Dnajb11 (DnaJ heat shock protein family (Hsp40) member B11)

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Gene: Dnajb11 (DnaJ heat shock protein family (Hsp40) member B11) Rattus norvegicus

Analyze

Symbol:

Dnajb11

Name:

DnaJ heat shock protein family (Hsp40) member B11

RGD ID:

1307373

Description:

Predicted to have misfolded protein binding activity; signaling receptor binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including mRNA modification; negative regulation of neurogenesis; and positive regulation of ATPase activity. Localizes to endoplasmic reticulum chaperone complex. Human ortholog(s) of this gene implicated in polycystic kidney disease. Orthologous to human DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

DnaJ (Hsp40) homolog, subfamily B, member 11; dnaJ homolog subfamily B member 11; endoplasmic reticulum DNA J domain-containing protein 3; ER-associated dnaJ protein 3; ER-associated Hsp40 co-chaperone; ER-resident protein ERdj3; ERdj3; ERj3p; liver regeneration-related protein LRRGT00084; LOC360734; LRRGT00084; MGC112680

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	78,151,750 - 78,168,259 (-)	NCBI
Rnor_6.0 Ensembl	11	81,741,297 - 81,757,813 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	11	81,741,342 - 81,757,806 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	11	84,829,171 - 84,845,635 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	80,360,406 - 80,376,870 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	11	80,417,995 - 80,434,459 (-)	NCBI
Celera	11	77,022,552 - 77,038,995 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3MC syndrome 1 (ISO)

Polycystic Kidney Disease 6 with or without Polycystic Liver Disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

1H-pyrazole (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrabromodibenzodioxine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2,4-dinitrotoluene (EXP)

2-amino-2-deoxy-D-glucopyranose (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3H-1,2-dithiole-3-thione (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (ISO)

aldehydo-D-glucose (ISO)

amiodarone (ISO)

arsenous acid (ISO)

benzo[b]fluoranthene (ISO)

beta-D-glucosamine (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bufalin (ISO)

buta-1,3-diene (ISO)

cadmium dichloride (EXP)

calcium atom (ISO)

calcium(0) (ISO)

carbon nanotube (ISO)

chenodeoxycholic acid (ISO)

choline (EXP)

cis-caffeic acid (ISO)

cisplatin (ISO)

clobetasol (ISO)

coumarin (EXP)

cyclosporin A (ISO)

D-glucose (ISO)

deoxycholic acid (ISO)

diarsenic trioxide (ISO)

doxorubicin (EXP,ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

ethanol (ISO)

folic acid (EXP,ISO)

furan (ISO)

glafenine (EXP)

glucose (ISO)

glycochenodeoxycholic acid (ISO)

glycocholic acid (ISO)

glycodeoxycholic acid (ISO)

isoprenaline (ISO)

L-methionine (EXP)

nefazodone (ISO)

nickel atom (ISO)

nimesulide (EXP)

obeticholic acid (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

progesterone (ISO)

propiconazole (ISO)

resveratrol (ISO)

rotenone (EXP)

sodium arsenite (ISO)

sunitinib (ISO)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP,ISO)

tetrahydropalmatine (ISO)

thapsigargin (ISO)

titanium dioxide (ISO)

trans-caffeic acid (ISO)

trichloroethene (ISO)

trichostatin A (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mRNA modification (ISO)

negative regulation of neurogenesis (ISO)

positive regulation of ATPase activity (ISO)

protein folding (IEA)

protein maturation (ISO,ISS)

Cellular Component

chaperone complex (ISO)

cytoplasm (ISO)

endoplasmic reticulum (ISO)

endoplasmic reticulum chaperone complex (IDA)

endoplasmic reticulum lumen (IEA)

extracellular space (ISO)

nucleus (ISO)

Molecular Function

misfolded protein binding (ISO)

protein binding (ISO)

signaling receptor binding (ISO)

unfolded protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

codeine and morphine pharmacodynamics pathway (ISO)

codeine and morphine pharmacokinetics pathway (ISO)

Endoplasmic Reticulum-associated degradation pathway (IEA)

etoposide pharmacodynamics pathway (ISO)

etoposide pharmacokinetics pathway (ISO)

ibuprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacokinetics pathway (ISO)

irinotecan pharmacodynamics pathway (ISO)

irinotecan pharmacokinetics pathway (ISO)

paracetamol pharmacokinetics pathway (ISO)

phenytoin pharmacodynamics pathway (ISO)

retinol metabolic pathway (ISO)

sorafenib pharmacokinetics pathway (ISO)

vitamin A deficiency pathway (ISO)

