Pcyt1a (phosphate cytidylyltransferase 1A, choline) - Rat Genome Database

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Gene: Pcyt1a (phosphate cytidylyltransferase 1A, choline) Rattus norvegicus
Analyze
Symbol: Pcyt1a
Name: phosphate cytidylyltransferase 1A, choline (Ensembl:phosphate cytidylyltransferase 1, choline, alpha)
RGD ID: 70515
Description: Enables several functions, including calmodulin binding activity; choline-phosphate cytidylyltransferase activity; and phosphatidylcholine binding activity. Involved in CDP-choline pathway. Located in endoplasmic reticulum; nuclear envelope; and plasma membrane. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to human PCYT1A (phosphate cytidylyltransferase 1A, choline); PARTICIPATES IN glycerophospholipid metabolic pathway; lamivudine pharmacokinetics pathway; INTERACTS WITH (R)-mevalonic acid; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CCT A; CCT-alpha; choline phosphate cytidylyltransferase 1 alpha; choline-phosphate cytidylyltransferase A; choline-phosphate cytidylyltransferase A-like; CT A; CTP; CTP:phosphocholine cytidylyl transferase; CTP:phosphocholine cytidylyltransferase A; CTP:phosphocholine cytidylyltransferase alpha; LOC100911343; MGC93248; phosphate cytidylyltransferase 1, choline, alpha; phosphate cytidylyltransferase 1, choline, alpha isoform; phosphorylcholine transferase A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21168,313,860 - 68,357,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,313,882 - 68,357,357 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,154,021 - 77,194,395 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01169,818,577 - 69,859,107 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01168,843,143 - 68,883,509 (-)NCBIRnor_WKY
Rnor_6.01171,547,865 - 71,592,037 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,548,222 - 71,591,502 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,632,576 - 74,676,227 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,133,325 - 70,173,686 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,190,913 - 70,212,531 (-)NCBI
Celera1167,749,599 - 67,789,957 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interdomain and membrane interactions of CTP:phosphocholine cytidylyltransferase revealed via limited proteolysis and mass spectrometry. Bogan MJ, etal., J Biol Chem. 2005 May 20;280(20):19613-24. doi: 10.1074/jbc.M414028200. Epub 2005 Feb 15.
2. Calmodulin binds and stabilizes the regulatory enzyme, CTP: phosphocholine cytidylyltransferase. Chen BB and Mallampalli RK, J Biol Chem. 2007 Nov 16;282(46):33494-506. Epub 2007 Sep 5.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Identification of lysine 122 and arginine 196 as important functional residues of rat CTP:phosphocholine cytidylyltransferase alpha. Helmink BA, etal., Biochemistry 2003 May 6;42(17):5043-51.
6. Both acidic and basic amino acids in an amphitropic enzyme, CTP:phosphocholine cytidylyltransferase, dictate its selectivity for anionic membranes. Johnson JE, etal., J Biol Chem 2003 Jan 3;278(1):514-22.
7. Cloning and expression of rat liver CTP: phosphocholine cytidylyltransferase: an amphipathic protein that controls phosphatidylcholine synthesis. Kalmar GB, etal., Proc Natl Acad Sci U S A 1990 Aug;87(16):6029-33.
8. Crystal structure of a mammalian CTP: phosphocholine cytidylyltransferase catalytic domain reveals novel active site residues within a highly conserved nucleotidyltransferase fold. Lee J, etal., J Biol Chem. 2009 Nov 27;284(48):33535-48. doi: 10.1074/jbc.M109.053363. Epub 2009 Sep 25.
9. Baculovirus-mediated expression of rat liver CTP:phosphocholine cytidylyltransferase. MacDonald JI and Kent C, Protein Expr Purif 1993 Feb;4(1):1-7.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Functions of membrane binding domain of CTP:phosphocholine cytidylyltransferase in alveolar type II cells. Ridsdale R, etal., Am J Respir Cell Mol Biol. 2010 Jul;43(1):74-87. doi: 10.1165/rcmb.2009-0231OC. Epub 2009 Aug 14.
19. CTP:Phosphocholine Cytidylyltransferase alpha Is a Cytosolic Protein in Pulmonary Epithelial Cells and Tissues. Ridsdale R, etal., J Biol Chem 2001 Dec 28;276(52):49148-55.
20. Expression of wild-type and mutant rat liver CTP: phosphocholine cytidylyltransferase in a cytidylyltransferase-deficient Chinese hamster ovary cell line. Sweitzer TD and Kent C, Arch Biochem Biophys. 1994 May 15;311(1):107-16. doi: 10.1006/abbi.1994.1215.
21. Identification of an 11-residue portion of CTP-phosphocholine cytidylyltransferase that is required for enzyme-membrane interactions. Yang J, etal., Biochem J. 1997 Jul 1;325 ( Pt 1):29-38.
Additional References at PubMed
PMID:8144639   PMID:8810902   PMID:8889548   PMID:11829742   PMID:12477932   PMID:12584202   PMID:15069071   PMID:15169678   PMID:15489334   PMID:15798219   PMID:18980580   PMID:21207859  
PMID:21504799   PMID:22988242   PMID:23155050   PMID:24275660   PMID:27032756  


Genomics

Comparative Map Data
Pcyt1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21168,313,860 - 68,357,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,313,882 - 68,357,357 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,154,021 - 77,194,395 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01169,818,577 - 69,859,107 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01168,843,143 - 68,883,509 (-)NCBIRnor_WKY
Rnor_6.01171,547,865 - 71,592,037 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,548,222 - 71,591,502 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,632,576 - 74,676,227 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,133,325 - 70,173,686 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,190,913 - 70,212,531 (-)NCBI
Celera1167,749,599 - 67,789,957 (-)NCBICelera
Cytogenetic Map11q22NCBI
PCYT1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383196,234,368 - 196,287,726 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3196,214,222 - 196,287,957 (-)EnsemblGRCh38hg38GRCh38
GRCh373195,961,239 - 196,014,597 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,449,650 - 197,498,981 (-)NCBINCBI36Build 36hg18NCBI36
Build 343197,453,567 - 197,502,894NCBI
Celera3194,546,889 - 194,595,863 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3193,264,968 - 193,311,721 (-)NCBIHuRef
CHM1_13195,936,083 - 195,985,409 (-)NCBICHM1_1
T2T-CHM13v2.03198,953,844 - 199,007,214 (-)NCBIT2T-CHM13v2.0
Pcyt1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,249,739 - 32,293,883 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1632,249,739 - 32,293,888 (+)EnsemblGRCm39 Ensembl
GRCm381632,430,921 - 32,475,065 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,430,921 - 32,475,070 (+)EnsemblGRCm38mm10GRCm38
MGSCv371632,431,007 - 32,475,151 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361632,350,743 - 32,391,762 (+)NCBIMGSCv36mm8
Celera1632,915,098 - 32,958,968 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1622.69NCBI
Pcyt1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542012,464,857 - 12,500,574 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542012,464,857 - 12,513,017 (-)NCBIChiLan1.0ChiLan1.0
PCYT1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13203,522,292 - 203,576,851 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3203,517,951 - 203,576,854 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03193,574,603 - 193,633,601 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PCYT1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13329,363,282 - 29,414,635 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3329,358,452 - 29,430,424 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3329,387,581 - 29,438,871 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03329,596,717 - 29,648,017 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3329,591,886 - 29,667,214 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13329,386,580 - 29,435,254 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03329,437,747 - 29,489,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03330,060,502 - 30,111,773 (-)NCBIUU_Cfam_GSD_1.0
Pcyt1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602124,946,958 - 125,000,520 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936784884,751 - 938,282 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936784884,751 - 938,901 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCYT1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13133,818,761 - 133,850,996 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113133,794,337 - 133,851,004 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213143,232,171 - 143,288,868 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCYT1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11590,905,691 - 90,944,485 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604164,720,023 - 64,792,685 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcyt1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,418,013 - 61,466,016 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473061,417,030 - 61,466,028 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pcyt1a
142 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:581
Count of miRNA genes:269
Interacting mature miRNAs:345
Transcripts:ENSRNOT00000002403
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat

Markers in Region
D11Rat106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,340,154 - 68,340,286 (+)MAPPERmRatBN7.2
Rnor_6.01171,574,148 - 71,574,279NCBIRnor6.0
Rnor_5.01174,658,871 - 74,659,002UniSTSRnor5.0
RGSC_v3.41170,156,499 - 70,156,631RGDRGSC3.4
RGSC_v3.41170,156,500 - 70,156,631UniSTSRGSC3.4
RGSC_v3.11170,214,089 - 70,214,220RGD
Celera1167,772,773 - 67,772,904UniSTS
RH 3.4 Map11377.3UniSTS
RH 3.4 Map11377.3RGD
SHRSP x BN Map1132.1299UniSTS
SHRSP x BN Map1132.1299RGD
Cytogenetic Map11q22UniSTS
RH130304  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,329,751 - 68,329,965 (+)MAPPERmRatBN7.2
Rnor_6.01171,563,743 - 71,563,956NCBIRnor6.0
Rnor_5.01174,648,466 - 74,648,679UniSTSRnor5.0
RGSC_v3.41170,146,095 - 70,146,308UniSTSRGSC3.4
Celera1167,762,368 - 67,762,581UniSTS
RH 3.4 Map11404.1UniSTS
Cytogenetic Map11q22UniSTS
STS-L28957  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,317,232 - 68,317,418 (+)MAPPERmRatBN7.2
mRatBN7.22177,510,964 - 177,511,135 (+)MAPPERmRatBN7.2
Rnor_6.01171,551,224 - 71,551,409NCBIRnor6.0
Rnor_6.02191,936,958 - 191,937,125NCBIRnor6.0
Rnor_5.01174,635,949 - 74,636,134UniSTSRnor5.0
RGSC_v3.41170,133,576 - 70,133,761UniSTSRGSC3.4
Celera2174,081,535 - 174,081,706UniSTS
Celera1167,749,850 - 67,750,035UniSTS
Cytogenetic Map2q34UniSTS
Cytogenetic Map11q22UniSTS
BE108960  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,355,414 - 68,355,611 (+)MAPPERmRatBN7.2
Rnor_6.01171,589,406 - 71,589,602NCBIRnor6.0
Rnor_5.01174,674,129 - 74,674,325UniSTSRnor5.0
RGSC_v3.41170,171,760 - 70,171,956UniSTSRGSC3.4
Celera1167,788,033 - 67,788,229UniSTS
RH 3.4 Map11373.83UniSTS
Cytogenetic Map11q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002403   ⟹   ENSRNOP00000002403
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,313,882 - 68,357,357 (-)Ensembl
Rnor_6.0 Ensembl1171,548,222 - 71,591,502 (-)Ensembl
RefSeq Acc Id: NM_078622   ⟹   NP_511177
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,316,982 - 68,357,340 (-)NCBI
Rnor_6.01171,550,973 - 71,591,504 (-)NCBI
Rnor_5.01174,632,576 - 74,676,227 (-)NCBI
RGSC_v3.41170,133,325 - 70,173,686 (-)RGD
Celera1167,749,599 - 67,789,957 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248444   ⟹   XP_006248506
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,313,860 - 68,357,363 (-)NCBI
Rnor_6.01171,547,865 - 71,591,401 (-)NCBI
Rnor_5.01174,632,576 - 74,676,227 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768694   ⟹   XP_008766916
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,313,860 - 68,357,828 (-)NCBI
Rnor_6.01171,547,865 - 71,592,037 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039087919   ⟹   XP_038943847
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,313,860 - 68,356,967 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_511177   ⟸   NM_078622
- UniProtKB: P19836 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006248506   ⟸   XM_006248444
- Peptide Label: isoform X1
- UniProtKB: P19836 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008766916   ⟸   XM_008768694
- Peptide Label: isoform X1
- UniProtKB: P19836 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002403   ⟸   ENSRNOT00000002403
RefSeq Acc Id: XP_038943847   ⟸   XM_039087919
- Peptide Label: isoform X1
- UniProtKB: P19836 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19836-F1-model_v2 AlphaFold P19836 1-367 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698210
Promoter ID:EPDNEW_R8734
Type:initiation region
Name:Pcyt1a_1
Description:phosphate cytidylyltransferase 1, choline, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,591,512 - 71,591,572EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70515 AgrOrtholog
BioCyc Gene G2FUF-21096 BioCyc
BioCyc Pathway PWY-3561 [choline biosynthesis III] BioCyc
  PWY-7782 [plasmalogen biosynthesis] BioCyc
  PWY3O-450 [phosphatidylcholine biosynthesis I] BioCyc
Ensembl Genes ENSRNOG00000001762 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000002403 ENTREZGENE
  ENSRNOP00000002403.3 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002403 ENTREZGENE
  ENSRNOT00000002403.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.620 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7127059 IMAGE-MGC_LOAD
InterPro CCT UniProtKB/Swiss-Prot
  Cyt_trans-like UniProtKB/Swiss-Prot
  Pcy1-like UniProtKB/Swiss-Prot
  Rossmann-like_a/b/a_fold UniProtKB/Swiss-Prot
KEGG Report rno:140544 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93248 IMAGE-MGC_LOAD
NCBI Gene 140544 ENTREZGENE
PANTHER CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE A UniProtKB/Swiss-Prot
  PTHR10739 UniProtKB/Swiss-Prot
Pfam CTP_transf_like UniProtKB/Swiss-Prot
PhenoGen Pcyt1a PhenoGen
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/Swiss-Prot
TIGRFAMs cyt_tran_rel UniProtKB/Swiss-Prot
UniProt P19836 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-18 Pcyt1a  phosphate cytidylyltransferase 1A, choline  Pcyt1a  phosphate cytidylyltransferase 1, choline, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Pcyt1a  phosphate cytidylyltransferase 1, choline, alpha  LOC100911343  choline-phosphate cytidylyltransferase A-like  Data Merged 737654 PROVISIONAL
2012-07-05 LOC100911343  choline-phosphate cytidylyltransferase A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-10-24 Pcyt1a  phosphate cytidylyltransferase 1, choline, alpha  Pcyt1a  phosphate cytidylyltransferase 1, choline, alpha isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Pcyt1a  phosphate cytidylyltransferase 1, choline, alpha isoform      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Pcyt1a  phosphate cytidylyltransferase 1, choline, alpha isoform      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a 58-residue amphipathic alpha-helix mediating binding to cell membranes 70012
gene_expression located in pulmonary epithelial cell 70012
gene_expression located in pulmonary epithelial cell 70228
gene_function catalyzes the transfer of choline from phosphocholine to CDP-choline in the Kennedy (CDP-choline) pathway 70012
gene_function catalyzes the transfer of choline from phosphocholine to CDP-choline in the Kennedy (CDP-choline) pathway 70228
gene_process rate-limiting enzyme in the synthesis of phosphotidylcholine 70012
gene_process rate-limiting enzyme in the synthesis of phosphotidylcholine 70228