acid A decreases expression ISO RGD:736907 6480464 squalestatin 1 results in decreased expression of HRG mRNA CTD PMID:27225895 zaragozic acid A decreases expression EXP 6480464 squalestatin 1 results in decreased expression of HRG mRNA CTD PMID:27225895 zinc atom increases activity ISO RGD:736906 6480464 Zinc results in increased activity of HRG protein CTD PMID:8690451 zinc atom affects binding ISO RGD:736906 6480464 HRG protein binds to Zinc CTD PMID:23896426 zinc atom multiple interactions ISO RGD:736906 6480464 Heparin inhibits the reaction [Zinc results in increased activity of HRG protein] CTD PMID:8690451 zinc(0) increases activity ISO RGD:736906 6480464 Zinc results in increased activity of HRG protein CTD PMID:8690451 zinc(0) multiple interactions ISO RGD:736906 6480464 Heparin inhibits the reaction [Zinc results in increased activity of HRG protein] CTD PMID:8690451 zinc(0) affects binding ISO RGD:736906 6480464 HRG protein binds to Zinc CTD PMID:23896426
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptide ISO RGD:736906 1624291 (PMID:18797515) RGD PMID:18797515 antimicrobial humoral immune response mediated by antimicrobial peptide ISO RGD:736907 1624291 (MGI:5294287, PMID:18797515) RGD MGI:5294287 , PMID:18797515 antimicrobial humoral immune response mediated by antimicrobial peptide IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 biological_process ND 1598407 04/2016: no relevant rat data RGD cytolysis by host of symbiont cells IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytolysis by host of symbiont cells ISO RGD:736906 1624291 (PMID:18797515) RGD PMID:18797515 defense response to fungus ISO RGD:736906 1624291 (PMID:18797515) RGD PMID:18797515 defense response to fungus ISO RGD:736907 1624291 (MGI:5294287, PMID:18797515) RGD MGI:5294287 , PMID:18797515 defense response to fungus ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 defense response to fungus IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 fibrinolysis IEA UniProtKB-KW:KW-0280 1600115 GO_REF:0000043 UniProt GO_REF:0000043 heme export ISO RGD:736907 1624291 (MGI:5527134, PMID:23395172) RGD MGI:5527134 , PMID:23395172 heme transport IBA MGI:MGI:2146636 , PANTHER:PTN001418583 13792537 PMID:21873635 GO_Central heme transport ISO RGD:736907 1624291 (MGI:5527134, PMID:23395172) RGD MGI:5527134 , PMID:23395172 negative regulation of angiogenesis ISO RGD:736906 1624291 (PMID:14744774), (PMID:16436387), (PMID:16489009), (PMID:19903770) RGD PMID:14744774 more ... negative regulation of angiogenesis ISO RGD:736907 1624291 (MGI:5427055, PMID:22348394) RGD MGI:5427055 , PMID:22348394 negative regulation of angiogenesis ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of angiogenesis ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of angiogenesis IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of blood vessel endothelial cell migration ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of blood vessel endothelial cell migration ISO RGD:736907 1624291 (MGI:5427055, PMID:22348394) RGD MGI:5427055 , PMID:22348394 negative regulation of cell adhesion ISO RGD:736906 1624291 (PMID:14744774) RGD PMID:14744774 negative regulation of cell adhesion ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of cell adhesion mediated by integrin ISO RGD:736906 1624291 (PMID:16489009) RGD PMID:16489009 negative regulation of cell adhesion mediated by integrin ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of cell adhesion mediated by integrin IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of cell growth ISO RGD:736906 1624291 (PMID:21215706) RGD PMID:21215706 negative regulation of cell growth ISO RGD:736907 1624291 (MGI:5427055, PMID:22348394) RGD MGI:5427055 , PMID:22348394 negative regulation of cell growth ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of cell growth ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of cell growth IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of cell population proliferation ISO RGD:736906 1624291 (PMID:14744774) RGD PMID:14744774 negative regulation of cell population proliferation ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of cell population proliferation IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of endopeptidase activity IEA GO:0004869 1600115 GO_REF:0000108 GOC GO_REF:0000108 negative regulation of endopeptidase activity