Clcn2 (chloride voltage-gated channel 2) - Rat Genome Database

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Gene: Clcn2 (chloride voltage-gated channel 2) Rattus norvegicus
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Symbol: Clcn2
Name: chloride voltage-gated channel 2
RGD ID: 2361
Description: Enables voltage-gated chloride channel activity and volume-sensitive chloride channel activity. Involved in several processes, including cellular hypotonic response; positive regulation of oligodendrocyte differentiation; and positive regulation of voltage-gated chloride channel activity. Located in several cellular components, including axon initial segment; dendritic spine membrane; and perikaryon. Used to study cystic fibrosis. Human ortholog(s) of this gene implicated in primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2); INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chloride channel 2; chloride channel protein 2; chloride channel, voltage-sensitive 2; ClC-2; LOC108348101
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,702,382 - 93,716,059 (+)NCBIGRCr8
mRatBN7.21180,197,741 - 80,211,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,198,153 - 80,211,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1188,920,899 - 88,934,364 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,574,316 - 81,587,781 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,635,378 - 80,648,843 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01182,862,664 - 82,876,165 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,883,879 - 83,897,394 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01186,935,748 - 86,969,314 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,427,792 - 82,441,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,485,379 - 82,498,880 (+)NCBI
Celera1179,037,893 - 79,051,394 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Clcn2Ratcystic fibrosis  IDA 704390 RGD 
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Clcn2Rat3-methylcrotonyl-CoA carboxylase 1 deficiency  ISOCLCN2 (Homo sapiens)8554872ClinVar Annotator: match by term: 3 Alpha methylcrotonylglycinuria 1ClinVarPMID:11181649 more ...
Clcn2Ratautistic disorder  ISOCLCN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Autistic behaviorClinVarPMID:25741868
Clcn2Ratcerebellar ataxia  ISOCLCN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Cerebellar ataxiaClinVarPMID:25741868
Clcn2Ratcerebral palsy  ISOCLCN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Cerebral palsyClinVarPMID:19191339 more ...
Clcn2Ratcongenital disorder of glycosylation Id  ISOCLCN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital disorder of glycosylation type 1DClinVarPMID:11181649 more ...
Clcn2RatCurrarino syndrome  ISOCLCN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Currarino triadClinVarPMID:21681106 and PMID:27549440
Clcn2Ratepilepsy  ISOCLCN2 (Homo sapiens)8554872ClinVar Annotator: match by term: SeizureClinVarPMID:17762171 more ...
Clcn2Ratfamilial focal epilepsy with variable foci 2  ISOCLCN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Epilepsy more ...ClinVarPMID:25741868
Clcn2RatFamilial Hyperaldosteronism, Type II  ISOCLCN2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:1521363 more ...
Clcn2Ratgenetic disease  ISOCLCN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Clcn2RatIdiopathic Generalized Epilepsy 11  ISOCLCN2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12612585 more ...
Clcn2Ratintellectual disability  ISOCLCN2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17762171 more ...
Clcn2RatLeukoencephalopathy with Ataxia  ISOCLCN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Leukoencephalopathy with ataxiaClinVarPMID:12612585 more ...
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Original Reference(s)
Clcn2RatFamilial Hyperaldosteronism, Type II  ISOCLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29403011
Clcn2Rathigh grade glioma  ISOCLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12843258
Clcn2RatIdiopathic Generalized Epilepsy  ISOCLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Clcn2Ratprimary hyperaldosteronism  ISOCLCN2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29403012
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Clcn2Ratleukodystrophy  ISSClcn2 (Mus musculus)13592920 MouseDO 
Clcn2Ratprimary hyperaldosteronism  ISSClcn2 (Mus musculus)13592920OMIM:605635 more ...MouseDO 
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Clcn2RatFamilial Hyperaldosteronism, Type II susceptibilityISOCLCN2 (Homo sapiens)7240710 OMIM 
Clcn2RatIdiopathic Generalized Epilepsy 11 susceptibilityISOCLCN2 (Homo sapiens)7240710 OMIM 
Clcn2RatLeukoencephalopathy with Ataxia susceptibilityISOCLCN2 (Homo sapiens)7240710 OMIM 

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Clcn2Rat(+)-pilocarpine affects expressionEXP 6480464Pilocarpine affects the expression of CLCN2 proteinCTDPMID:16930566
Clcn2Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CLCN2 mRNA]CTDPMID:31150632
Clcn2Rat1,2-dimethylhydrazine multiple interactionsISOClcn2 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CLCN2 mRNACTDPMID:22206623
Clcn2Rat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in increased expression of CLCN2 mRNACTDPMID:26496021
Clcn2Rat17beta-estradiol decreases expressionISOClcn2 (Mus musculus)6480464Estradiol results in decreased expression of CLCN2 mRNACTDPMID:39298647
Clcn2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOClcn2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of CLCN2 mRNACTDPMID:15251184
Clcn2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCLCN2 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of CLCN2 mRNACTDPMID:27913140
Clcn2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOClcn2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CLCN2 mRNACTDPMID:21570461
Clcn2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of CLCN2 mRNACTDPMID:21215274
Clcn2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of CLCN2 mRNACTDPMID:22298810
Clcn2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOClcn2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of CLCN2 mRNACTDPMID:19770486
Clcn2Rat4,4'-sulfonyldiphenol increases expressionISOClcn2 (Mus musculus)6480464bisphenol S results in increased expression of CLCN2 mRNACTDPMID:30951980
Clcn2Rat4,4'-sulfonyldiphenol decreases expressionISOClcn2 (Mus musculus)6480464bisphenol S results in decreased expression of CLCN2 mRNACTDPMID:39298647
Clcn2Rat5-aza-2'-deoxycytidine multiple interactionsISOClcn2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Decitabine] results in increased expression of CLCN2 mRNACTDPMID:15251184
Clcn2Rat5-aza-2'-deoxycytidine increases expressionISOClcn2 (Mus musculus)6480464Decitabine results in increased expression of CLCN2 mRNACTDPMID:15251184
Clcn2Ratacrylamide increases expressionISOCLCN2 (Homo sapiens)6480464Acrylamide results in increased expression of CLCN2 mRNACTDPMID:32763439
Clcn2Ratall-trans-retinoic acid decreases expressionISOCLCN2 (Homo sapiens)6480464Tretinoin results in decreased expression of CLCN2 mRNACTDPMID:33167477
Clcn2Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of CLCN2 mRNACTDPMID:16483693
Clcn2RatAzoxymethane multiple interactionsISOClcn2 (Mus musculus)6480464[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CLCN2 mRNACTDPMID:29950665
Clcn2Ratbenzo[a]pyrene decreases expressionISOClcn2 (Mus musculus)6480464Benzo(a)pyrene results in decreased expression of CLCN2 mRNACTDPMID:19770486

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Biological Process
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Clcn2Ratacinar cell differentiation acts_upstream_of_or_withinIEAUniProtKB:Q9R0A1 and ensembl:ENSMUSP000000072071600115GO_REF:0000107EnsemblGO_REF:0000107
Clcn2Ratacinar cell differentiation acts_upstream_of_or_withinISOClcn2 (Mus musculus)1624291MGI:2183262 PMID:11976342RGDPMID:11976342
Clcn2Ratcell differentiation involved in salivary gland development acts_upstream_of_or_withinISOClcn2 (Mus musculus)1624291MGI:2183262 PMID:11976342RGDPMID:11976342
Clcn2Ratcell differentiation involved in salivary gland development acts_upstream_of_or_withinIEAUniProtKB:Q9R0A1 and ensembl:ENSMUSP000000072071600115GO_REF:0000107EnsemblGO_REF:0000107
Clcn2Ratcellular hypotonic response involved_inIMP 405650350PMID:1334533UniProt 
Clcn2Ratchloride transmembrane transport involved_inIEAGO:00052541600115GO_REF:0000108GOCGO_REF:0000108
Clcn2Ratchloride transmembrane transport involved_inIEAGO:00052471600115GO_REF:0000108GOCGO_REF:0000108
Clcn2Ratchloride transmembrane transport involved_inIEAGO:00151081600115GO_REF:0000108GOCGO_REF:0000108
Clcn2Ratchloride transport  IDA 69809 RGD 
Clcn2Ratchloride transport involved_inISOClcn2 (Mus musculus)1624291 PMID:20357128RGDPMID:20357128
Clcn2Ratchloride transport involved_inIEAUniProtKB-KW:KW-08691600115GO_REF:0000043UniProtGO_REF:0000043
Clcn2Ratchloride transport involved_inIBAFB:FBgn0051116 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Clcn2Ratchloride transport involved_inIEAUniProtKB:Q9R0A1 and ensembl:ENSMUSP000000072071600115GO_REF:0000107EnsemblGO_REF:0000107
Clcn2Ratchloride transport involved_inIEAInterPro:IPR001807 and InterPro:IPR0022441600115GO_REF:0000002InterProGO_REF:0000002
Clcn2Ratchloride transport involved_inIEAARBA:ARBA000338601600115GO_REF:0000117UniProtGO_REF:0000117
Clcn2Ratlung development  IMP 1358647 RGD 
Clcn2Ratmonoatomic anion transmembrane transport involved_inIEAGO:00083081600115GO_REF:0000108GOCGO_REF:0000108
Clcn2Ratmonoatomic ion transmembrane transport involved_inIEAUniProtKB-KW:KW-0407 and UniProtKB-KW:KW-08511600115GO_REF:0000043UniProtGO_REF:0000043
Clcn2Ratmonoatomic ion transport involved_inIEAUniProtKB-KW:KW-04061600115GO_REF:0000043UniProtGO_REF:0000043
Clcn2Ratphagocytosis, engulfment involved_inISOCLCN2 (Homo sapiens)1624291 PMID:36964785RGDPMID:36964785
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Cellular Component
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Clcn2Ratactin cytoskeleton located_inISSUniProtKB:Q9NZA11600115GO_REF:0000024UniProtGO_REF:0000024
Clcn2Ratastrocyte end-foot located_inISOCLCN2 (Homo sapiens)1624291 PMID:22405205RGDPMID:22405205
Clcn2Ratastrocyte end-foot located_inIEAUniProtKB:Q9R0A1 and ensembl:ENSMUSP000000072071600115GO_REF:0000107EnsemblGO_REF:0000107
Clcn2Ratastrocyte end-foot located_inIEAUniProtKB:P51788 and ensembl:ENSP000002655931600115GO_REF:0000107EnsemblGO_REF:0000107
Clcn2Ratastrocyte end-foot located_inISOClcn2 (Mus musculus)1624291 PMID:17567819RGDPMID:17567819
Clcn2Ratastrocyte end-foot located_inIDA 405650339PMID:11068136UniProt 
Clcn2Rataxon located_inIEAUniProtKB-SubCell:SL-02791600115GO_REF:0000044UniProtGO_REF:0000044
Clcn2Rataxon initial segment located_inIDA 405650339PMID:11068136UniProt 
Clcn2Ratbasolateral plasma membrane located_inISOCLCN2 (Homo sapiens)1624291 PMID:16155254RGDPMID:16155254
Clcn2Ratbasolateral plasma membrane located_inIEAUniProtKB:P51788 and ensembl:ENSP000002655931600115GO_REF:0000107EnsemblGO_REF:0000107
Clcn2Ratbasolateral plasma membrane located_inIEAUniProtKB:Q9R0A1 and ensembl:ENSMUSP000000072071600115GO_REF:0000107EnsemblGO_REF:0000107
Clcn2Ratbasolateral plasma membrane located_inIEAUniProtKB-SubCell:SL-00261600115GO_REF:0000044UniProtGO_REF:0000044
Clcn2Ratbasolateral plasma membrane located_inISOClcn2 (Mus musculus)1624291 PMID:16155254RGDPMID:16155254
Clcn2Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Clcn2Ratchloride channel complex part_ofIEAUniProtKB-KW:KW-08691600115GO_REF:0000043UniProtGO_REF:0000043
Clcn2Ratdendrite  IDA 2303820 RGD 
Clcn2Ratdendritic spine membrane located_inIDA 405650339PMID:11068136UniProt 
Clcn2Ratdendritic spine membrane located_inIEAUniProtKB-SubCell:SL-02851600115GO_REF:0000044UniProtGO_REF:0000044
Clcn2Ratmembrane located_inIEAInterPro:IPR001807 and InterPro:IPR0022441600115GO_REF:0000002InterProGO_REF:0000002
Clcn2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Clcn2Ratchloride channel activity enablesIEAUniProtKB-KW:KW-08691600115GO_REF:0000043UniProtGO_REF:0000043
Clcn2Ratchloride channel regulator activity enablesISOCLCN2 (Homo sapiens)1624291 PMID:38345841RGDPMID:38345841
Clcn2Ratchloride channel regulator activity enablesIEAUniProtKB:P51788 and ensembl:ENSP000002655931600115GO_REF:0000107EnsemblGO_REF:0000107
Clcn2Ratchloride transmembrane transporter activity enablesIEAInterPro:IPR0018071600115GO_REF:0000002InterProGO_REF:0000002
Clcn2Ratprotein binding enablesISOCLCN2 (Homo sapiens) and UniProtKB:P51788-41624291UniProtKB:Q9UMX0-2 and PMID:26871637RGDPMID:26871637
Clcn2Ratprotein binding enablesISOCLCN2 (Homo sapiens)1624291UniProtKB:Q13643 and PMID:26871637RGDPMID:26871637
Clcn2Ratprotein binding enablesISOClcn2 (Mus musculus)1624291UniProtKB:Q640R3 and PMID:22405205RGDPMID:22405205
Clcn2Ratvoltage-gated chloride channel activity  IDA 69809 RGD 
Clcn2Ratvoltage-gated chloride channel activity enablesISOClcn2 (Mus musculus)1624291MGI:2183262 PMID:11976342RGDPMID:11976342
Clcn2Ratvoltage-gated chloride channel activity enablesIBAMGI:105061 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Clcn2Ratvoltage-gated chloride channel activity enablesIEAUniProtKB:Q9R0A1 and ensembl:ENSMUSP000000072071600115GO_REF:0000107EnsemblGO_REF:0000107
Clcn2Ratvoltage-gated chloride channel activity enablesIEAInterPro:IPR0022441600115GO_REF:0000002InterProGO_REF:0000002
Clcn2Ratvoltage-gated chloride channel activity enablesIEAUniProtKB:P51788 and ensembl:ENSP000002655931600115GO_REF:0000107EnsemblGO_REF:0000107
Clcn2Ratvoltage-gated chloride channel activity enablesIMP 405650350PMID:1334533UniProt 
Clcn2Ratvoltage-gated chloride channel activity enablesISOCLCN2 (Homo sapiens)1624291 PMID:16155254 more ...RGDPMID:16155254 more ...
Clcn2Ratvoltage-gated chloride channel activity enablesIDA 405650388PMID:8816717UniProt 
Clcn2Ratvoltage-gated monoatomic anion channel activity enablesIDA 405650250PMID:22405205UniProt 
Clcn2Ratvoltage-gated monoatomic anion channel activity enablesIEAUniProtKB:Q9R0A1 and ensembl:ENSMUSP000000072071600115GO_REF:0000107EnsemblGO_REF:0000107
Clcn2Ratvoltage-gated monoatomic anion channel activity enablesISOClcn2 (Mus musculus)1624291 PMID:26666914RGDPMID:26666914
Clcn2Ratvolume-sensitive chloride channel activity enablesIMP 405650350PMID:1334533UniProt 
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Reference Title
Reference Citation
1. Inhibition of CLC-2 chloride channel expression interrupts expansion of fetal lung cysts. Blaisdell CJ, etal., Am J Physiol Lung Cell Mol Physiol 2004 Feb;286(2):L420-6.
2. Alternative mRNA splice variants of the rat ClC-2 chloride channel gene are expressed in lung: genomic sequence and organization of ClC-2. Chu S and Zeitlin PL, Nucleic Acids Res 1997 Oct 15;25(20):4153-9.
3. A short CIC-2 mRNA transcript is produced by exon skipping. Chu S, etal., Nucleic Acids Res 1996 Sep 1;24(17):3453-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume. Gründer S, etal., Nature. 1992 Dec 24-31;360(6406):759-62. doi: 10.1038/360759a0.
7. Cell type-specific differences in chloride-regulatory mechanisms and GABA(A) receptor-mediated inhibition in rat substantia nigra. Gulacsi A, etal., J Neurosci. 2003 Sep 10;23(23):8237-46.
8. CLC-2 is a positive modulator of oligodendrocyte precursor cell differentiation and myelination. Hou X, etal., Mol Med Rep. 2018 Mar;17(3):4515-4523. doi: 10.3892/mmr.2018.8439. Epub 2018 Jan 17.
9. GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit. Jeworutzki E, etal., Neuron. 2012 Mar 8;73(5):951-61. doi: 10.1016/j.neuron.2011.12.039.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel. Staley K, etal., Neuron. 1996 Sep;17(3):543-51. doi: 10.1016/s0896-6273(00)80186-5.
18. Distribution of chloride channel-2-immunoreactive neuronal and astrocytic processes in the hippocampus. Sík A, etal., Neuroscience. 2000;101(1):51-65. doi: 10.1016/s0306-4522(00)00360-2.
19. A chloride channel widely expressed in epithelial and non-epithelial cells. Thiemann A, etal., Nature 1992 Mar 5;356(6364):57-60.
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PMID:11976342   PMID:12381811   PMID:12811561   PMID:14724195   PMID:15358597   PMID:15388342   PMID:15883157   PMID:16526942   PMID:16930566   PMID:17110372   PMID:20411246   PMID:20676104  
PMID:21052544   PMID:21549811   PMID:28255270   PMID:29403011   PMID:38418461  



Clcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,702,382 - 93,716,059 (+)NCBIGRCr8
mRatBN7.21180,197,741 - 80,211,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,198,153 - 80,211,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1188,920,899 - 88,934,364 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,574,316 - 81,587,781 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,635,378 - 80,648,843 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01182,862,664 - 82,876,165 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,883,879 - 83,897,394 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01186,935,748 - 86,969,314 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,427,792 - 82,441,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,485,379 - 82,498,880 (+)NCBI
Celera1179,037,893 - 79,051,394 (+)NCBICelera
Cytogenetic Map11q23NCBI
CLCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383184,346,185 - 184,361,605 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3184,346,185 - 184,361,650 (-)EnsemblGRCh38hg38GRCh38
GRCh373184,063,973 - 184,079,393 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,547,034 - 185,562,085 (-)NCBINCBI36Build 36hg18NCBI36
Build 343185,547,095 - 185,561,969NCBI
Celera3182,504,875 - 182,520,290 (-)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3181,470,404 - 181,485,871 (-)NCBIHuRef
CHM1_13184,028,432 - 184,043,898 (-)NCBICHM1_1
T2T-CHM13v2.03187,155,451 - 187,170,873 (-)NCBIT2T-CHM13v2.0
Clcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,521,185 - 20,536,496 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1620,521,714 - 20,536,496 (-)EnsemblGRCm39 Ensembl
GRCm381620,702,435 - 20,717,746 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,702,964 - 20,717,746 (-)EnsemblGRCm38mm10GRCm38
MGSCv371620,703,039 - 20,716,709 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361620,616,509 - 20,629,657 (-)NCBIMGSCv36mm8
Celera1621,268,322 - 21,281,991 (-)NCBICelera
Cytogenetic Map16A3- B1NCBI
cM Map1612.5NCBI
