Cd86 (CD86 molecule) - Rat Genome Database

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Gene: Cd86 (CD86 molecule) Rattus norvegicus
Symbol: Cd86
Name: CD86 molecule
RGD ID: 628714
Description: Enables signaling receptor binding activity. Involved in several processes, including defense response to other organism; negative regulation of T cell anergy; and positive regulation of activated T cell proliferation. Located in cell surface. Used to study adult T-cell leukemia/lymphoma and bronchiolitis obliterans. Biomarker of asthma; corneal disease; middle cerebral artery infarction; and orchitis. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule); PARTICIPATES IN allograft rejection pathway; autoimmune thyroiditis pathway; graft-versus-host disease pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B7-2; cd86 antigen; membrane glycoprotein; T-lymphocyte activation antigen CD86
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21164,142,193 - 64,200,816 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,163,828 - 64,200,818 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1172,976,468 - 73,012,708 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01165,638,701 - 65,674,935 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,669,718 - 64,705,519 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,060,305 - 67,117,990 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,082,193 - 67,118,795 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,150,748 - 70,208,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41166,215,233 - 66,238,882 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11166,272,821 - 66,296,468 (-)NCBI
Celera1163,635,203 - 63,670,914 (+)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (EXP)
1,10-phenanthroline  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-Methoxy-4-methylphenol  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
adenosine 5'-[gamma-thio]triphosphate  (ISO)
albendazole  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alternariol  (ISO)
aluminium hydroxide  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atorvastatin calcium  (ISO)
Bandrowski's base  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzoyl chloride  (ISO)
benzyl benzoate  (ISO)
benzyl cinnamate  (ISO)
benzylpenicillin  (ISO)
beryllium sulfate  (ISO)
beta-D-glucan  (ISO)
beta-naphthoflavone  (ISO)
betamethasone valerate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
calcitriol  (ISO)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chloramine T  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
citral  (ISO)
citric acid  (ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
clopidogrel  (ISO)
cobalt dichloride  (ISO)
cortisol  (ISO)
Cyclopamine  (ISO)
daidzein  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dicoumarol  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diiodine  (EXP)
diisononyl phthalate  (ISO)
dimethoate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diphenylmethane-4,4'-diisocyanate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
equol  (ISO)
estriol  (ISO)
ethylene glycol dimethacrylate  (ISO)
ethylmercuric chloride  (ISO)
eugenol  (ISO)
fluorescein 5-isothiocyanate  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
geranial  (ISO)
geraniol  (ISO)
glucuronoxylomannan  (ISO)
glutaraldehyde  (ISO)
glutathione  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
helenalin  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxycitronellal  (ISO)
imidurea  (ISO)
imiquimod  (ISO)
immunological adjuvant  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
ionomycin  (ISO)
kanamycin A  (ISO)
L-cysteine  (ISO)
lead diacetate  (ISO)
lead nitrate  (ISO)
levonorgestrel  (ISO)
lidocaine  (EXP)
linalool  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lupane  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
MK-2206  (ISO)
monosodium L-glutamate  (ISO)
muramyl dipeptide  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
n-propyl gallate  (ISO)
nandrolone  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP)
nitric oxide  (ISO)
nonanoic acid  (ISO)
nystatin  (ISO)
ochratoxin A  (EXP)
octanoic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenanthridone  (ISO)
phenethyl caffeate  (EXP)
phenyl benzoate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
pyridine  (ISO)
pyrithione  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitrosoglutathione  (ISO)
SB 203580  (ISO)
SCH 23390  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
Soman  (EXP)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulpiride  (ISO)
tacrolimus hydrate  (ISO)
testosterone  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
tributyrin  (ISO)
trimethyltin  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
ursolic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
Y-27632  (ISO)
zearalenone  (ISO)
zinc dichloride  (ISO)
zinc protoporphyrin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Activated microglial cells acquire an immature dendritic cell phenotype and may terminate the immune response in an acute model of EAE. Almolda B, etal., J Neuroimmunol. 2010 Jun;223(1-2):39-54. Epub 2010 May 6.
2. Altered phenotype and function of dendritic cells in children with type 1 diabetes. Angelini F, etal., Clin Exp Immunol. 2005 Nov;142(2):341-6.
3. Small interfering RNA against CD86 during allergen challenge blocks experimental allergic asthma. Asai-Tajiri Y, etal., Respir Res. 2014 Oct 27;15:132. doi: 10.1186/s12931-014-0132-z.
4. A role for dendritic cells in bleomycin-induced pulmonary fibrosis in mice? Bantsimba-Malanda C, etal., Am J Respir Crit Care Med. 2010 Aug 1;182(3):385-95. Epub 2010 Apr 15.
5. Differential activation of peritoneal cells by subcutaneous treatment of rats with cryptococcal antigens. Baronetti JL, etal., Clin Vaccine Immunol. 2009 Aug;16(8):1213-21. Epub 2009 Jun 3.
6. Francisella tularensis induces aberrant activation of pulmonary dendritic cells. Bosio CM and Dow SW, J Immunol. 2005 Nov 15;175(10):6792-801.
7. CD86+ or HLA-G+ can be transferred via trogocytosis from myeloma cells to T cells and are associated with poor prognosis. Brown R, etal., Blood. 2012 Sep 6;120(10):2055-63. doi: 10.1182/blood-2012-03-416792. Epub 2012 Jun 15.
8. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. Chang TT, etal., J Exp Med. 1999 Sep 6;190(5):733-40.
9. Cauterization of central cornea induces recruitment of major histocompatibility complex class II+ Langerhans cells from limbal basal epithelium. Chen W, etal., Cornea. 2010 Jan;29(1):73-9.
10. Anti-tumor immunity in a model of acute myeloid leukemia. Cheuk AT, etal., Leuk Lymphoma. 2009 Mar;50(3):447-54.
11. Increased gene expression of Toll-like receptors and antigen-presenting cell-related molecules in the onset of experimentally induced furcation lesions of endodontic origin in rat molars. Chokechanachaisakul U, etal., J Endod. 2010 Feb;36(2):251-5. Epub 2009 Dec 4.
12. Dexamethasone inhibits immunoreactivity of dendritic cells in patients with chronic idiopathic thrombocytopenic purpura. Chu XX, etal., Blood Coagul Fibrinolysis. 2010 Sep;21(6):564-7. doi: 10.1097/MBC.0b013e32833c2b8c.
13. A functional CD86 polymorphism associated with asthma and related allergic disorders. Corydon TJ, etal., J Med Genet. 2007 Aug;44(8):509-15. Epub 2007 May 18.
14. Low CD86 expression in the nonobese diabetic mouse results in the impairment of both T cell activation and CTLA-4 up-regulation. Dahlen E, etal., J Immunol. 2000 Mar 1;164(5):2444-56.
15. Rapamycin modulates the maturation of rat bone marrow-derived dendritic cells. Ding Y, etal., J Huazhong Univ Sci Technolog Med Sci. 2008 Aug;28(4):391-5. Epub 2008 Aug 15.
16. Low expression of antigen-presenting and costimulatory molecules by lung cells from tuberculosis patients. Flores-Batista VC, etal., Braz J Med Biol Res. 2007 Dec;40(12):1671-9. Epub 2007 Oct 29.
17. mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging. Frank MG, etal., Neurobiol Aging. 2006 May;27(5):717-22.
18. Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease. Freeman CM, etal., Am J Respir Crit Care Med. 2009 Dec 15;180(12):1179-88. Epub 2009 Sep 3.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Mature CD11c(+) cells are enhanced in hypersensitivity pneumonitis. Girard M, etal., Eur Respir J. 2009 Sep;34(3):749-56. Epub 2009 Mar 12.
21. Development of human T-cell leukemia virus type 1-transformed tumors in rats following suppression of T-cell immunity by CD80 and CD86 blockade. Hanabuchi S, etal., J Virol. 2000 Jan;74(1):428-35.
22. CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of streptozotocin. Herold KC, etal., J Immunol. 1997 Jan 15;158(2):984-91.
23. Streptococcus pneumoniae Infection aggravates experimental autoimmune encephalomyelitis via Toll-like receptor 2. Herrmann I, etal., Infect Immun. 2006 Aug;74(8):4841-8.
24. Upregulation of B7.2, but not B7.1, on B cells from patients with allergic asthma. Hofer MF, etal., J Allergy Clin Immunol. 1998 Jan;101(1 Pt 1):96-102.
25. House dust mite regulate the lung inflammation of asthmatic mice through TLR4 pathway in airway epithelial cells. Hongjia L, etal., Cell Biochem Funct. 2010 Oct;28(7):597-603.