References

References - curated


1.	GOA data from the GO Consortium
2.	Meunier L, etal., Mol Biol Cell. 2002 Dec;13(12):4456-69.
3.	MGD data from the GO Consortium
4.	Pipeline to import KEGG annotations from KEGG into RGD
5.	Pipeline to import SMPDB annotations from SMPDB into RGD
6.	RGD automated data pipeline
7.	RGD automated import pipeline for gene-chemical interactions
8.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:11584023	PMID:19946888	PMID:20335166	PMID:20335479	PMID:25002582	PMID:29706351	PMID:32203149

Genomics

Comparative Map Data

Dnajb11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	78,151,750 - 78,168,259 (-)	NCBI
Rnor_6.0 Ensembl	11	81,741,297 - 81,757,813 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	11	81,741,342 - 81,757,806 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	11	84,829,171 - 84,845,635 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	80,360,406 - 80,376,870 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	11	80,417,995 - 80,434,459 (-)	NCBI
Celera	11	77,022,552 - 77,038,995 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

DNAJB11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	3	186,567,403 - 186,585,800 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	3	186,570,720 - 186,585,793 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	3	186,288,509 - 186,303,582 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	187,771,161 - 187,786,283 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	3	187,771,168 - 187,786,290	NCBI
Celera	3	184,724,844 - 184,739,974 (+)	NCBI
Cytogenetic Map	3	q27.3	NCBI
HuRef	3	183,697,521 - 183,712,654 (+)	NCBI		HuRef
CHM1_1	3	186,252,403 - 186,267,524 (+)	NCBI		CHM1_1

Dnajb11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	22,676,595 - 22,698,384 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	16	22,676,595 - 22,698,384 (+)	Ensembl
GRCm38	16	22,857,845 - 22,879,634 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	22,857,845 - 22,879,634 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	22,857,939 - 22,879,707 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	16	22,773,252 - 22,787,713 (+)	NCBI			mm8
Celera	16	23,418,190 - 23,439,958 (+)	NCBI		Celera
Cytogenetic Map	16	B1	NCBI

Dnajb11
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955420	21,097,292 - 21,113,053 (-)	NCBI	ChiLan1.0	ChiLan1.0

DNAJB11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	3	192,069,326 - 192,084,943 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	3	183,601,386 - 183,617,013 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

DNAJB11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	34	19,182,400 - 19,202,238 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	34	19,182,850 - 19,202,229 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Dnajb11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936578	3,360,259 - 3,374,634 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DNAJB11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	13	124,387,921 - 124,409,967 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	133,779,407 - 133,801,470 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DNAJB11
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	2,841,377 - 2,858,192 (-)	NCBI

Dnajb11
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624730	70,173,024 - 70,185,492 (-)	NCBI

Position Markers

AU047899

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	11	81,752,417 - 81,752,593	NCBI	Rnor6.0
Rnor_5.0	11	84,840,246 - 84,840,422	UniSTS	Rnor5.0
RGSC_v3.4	11	80,371,481 - 80,371,657	UniSTS	RGSC3.4
Celera	11	77,033,606 - 77,033,782	UniSTS
Cytogenetic Map	11	q23	UniSTS

RH137511

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	11	81,741,466 - 81,741,652	NCBI	Rnor6.0
Rnor_5.0	11	84,829,295 - 84,829,481	UniSTS	Rnor5.0
RGSC_v3.4	11	80,360,530 - 80,360,716	UniSTS	RGSC3.4
Celera	11	77,022,676 - 77,022,862	UniSTS
Cytogenetic Map	11	q23	UniSTS

RH125461

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	11	81,741,566 - 81,741,660	NCBI	Rnor6.0
Rnor_5.0	11	84,829,395 - 84,829,489	UniSTS	Rnor5.0
RGSC_v3.4	11	80,360,630 - 80,360,724	UniSTS	RGSC3.4
Celera	11	77,022,776 - 77,022,870	UniSTS
Cytogenetic Map	11	q23	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	19016272	90463843	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	28314665	86994795	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	30435339	86714631	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	32155520	82443118	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	43090338	86714631	Rat
2312566	Glom20	Glomerulus QTL 20	3.6	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	46583209	86714631	Rat
1581565	Pur10	Proteinuria QTL 10		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	47264023	86994547	Rat
1581572	Uae35	Urinary albumin excretion QTL 35		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	47264023	86994547	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	57858810	90463843	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	59943023	90463843	Rat
4889521	Gluco62	Glucose level QTL 62	2.82	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	60109842	87141948	Rat
631506	Bp104	Blood pressure QTL 104	2.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	62653365	86714475	Rat
70208	Niddm22	Non-insulin dependent diabetes mellitus QTL 22	3.61		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	62653365	86714483	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	64494671	90463843	Rat
1549848	Bvd6	Brain ventricular dilatation QTL 6	3.1	0.0001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	69342319	86312439	Rat
1354593	Stl12	Serum triglyceride level QTL 12	3.36		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	11	69649708	90463843	Rat
1354656	Bvd3	Brain ventricular dilatation QTL 3	3.64	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	72720029	86994795	Rat
10450831	Scl80	Serum cholesterol level QTL 80	4.7	0.01	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	11	80358408	87200449	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	91
Count of miRNA genes:	74
Interacting mature miRNAs:	83
Transcripts:	ENSRNOT00000002462
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001015021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088500	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY387070	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC093384	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000002462 ⟹ ENSRNOP00000002462

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	11	81,741,297 - 81,757,813 (-)	Ensembl

RefSeq Acc Id:

NM_001015021 ⟹ NP_001015021

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	78,151,750 - 78,168,216 (-)	NCBI
Rnor_6.0	11	81,741,342 - 81,757,806 (-)	NCBI
Rnor_5.0	11	84,829,171 - 84,845,635 (-)	NCBI
RGSC_v3.4	11	80,360,406 - 80,376,870 (-)	RGD
Celera	11	77,022,552 - 77,038,995 (-)	RGD

Sequence:

show sequence

GCCTGGCTGCTCGCCGGCTTTGGGGCTCCCGGAAAGTGGCAGCTGAGGAAGGGGCGCACTACCT
GTCTCCGCGGCCAGGCAAGAGAGAGACCCGGGCGTGAGGCGGCCTCCTTGGGCTGGAAAGGCTG
GTCAGCCGACGCAGCGGCACGGGAGGCTGAGAGGGTGGGACCAGGGGACACCATGGCCCCGCAG
AACCTGAGCACCTTCTGCCTGTTGCTGCTGTACCTCATTGGGGCTGTGATCGCCGGGCGGGATT
TCTATAAGATCTTGGGAGTGCCTCGAAGCGCCTCCATAAAGGATATTAAGAAGGCCTACAGGAA
ACTGGCCCTGCAGCTTCACCCTGACCGGAACCCTGACGACCCCCAAGCCCAGGAGAAATTCCAG
GATCTGGGTGCTGCTTATGAGGTTCTGTCAGATAGTGAAAAACGAAAACAGTATGATACCTATG
GTGAAGAAGGCTTGAAAGATGGGCATCAGAGCTCCCACGGGGACATTTTTTCACACTTCTTCGG
AGATTTTGGGTTCATGTTTGGAGGAGCCCCTCGTCAGCAGGACAGGAATATTCCAAGAGGAAGT
GACATCATCGTAGATCTAGAAGTCACCTTGGAAGAAGTGTACGCAGGGAACTTTGTGGAAGTAG
TTAGAAACAAGCCCGTAGCCAGGCAGGCTCCTGGCAAACGGAAATGCAACTGTCGGCAGGAGAT
GCGAACCACACAGCTGGGACCAGGGCGCTTCCAAATGACCCAGGAAGTGGTTTGTGACGAGTGC
CCTAATGTCAAACTAGTGAATGAAGAACGAACACTAGAAGTGGAAATAGAGCCTGGGGTGAGAG
ATGGCATGGAGTACCCCTTTATTGGAGAAGGTGAGCCTCATGTGGATGGGGAACCCGGAGACTT
ACGGTTCCGAATCAAAGTTGTCAAGCACCGGATATTTGAGAGGAGAGGGGATGACCTGTACACA
AATGTGACTGTCTCACTGGTTGAGGCTCTGGTTGGCTTTGAGATGGACATAACTCACTTGGATG
GTCACAAGGTACACATTTCCCGGGACAAGATCACCAGGCCAGGAGCCAAGCTGTGGAAGAAAGG
GGAAGGACTGCCCAACTTTGATAACAACAACATCAAGGGCTCCTTGATAATCACCTTTGATGTG
GACTTTCCAAAGGAGCAGCTCACAGAGGAAGCAAAAGAAGGTATCAAGCAGCTTCTCAAACAAG
GGCCAGTGCAGAAGGTATACAACGGGCTGCAGGGCTATTAGAACTGAAGAACTGGACTCTGAAA
GAGTGGATCAGCGATATTTATTATCTGCAGGGGTTTTTGTGTGTGTTTCATTATTTTCAATATG
CAAGTTTGTCTTAATCCTTTTTTCCCTGATGATCGTCATGACACGAGCTAGAGGTTTGCGAATC
TGTCTATTGCATTCAGACAATGACCAGCAGAAGGTTACCTAATACCTCTCCCTCTGGGGATTTA
ACGTCTGGTGCTGCCCAAGGTTCAAGGAATAAAGTCTCAGAGGACTCCAGAGCACAGATGAGGG
TCAGAGACAACTGTTAGCTCTTTCAAAATGCCAACTGGAGAAGTGTGTTTTTAAATACACCTTG
TTATTTTTCCTTGACTCCTGCTTCTGTTTCCCGTGAGCCGATGGTAGTCTCCCATGAGGATGGG
CACACAGCATGCAGAGGAATGGTGAGCGCCCAGTTCCCAGGCCCCACTGAACACACATGGTGTC
TATAGCAACGAGCTCAAAGAGGCCCAATAGAGTAGAGACTGAGCCACACGAATTAAAGTTACAC
AAAGACCTCATTGTCTGTGAGAGAACATAATTTCCCGATTTCTTTGGTAATAATAAAATCTGAT
ATGGCTATTTTACTGTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039088500 ⟹ XP_038944428

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	78,151,757 - 78,168,259 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001015021	(Get FASTA)	NCBI Sequence Viewer
	XP_038944428	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH93384	(Get FASTA)	NCBI Sequence Viewer
	AAQ91040	(Get FASTA)	NCBI Sequence Viewer
	EDL78055	(Get FASTA)	NCBI Sequence Viewer
	Q6TUG0	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001015021 ⟸ NM_001015021
- Peptide Label:	precursor
- UniProtKB:	Q6TUG0 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAPQNLSTFCLLLLYLIGAVIAGRDFYKILGVPRSASIKDIKKAYRKLALQLHPDRNPDDPQAQ EKFQDLGAAYEVLSDSEKRKQYDTYGEEGLKDGHQSSHGDIFSHFFGDFGFMFGGAPRQQDRNI PRGSDIIVDLEVTLEEVYAGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVV CDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVVKHRIFERRGD DLYTNVTVSLVEALVGFEMDITHLDGHKVHISRDKITRPGAKLWKKGEGLPNFDNNNIKGSLII TFDVDFPKEQLTEEAKEGIKQLLKQGPVQKVYNGLQGY hide sequence

RefSeq Acc Id:

ENSRNOP00000002462 ⟸ ENSRNOT00000002462

RefSeq Acc Id:	XP_038944428 ⟸ XM_039088500
- Peptide Label:	isoform X1

Protein Domains

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698251

Promoter ID:

EPDNEW_R8776

Type:

initiation region

Name:

Dnajb11_1

Description:

DnaJ heat shock protein family member B11

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	81,757,804 - 81,757,864	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307373	AgrOrtholog
Ensembl Genes	ENSRNOG00000001803	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000002462	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000002462	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.287.110	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7389370	IMAGE-MGC_LOAD
InterPro	DnaJ_C	UniProtKB/Swiss-Prot
	DnaJ_domain	UniProtKB/Swiss-Prot
	DnaJ_domain_CS	UniProtKB/Swiss-Prot
	HSP40/DnaJ_pept-bd	UniProtKB/Swiss-Prot
	J_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:360734	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112680	IMAGE-MGC_LOAD
NCBI Gene	360734	ENTREZGENE
Pfam	DnaJ	UniProtKB/Swiss-Prot
	DnaJ_C	UniProtKB/Swiss-Prot
PhenoGen	Dnajb11	PhenoGen
PRINTS	JDOMAIN	UniProtKB/Swiss-Prot
PROSITE	DNAJ_1	UniProtKB/Swiss-Prot
	DNAJ_2	UniProtKB/Swiss-Prot
SMART	DnaJ	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF46565	UniProtKB/Swiss-Prot
	SSF49493	UniProtKB/Swiss-Prot
UniProt	DJB11_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-25	Dnajb11	DnaJ heat shock protein family (Hsp40) member B11	Dnajb11	DnaJ (Hsp40) homolog, subfamily B, member 11	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Dnajb11	DnaJ (Hsp40) homolog, subfamily B, member 11	Dnajb11_predicted	DnaJ (Hsp40) homolog, subfamily B, member 11 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Dnajb11_predicted	DnaJ (Hsp40) homolog, subfamily B, member 11 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)