Mcm4 (minichromosome maintenance complex component 4) - Rat Genome Database

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Gene: Mcm4 (minichromosome maintenance complex component 4) Mus musculus
Analyze
Symbol: Mcm4
Name: minichromosome maintenance complex component 4
RGD ID: 735579
MGI Page MGI
Description: Enables single-stranded DNA binding activity. Contributes to DNA helicase activity. Acts upstream of or within DNA unwinding involved in DNA replication. Part of MCM complex. Is expressed in several structures, including brain; future brain; limb; metanephros; and myocardium layer. Human ortholog(s) of this gene implicated in immunodeficiency 54. Orthologous to human MCM4 (minichromosome maintenance complex component 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 19G; AI325074; AU045576; Cdc21; CDC21 homolog; DNA replication licensing factor MCM4; KIAA4003; mcdc21; Mcmd4; mini chromosome maintenance deficient 4 homolog; minichromosome maintenance deficient 4 homolog; mKIAA4003; P1-CDC21
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm9577  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391615,441,761 - 15,455,264 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1615,441,761 - 15,455,264 (-)EnsemblGRCm39 Ensembl
GRCm381615,623,897 - 15,637,400 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1615,623,897 - 15,637,400 (-)EnsemblGRCm38mm10GRCm38
MGSCv371615,623,990 - 15,637,493 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361615,537,681 - 15,550,934 (-)NCBIMGSCv36mm8
Celera1616,200,304 - 16,213,825 (-)NCBICelera
Cytogenetic Map16A2NCBI
cM Map1610.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-butoxyethanol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nitrophenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atropine  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
DDT  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl maleate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
equol  (ISO)
ethanol  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (ISO)
geldanamycin  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lidocaine  (ISO)
lithium chloride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
N-(6-acetamidohexyl)acetamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel dichloride  (ISO)
nimesulide  (ISO)
Nonylphenol  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (ISO)
parathion  (ISO)
PCB138  (EXP)
pentachlorophenol  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
CMG complex  (ISO)
MCM complex  (IBA,IDA,ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO,NAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cell cycle  (IAGP)
abnormal cell nucleus morphology  (IAGP)
abnormal digestive system development  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal pluripotent precursor cell morphology  (IAGP)
absent inner cell mass proliferation  (IAGP)
chromosomal instability  (IAGP)
decreased body weight  (IAGP)
decreased cell proliferation  (IAGP)
decreased DN1 thymic pro-T cell number  (IAGP)
decreased fibroblast proliferation  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality prior to organogenesis  (IEA)
embryonic lethality prior to tooth bud stage  (IEA)
embryonic lethality, complete penetrance  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
fetal growth retardation  (IAGP)
increased acute lymphoblastic leukemia incidence  (IAGP)
increased grip strength  (IEA)
increased hepatocellular carcinoma incidence  (IAGP)
increased leukemia incidence  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased mammary gland tumor incidence  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased tumor incidence  (IAGP)
induced chromosome breakage  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
reticulocytosis  (IAGP)
spontaneous chromosome breakage  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1628827   PMID:7610039   PMID:9077461   PMID:9716665   PMID:9747039   PMID:9798653   PMID:10349636   PMID:10567526   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11568184  
PMID:12207017   PMID:12477932   PMID:12520002   PMID:12807961   PMID:12904583   PMID:14610273   PMID:15782199   PMID:15890332   PMID:15917436   PMID:16141072   PMID:16141073   PMID:17046832  
PMID:17143284   PMID:17389615   PMID:17495541   PMID:18606811   PMID:18799693   PMID:20059953   PMID:20421204   PMID:20838603   PMID:21220507   PMID:21267068   PMID:21440680   PMID:21611832  
PMID:21873635   PMID:21987787   PMID:22354167   PMID:22354170   PMID:22362746   PMID:22474384   PMID:22516201   PMID:22560297   PMID:22851646   PMID:23133403   PMID:23264620   PMID:23471215  
PMID:23975433   PMID:24194600   PMID:24457600   PMID:24589582   PMID:24821722   PMID:26167872   PMID:26206133   PMID:26365490   PMID:27280691   PMID:27757957   PMID:28378742   PMID:30069701  
PMID:30108253   PMID:30333137   PMID:30457570   PMID:30550785   PMID:30787433   PMID:31601942   PMID:32071286   PMID:32325033   PMID:34162889   PMID:34321999   PMID:36114006   PMID:37028609  


