MCM4 (minichromosome maintenance complex component 4) - Rat Genome Database

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Gene: MCM4 (minichromosome maintenance complex component 4) Canis lupus familiaris
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Symbol: MCM4
Name: minichromosome maintenance complex component 4
RGD ID: 12209120
Description: ENCODES a protein that exhibits DNA helicase activity (ortholog); INVOLVED IN DNA unwinding involved in DNA replication (ortholog); ASSOCIATED WITH immunodeficiency 54 (ortholog); microcephaly (ortholog); FOUND IN CMG complex (ortholog); MCM complex (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: DNA replication licensing factor MCM4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.129244,634 - 261,154 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl29244,656 - 260,991 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha29670,093 - 687,010 (+)NCBI
ROS_Cfam_1.029242,674 - 259,603 (+)NCBI
UMICH_Zoey_3.129241,027 - 256,505 (+)NCBI
UNSW_CanFamBas_1.029435,880 - 453,002 (+)NCBI
UU_Cfam_GSD_1.029504,123 - 521,263 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
CMG complex  (ISO)
MCM complex  (IBA,ISO)
nucleoplasm  (ISO)
nucleus  (IBA)

Molecular Function

References

Genomics

Comparative Map Data
MCM4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.129244,634 - 261,154 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl29244,656 - 260,991 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha29670,093 - 687,010 (+)NCBI
ROS_Cfam_1.029242,674 - 259,603 (+)NCBI
UMICH_Zoey_3.129241,027 - 256,505 (+)NCBI
UNSW_CanFamBas_1.029435,880 - 453,002 (+)NCBI
UU_Cfam_GSD_1.029504,123 - 521,263 (+)NCBI
MCM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl847,960,185 - 47,978,160 (+)EnsemblGRCh38hg38GRCh38
GRCh38847,960,941 - 47,978,160 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37848,873,501 - 48,890,720 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36849,036,047 - 49,052,621 (+)NCBINCBI36hg18NCBI36
Build 34849,036,046 - 49,052,621NCBI
Celera844,858,902 - 44,875,475 (+)NCBI
Cytogenetic Map8q11.21NCBI
HuRef844,335,726 - 44,353,327 (+)NCBIHuRef
CHM1_1848,925,125 - 48,943,082 (+)NCBICHM1_1
Mcm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391615,441,761 - 15,455,264 (-)NCBIGRCm39mm39
GRCm39 Ensembl1615,441,761 - 15,455,264 (-)Ensembl
GRCm381615,623,897 - 15,637,400 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1615,623,897 - 15,637,400 (-)EnsemblGRCm38mm10GRCm38
MGSCv371615,623,990 - 15,637,493 (-)NCBIGRCm37mm9NCBIm37
MGSCv361615,537,681 - 15,550,934 (-)NCBImm8
Celera1616,200,304 - 16,213,825 (-)NCBICelera
Cytogenetic Map16A2NCBI
cM Map1610.09NCBI
Mcm4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21185,258,443 - 85,272,144 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1185,258,443 - 85,272,144 (+)Ensembl
Rnor_6.01189,511,191 - 89,524,892 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,511,191 - 89,524,892 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01192,565,514 - 92,579,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,169,742 - 87,183,443 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11187,215,525 - 87,215,708 (+)NCBI
Celera1183,998,817 - 84,012,516 (+)NCBICelera
Cytogenetic Map11q23NCBI
Mcm4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554547,891,456 - 7,908,462 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554547,891,646 - 7,908,240 (+)NCBIChiLan1.0ChiLan1.0
MCM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1841,779,624 - 41,794,996 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl841,778,247 - 41,794,783 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0844,387,529 - 44,404,773 (+)NCBIMhudiblu_PPA_v0panPan3
Mcm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530379,515,218 - 79,532,505 (-)NCBI
SpeTri2.0NW_0049365904,705,028 - 4,722,320 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCM4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl479,674,737 - 79,687,307 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1479,674,737 - 79,686,964 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2487,134,029 - 87,142,341 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MCM4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1844,120,291 - 44,136,625 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl844,120,301 - 44,138,193 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603997,951,742 - 97,968,921 (-)NCBIVero_WHO_p1.0
Mcm4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247357,516,510 - 7,533,789 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 10 6 6 5 5
Low 2 5 12 6 6 6 7 8 5 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000010664   ⟹   ENSCAFP00000009885
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl29244,656 - 260,991 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000067077   ⟹   ENSCAFP00000058582
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl29244,656 - 260,991 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000089452   ⟹   ENSCAFP00000064711
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl29244,656 - 260,991 (+)Ensembl
RefSeq Acc Id: XM_038441130   ⟹   XP_038297058
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.029242,674 - 259,603 (+)NCBI
RefSeq Acc Id: XM_038515697   ⟹   XP_038371625
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.129241,027 - 256,505 (+)NCBI
RefSeq Acc Id: XM_038515698   ⟹   XP_038371626
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.129241,342 - 256,505 (+)NCBI
RefSeq Acc Id: XM_038579263   ⟹   XP_038435191
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.029504,123 - 521,263 (+)NCBI
RefSeq Acc Id: XM_038643503   ⟹   XP_038499431
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.029435,880 - 453,002 (+)NCBI
RefSeq Acc Id: XM_535063   ⟹   XP_535063
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.129244,634 - 261,154 (+)NCBI
Dog10K_Boxer_Tasha29670,093 - 687,010 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_535063   ⟸   XM_535063
- Peptide Label: isoform X1
- UniProtKB: F6V1U9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000009885   ⟸   ENSCAFT00000010664
RefSeq Acc Id: ENSCAFP00000058582   ⟸   ENSCAFT00000067077
RefSeq Acc Id: ENSCAFP00000064711   ⟸   ENSCAFT00000089452
RefSeq Acc Id: XP_038371625   ⟸   XM_038515697
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038371626   ⟸   XM_038515698
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038499431   ⟸   XM_038643503
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038297058   ⟸   XM_038441130
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038435191   ⟸   XM_038579263
- Peptide Label: isoform X1

Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
29 245247 245248 G T snv Doberman Pinscher (DO263), Alpine Dachsbracke (AD009), Doberman Pinscher (DO159), Malinois (MA142), Doberman Pinscher (DO242)
29 249468 249469 A G snv Lagotto Romagnolo (LR390)
29 254812 254813 G A snv Border Terrier (SRS932144)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006598 Ensembl
NCBI Gene MCM4 ENTREZGENE
UniProt F6V1U9 ENTREZGENE
VGNC ID VGNC:43084 ENTREZGENE