Mcm4 (minichromosome maintenance complex component 4)

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Gene: Mcm4 (minichromosome maintenance complex component 4) Rattus norvegicus

Analyze

Symbol:

Mcm4

Name:

minichromosome maintenance complex component 4

RGD ID:

3060

Description:

Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Predicted to be involved in DNA metabolic process. Predicted to be located in nucleoplasm. Predicted to be part of CMG complex and MCM complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 54. Orthologous to human MCM4 (minichromosome maintenance complex component 4); PARTICIPATES IN cell cycle pathway, mitotic; DNA replication pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

DNA replication licensing factor MCM4; Mcmd4; mini chromosome maintenance deficient 4 homolog; mini chromosome maintenance deficient 4 homolog (S. cerevisiae); minichromosome maintenance deficient 4; minichromosome maintenance deficient 4 homolog; minichromosome maintenance deficient 4 homolog (S. cerevisiae)

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Related Pseudogenes:

Mcm4-ps1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	85,258,443 - 85,272,144 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	85,258,443 - 85,272,144 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	93,985,465 - 93,999,169 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	11	86,646,623 - 86,660,327 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	11	85,700,230 - 85,713,934 (+)	NCBI	Rnor_WKY
Rnor_6.0	11	89,511,191 - 89,524,892 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	89,511,191 - 89,524,892 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	92,565,514 - 92,579,215 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	87,169,742 - 87,183,443 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	87,215,525 - 87,215,708 (+)	NCBI
Celera	11	83,998,817 - 84,012,516 (+)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

immunodeficiency 26 (ISO)

immunodeficiency 54 (ISO)

microcephaly (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2-butoxyethanol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (EXP)

3-methylcholanthrene (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

4-nitrophenol (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atropine (ISO)

avobenzone (ISO)

azathioprine (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

corticosterone (EXP)

coumarin (EXP,ISO)

coumestrol (ISO)

CU-O LINKAGE (ISO)

cyclosporin A (ISO)

DDT (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP,ISO)

diethyl maleate (EXP)

dioxygen (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

equol (ISO)

ethanol (ISO)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

geldanamycin (ISO)

glycine betaine (EXP)

glyphosate (ISO)

GW 3965 (ISO)

GW 4064 (ISO)

hydrogen chloride (ISO)

hydrogen peroxide (ISO)

irinotecan (ISO)

ivermectin (ISO)

L-ascorbic acid (ISO)

lead(0) (ISO)

lead(2+) (ISO)

lidocaine (EXP)

lithium chloride (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methylmercury chloride (ISO)

N-(6-acetamidohexyl)acetamide (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (ISO)

N-nitrosodiethylamine (EXP,ISO)

nickel dichloride (ISO)

nimesulide (EXP)

Nonylphenol (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (ISO)

parathion (ISO)

PCB138 (ISO)

pentachlorophenol (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

piroxicam (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (EXP)

silicon dioxide (ISO)

silver(1+) nitrate (ISO)

simvastatin (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sunitinib (ISO)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

toluene 2,4-diisocyanate (ISO)

topotecan (EXP)

Tributyltin oxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (EXP)

troglitazone (ISO)

tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

vincristine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA strand elongation involved in DNA replication (IBA)

DNA unwinding involved in DNA replication (IBA,ISO)

double-strand break repair via break-induced replication (IBA)

mitotic DNA replication initiation (IBA)

Cellular Component

CMG complex (ISO)

MCM complex (IBA,ISO)

membrane (IEA)

nucleoplasm (ISO)

nucleus (IBA,ISO)

Molecular Function

ATP binding (IEA)

DNA helicase activity (ISO)

hydrolase activity (IEA)

protein binding (ISO)

single-stranded DNA binding (IBA,ISO)

single-stranded DNA helicase activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

cell cycle pathway, mitotic (IEA)

DNA replication pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Information Derived from GenBank Report	RGD, Sept. 2003

Additional References at PubMed

PMID:9305914	PMID:15917436	PMID:17296731	PMID:19135898	PMID:19946888	PMID:22082260	PMID:23264620	PMID:31505169

Genomics

Comparative Map Data

Mcm4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	85,258,443 - 85,272,144 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	85,258,443 - 85,272,144 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	93,985,465 - 93,999,169 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	11	86,646,623 - 86,660,327 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	11	85,700,230 - 85,713,934 (+)	NCBI	Rnor_WKY
Rnor_6.0	11	89,511,191 - 89,524,892 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	89,511,191 - 89,524,892 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	92,565,514 - 92,579,215 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	87,169,742 - 87,183,443 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	87,215,525 - 87,215,708 (+)	NCBI
Celera	11	83,998,817 - 84,012,516 (+)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

MCM4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	47,960,941 - 47,978,160 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	8	47,960,185 - 47,978,160 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	48,873,501 - 48,890,720 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	49,036,047 - 49,052,621 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	49,036,046 - 49,052,621	NCBI
Celera	8	44,858,902 - 44,875,475 (+)	NCBI		Celera
Cytogenetic Map	8	q11.21	NCBI
HuRef	8	44,335,726 - 44,353,327 (+)	NCBI		HuRef
CHM1_1	8	48,925,125 - 48,943,082 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	48,337,189 - 48,354,408 (+)	NCBI		T2T-CHM13v2.0

Mcm4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	15,441,761 - 15,455,264 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	15,441,761 - 15,455,264 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	15,623,897 - 15,637,400 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	15,623,897 - 15,637,400 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	15,623,990 - 15,637,493 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	15,537,681 - 15,550,934 (-)	NCBI		MGSCv36	mm8
Celera	16	16,200,304 - 16,213,825 (-)	NCBI		Celera
Cytogenetic Map	16	A2	NCBI
cM Map	16	10.09	NCBI

Mcm4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955454	7,891,456 - 7,908,462 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955454	7,891,646 - 7,908,240 (+)	NCBI	ChiLan1.0	ChiLan1.0

MCM4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	8	41,779,624 - 41,794,996 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	41,778,247 - 41,794,783 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	8	44,387,529 - 44,404,773 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

MCM4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	244,634 - 261,154 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	244,656 - 260,991 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	670,093 - 687,010 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	242,674 - 259,603 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	242,628 - 259,596 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	241,027 - 256,505 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	435,880 - 453,002 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	504,123 - 521,263 (+)	NCBI		UU_Cfam_GSD_1.0

Mcm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	79,515,218 - 79,532,505 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936590	4,704,972 - 4,722,427 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936590	4,705,028 - 4,722,320 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MCM4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	79,674,739 - 79,686,685 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	79,674,737 - 79,686,964 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	87,134,029 - 87,142,341 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MCM4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	44,120,291 - 44,136,625 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	44,120,301 - 44,138,193 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	97,951,742 - 97,968,921 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mcm4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	7,516,516 - 7,533,760 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624735	7,516,510 - 7,533,789 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mcm4
40 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	174
Count of miRNA genes:	129
Interacting mature miRNAs:	140
Transcripts:	ENSRNOT00000002510
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	54457534	86241447	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	56351424	86241447	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	60346590	86241447	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	66422148	86241447	Rat
1354593	Stl12	Serum triglyceride level QTL 12	3.36		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	11	66422148	86241447	Rat

Markers in Region

RH134441

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	141,554,236 - 141,554,419 (+)	MAPPER	mRatBN7.2
mRatBN7.2	11	85,271,807 - 85,271,994 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	89,524,556 - 89,524,742	NCBI	Rnor6.0
Rnor_6.0	2	147,480,234 - 147,480,416	NCBI	Rnor6.0
Rnor_5.0	11	92,578,879 - 92,579,065	UniSTS	Rnor5.0
Rnor_5.0	2	166,889,221 - 166,889,403	UniSTS	Rnor5.0
RGSC_v3.4	2	146,617,085 - 146,617,267	UniSTS	RGSC3.4
RGSC_v3.4	11	87,183,107 - 87,183,293	UniSTS	RGSC3.4
Celera	11	84,012,180 - 84,012,366	UniSTS
Celera	2	136,007,187 - 136,007,369	UniSTS
RH 3.4 Map	2	860.0	UniSTS
Cytogenetic Map	11	q23.2	UniSTS
Cytogenetic Map	2	q31	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	29	37	27	19	27	1	1	74	22	33	11	1
Low		14	20	14		14	7	10		13	8		7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_033651	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_358443	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_358444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF241614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226176	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000002510 ⟹ ENSRNOP00000002510

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	85,258,443 - 85,272,144 (+)	Ensembl
Rnor_6.0 Ensembl	11	89,511,191 - 89,524,892 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098009 ⟹ ENSRNOP00000090013

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	85,258,443 - 85,272,132 (+)	Ensembl

RefSeq Acc Id:

NM_033651 ⟹ NP_387500

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	85,258,443 - 85,272,144 (+)	NCBI
Rnor_6.0	11	89,511,191 - 89,524,892 (+)	NCBI
Rnor_5.0	11	92,565,514 - 92,579,215 (+)	NCBI
RGSC_v3.4	11	87,169,742 - 87,183,443 (+)	RGD
Celera	11	83,998,817 - 84,012,516 (+)	RGD

Sequence:

show sequence

GCCTCTCTGATTGGTCAGAAGCTGCTGGGCGCTGTGACGACAGAGCGGCTGGCGGGAATCGCTT
CAACCTGCGAGCCAGGAACGCACTCCTGGGTGTGCGTGTTTGCAACTAACCCGGATCCGAAGTA
CGAGAAGTCCCGTAACGGGACAACTGAGAGCCAGATTTCTCTAGTCGCGCAGCTACCACAGCAC
CATGTCGTCCCCGGCATCCACCCCAAGTCGCCGCAGCAGCCGACGCGGACGAGTCACCCCAACC
CAGTCGCTTCGAAGTGAGGAAAGCCGATCATCTCCCAGTGGGAGACGTAGAGGCGAAGATTCTT
CCACCGGAGAGTTGCTGCCAATGCCCACCTCACCAGGAGCAGACCTGCAGAGCCCAGCTGCACA
GAATGCCTTGTTTTCCAGCCCTCCTCAGATGCATTCTTCAGCTATTCCTTTGGAATTTGATGTT
AGTTCGCCATTGACATATGGCACTCCCAGCTCTCGAGTGGAAGGAACCCCAAGAAGTGGGGTGA
GAGGCACACCCATGAGGCAGAGGCCAGACCTGGGCTCAGCACGAAAGGGTTTGCAGGTGGATCT
GCAGTCTGACGGAGCAGCAGCAGAAGACACAGTAGCAAGTGAACAGTCTCTAGGCCAAAAGCTT
GTGATTTGGGGAACAGACGTGAATGTGGCAACATGCAAAGAACATTTTCAGAGATTCCTTCAAT
GTTTTACTGATCCTCTGGCCAAAGAAGAAGAAAATGTTGGCATAGATATTACGCAACCTTTGTA
CATGCAACGACTTGGAGAGATTAATATTACAGGAGAGCCATTTTTAAATGTGAACTGTGAACAC
ATAAAATCATTTGGCAAAAACTTGTATAGACAGCTCATCTCCTACCCACAGGAGGTTATACCAA
CCTTTGACATGGCTGTCAATGAGATCTTCTTTGACCGTTATCCTGACTCCATCTTAGAACATCA
GATTCAAGTCAGACCTTTTAATGCATTGAAGACAAAGAGTATGAGAAACTTGAATCCAGAAGAC
ATTGATCAGCTCATCACCATCAGTGGCATGGTTATCAGAACGTCACAGCTGATTCCCGAGATGC
AGGAGGCCTTTTTCCAGTGCCAAGTCTGTGCCCATACCACCCGGGTAGAGATGGACCGAGGCCG
AATTGCTGAGCCCTGCACTTGCGTACACTGCCACACTACCCACAGTATGGCACTGATCCACAAC
CGTTCACTATTCTCTGACAAGCAGATGATCAAGCTTCAAGAGTCTCCTGAAGATATGCCTGCTG
GGCAGACACCTCACACTGTTGTCCTTTTTGCCCACAATGATCTTGTAGACAAGGTTCAGCCAGG
GGACAGAGTGAATGTCACAGGCATATATCGAGCAGTACCTATTCGAGTTAATCCAAGAGTGAGC
AACGTGAAGTCTGTCTATAAAACCCACATTGATGTCATCCATTATCGGAAAACGGATGCAAAAC
GTCTGCATGGCCTTGATGAAGAAGCAGAACAGAAACTTTTTTCAGAGAAACGTGTGAAATTGCT
TAAGGAACTTTCCAGGAAGCCAGATATTTATGAGCGGCTTGCTTCAGCCTTGGCTCCCAGCATT
TATGAACATGAAGATATAAAAAAGGGAATCCTACTTCAACTCTTTGGTGGAACAAGGAAGGATT
TCAGTCACACTGGAAGGGGTAAATTCCGTGCTGAGATTAACATCCTTCTGTGTGGTGACCCTGG
CACCAGCAAGTCCCAGCTGCTACAGTATGTATACAACCTGGTTCCCAGAGGCCAGTACACATCT
GGAAAAGGCTCCAGTGCAGTTGGCCTCACAGCCTATGTGATGAAAGACCCTGAGACCAGGCAGC
TTGTCCTCCAGACAGGTGCCCTTGTACTGAGTGACAATGGCATATGTTGCATTGATGAGTTTGA
CAAAATGAATGAAAGCACAAGGTCCGTGCTGCATGAGGTCATGGAACAGCAGACTCTGTCCATT
GCAAAGGCTGGGATCATCTGTCAGCTCAATGCACGAACCTCTGTCCTGGCAGCAGCAAACCCTA
TTGAGTCCCAGTGGAACCCTAAAAAAACAACCATTGAAAATATCCAACTACCACACACACTGTT
GTCAAGGTTTGATCTCATTTTCCTCATGCTAGACCCTCAAGATGAGGCATATGACCGACGCCTA
GCCCACCACCTGGTTTCATTGTACTACCAAAGTGAGGAGCAGGTGGAGCAGGAGTTCCTGGACA
TGGCAGTGCTGAAAGACTACATTGCCTATGCACATAGTACTATCATGCCCCGGCTGAGTGAGGA
GGCCAGCCAGGCTCTCATTGAGGCTTATGTAAACATGAGGAAGATCGGGAGTAGTCGGGGGATG
GTTTCTGCTTACCCTCGACAGCTAGAGTCATTAATTCGCTTAGCAGAAGCCCATGCTAAAGTAA
GATTTTCAGACAAAGTTGAAGCAATCGATGTGGAAGAGGCAAAACGCCTTCACCGGGAGGCTCT
GAAGCAGTCTGCCACTGACCCTCGCACTGGCATTGTGGACATATCTATTCTTACTACAGGAATG
AGTGCCACTTCTCGTAAACGGAAAGAAGAATTAGCTGAAGCACTGAGAAAACTTATTTTATCTA
AGGGTAAAACACCAGCCTTAAAGTACCAACAGCTATTTGAGGATATTCGGGGACAATCTGACAC
AGCAATTACCAAGGACATGTTTGAAGAGGCCCTGCGTGCTTTGGCTGATGATGATTTCCTAACA
GTGACTGGGAAGACTGTCCGCCTACTCTGAGCTGCATGTTCCTTGGACTAGAGTCAGTCACTAT
TGTTACTGATGCAAATGGAGTCTGAAAGGCAGTATTCCACTATATAAACATTTTCTATAGGGAT
GTGTTTTGTTAGTAAATGTATGTTTTCACCTTTAAATTTTAAATTATATCAGCATATACAGGAG
AGGTTATATTTTCAATATGCCATAGTTTTTAAGCAGCTTGCATCTTACCTGTTTAAATGCAAAG
AGCCTAAGCCCAGTTTTGGATTTTTTTTTTTTTTTTTTTTAATCTGGGGGCTTTTCCTTTGTTG
TGCTGCAGGGCTGGGGATAGAGCTAAGAGTACCATGCATGCTGTATGTCTAATTATGTGCGTGG
AGGTAACAAATTGGCCGAGATACATCCTTTATTGTGATGTGAAGGGCTAAGGATTTTTATAGCA
CCTGGACTTAACTTTCTTTATAGAGAGTTTTCCCCCTATTATTAGAACAAAAATATGCTTGAAA
AATTATTAGATCAAGTTGCCTTCTGTTTTTTCCTAATATGTAAAACATGTTCCTAAATAAATGA
TAGAAAAGTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_387500	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAK01320	(Get FASTA)	NCBI Sequence Viewer
	EDL77837	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_387500 ⟸ NM_033651

- UniProtKB:

G3V681 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSSPASTPSRRSSRRGRVTPTQSLRSEESRSSPSGRRRGEDSSTGELLPMPTSPGADLQSPAAQ
NALFSSPPQMHSSAIPLEFDVSSPLTYGTPSSRVEGTPRSGVRGTPMRQRPDLGSARKGLQVDL
QSDGAAAEDTVASEQSLGQKLVIWGTDVNVATCKEHFQRFLQCFTDPLAKEEENVGIDITQPLY
MQRLGEINITGEPFLNVNCEHIKSFGKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQ
IQVRPFNALKTKSMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGR
IAEPCTCVHCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVVLFAHNDLVDKVQPG
DRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVKLL
KELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPG
TSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFD
KMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLL
SRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEEQVEQEFLDMAVLKDYIAYAHSTIMPRLSEE
ASQALIEAYVNMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRFSDKVEAIDVEEAKRLHREAL
KQSATDPRTGIVDISILTTGMSATSRKRKEELAEALRKLILSKGKTPALKYQQLFEDIRGQSDT
AITKDMFEEALRALADDDFLTVTGKTVRLL

hide sequence

RefSeq Acc Id:

ENSRNOP00000002510 ⟸ ENSRNOT00000002510

RefSeq Acc Id:

ENSRNOP00000090013 ⟸ ENSRNOT00000098009

Protein Domains

MCM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V681-F1-model_v2	AlphaFold	G3V681	1-862	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698352

Promoter ID:

EPDNEW_R8877

Type:

initiation region

Name:

Mcm4_1

Description:

minichromosome maintenance complex component 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	89,511,256 - 89,511,316	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3060	AgrOrtholog
BioCyc Gene	G2FUF-20540	BioCyc
Ensembl Genes	ENSRNOG00000001833	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000002510	ENTREZGENE
	ENSRNOP00000002510.5	UniProtKB/TrEMBL
	ENSRNOP00000090013.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002510	ENTREZGENE
	ENSRNOT00000002510.7	UniProtKB/TrEMBL
	ENSRNOT00000098009.1	UniProtKB/TrEMBL
Gene3D-CATH	2.20.28.10	UniProtKB/TrEMBL
	2.40.50.140	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	mini-chromosome maintenance (MCM) complex, chain A, domain 1	UniProtKB/TrEMBL
InterPro	MCM	UniProtKB/TrEMBL
	MCM_4	UniProtKB/TrEMBL
	MCM_CS	UniProtKB/TrEMBL
	MCM_DNA-dep_ATPase	UniProtKB/TrEMBL
	MCM_lid	UniProtKB/TrEMBL
	MCM_N	UniProtKB/TrEMBL
	MCM_OB	UniProtKB/TrEMBL
	NA-bd_OB-fold	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
KEGG Report	rno:29728	UniProtKB/TrEMBL
NCBI Gene	29728	ENTREZGENE
PANTHER	PTHR11630	UniProtKB/TrEMBL
	PTHR11630:SF66	UniProtKB/TrEMBL
Pfam	MCM	UniProtKB/TrEMBL
	MCM_lid	UniProtKB/TrEMBL
	MCM_N	UniProtKB/TrEMBL
	MCM_OB	UniProtKB/TrEMBL
PhenoGen	Mcm4	PhenoGen
PRINTS	MCMFAMILY	UniProtKB/TrEMBL
	MCMPROTEIN4	UniProtKB/TrEMBL
PROSITE	MCM_1	UniProtKB/TrEMBL
	MCM_2	UniProtKB/TrEMBL
SMART	MCM	UniProtKB/TrEMBL
Superfamily-SCOP	Nucleic_acid_OB	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8I6AAZ2_RAT	UniProtKB/TrEMBL
	G3V681	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-24	Mcm4	minichromosome maintenance complex component 4	Mcm4	minichromosome maintenance deficient 4 homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	Mcm4	minichromosome maintenance deficient 4 homolog (S. cerevisiae)	Mcmd4	mini chromosome maintenance deficient 4 homolog (S. cerevisiae)	Symbol and Name updated	1299863	APPROVED
2002-06-10	Mcmd4	Mini chromosome maintenance deficient 4 homolog (S. cerevisiae)			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)