Genomics

Comparative Map Data
Mcm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391615,441,761 - 15,455,264 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1615,441,761 - 15,455,264 (-)EnsemblGRCm39 Ensembl
GRCm381615,623,897 - 15,637,400 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1615,623,897 - 15,637,400 (-)EnsemblGRCm38mm10GRCm38
MGSCv371615,623,990 - 15,637,493 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361615,537,681 - 15,550,934 (-)NCBIMGSCv36mm8
Celera1616,200,304 - 16,213,825 (-)NCBICelera
Cytogenetic Map16A2NCBI
cM Map1610.09NCBI
MCM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38847,960,941 - 47,978,160 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl847,960,185 - 47,978,160 (+)EnsemblGRCh38hg38GRCh38
GRCh37848,873,501 - 48,890,720 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36849,036,047 - 49,052,621 (+)NCBINCBI36Build 36hg18NCBI36
Build 34849,036,046 - 49,052,621NCBI
Celera844,858,902 - 44,875,475 (+)NCBICelera
Cytogenetic Map8q11.21NCBI
HuRef844,335,726 - 44,353,327 (+)NCBIHuRef
CHM1_1848,925,125 - 48,943,082 (+)NCBICHM1_1
T2T-CHM13v2.0848,337,189 - 48,354,408 (+)NCBIT2T-CHM13v2.0
Mcm4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,762,599 - 98,776,300 (+)NCBIGRCr8
mRatBN7.21185,258,443 - 85,272,144 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1185,258,443 - 85,272,144 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,985,465 - 93,999,169 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,646,623 - 86,660,327 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,700,230 - 85,713,934 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01189,511,191 - 89,524,892 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,511,191 - 89,524,892 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01192,565,514 - 92,579,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,169,742 - 87,183,443 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,215,525 - 87,215,708 (+)NCBI
Celera1183,998,817 - 84,012,516 (+)NCBICelera
Cytogenetic Map11q23NCBI
Mcm4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554547,891,456 - 7,908,462 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554547,891,646 - 7,908,240 (+)NCBIChiLan1.0ChiLan1.0
MCM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2763,594,184 - 63,611,453 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1839,287,937 - 39,304,974 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0844,387,529 - 44,404,773 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1841,779,624 - 41,794,996 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl841,778,247 - 41,794,783 (+)Ensemblpanpan1.1panPan2
MCM4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.129244,634 - 261,154 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl29244,656 - 260,991 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha29670,093 - 687,010 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.029242,674 - 259,603 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl29242,628 - 259,596 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.129241,027 - 256,505 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.029435,880 - 453,002 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.029504,123 - 521,263 (+)NCBIUU_Cfam_GSD_1.0
Mcm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530379,515,218 - 79,532,505 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365904,704,972 - 4,722,427 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365904,705,028 - 4,722,320 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCM4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl479,674,739 - 79,686,685 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1479,674,737 - 79,686,964 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2487,134,029 - 87,142,341 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MCM4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1844,120,291 - 44,136,625 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl844,120,301 - 44,138,193 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603997,951,742 - 97,968,921 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcm4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247357,516,516 - 7,533,760 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247357,516,510 - 7,533,789 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mcm4
165 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:167
Count of miRNA genes:151
Interacting mature miRNAs:156
Transcripts:ENSMUST00000023353
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
1302106Rapop1_mradiation-induced apoptosis 1 (mouse)Not determined16378077915731053Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
15092082Igly9_mIgG glycosylation 9, GP17b (mouse)161477522320103513Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse

Markers in Region
AI325074  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381615,624,288 - 15,624,399UniSTSGRCm38
MGSCv371615,624,381 - 15,624,492UniSTSGRCm37
Celera1616,200,695 - 16,200,806UniSTS
Cytogenetic Map16B1UniSTS
cM Map169.2UniSTS
Whitehead/MRC_RH16123.99UniSTS
AU045576  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381615,624,288 - 15,624,441UniSTSGRCm38
MGSCv371615,624,381 - 15,624,534UniSTSGRCm37
Celera1616,200,695 - 16,200,848UniSTS
Cytogenetic Map16B1UniSTS
cM Map169.2UniSTS
Whitehead/MRC_RH16123.79UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB000629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D26089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH769492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U89402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000023353   ⟹   ENSMUSP00000023353
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1615,441,761 - 15,455,264 (-)Ensembl
GRCm38.p6 Ensembl1615,623,897 - 15,637,400 (-)Ensembl
RefSeq Acc Id: ENSMUST00000229606   ⟹   ENSMUSP00000155603
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1615,441,974 - 15,453,170 (-)Ensembl
GRCm38.p6 Ensembl1615,624,110 - 15,635,306 (-)Ensembl
RefSeq Acc Id: ENSMUST00000230437   ⟹   ENSMUSP00000155284
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1615,449,657 - 15,454,122 (-)Ensembl
GRCm38.p6 Ensembl1615,631,793 - 15,636,258 (-)Ensembl
RefSeq Acc Id: NM_008565   ⟹   NP_032591
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391615,441,761 - 15,455,264 (-)NCBI
GRCm381615,623,897 - 15,637,400 (-)ENTREZGENE
MGSCv371615,623,990 - 15,637,493 (-)RGD
Celera1616,200,304 - 16,213,825 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032591   ⟸   NM_008565
- UniProtKB: O89056 (UniProtKB/Swiss-Prot),   P49717 (UniProtKB/Swiss-Prot),   Q3UA65 (UniProtKB/TrEMBL),   Q542F4 (UniProtKB/TrEMBL),   Q921D5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000155284   ⟸   ENSMUST00000230437
RefSeq Acc Id: ENSMUSP00000155603   ⟸   ENSMUST00000229606
RefSeq Acc Id: ENSMUSP00000023353   ⟸   ENSMUST00000023353
Protein Domains
MCM   MCM AAA-lid   MCM N-terminal   MCM OB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49717-F1-model_v2 AlphaFold P49717 1-862 view protein structure

Promoters
RGD ID:6827382
Promoter ID:MM_KWN:20228
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_008565,   NM_011159,   UC007YHS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361615,637,301 - 15,638,067 (+)MPROMDB
RGD ID:8685534
Promoter ID:EPDNEW_M20798
Type:initiation region
Name:Mcm4_1
Description:Mus musculus minichromosome maintenance complex component 4 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381615,637,335 - 15,637,395EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103199 AgrOrtholog
Ensembl Genes ENSMUSG00000022673 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023353 ENTREZGENE
  ENSMUST00000023353.4 UniProtKB/Swiss-Prot
  ENSMUST00000229606.2 UniProtKB/TrEMBL
  ENSMUST00000230437.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  2.20.28.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mini-chromosome maintenance (MCM) complex, chain A, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MCM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_lid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_OB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report mmu:17217 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:103199 ENTREZGENE
NCBI Gene 17217 ENTREZGENE
PANTHER PTHR11630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11630:SF66 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MCM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM4_WHD UniProtKB/TrEMBL
  MCM_lid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_OB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mcm4 PhenoGen
PRINTS MCMFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCMPROTEIN4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MCM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MCM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50249 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2R8VHP7_MOUSE UniProtKB/TrEMBL
  A0A2R8VKJ4_MOUSE UniProtKB/TrEMBL
  MCM4_MOUSE UniProtKB/Swiss-Prot
  O89056 ENTREZGENE
  P49717 ENTREZGENE
  Q3UA65 ENTREZGENE, UniProtKB/TrEMBL
  Q3UXG9_MOUSE UniProtKB/TrEMBL
  Q542F4 ENTREZGENE, UniProtKB/TrEMBL
  Q5DTS8_MOUSE UniProtKB/TrEMBL
  Q8C1Z0_MOUSE UniProtKB/TrEMBL
  Q921D5 ENTREZGENE, UniProtKB/TrEMBL
  Q9D077_MOUSE UniProtKB/TrEMBL
UniProt Secondary O89056 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Mcm4  minichromosome maintenance complex component 4    minichromosome maintenance deficient 4 homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED