Cfap91 (cilia and flagella associated protein 91) - Rat Genome Database

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Gene: Cfap91 (cilia and flagella associated protein 91) Rattus norvegicus
Analyze
Symbol: Cfap91
Name: cilia and flagella associated protein 91
RGD ID: 1305539
Description: Predicted to be involved in axonemal central apparatus assembly and spermatogenesis. Predicted to be located in cell projection; cytoplasm; and cytoskeleton. Human ortholog(s) of this gene implicated in spermatogenic failure 51. Orthologous to human CFAP91 (cilia and flagella associated protein 91); INTERACTS WITH 1-naphthyl isothiocyanate; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cilia- and flagella-associated protein 91; LOC303920; Maats1; MYCBP associated and testis expressed 1; MYCBP-associated, testis expressed 1; MYCBP/AMY-1-associated, testis expressed 1; RGD1305539; similar to hypothetical protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81175,919,129 - 75,962,786 (+)NCBIGRCr8
mRatBN7.21162,413,613 - 62,457,281 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,413,602 - 62,457,293 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01164,975,499 - 65,019,169 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,975,594 - 65,018,108 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01167,063,347 - 67,106,696 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,193,279 - 64,236,576 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,250,867 - 64,294,165 (+)NCBI
Celera1161,914,219 - 61,957,735 (+)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Cfap91
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81175,919,129 - 75,962,786 (+)NCBIGRCr8
mRatBN7.21162,413,613 - 62,457,281 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,413,602 - 62,457,293 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01164,975,499 - 65,019,169 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,975,594 - 65,018,108 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01167,063,347 - 67,106,696 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,193,279 - 64,236,576 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,250,867 - 64,294,165 (+)NCBI
Celera1161,914,219 - 61,957,735 (+)NCBICelera
Cytogenetic Map11q21NCBI
CFAP91
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383119,703,022 - 119,767,102 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3119,703,022 - 119,767,102 (+)EnsemblGRCh38hg38GRCh38
GRCh373119,421,869 - 119,485,949 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363120,904,559 - 120,968,639 (+)NCBINCBI36Build 36hg18NCBI36
Build 343120,904,562 - 120,968,377NCBI
Celera3117,830,398 - 117,895,034 (+)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3116,797,531 - 116,861,550 (+)NCBIHuRef
CHM1_13119,385,371 - 119,449,463 (+)NCBICHM1_1
T2T-CHM13v2.03122,422,727 - 122,486,822 (+)NCBIT2T-CHM13v2.0
Cfap91
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391638,118,116 - 38,162,222 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1638,118,116 - 38,162,505 (-)EnsemblGRCm39 Ensembl
GRCm381638,297,754 - 38,341,860 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,297,754 - 38,342,143 (-)EnsemblGRCm38mm10GRCm38
MGSCv371638,297,840 - 38,341,946 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361638,216,993 - 38,261,099 (-)NCBIMGSCv36mm8
Celera1638,706,884 - 38,752,181 (-)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1626.71NCBI
Cfap91
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,389,519 - 19,454,947 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542719,389,866 - 19,451,136 (+)NCBIChiLan1.0ChiLan1.0
CFAP91
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22117,676,988 - 117,742,148 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13117,681,766 - 117,746,926 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03116,822,455 - 116,890,913 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13123,736,045 - 123,799,905 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3123,736,045 - 123,799,905 (+)Ensemblpanpan1.1panPan2
CFAP91
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13323,315,184 - 23,447,307 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,313,821 - 23,415,660 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3323,343,055 - 23,449,075 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03323,550,851 - 23,656,791 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3323,562,253 - 23,653,892 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13323,353,130 - 23,460,796 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03323,389,137 - 23,501,179 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03323,958,929 - 24,064,752 (+)NCBIUU_Cfam_GSD_1.0
Cfap91
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602130,851,451 - 130,916,273 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365366,605,815 - 6,651,387 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365366,605,766 - 6,651,387 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFAP91