26. A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis. Hu X, etal., PLoS One. 2016 Mar 31;11(3):e0152368. doi: 10.1371/journal.pone.0152368. eCollection 2016.
27. AID induces intraclonal diversity and genomic damage in CD86(+) chronic lymphocytic leukemia cells. Huemer M, etal., Eur J Immunol. 2014 Dec;44(12):3747-57. doi: 10.1002/eji.201344421. Epub 2014 Oct 18.
28. Islet-infiltrating t lymphocytes in insulin-dependent diabetic patients express CD80 (B7-1) and CD86 (B7-2). Imagawa A, etal., J Autoimmun. 1996 Jun;9(3):391-6.
29. Distinct transcriptional control in major immunogenetic subsets of chronic lymphocytic leukemia exhibiting subset-biased global DNA methylation profiles. Kanduri M, etal., Epigenetics. 2012 Dec 1;7(12):1435-42. doi: 10.4161/epi.22901. Epub 2012 Nov 15.
30. Artificial dental pulp exposure injury up-regulates antigen-presenting cell-related molecules in rat central nervous system. Kaneko T, etal., J Endod. 2010 Mar;36(3):459-64.
31. Development of murine allergic asthma is dependent upon B7-2 costimulation. Keane-Myers AM, etal., J Immunol. 1998 Jan 15;160(2):1036-43.
32. An essential role for dendritic cells in human and experimental allergic rhinitis. KleinJan A, etal., J Allergy Clin Immunol. 2006 Nov;118(5):1117-25. Epub 2006 Aug 28.
33. Monovalent antibody scFv fragments selected to modulate T-cell activation by inhibition of CD86-CD28 interaction. Kolly R, etal., Protein Eng Des Sel. 2007 Feb;20(2):91-8. Epub 2007 Feb 8.
34. CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease. Liu Y, etal., Hum Immunol. 2010 Nov;71(11):1141-6. Epub 2010 Aug 21.
35. [Expression of co-stimulatory molecules in peripheral blood of patients with idiopathic thrombocytopenic purpura in relation with platelet antibodies]. Ma XR, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Apr;17(2):483-6.
36. Characterization of rat CD80 and CD86 by molecular cloning and mAb. Maeda K, etal., Int Immunol 1997 Jul;9(7):993-1000.
37. Fc gamma receptors regulate immune activation and susceptibility during Mycobacterium tuberculosis infection. Maglione PJ, etal., J Immunol. 2008 Mar 1;180(5):3329-38.
38. Increased expression of costimulatory molecules CD86 and sCTLA-4 in patients with acute lymphoblastic leukemia. Mansour A, etal., Leuk Lymphoma. 2014 Sep;55(9):2120-4. doi: 10.3109/10428194.2013.869328. Epub 2014 Mar 7.
39. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
40. Low expression of T-cell co-stimulatory molecules in bone marrow-derived dendritic cells in a mouse model of chronic respiratory infection with Pseudomonas aeruginosa. Mukae H, etal., Tohoku J Exp Med. 2010 Jan;220(1):59-65.
41. An in vitro study of the effect of size and timing of administration of titanium dioxide particles on antigen presenting activity of alveolar macrophages and peripheral blood monocytes. Munidasa DT, etal., Inhal Toxicol. 2009 Aug;21(10):849-56.
42. Differential control of T regulatory cell proliferation and suppressive activity by mature plasmacytoid versus conventional spleen dendritic cells. Ouabed A, etal., J Immunol. 2008 May 1;180(9):5862-70.
43. Donor antigen-loaded IKK2dn gene-modified dendritic cells prolong allograft survival. Ouyang J, etal., Scand J Immunol. 2010 May;71(5):336-44.
44. A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes. Phillips B, etal., Diabetes. 2008 Jun;57(6):1544-55. Epub 2008 Mar 3.
45. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
46. TSLP from RSV-stimulated rat airway epithelial cells activates myeloid dendritic cells. Qiao J, etal., Immunol Cell Biol. 2010 Jul 6.
47. HSP60 as a target of anti-ergotypic regulatory T cells. Quintana FJ, etal., PLoS One. 2008;3(12):e4026. Epub 2008 Dec 24.
48. B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion. Rau FC, etal., J Immunol. 2009 Dec 15;183(12):7661-71. Epub .
49. Arming parvoviruses with CpG motifs to improve their oncosuppressive capacity. Raykov Z, etal., Int J Cancer. 2008 Jun 15;122(12):2880-4.
50. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
52. Comprehensive gene review and curation RGD comprehensive gene curation
53. Functional and phenotypic characteristics of testicular macrophages in experimental autoimmune orchitis. Rival C, etal., J Pathol. 2008 Jun;215(2):108-17.
54. CpG-ODN and MPLA prevent mortality in a murine model of post-hemorrhage-Staphyloccocus aureus pneumonia. Roquilly A, etal., PLoS One. 2010 Oct 7;5(10):e13228.
55. Appearance of cells expressing CD80 and CD86 costimulatory antigens in the pancreas of nonobese diabetic mice. Sainio-Pollanen S, etal., Pancreas. 1996 Nov;13(4):388-94.
56. Enhanced activation of memory, but not naive, B cells in chronic hepatitis C virus-infected patients with cryoglobulinemia and advanced liver fibrosis. Santer DM, etal., PLoS One. 2013 Jun 28;8(6):e68308. doi: 10.1371/journal.pone.0068308. Print 2013.
57. Effects of in vivo administration of anti-B7-1/B7-2 monoclonal antibodies on the survival of mice with chronic ongoing myocarditis caused by Coxsackievirus B3. Seko Y, etal., J Pathol. 1999 May;188(1):107-12. doi: 10.1002/(SICI)1096-9896(199905)188:1<107::AID-PATH319>3.0.CO;2-7.
58. Expression of B7 molecules in the eye during experimental autoimmune anterior uveitis (EAAU). Shao H, etal., Curr Eye Res 2002 Nov;25(5):271-7.
59. Upregulated functional expression of Toll like receptor 4 in mesenchymal stem cells induced by lipopolysaccharide. Shi L, etal., Chin Med J (Engl). 2007 Oct 5;120(19):1685-8.
60. High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection. Silveira-Lemos D, etal., Mem Inst Oswaldo Cruz. 2006 Sep;101 Suppl 1:345-51.
61. HLA-G-treated tolerogenic dendritic cells induce tolerogenic potential by increasing expression of B7-1 (CD80) molecules. Smith M, etal., Transplant Proc. 2008 Jun;40(5):1598-603.
62. Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. Spatz M, etal., Cell Immunol. 2003 Jan;221(1):15-26.
63. Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control. Strickland DH, etal., Mucosal Immunol. 2011 Jan;4(1):43-52. Epub 2010 Jul 28.
64. rSj16, a recombinant protein of Schistosoma japonicum-derived molecule, reduces severity of the complete Freund's adjuvant-induced adjuvant arthritis in rats' model. Sun X, etal., Parasite Immunol. 2010 Nov-Dec;32(11-12):739-48. doi: 10.1111/j.1365-3024.2010.01240.x.
65. Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia. Tamura H, etal., Clin Cancer Res. 2005 Aug 15;11(16):5708-17.
66. CD86 has sustained costimulatory effects on CD8 T cells. Thomas IJ, etal., J Immunol. 2007 Nov 1;179(9):5936-46.
67. Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. Thored P, etal., Glia. 2009 Jun;57(8):835-49.
68. CD28-B7-2 but not CD28-B7-1 interaction is required for T cell costimulation in experimental obliterative bronchiolitis in the rat. Tikkanen JM, etal., Transplant Proc. 2001 Feb-Mar;33(1-2):535.
69. Polymorphisms in CD28, CTLA-4, CD80 and CD86 genes may influence the risk of multiple sclerosis and its age of onset. Wagner M, etal., J Neuroimmunol. 2015 Nov 15;288:79-86. doi: 10.1016/j.jneuroim.2015.09.004. Epub 2015 Sep 18.
70. Impairment of monocyte-derived dendritic cells in idiopathic pulmonary arterial hypertension. Wang W, etal., J Clin Immunol. 2009 Nov;29(6):705-13. Epub 2009 Aug 20.
71. In vivo role of dendritic cells in a murine model of pulmonary cryptococcosis. Wozniak KL, etal., Infect Immun. 2006 Jul;74(7):3817-24.
72. B7-2 (CD86) controls the priming of autoreactive CD4 T cell response against pancreatic islets. Yadav D, etal., J Immunol. 2004 Sep 15;173(6):3631-9.
73. Phenotype and function of GM-CSF independent dendritic cells generated by long-term propagation of rat bone marrow cells. Yan H, etal., Cell Immunol. 2004 Jun;229(2):117-29. doi: 10.1016/j.cellimm.2004.07.006.
74. 5HT4 agonists inhibit interferon-gamma-induced MHC class II and B7 costimulatory molecules expression on cultured astrocytes. Zeinstra EM, etal., J Neuroimmunol. 2006 Oct;179(1-2):191-5. Epub 2006 Jul 12.
75. Association between high-mobility group box-1 protein release and immune function of dendritic cells in thermal injury. Zhang LT, etal., J Interferon Cytokine Res. 2010 Jul;30(7):487-95.
76. The effect of high mobility group box-1 protein on splenic dendritic cell maturation in rats. Zhu XM, etal., J Interferon Cytokine Res. 2009 Oct;29(10):677-86.
77. Circulating myeloid dendritic cells are increased in individuals with severe aplastic anemia. Zonghong S, etal., Int J Hematol. 2011 Feb;93(2):156-62. doi: 10.1007/s12185-010-0761-z. Epub 2011 Jan 14.
Additional References at PubMed
PMID:12801066   PMID:14560001   PMID:14643301   PMID:14698851   PMID:15240714   PMID:15314074   PMID:15908444   PMID:16708399   PMID:17068184   PMID:17277142   PMID:19047410   PMID:19734906  
PMID:20458337   PMID:23793062   PMID:23981064   PMID:25158758   PMID:32733939  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21164,142,193 - 64,200,816 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,163,828 - 64,200,818 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1172,976,468 - 73,012,708 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01165,638,701 - 65,674,935 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,669,718 - 64,705,519 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,060,305 - 67,117,990 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,082,193 - 67,118,795 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,150,748 - 70,208,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41166,215,233 - 66,238,882 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11166,272,821 - 66,296,468 (-)NCBI
Celera1163,635,203 - 63,670,914 (+)NCBICelera
Cytogenetic Map11q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh383122,055,362 - 122,121,136 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3122,055,362 - 122,121,139 (+)EnsemblGRCh38hg38GRCh38
GRCh373121,774,209 - 121,839,983 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363123,256,911 - 123,322,673 (+)NCBINCBI36Build 36hg18NCBI36
Celera3120,183,894 - 120,249,657 (+)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3119,148,000 - 119,213,630 (+)NCBIHuRef
CHM1_13121,738,233 - 121,803,970 (+)NCBICHM1_1
T2T-CHM13v2.03124,775,351 - 124,841,114 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391636,389,318 - 36,486,439 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1636,424,231 - 36,486,443 (-)EnsemblGRCm39 Ensembl
GRCm381636,568,956 - 36,666,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1636,603,869 - 36,666,081 (-)EnsemblGRCm38mm10GRCm38
MGSCv371636,603,955 - 36,666,163 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361636,523,113 - 36,585,290 (-)NCBIMGSCv36mm8
Celera1637,019,467 - 37,081,856 (-)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1625.72NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542721,375,794 - 21,435,874 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542721,375,820 - 21,436,767 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan13120,011,537 - 120,077,290 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03119,151,884 - 119,217,641 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13126,059,008 - 126,124,339 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3126,059,008 - 126,124,339 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13325,256,267 - 25,318,855 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3325,256,267 - 25,318,087 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3325,281,506 - 25,343,086 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03325,491,858 - 25,554,625 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3325,491,761 - 25,553,455 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13325,289,910 - 25,351,816 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03325,332,469 - 25,394,248 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03325,890,298 - 25,952,478 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405602129,038,128 - 129,107,520 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365368,414,491 - 8,481,712 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl13138,427,533 - 138,504,310 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113138,427,573 - 138,504,307 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213148,055,863 - 148,130,754 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12258,741,534 - 58,805,417 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2258,741,525 - 58,805,366 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041107,540,631 - 107,604,240 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624912350,157 - 426,712 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624912350,201 - 432,410 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cd86
383 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:21
Interacting mature miRNAs:21
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21164,200,533 - 64,200,742 (+)MAPPERmRatBN7.2
Rnor_6.01167,118,170 - 67,118,378NCBIRnor6.0
Rnor_5.01170,208,710 - 70,208,918UniSTSRnor5.0
RGSC_v3.41166,214,803 - 66,215,011UniSTSRGSC3.4
Celera1163,671,136 - 63,671,344UniSTS
RH 3.4 Map11485.4UniSTS
Cytogenetic Map11q22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 8 19 1 6 8
Low 1 43 49 41 41 8 9 74 34 33 3 8
Below cutoff 2 2


RefSeq Acc Id: ENSRNOT00000003129   ⟹   ENSRNOP00000003129
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1164,183,653 - 64,200,818 (+)Ensembl
Rnor_6.0 Ensembl1167,082,193 - 67,117,948 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078936   ⟹   ENSRNOP00000070253
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1164,163,828 - 64,200,818 (+)Ensembl
Rnor_6.0 Ensembl1167,101,714 - 67,118,795 (+)Ensembl
RefSeq Acc Id: NM_020081   ⟹   NP_064466
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21164,163,902 - 64,200,815 (+)NCBI
Rnor_6.01167,082,193 - 67,117,948 (+)NCBI
Rnor_5.01170,150,748 - 70,208,995 (+)NCBI
RGSC_v3.41166,215,233 - 66,238,882 (-)RGD
Celera1163,635,203 - 63,670,914 (+)RGD
RefSeq Acc Id: XM_006248399   ⟹   XP_006248461
Rat AssemblyChrPosition (strand)Source
mRatBN7.21164,142,193 - 64,200,816 (+)NCBI
Rnor_6.01167,060,305 - 67,117,990 (+)NCBI
Rnor_5.01170,150,748 - 70,208,995 (+)NCBI
RefSeq Acc Id: XM_006248400   ⟹   XP_006248462
Rat AssemblyChrPosition (strand)Source
mRatBN7.21164,159,092 - 64,200,816 (+)NCBI
Rnor_6.01167,077,220 - 67,117,990 (+)NCBI
Rnor_5.01170,150,748 - 70,208,995 (+)NCBI
RefSeq Acc Id: XM_039088600   ⟹   XP_038944528
Rat AssemblyChrPosition (strand)Source
mRatBN7.21164,163,833 - 64,200,816 (+)NCBI
RefSeq Acc Id: NP_064466   ⟸   NM_020081
- Peptide Label: precursor
- UniProtKB: O35531 (UniProtKB/TrEMBL),   F1LNG0 (UniProtKB/TrEMBL),   A0A0G2JXF7 (UniProtKB/TrEMBL),   A0A9K3Y6P6 (UniProtKB/TrEMBL),   A0A8J8XMF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248461   ⟸   XM_006248399
- Peptide Label: isoform X1
- UniProtKB: A6IRC5 (UniProtKB/TrEMBL),   A0A8J8XMF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248462   ⟸   XM_006248400
- Peptide Label: isoform X1
- UniProtKB: A6IRC5 (UniProtKB/TrEMBL),   A0A8J8XMF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070253   ⟸   ENSRNOT00000078936
RefSeq Acc Id: ENSRNOP00000003129   ⟸   ENSRNOT00000003129
RefSeq Acc Id: XP_038944528   ⟸   XM_039088600
- Peptide Label: isoform X1
- UniProtKB: A6IRC5 (UniProtKB/TrEMBL),   A0A8J8XMF6 (UniProtKB/TrEMBL)
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35531-F1-model_v2 AlphaFold O35531 1-313 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628714 AgrOrtholog
BioCyc Gene G2FUF-21237 BioCyc
Ensembl Genes ENSRNOG00000038835 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003129 ENTREZGENE
  ENSRNOT00000003129.7 UniProtKB/TrEMBL
  ENSRNOT00000078936.2 UniProtKB/TrEMBL
InterPro CD80_C2-set UniProtKB/TrEMBL
  CD86_IgV UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
KEGG Report rno:56822 UniProtKB/TrEMBL
Pfam C2-set_2 UniProtKB/TrEMBL
PhenoGen Cd86 PhenoGen
RatGTEx ENSRNOG00000038835 RatGTEx
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt Secondary A0A0G2JXF7 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Cd86  CD86 molecule  Cd86  cd86 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cd86  cd86 antigen    CD86 antigen  Name updated 1299863 APPROVED
2003-02-27 Cd86  CD86 antigen      Symbol and Name status set to provisional 70820 PROVISIONAL