Clcn2 (chloride voltage-gated channel 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Clcn2 (chloride voltage-gated channel 2) Rattus norvegicus
Analyze
Symbol: Clcn2
Name: chloride voltage-gated channel 2
RGD ID: 2361
Description: Enables voltage-gated chloride channel activity and volume-sensitive chloride channel activity. Involved in several processes, including cellular hypotonic response; positive regulation of oligodendrocyte differentiation; and positive regulation of voltage-gated chloride channel activity. Located in several cellular components, including axon initial segment; dendritic spine membrane; and perikaryon. Used to study cystic fibrosis. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 11 and primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2); INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chloride channel 2; chloride channel protein 2; chloride channel, voltage-sensitive 2; ClC-2; LOC108348101
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,702,382 - 93,716,059 (+)NCBIGRCr8
mRatBN7.21180,197,741 - 80,211,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,198,153 - 80,211,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1188,920,899 - 88,934,364 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,574,316 - 81,587,781 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,635,378 - 80,648,843 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01182,862,664 - 82,876,165 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,883,879 - 83,897,394 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01186,935,748 - 86,969,314 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,427,792 - 82,441,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,485,379 - 82,498,880 (+)NCBI
Celera1179,037,893 - 79,051,394 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Inhibition of CLC-2 chloride channel expression interrupts expansion of fetal lung cysts. Blaisdell CJ, etal., Am J Physiol Lung Cell Mol Physiol 2004 Feb;286(2):L420-6.
2. Alternative mRNA splice variants of the rat ClC-2 chloride channel gene are expressed in lung: genomic sequence and organization of ClC-2. Chu S and Zeitlin PL, Nucleic Acids Res 1997 Oct 15;25(20):4153-9.
3. A short CIC-2 mRNA transcript is produced by exon skipping. Chu S, etal., Nucleic Acids Res 1996 Sep 1;24(17):3453-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume. Gründer S, etal., Nature. 1992 Dec 24-31;360(6406):759-62. doi: 10.1038/360759a0.
7. Cell type-specific differences in chloride-regulatory mechanisms and GABA(A) receptor-mediated inhibition in rat substantia nigra. Gulacsi A, etal., J Neurosci. 2003 Sep 10;23(23):8237-46.
8. CLC-2 is a positive modulator of oligodendrocyte precursor cell differentiation and myelination. Hou X, etal., Mol Med Rep. 2018 Mar;17(3):4515-4523. doi: 10.3892/mmr.2018.8439. Epub 2018 Jan 17.
9. GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit. Jeworutzki E, etal., Neuron. 2012 Mar 8;73(5):951-61. doi: 10.1016/j.neuron.2011.12.039.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel. Staley K, etal., Neuron. 1996 Sep;17(3):543-51. doi: 10.1016/s0896-6273(00)80186-5.
18. Distribution of chloride channel-2-immunoreactive neuronal and astrocytic processes in the hippocampus. Sík A, etal., Neuroscience. 2000;101(1):51-65. doi: 10.1016/s0306-4522(00)00360-2.
19. A chloride channel widely expressed in epithelial and non-epithelial cells. Thiemann A, etal., Nature 1992 Mar 5;356(6364):57-60.
Additional References at PubMed
PMID:11976342   PMID:12381811   PMID:12811561   PMID:14724195   PMID:15358597   PMID:15388342   PMID:15883157   PMID:16526942   PMID:16930566   PMID:17110372   PMID:20411246   PMID:20676104  
PMID:21052544   PMID:21549811   PMID:28255270   PMID:29403011   PMID:38418461  


Genomics

Comparative Map Data
Clcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,702,382 - 93,716,059 (+)NCBIGRCr8
mRatBN7.21180,197,741 - 80,211,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,198,153 - 80,211,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1188,920,899 - 88,934,364 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,574,316 - 81,587,781 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,635,378 - 80,648,843 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01182,862,664 - 82,876,165 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,883,879 - 83,897,394 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01186,935,748 - 86,969,314 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,427,792 - 82,441,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,485,379 - 82,498,880 (+)NCBI
Celera1179,037,893 - 79,051,394 (+)NCBICelera
Cytogenetic Map11q23NCBI
CLCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383184,346,185 - 184,361,605 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3184,346,185 - 184,361,650 (-)EnsemblGRCh38hg38GRCh38
GRCh373184,063,973 - 184,079,393 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,547,034 - 185,562,085 (-)NCBINCBI36Build 36hg18NCBI36
Build 343185,547,095 - 185,561,969NCBI
Celera3182,504,875 - 182,520,290 (-)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3181,470,404 - 181,485,871 (-)NCBIHuRef
CHM1_13184,028,432 - 184,043,898 (-)NCBICHM1_1
T2T-CHM13v2.03187,155,451 - 187,170,873 (-)NCBIT2T-CHM13v2.0
Clcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,521,185 - 20,536,496 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1620,521,714 - 20,536,496 (-)EnsemblGRCm39 Ensembl
GRCm381620,702,435 - 20,717,746 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,702,964 - 20,717,746 (-)EnsemblGRCm38mm10GRCm38
MGSCv371620,703,039 - 20,716,709 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361620,616,509 - 20,629,657 (-)NCBIMGSCv36mm8
Celera1621,268,322 - 21,281,991 (-)NCBICelera
Cytogenetic Map16A3- B1NCBI
cM Map1612.5NCBI
Clcn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,138,605 - 23,152,311 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,138,558 - 23,152,462 (+)NCBIChiLan1.0ChiLan1.0
CLCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22182,219,532 - 182,235,030 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13182,223,590 - 182,239,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03181,383,608 - 181,399,200 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13189,865,627 - 189,881,049 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,862,489 - 189,881,049 (-)Ensemblpanpan1.1panPan2
CLCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13417,224,136 - 17,238,755 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3417,223,215 - 17,239,621 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3421,309,705 - 21,324,280 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03417,131,619 - 17,146,202 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3417,131,648 - 17,146,119 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13417,168,519 - 17,183,094 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03417,164,603 - 17,179,167 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03417,393,559 - 17,408,134 (-)NCBIUU_Cfam_GSD_1.0
Clcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,433,596 - 119,447,715 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365785,525,601 - 5,539,472 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365785,525,461 - 5,539,351 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13122,234,736 - 122,249,867 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113122,234,731 - 122,249,889 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,674,508 - 131,689,583 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,057,687 - 5,073,596 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,057,900 - 5,073,184 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606313,835,604 - 13,851,241 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clcn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473072,228,189 - 72,244,332 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473072,228,912 - 72,242,636 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Clcn2