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13140,437,096 - 140,566,877 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113140,437,096 - 140,566,976 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213149,774,751 - 149,898,945 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CFAP91
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12261,057,893 - 61,117,623 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2261,054,817 - 61,117,587 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041105,194,733 - 105,254,995 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cfap91
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473128,421,998 - 28,469,829 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473128,408,735 - 28,469,907 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cfap91
329 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:27
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000040773
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 6 40 107 54 59 28 24 28 6 162 80 93 41 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000040773   ⟹   ENSRNOP00000040027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,413,602 - 62,457,293 (+)Ensembl
Rnor_6.0 Ensembl1164,975,594 - 65,018,108 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094004   ⟹   ENSRNOP00000091943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,413,602 - 62,431,747 (+)Ensembl
RefSeq Acc Id: XM_008768768   ⟹   XP_008766990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81175,919,129 - 75,962,786 (+)NCBI
mRatBN7.21162,413,614 - 62,457,281 (+)NCBI
Rnor_6.01164,975,499 - 65,019,169 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598164   ⟹   XP_017453653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81175,925,200 - 75,962,786 (+)NCBI
mRatBN7.21162,419,690 - 62,457,281 (+)NCBI
Rnor_6.01164,981,465 - 65,019,169 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088902   ⟹   XP_038944830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81175,919,129 - 75,962,786 (+)NCBI
mRatBN7.21162,413,613 - 62,457,281 (+)NCBI
RefSeq Acc Id: XM_039088903   ⟹   XP_038944831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81175,919,273 - 75,962,786 (+)NCBI
mRatBN7.21162,413,680 - 62,457,281 (+)NCBI
RefSeq Acc Id: XP_008766990   ⟸   XM_008768768
- Peptide Label: isoform X1
- UniProtKB: D3ZBC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453653   ⟸   XM_017598164
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000040027   ⟸   ENSRNOT00000040773
RefSeq Acc Id: XP_038944830   ⟸   XM_039088902
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038944831   ⟸   XM_039088903
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000091943   ⟸   ENSRNOT00000094004
Protein Domains
CFAP91

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZBC9-F1-model_v2 AlphaFold D3ZBC9 1-771 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698183
Promoter ID:EPDNEW_R8693
Type:single initiation site
Name:Maats1_1
Description:MYCBP-associated, testis expressed 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01164,975,521 - 64,975,581EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305539 AgrOrtholog
BioCyc Gene G2FUF-21268 BioCyc
Ensembl Genes ENSRNOG00000002976 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040773.6 UniProtKB/TrEMBL
  ENSRNOT00000094004.1 UniProtKB/TrEMBL
InterPro CFAP91 UniProtKB/TrEMBL
  CFAP91_dom UniProtKB/TrEMBL
KEGG Report rno:303920 UniProtKB/TrEMBL
NCBI Gene 303920 ENTREZGENE
PANTHER CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91 UniProtKB/TrEMBL
  PTHR22455 UniProtKB/TrEMBL
Pfam CFAP91 UniProtKB/TrEMBL
PhenoGen Cfap91 PhenoGen
RatGTEx ENSRNOG00000002976 RatGTEx
UniProt A0A8I6GJC9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZBC9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-13 Cfap91  cilia and flagella associated protein 91  Maats1  MYCBP associated and testis expressed 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-04-14 Maats1  MYCBP associated and testis expressed 1  Maats1  MYCBP-associated, testis expressed 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-12-18 Maats1  MYCBP-associated, testis expressed 1  Maats1  MYCBP/AMY-1-associated, testis expressed 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-10 Maats1  MYCBP/AMY-1-associated, testis expressed 1  RGD1305539  similar to hypothetical protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1305539  similar to hypothetical protein   RGD1305539_predicted  similar to hypothetical protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1305539_predicted  similar to hypothetical protein (predicted)  LOC303920_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC303920_predicted  similar to hypothetical protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL