Hrg (histidine-rich glycoprotein)

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Gene: Hrg (histidine-rich glycoprotein) Rattus norvegicus

Analyze

Symbol:

Hrg (Ensembl: LOC681544)

Name:

histidine-rich glycoprotein (Ensembl:similar to histidine-rich glycoprotein)

RGD ID:

619808

Description:

Predicted to enable several functions, including heme binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of endothelial cell migration; and negative regulation of lamellipodium assembly. Predicted to act upstream of or within several processes, including heme export; negative regulation of fibrinolysis; and regulation of transcription by RNA polymerase II. Predicted to be located in cell surface; extracellular region; and lysosome. Human ortholog(s) of this gene implicated in thrombophilia due to HRG deficiency and thrombosis. Orthologous to human HRG (histidine rich glycoprotein); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

histidine-proline-rich glycoprotein; histidine-rich glycoprotein 1; HPRG; HRG1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HRG (histidine rich glycoprotein)	HGNC	Ensembl, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Hrg (histidine-rich glycoprotein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hrg (histidine rich glycoprotein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HRG (histidine rich glycoprotein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HRG (histidine rich glycoprotein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hrg (histidine rich glycoprotein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HRG (histidine rich glycoprotein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HRG (histidine rich glycoprotein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hrg (histidine rich glycoprotein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	HRG (histidine rich glycoprotein)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Hrg (histidine-rich glycoprotein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fetub (fetuin B)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	hrg	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	78,054,488 - 78,069,402 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	78,054,498 - 78,069,389 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	86,804,961 - 86,819,853 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	79,463,216 - 79,478,058 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	78,519,273 - 78,534,165 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	81,621,274 - 81,639,938 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	81,621,283 - 81,639,952 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	84,718,226 - 84,736,651 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	80,248,578 - 80,264,179 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	80,306,169 - 80,321,768 (-)	NCBI
Celera	11	76,927,058 - 76,941,902 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3MC syndrome 1 (ISO)

Breast Neoplasms (ISO)

Carotid Atherosclerosis (ISO)

genetic disease (ISO)

hemorrhagic disease (ISO)

pancreatic adenocarcinoma (ISO)

thrombophilia due to HRG deficiency (ISO)

thrombosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dinitrotoluene (EXP)

3-chloropropane-1,2-diol (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

cadmium atom (ISO)

cefaloridine (EXP)

CGP 52608 (ISO)

clofibrate (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

cyclosporin A (ISO)

D-glucose (ISO)

diarsenic trioxide (ISO)

doxorubicin (EXP)

endosulfan (ISO)

fructose (ISO)

furan (EXP)

gentamycin (EXP)

glucose (ISO)

glycidol (ISO)

graphite (EXP)

GW 4064 (ISO)

heparin (ISO)

irinotecan (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

Mesaconitine (EXP)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

nitrofen (EXP)

O-methyleugenol (ISO)

olanzapine (ISO)

ouabain (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (EXP,ISO)

potassium dichromate (ISO)

pravastatin (EXP,ISO)

resveratrol (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tauroursodeoxycholic acid (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

Triptolide (EXP,ISO)

troglitazone (ISO)

ursodeoxycholic acid (EXP)

valproic acid (EXP,ISO)

zaragozic acid A (EXP,ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antimicrobial humoral immune response mediated by antimicrobial peptide (ISO)

biological_process (ND)

defense response to fungus (ISO,ISS)

fibrinolysis (ISO)

heme export (ISO)

heme transport (IBA,ISO)

negative regulation of angiogenesis (ISO,ISS)

negative regulation of blood vessel endothelial cell migration (ISO,ISS)

negative regulation of cell adhesion (ISO,ISS)

negative regulation of cell adhesion mediated by integrin (ISO,ISS)

negative regulation of cell growth (ISO,ISS)

negative regulation of cell population proliferation (ISO,ISS)

negative regulation of endothelial cell chemotaxis (ISO,ISS)

negative regulation of fibrinolysis (IBA,ISO)

negative regulation of lamellipodium assembly (ISO,ISS)

negative regulation of vascular endothelial growth factor signaling pathway (ISO,ISS)

platelet activation (ISO,ISS)

positive regulation of apoptotic process (ISO,ISS)

positive regulation of blood vessel remodeling (ISO,ISS)

positive regulation of focal adhesion assembly (ISO,ISS)

positive regulation of immune response to tumor cell (ISO,ISS)

regulation of actin cytoskeleton organization (ISO,ISS)

regulation of blood coagulation (ISO,ISS)

regulation of gene expression (ISO,ISS)

regulation of peptidyl-tyrosine phosphorylation (ISO,ISS)

regulation of platelet activation (IBA,ISO,ISS)

regulation of protein-containing complex assembly (ISO,ISS)

regulation of transcription by RNA polymerase II (ISO)

response to organic cyclic compound (ISO)

Cellular Component

cell surface (ISO)

endolysosome (IBA,ISO)

extracellular region (IBA,ISO)

phagolysosome membrane (ISO)

vesicle (ISO)

Molecular Function

cysteine-type endopeptidase inhibitor activity (IEA)

heme binding (ISO,ISS)

heparan sulfate proteoglycan binding (ISO,ISS)

heparin binding (IBA,ISO,ISS)

immunoglobulin binding (ISO,ISS)

metal ion binding (ISO,ISS)

protein binding (ISO)

serine-type endopeptidase inhibitor activity (IBA,ISO)

signaling receptor binding (ISO,ISS)

zinc ion binding (IBA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Murine histidine-rich glycoprotein: cloning, characterization and cellular origin.	Hulett MD and Parish CR, Immunol Cell Biol 2000 Jun;78(3):280-7.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	Identification of potential prognostic biomarkers in patients with untreated, advanced pancreatic cancer from a phase 3 trial (Cancer and Leukemia Group B 80303).	Roberts AS, etal., Cancer. 2012 Jan 15;118(2):571-8. doi: 10.1002/cncr.26270. Epub 2011 Jun 28.
12.	HRG Tokushima: molecular and cellular characterization of histidine-rich glycoprotein (HRG) deficiency.	Shigekiyo T, etal., Blood. 1998 Jan 1;91(1):128-33.
13.	Heregulin, cysteine rich-61 and matrix metalloproteinase 9 expression in human carotid atherosclerotic plaques: relationship with clinical data.	Sigala F, etal., Eur J Vasc Endovasc Surg. 2006 Sep;32(3):238-45. doi: 10.1016/j.ejvs.2006.01.026. Epub 2006 Jun 13.

Additional References at PubMed

PMID:678554	PMID:6740558	PMID:10514432	PMID:12477932	PMID:14744774	PMID:15138272	PMID:15220341	PMID:15869579	PMID:16436387	PMID:16489009	PMID:18797515	PMID:19056867
PMID:19903770	PMID:21215706	PMID:21264222	PMID:21304106	PMID:22348394	PMID:22516433	PMID:23376485	PMID:23395172	PMID:23533145	PMID:27068509	PMID:31880188

Genomics

Comparative Map Data

Hrg
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	78,054,488 - 78,069,402 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	78,054,498 - 78,069,389 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	86,804,961 - 86,819,853 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	79,463,216 - 79,478,058 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	78,519,273 - 78,534,165 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	81,621,274 - 81,639,938 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	81,621,283 - 81,639,952 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	84,718,226 - 84,736,651 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	80,248,578 - 80,264,179 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	80,306,169 - 80,321,768 (-)	NCBI
Celera	11	76,927,058 - 76,941,902 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

HRG
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	186,666,014 - 186,678,234 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	186,660,216 - 186,678,234 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	186,383,803 - 186,396,023 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	187,866,492 - 187,878,717 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	187,866,499 - 187,878,724	NCBI
Celera	3	184,820,230 - 184,832,456 (+)	NCBI		Celera
Cytogenetic Map	3	q27.3	NCBI
HuRef	3	183,793,470 - 183,805,692 (+)	NCBI		HuRef
CHM1_1	3	186,347,752 - 186,359,974 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	189,487,766 - 189,499,996 (+)	NCBI		T2T-CHM13v2.0

Hrg
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	22,769,822 - 22,780,409 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	22,769,822 - 22,780,406 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	22,951,072 - 22,961,659 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	22,951,072 - 22,961,656 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	22,951,145 - 22,961,732 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	22,866,448 - 22,876,980 (+)	NCBI		MGSCv36	mm8
Celera	16	23,511,005 - 23,521,593 (+)	NCBI		Celera
Cytogenetic Map	16	B1	NCBI
cM Map	16	13.79	NCBI

Hrg
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	21,019,212 - 21,032,976 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	21,020,938 - 21,033,022 (-)	NCBI	ChiLan1.0	ChiLan1.0

HRG
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	3	184,546,549 - 184,558,787 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	183,701,069 - 183,712,365 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	192,168,299 - 192,180,539 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	192,168,299 - 192,180,539 (+)	Ensembl	panpan1.1		panPan2

HRG
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	19,276,487 - 19,286,540 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	19,276,549 - 19,286,537 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	23,361,891 - 23,371,917 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	19,187,471 - 19,197,522 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	19,187,509 - 19,197,783 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	19,219,778 - 19,229,696 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	19,219,621 - 19,229,772 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	19,448,102 - 19,458,128 (+)	NCBI		UU_Cfam_GSD_1.0

Hrg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	117,193,744 - 117,204,015 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936578	3,285,986 - 3,295,876 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936578	3,285,986 - 3,295,876 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HRG
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	124,505,312 - 124,516,705 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	124,505,305 - 124,516,387 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	133,895,233 - 133,906,338 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HRG
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	2,753,819 - 2,766,946 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	2,753,810 - 2,766,478 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	11,490,597 - 11,503,244 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hrg
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624730	70,070,302 - 70,086,256 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Hrg
306 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	56
Count of miRNA genes:	55
Interacting mature miRNAs:	56
Transcripts:	ENSRNOT00000047595
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	29528418	82566702	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	31239134	78851519	Rat
70180	BpQTLcluster10	Blood pressure QTL cluster 10	3.19		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	11	34918041	79918041	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	40946188	82566702	Rat
2312566	Glom20	Glomerulus QTL 20	3.6	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	44285759	82566702	Rat
1581565	Pur10	Proteinuria QTL 10		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
1581572	Uae35	Urinary albumin excretion QTL 35		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	54457534	86241447	Rat
4889521	Gluco62	Glucose level QTL 62	2.82	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	55136729	82993457	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	56351424	86241447	Rat
631506	Bp104	Blood pressure QTL 104	2.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	59802794	82566545	Rat
70208	Niddm22	Non-insulin dependent diabetes mellitus QTL 22	3.61		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	59802794	82566553	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	60346590	86241447	Rat
1549848	Bvd6	Brain ventricular dilatation QTL 6	3.1	0.0001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	66113321	82169223	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	66422148	86241447	Rat
1354593	Stl12	Serum triglyceride level QTL 12	3.36		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	11	66422148	86241447	Rat
1354656	Bvd3	Brain ventricular dilatation QTL 3	3.64	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	69446070	82846715	Rat
10450831	Scl80	Serum cholesterol level QTL 80	4.7	0.01	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	11	76957131	83051965	Rat

Markers in Region

RH130910

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	78,054,621 - 78,054,822 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	81,621,402 - 81,621,602	NCBI	Rnor6.0
Rnor_5.0	11	84,718,354 - 84,718,554	UniSTS	Rnor5.0
RGSC_v3.4	11	80,248,706 - 80,248,906	UniSTS	RGSC3.4
RGSC_v3.4	11	80,230,715 - 80,230,915	UniSTS	RGSC3.4
Celera	11	76,927,186 - 76,927,386	UniSTS
Celera	11	76,912,075 - 76,912,275	UniSTS
RH 3.4 Map	11	642.2	UniSTS
Cytogenetic Map	11	q23	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High		21	21		21
Medium		18	16		16				7	2	1
Low	5	17	4	14	4	7	7	7	16	8	7	7
Below cutoff	5	1		4		1	2	14	10	17		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133428	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB055895	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC089779	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000047595 ⟹ ENSRNOP00000049290

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	11	81,621,346 - 81,639,872 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000081864 ⟹ ENSRNOP00000072623

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	78,054,498 - 78,069,389 (-)	Ensembl
Rnor_6.0 Ensembl	11	81,621,283 - 81,639,952 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000090031 ⟹ ENSRNOP00000075182

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	11	81,621,325 - 81,639,876 (-)	Ensembl

RefSeq Acc Id:

NM_133428 ⟹ NP_596919

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	78,054,494 - 78,069,389 (-)	NCBI
Rnor_6.0	11	81,621,274 - 81,639,923 (-)	NCBI
Rnor_5.0	11	84,718,226 - 84,736,651 (-)	NCBI
RGSC_v3.4	11	80,248,578 - 80,264,179 (-)	RGD
Celera	11	76,927,058 - 76,941,902 (-)	NCBI

Sequence:

show sequence

ACTGTAGCATTCTCCACTATGGTGGACCACAGCCGAGGATGGTTTTGCACCATGAAGGTGCTCA
CCACGGCATTGCTTCTAGTCACCCTGCAGTGTTCCCATGCCCTGAGTCCCACCAACTGTGATGC
CTCCAAGCCTTTGGCTGAGAAAGTTCTAGACTTGATCAATAAAGGGCGGAGGAGTGGCTATACT
TTTCAGCTGCTGCGGGTCTCTGATGCCCACTTGGACAGAGTGGAAACTGCCACCATCTACTACT
TAGTTTTAGATGTGGTAGAATCTGACTGTTGGGTCCTCTCCACAAAAGCCCAGGATGAGTGTCT
TCCAGCCATGAGGACATCTGAGGTTGTGATTGGACAGTGTAAGGTAATAGCCACAAGATACTCC
AATGAGTCTCAAGATCTTAGCGTGAATGGCTATAACTGCACCATGAGATCCGTCTCTTCGGCAT
ATATCAACACCAAAGACAGTCCTGTACTAGTGGACTCATTTGAGGATTCCGAGCCCTACAGAAA
GCTAGCCCGTAAAGCCCTCGACAAGTACAAAGCGGAGAATGGTGACTTTGCCTCATTCAGAGTG
GAAAGGGCTGAAAGGGTTATAAGAATGAGAGGAGGGGAAAGAACCAGCTACTTCATAGAATTCT
CGGTGAGGAACTGTTCCACACAACACTTCCCCAGACACCCTCCGGTCTTTGGATTGTGCAGAGT
AGTTTTGACCTACAGTACAGAAGCCTCTGACTTGGAAACCCCAGAATACACTGACCTGATCTGT
GAAGTCTTCAACACTGAGGATCTTAAAAACAGGAGTGACATGAAACCCCATCGGGGCCATGAGC
ATCCTCATTGTGACAAACATCTGTGTAAGCTCAGTGGACCCAGGGACCATCATCATACCCATAA
GACACATGAAATTGGATGCCCACCACCACCAGAAGGAAAAGATAACTCAGACAGACCACCCCTT
CAAGAAGGAGCCCTTCCACAAATGCTCCCTGGCCATTCTGGTCCTTCTGGTACCAACAGGAGCC
ATAGACCCCCTCATAATCACAGTTGTAATGAGCATCCGTGCCATGGACAGCATCCCCATGGACA
CCACCCTCATGGTCAGCATCCCCATGGACACCACCCTCATGGTCAGCATCCCCATGGACACCAC
CCTCATGGTCAGCATCCCCATGGACACCACCCTCATGGTCAGCATCCCCATGGACACCACCCCC
ATGGTCACCATCCTCATGGTGACCATCCCCATGGACACCACCCCCATGGACATGATTTCCTTGA
CTATGGACCTTGTGACCCACCCTCCAATAGCCAAGAACTCAAGGGTCAGTATCATCGGGGACAT
GGTCCACCACACGGACACTCAAGGAAAAGAGGGCCAGGTAAAGGACTCTTTCCTTTCCACCAAC
GACAAATCGGATATGTCTACCGACTCCCTCCACTGAATGTAGGTGAAGTTCTCACTCCTCCTGA
AGCCAATTTCCCCATCTTCTCTTTGCCAAATTGCAACAGACCCCCACAACCAGAGATTCGGCCC
TTCCCTCAGACAGCCTCAAAGTCCTGTCCAGGGAAATTTGAGGGTAAGTTTCCACAAGTTTCCA
ACTTTTTTGAACATACGCCTCCAAAATAAAACCTGATTTCTTGGTAGGGGAAAGAGTACAATAT
TCTGAATAAATAAAATATGACCAGTTAGAAATGAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017597864 ⟹ XP_017453353

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	78,054,488 - 78,069,402 (-)	NCBI
Rnor_6.0	11	81,621,274 - 81,639,938 (-)	NCBI

Sequence:

show sequence

AACTGAGTGTGAGTCACTGTAGCATTCTCCACTATGGTGGACCACAGCCGAGGATGGTTTTGCA
CCATGAAGGTGCTCACCACGGCATTGCTTCTAGTCACCCTGCAGTGTTCCCATGCCCTGAGTCC
CACCAACTGTGATGCCTCCAAGCCTTTGGCTGAGAAAGTTCTAGACTTGATCAATAAAGGGCGG
AGGAGTGGCTATACTTTTCAGCTGCTGCGGGTCTCTGATGCCCACTTGGACAGAGTGGAAACTG
CCACCATCTACTACTTAGTTTTAGATGTGGTAGAATCTGACTGTTGGGTCCTCTCCACAAAAGC
CCAGGATGAGTGTCTTCCAGCCATGAGGACATCTGAGGTTGTGATTGGACAGTGTAAGGTAATA
GCCACAAGATACTCCAATGAGTCTCAAGATCTTAGCGTGAATGGCTATAACTGCACCATGAGAT
CCGTCTCTTCGGCATATATCAACACCAAAGACAGTCCTGTACTAGTGGACTCATTTGAGGATTC
CGAGCCCTACAGAAAGCTAGCCCGTAAAGCCCTCGACAAGTACAAAGCGGAGAATGGTGACTTT
GCCTCATTCAGAGTGGAAAGGGCTGAAAGGGTTATAAGAATGAGAGGAGGGGAAAGAACCAGCT
ACTTCATAGAATTCTCGGTGAGGAACTGTTCCACACAACACTTCCCCAGACACCCTCCGGTCTT
TGGATTGTGCAGAGTAGTTTTGACCTACAGTACAGAAGCCTCTGACTTGGAAACCCCAGAATAC
ACTGACCTGATCTGTGAAGTCTTCAACACTGAGGATCTTAAAAACAGGAGTGACATGAAACCCC
ATCGGGGCCATGAGCATCCTCATTGTGACAAACATCTGTGTAAGCTCAGTGGACCCAGGGACCA
TCATCATACCCATAAGACACATGAAATTGGATGCCCACCACCACCAGAAGGAAAAGATAACTCA
GACAGACCACCCCTTCAAGAAGGAGCCCTTCCACAAATGCTCCCTGGCCATTCTGGTCCTTCTG
GTACCAACAGGAGCCATAGACCCCCTCATAATCACAGTTGTAATGAGCATCCGTGCCATGGACA
GCATCCCCATGGACACCACCCTCATGGTCAGCATCCCCATGGACACCACCCTCATGGTCAGCAT
CCCCATGGACACCACCCTCATGGTCAGCATCCCCATGGACACCACCCCCATGGTCACCATCCTC
ATGGTGACCATCCCCATGGACACCACCCCCATGGACATGATTTCCTTGACTATGGACCTTGTGA
CCCACCCTCCAATAGCCAAGAACTCAAGGGTCAGTATCATCGGGGACATGGTCCACCACACGGA
CACTCAAGGAAAAGAGGGCCAGGTAAAGGACTCTTTCCTTTCCACCAACGACAAATCGGATATG
TCTACCGACTCCCTCCACTGAATGTAGGTGAAGTTCTCACTCCTCCTGAAGCCAATTTCCCCAT
CTTCTCTTTGCCAAATTGCAACAGACCCCCACAACCAGAGATTCGGCCCTTCCCTCAGACAGCC
TCAAAGTCCTGTCCAGGGAAATTTGAGGGTAAGTTTCCACAAGTTTCCAACTTTTTTGAACATA
CGCCTCCAAAATAAAACCTGATTTCTTGGTAGGGGAAAGAGTACAATATTCTGAATAAATAAAA
TATGACCAGTTAGAAATGAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_596919	(Get FASTA)	NCBI Sequence Viewer
	XP_017453353	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89779	(Get FASTA)	NCBI Sequence Viewer
	BAB33092	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000072623
	ENSRNOP00000072623.1
GenBank Protein	Q99PS8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_596919 ⟸ NM_133428
- Peptide Label:	precursor
- UniProtKB:	Q99PS7 (UniProtKB/Swiss-Prot), D3ZJN0 (UniProtKB/Swiss-Prot), Q9ESB2 (UniProtKB/Swiss-Prot), Q99PS8 (UniProtKB/Swiss-Prot), A0A0G2K3G0 (UniProtKB/TrEMBL), A6JS43 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKVLTTALLLVTLQCSHALSPTNCDASKPLAEKVLDLINKGRRSGYTFQLLRVSDAHLDRVETA TIYYLVLDVVESDCWVLSTKAQDECLPAMRTSEVVIGQCKVIATRYSNESQDLSVNGYNCTMRS VSSAYINTKDSPVLVDSFEDSEPYRKLARKALDKYKAENGDFASFRVERAERVIRMRGGERTSY FIEFSVRNCSTQHFPRHPPVFGLCRVVLTYSTEASDLETPEYTDLICEVFNTEDLKNRSDMKPH RGHEHPHCDKHLCKLSGPRDHHHTHKTHEIGCPPPPEGKDNSDRPPLQEGALPQMLPGHSGPSG TNRSHRPPHNHSCNEHPCHGQHPHGHHPHGQHPHGHHPHGQHPHGHHPHGQHPHGHHPHGQHPH GHHPHGHHPHGDHPHGHHPHGHDFLDYGPCDPPSNSQELKGQYHRGHGPPHGHSRKRGPGKGLF PFHQRQIGYVYRLPPLNVGEVLTPPEANFPIFSLPNCNRPPQPEIRPFPQTASKSCPGKFEGKF PQVSNFFEHTPPK hide sequence

RefSeq Acc Id:	XP_017453353 ⟸ XM_017597864
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K3G0 (UniProtKB/TrEMBL), A6JS43 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVDHSRGWFCTMKVLTTALLLVTLQCSHALSPTNCDASKPLAEKVLDLINKGRRSGYTFQLLRV SDAHLDRVETATIYYLVLDVVESDCWVLSTKAQDECLPAMRTSEVVIGQCKVIATRYSNESQDL SVNGYNCTMRSVSSAYINTKDSPVLVDSFEDSEPYRKLARKALDKYKAENGDFASFRVERAERV IRMRGGERTSYFIEFSVRNCSTQHFPRHPPVFGLCRVVLTYSTEASDLETPEYTDLICEVFNTE DLKNRSDMKPHRGHEHPHCDKHLCKLSGPRDHHHTHKTHEIGCPPPPEGKDNSDRPPLQEGALP QMLPGHSGPSGTNRSHRPPHNHSCNEHPCHGQHPHGHHPHGQHPHGHHPHGQHPHGHHPHGQHP HGHHPHGHHPHGDHPHGHHPHGHDFLDYGPCDPPSNSQELKGQYHRGHGPPHGHSRKRGPGKGL FPFHQRQIGYVYRLPPLNVGEVLTPPEANFPIFSLPNCNRPPQPEIRPFPQTASKSCPGKFEGK FPQVSNFFEHTPPK hide sequence

RefSeq Acc Id:

ENSRNOP00000075182 ⟸ ENSRNOT00000090031

RefSeq Acc Id:

ENSRNOP00000049290 ⟸ ENSRNOT00000047595

RefSeq Acc Id:

ENSRNOP00000072623 ⟸ ENSRNOT00000081864

Protein Domains

Cystatin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q99PS8-F1-model_v2	AlphaFold	Q99PS8	1-525	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698250

Promoter ID:

EPDNEW_R8773

Type:

multiple initiation site

Name:

Hrg_1

Description:

histidine-rich glycoprotein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	81,639,923 - 81,639,983	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619808	AgrOrtholog
BioCyc Gene	G2FUF-20831	BioCyc
Ensembl Genes	ENSRNOG00000001809	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000081864	ENTREZGENE
	ENSRNOT00000081864.2	UniProtKB/TrEMBL
Gene3D-CATH	3.10.450.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7371893	IMAGE-MGC_LOAD
InterPro	Cystatin_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cystatin_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:171016	UniProtKB/Swiss-Prot
	rno:681544	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108609	IMAGE-MGC_LOAD
NCBI Gene	171016	ENTREZGENE
PANTHER	FETUIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HISTIDINE-RICH GLYCOPROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Hrg	PhenoGen
RatGTEx	ENSRNOG00000001809	RatGTEx
SMART	SM00043	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF54403	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K3G0	ENTREZGENE, UniProtKB/TrEMBL
	A6JS43	ENTREZGENE, UniProtKB/TrEMBL
	D3ZJN0	ENTREZGENE
	HRG_RAT	UniProtKB/Swiss-Prot
	Q99PS7	ENTREZGENE
	Q99PS8	ENTREZGENE
	Q9ESB2	ENTREZGENE
UniProt Secondary	D3ZJN0	UniProtKB/Swiss-Prot
	Q99PS7	UniProtKB/Swiss-Prot
	Q9ESB2	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-26	Hrg	histidine-rich glycoprotein			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Hrg	histidine-rich glycoprotein			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_protein	contains 510 amino acids	632990

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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