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:589
Count of miRNA genes:215
Interacting mature miRNAs:261
Transcripts:ENSRNOT00000002376, ENSRNOT00000050927, ENSRNOT00000071707, ENSRNOT00000071956, ENSRNOT00000073435, ENSRNOT00000073841
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat

Markers in Region
D11Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,208,450 - 80,208,686 (+)MAPPERmRatBN7.2
Rnor_6.01182,872,959 - 82,873,194NCBIRnor6.0
Rnor_6.01183,894,190 - 83,894,425NCBIRnor6.0
Rnor_5.01185,952,052 - 85,952,287UniSTSRnor5.0
Rnor_5.01186,966,108 - 86,966,343UniSTSRnor5.0
RGSC_v3.41182,438,087 - 82,438,322UniSTSRGSC3.4
Celera1179,048,188 - 79,048,423UniSTS
Cytogenetic Map11q23UniSTS
RH129159  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,193,708 - 80,193,923 (+)MAPPERmRatBN7.2
Rnor_6.01183,879,450 - 83,879,664NCBIRnor6.0
Rnor_6.01182,858,219 - 82,858,433NCBIRnor6.0
Rnor_5.01186,951,368 - 86,951,582UniSTSRnor5.0
Rnor_5.01185,937,312 - 85,937,526UniSTSRnor5.0
RGSC_v3.41182,423,347 - 82,423,561UniSTSRGSC3.4
Celera1179,033,448 - 79,033,662UniSTS
RH 3.4 Map11656.5UniSTS
Cytogenetic Map11q23UniSTS
BF387879  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,188,772 - 80,188,925 (+)MAPPERmRatBN7.2
Rnor_6.01183,874,516 - 83,874,668NCBIRnor6.0
Rnor_6.01182,853,285 - 82,853,437NCBIRnor6.0
Rnor_5.01186,946,434 - 86,946,586UniSTSRnor5.0
Rnor_5.01185,932,378 - 85,932,530UniSTSRnor5.0
RGSC_v3.41182,418,413 - 82,418,565UniSTSRGSC3.4
Celera1179,028,514 - 79,028,666UniSTS
RH 3.4 Map11657.9UniSTS
Cytogenetic Map11q23UniSTS
RH94517  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,187,994 - 80,188,141 (+)MAPPERmRatBN7.2
Rnor_6.01182,852,507 - 82,852,653NCBIRnor6.0
Rnor_6.01183,873,738 - 83,873,884NCBIRnor6.0
Rnor_5.01186,945,656 - 86,945,802UniSTSRnor5.0
Rnor_5.01185,931,600 - 85,931,746UniSTSRnor5.0
RGSC_v3.41182,417,635 - 82,417,781UniSTSRGSC3.4
Celera1179,027,736 - 79,027,882UniSTS
RH 3.4 Map11658.0UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
nervous system
renal system
reproductive system
2 8 3 3 3 3 8 8 3 10

Sequence


Ensembl Acc Id: ENSRNOT00000002376   ⟹   ENSRNOP00000002376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,198,153 - 80,211,653 (+)Ensembl
Rnor_6.0 Ensembl1183,884,048 - 83,897,084 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000050927   ⟹   ENSRNOP00000050925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,198,153 - 80,211,653 (+)Ensembl
Rnor_6.0 Ensembl1183,883,879 - 83,897,394 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071707   ⟹   ENSRNOP00000066524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,198,153 - 80,211,653 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000073435   ⟹   ENSRNOP00000065970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,199,817 - 80,211,657 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119058   ⟹   ENSRNOP00000089386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,199,817 - 80,211,657 (+)Ensembl
RefSeq Acc Id: NM_017137   ⟹   NP_058833
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,594 - 93,716,059 (+)NCBI
mRatBN7.21180,198,190 - 80,211,657 (+)NCBI
Rnor_6.01182,862,664 - 82,876,165 (+)NCBI
Rnor_5.01186,935,748 - 86,969,314 (+)NCBI
RGSC_v3.41182,427,792 - 82,441,293 (+)RGD
Celera1179,037,893 - 79,051,394 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248563   ⟹   XP_006248625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,382 - 93,716,059 (+)NCBI
mRatBN7.21180,197,741 - 80,211,648 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088239   ⟹   XP_038944167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,382 - 93,716,059 (+)NCBI
mRatBN7.21180,197,741 - 80,211,648 (+)NCBI
RefSeq Acc Id: XM_039088240   ⟹   XP_038944168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,706,129 - 93,716,059 (+)NCBI
mRatBN7.21180,201,724 - 80,211,648 (+)NCBI
RefSeq Acc Id: XM_039088243   ⟹   XP_038944171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,382 - 93,709,819 (+)NCBI
mRatBN7.21180,197,741 - 80,205,414 (+)NCBI
RefSeq Acc Id: XM_039088244   ⟹   XP_038944172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,708,699 - 93,716,059 (+)NCBI
mRatBN7.21180,204,364 - 80,211,648 (+)NCBI
RefSeq Acc Id: XM_063270437   ⟹   XP_063126507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,382 - 93,711,386 (+)NCBI
RefSeq Acc Id: XM_063270438   ⟹   XP_063126508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,382 - 93,711,844 (+)NCBI
RefSeq Acc Id: XR_358402