IBA MGI:MGI:1890221 , PANTHER:PTN002674770 13792537 PMID:21873635 GO_Central negative regulation of endothelial cell chemotaxis ISO RGD:736906 1624291 (PMID:14744774), (PMID:16436387), (PMID:16489009) RGD PMID:14744774 more ... negative regulation of endothelial cell chemotaxis ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of endothelial cell chemotaxis IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of fibrinolysis IBA MGI:MGI:2146636 , PANTHER:PTN001418583 13792537 PMID:21873635 GO_Central negative regulation of fibrinolysis ISO RGD:736907 1624291 MGI:3789962 (MGI:3789419 , PMID:15869579) RGD MGI:3789419 , PMID:15869579 negative regulation of lamellipodium assembly ISO RGD:736906 1624291 (PMID:16489009) RGD PMID:16489009 negative regulation of lamellipodium assembly ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of lamellipodium assembly IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of vascular endothelial growth factor signaling pathway ISO RGD:736906 1624291 (PMID:16489009) RGD PMID:16489009 negative regulation of vascular endothelial growth factor signaling pathway ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of vascular endothelial growth factor signaling pathway IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 platelet activation ISO RGD:736906 1624291 (PMID:19903770) RGD PMID:19903770 platelet activation ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 platelet activation IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of apoptotic process ISO RGD:736906 1624291 (PMID:14744774) RGD PMID:14744774 positive regulation of apoptotic process ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of apoptotic process IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of blood vessel remodeling ISO RGD:736906 1624291 (PMID:21215706) RGD PMID:21215706 positive regulation of blood vessel remodeling ISO RGD:736907 1624291 (MGI:5427055, PMID:22348394) RGD MGI:5427055 , PMID:22348394 positive regulation of blood vessel remodeling ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of blood vessel remodeling ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of blood vessel remodeling IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of focal adhesion assembly ISO RGD:736906 1624291 (PMID:14744774), (PMID:16436387) RGD PMID:14744774 , PMID:16436387 positive regulation of focal adhesion assembly ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of focal adhesion assembly IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of immune response to tumor cell ISO RGD:736906 1624291 (PMID:21215706) RGD PMID:21215706 positive regulation of immune response to tumor cell ISO RGD:736907 1624291 (MGI:5427055, PMID:22348394) RGD MGI:5427055 , PMID:22348394 positive regulation of immune response to tumor cell ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of immune response to tumor cell ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of immune response to tumor cell IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of actin cytoskeleton organization ISO RGD:736906 1624291 (PMID:16489009) RGD PMID:16489009 regulation of actin cytoskeleton organization ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of actin cytoskeleton organization IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of blood coagulation ISO RGD:736906 1624291 (PMID:21304106), (PMID:6740558) RGD PMID:21304106 , PMID:6740558 regulation of blood coagulation ISO RGD:736907 1624291 (MGI:3789419, PMID:15869579) RGD MGI:3789419 , PMID:15869579 regulation of blood coagulation ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of blood coagulation ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of blood coagulation IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of gene expression ISO RGD:736906 1624291 (PMID:21215706) RGD PMID:21215706 regulation of gene expression ISO RGD:736907 1624291 (MGI:5427055, PMID:22348394) RGD MGI:5427055 , PMID:22348394 regulation of gene expression ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of gene expression ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of gene expression IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of peptidyl-tyrosine phosphorylation ISO RGD:736906 1624291 (PMID:16489009) RGD PMID:16489009 regulation of peptidyl-tyrosine phosphorylation ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of