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,382 - 93,711,841 (+)NCBI
mRatBN7.21180,197,741 - 80,207,443 (+)NCBI
Sequence:
RefSeq Acc Id: XR_595156
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,382 - 93,711,792 (+)NCBI
mRatBN7.21180,197,741 - 80,207,391 (+)NCBI
Sequence:
RefSeq Acc Id: XR_595157
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,382 - 93,711,841 (+)NCBI
mRatBN7.21180,197,741 - 80,211,637 (+)NCBI
Sequence:
RefSeq Acc Id: NP_058833   ⟸   NM_017137
- UniProtKB: P35525 (UniProtKB/Swiss-Prot),   A6JS86 (UniProtKB/TrEMBL),   O54821 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248625   ⟸   XM_006248563
- Peptide Label: isoform X1
- UniProtKB: A0A0A0MXT6 (UniProtKB/TrEMBL),   O54822 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038944167   ⟸   XM_039088239
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QXG3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944171   ⟸   XM_039088243
- Peptide Label: isoform X6
- UniProtKB: O54823 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944168   ⟸   XM_039088240
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038944172   ⟸   XM_039088244
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000002376   ⟸   ENSRNOT00000002376
Ensembl Acc Id: ENSRNOP00000050925   ⟸   ENSRNOT00000050927
Ensembl Acc Id: ENSRNOP00000066524   ⟸   ENSRNOT00000071707
Ensembl Acc Id: ENSRNOP00000065970   ⟸   ENSRNOT00000073435
Ensembl Acc Id: ENSRNOP00000089386   ⟸   ENSRNOT00000119058
RefSeq Acc Id: XP_063126508   ⟸   XM_063270438
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063126507   ⟸   XM_063270437
- Peptide Label: isoform X3
Protein Domains
CBS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35525-F1-model_v2 AlphaFold P35525 1-907 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2361 AgrOrtholog
BioCyc Gene G2FUF-20754 BioCyc
Ensembl Genes ENSRNOG00000001742 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055004767 UniProtKB/Swiss-Prot
  ENSRNOG00060011694 UniProtKB/Swiss-Prot
  ENSRNOG00065003893 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002376.9 UniProtKB/TrEMBL
  ENSRNOT00000050927.7 UniProtKB/Swiss-Prot
  ENSRNOT00000071707.4 UniProtKB/TrEMBL
  ENSRNOT00000073435.3 UniProtKB/TrEMBL
  ENSRNOT00000119058.1 UniProtKB/TrEMBL
  ENSRNOT00055007631 UniProtKB/Swiss-Prot
  ENSRNOT00060020042 UniProtKB/Swiss-Prot
  ENSRNOT00065005866 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.580.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clc chloride channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CBS_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl-channel-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl-channel_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl-channel_volt-gated UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl_channel_volt-gated UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29232 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29232 ENTREZGENE
PANTHER CHLORIDE CHANNEL PROTEIN 2 UniProtKB/Swiss-Prot
  CHLORIDE CHANNEL PROTEIN 2 UniProtKB/Swiss-Prot
  CHLORIDE CHANNEL PROTEIN 2 UniProtKB/TrEMBL
  CHLORIDE CHANNEL PROTEIN 2 UniProtKB/TrEMBL
Pfam Voltage_CLC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Clcn2 PhenoGen
PRINTS CLCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLCHANNEL2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CBS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001742 RatGTEx
  ENSRNOG00055004767 RatGTEx
  ENSRNOG00060011694 RatGTEx
  ENSRNOG00065003893 RatGTEx
Superfamily-SCOP SSF54631 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MXT6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ABL4_RAT UniProtKB/TrEMBL
  A0A8L2QXG3 ENTREZGENE, UniProtKB/TrEMBL
  A6JS86 ENTREZGENE, UniProtKB/TrEMBL
  CLCN2_RAT UniProtKB/Swiss-Prot
  E9PU32_RAT UniProtKB/TrEMBL
  O54821 ENTREZGENE, UniProtKB/TrEMBL
  O54822 ENTREZGENE, UniProtKB/TrEMBL
  O54823 ENTREZGENE, UniProtKB/TrEMBL
  P35525 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Clcn2  chloride voltage-gated channel 2  LOC108348101  chloride channel protein 2  Data merged from RGD:11384925 737654 PROVISIONAL
2016-08-02 LOC108348101  chloride channel protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2016-02-11 Clcn2  chloride voltage-gated channel 2  Clcn2  chloride channel, voltage-sensitive 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Clcn2  chloride channel, voltage-sensitive 2  Clcn2  chloride channel 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Clcn2  chloride channel 2      Symbol and Name status set to approved 70586 APPROVED