peptidyl-tyrosine phosphorylation IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of platelet activation ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of platelet activation ISO RGD:736907 1624291 (MGI:3789419 more ... RGD MGI:3789419 more ... regulation of platelet activation IBA MGI:MGI:2146636 , PANTHER:PTN001418583 13792537 PMID:21873635 GO_Central regulation of protein-containing complex assembly ISO RGD:736906 1624291 (PMID:16489009) RGD PMID:16489009 regulation of protein-containing complex assembly ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of protein-containing complex assembly IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of transcription from RNA polymerase II promoter in response to iron ISO RGD:736907 1624291 (MGI:5527134, PMID:23395172) RGD MGI:5527134 , PMID:23395172 response to organic cyclic compound ISO RGD:736907 1624291 (MGI:5527134, PMID:23395172) RGD MGI:5527134 , PMID:23395172 Cellular Component cell surface ISO RGD:736906 1624291 (PMID:15220341) RGD PMID:15220341 cell surface IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular_component ND 1598407 04/2016: no relevant rat data RGD endolysosome IBA MGI:MGI:2146636 , PANTHER:PTN001418583 13792537 PMID:21873635 GO_Central endolysosome ISO RGD:736907 1624291 (MGI:5527134, PMID:23395172) RGD MGI:5527134 , PMID:23395172 extracellular region IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 extracellular region ISO RGD:736906 1624291 (PMID:18797515) RGD PMID:18797515 extracellular region IBA PANTHER:PTN002674770 more ... 13792537 PMID:21873635 GO_Central phagolysosome membrane ISO RGD:736907 1624291 (MGI:5527134, PMID:23395172) RGD MGI:5527134 , PMID:23395172 vesicle ISO RGD:736907 1624291 (MGI:5527134, PMID:23395172) RGD MGI:5527134 , PMID:23395172 Molecular Function cysteine-type endopeptidase inhibitor activity IEA InterPro:IPR000010 1600115 GO_REF:0000002 InterPro GO_REF:0000002 endopeptidase inhibitor activity IBA MGI:MGI:1890221 more ... 13792537 PMID:21873635 GO_Central heme binding ISO RGD:736906 1624291 (PMID:678554) RGD PMID:678554 heme binding ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 heme binding IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 heparan sulfate proteoglycan binding ISO RGD:736906 1624291 (PMID:15138272), (PMID:16436387) RGD PMID:15138272 , PMID:16436387 heparan sulfate proteoglycan binding ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 heparan sulfate proteoglycan binding IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 heparin binding ISO RGD:736906 1624291 (PMID:16436387), (PMID:21304106) RGD PMID:16436387 , PMID:21304106 heparin binding IBA PANTHER:PTN001418583 , UniProtKB:P04196 13792537 PMID:21873635 GO_Central heparin binding ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 heparin binding IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 immunoglobulin binding ISO RGD:736906 1624291 (PMID:10514432) RGD PMID:10514432 immunoglobulin binding ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 immunoglobulin binding IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 metal ion binding ISO RGD:736906 1624291 (PMID:678554) RGD PMID:678554 metal ion binding ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 molecular_function ND 1598407 04/2016: no relevant rat data RGD protein binding ISO RGD:736906 1624291 UniProtKB:A8MQ03 more ... RGD PMID:11134179 more ... protein binding ISO RGD:736907 1624291 UniProtKB:Q03350 (MGI:3530701 , PMID:15748999) RGD MGI:3530701 , PMID:15748999 serine-type endopeptidase inhibitor activity IBA MGI:MGI:2146636 , PANTHER:PTN001418583 13792537 PMID:21873635 GO_Central serine-type endopeptidase inhibitor activity ISO RGD:736907 1624291 MGI:3789962 (MGI:3789419 , PMID:15869579) RGD MGI:3789419 , PMID:15869579 signaling receptor binding ISO RGD:736906 1624291 (PMID:16436387) RGD PMID:16436387 signaling receptor binding ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 signaling receptor binding IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 zinc ion binding ISO RGD:736906 1624291 (PMID:15138272), (PMID:16436387), (PMID:21304106) RGD PMID:15138272 more ... zinc ion binding IBA PANTHER:PTN001418583 , UniProtKB:P04196 13792537 PMID:21873635 GO_Central zinc ion binding ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 zinc ion binding IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