Clcn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,138,605 - 23,152,311 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,138,558 - 23,152,462 (+)NCBIChiLan1.0ChiLan1.0
CLCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22182,219,532 - 182,235,030 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13182,223,590 - 182,239,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03181,383,608 - 181,399,200 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13189,865,627 - 189,881,049 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,862,489 - 189,881,049 (-)Ensemblpanpan1.1panPan2
CLCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13417,224,136 - 17,238,755 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3417,223,215 - 17,239,621 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3421,309,705 - 21,324,280 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03417,131,619 - 17,146,202 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3417,131,648 - 17,146,119 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13417,168,519 - 17,183,094 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03417,164,603 - 17,179,167 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03417,393,559 - 17,408,134 (-)NCBIUU_Cfam_GSD_1.0
Clcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,433,596 - 119,447,715 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365785,525,601 - 5,539,472 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365785,525,461 - 5,539,351 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13122,234,736 - 122,249,867 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113122,234,731 - 122,249,889 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,674,508 - 131,689,583 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,057,687 - 5,073,596 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,057,900 - 5,073,184 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606313,835,604 - 13,851,241 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clcn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473072,228,189 - 72,244,332 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473072,228,912 - 72,242,636 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Clcn2
26 total Variants

Predicted Target Of
Summary Value
Count of predictions:589
Count of miRNA genes:215
Interacting mature miRNAs:261
Transcripts:ENSRNOT00000002376, ENSRNOT00000050927, ENSRNOT00000071707, ENSRNOT00000071956, ENSRNOT00000073435, ENSRNOT00000073841
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 18 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat

1 to 10 of 18 rows
D11Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,208,450 - 80,208,686 (+)MAPPERmRatBN7.2
Rnor_6.01182,872,959 - 82,873,194NCBIRnor6.0
Rnor_6.01183,894,190 - 83,894,425NCBIRnor6.0
Rnor_5.01185,952,052 - 85,952,287UniSTSRnor5.0
Rnor_5.01186,966,108 - 86,966,343UniSTSRnor5.0
RGSC_v3.41182,438,087 - 82,438,322UniSTSRGSC3.4
Celera1179,048,188 - 79,048,423UniSTS
Cytogenetic Map11q23UniSTS
RH129159  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,193,708 - 80,193,923 (+)MAPPERmRatBN7.2
Rnor_6.01183,879,450 - 83,879,664NCBIRnor6.0
Rnor_6.01182,858,219 - 82,858,433NCBIRnor6.0
Rnor_5.01186,951,368 - 86,951,582UniSTSRnor5.0
Rnor_5.01185,937,312 - 85,937,526UniSTSRnor5.0
RGSC_v3.41182,423,347 - 82,423,561UniSTSRGSC3.4
Celera1179,033,448 - 79,033,662UniSTS
RH 3.4 Map11656.5UniSTS
Cytogenetic Map11q23UniSTS
BF387879  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,188,772 - 80,188,925 (+)MAPPERmRatBN7.2
Rnor_6.01183,874,516 - 83,874,668NCBIRnor6.0
Rnor_6.01182,853,285 - 82,853,437NCBIRnor6.0
Rnor_5.01186,946,434 - 86,946,586UniSTSRnor5.0
Rnor_5.01185,932,378 - 85,932,530UniSTSRnor5.0
RGSC_v3.41182,418,413 - 82,418,565UniSTSRGSC3.4
Celera1179,028,514 - 79,028,666UniSTS
RH 3.4 Map11657.9UniSTS
Cytogenetic Map11q23UniSTS
RH94517  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,187,994 - 80,188,141 (+)MAPPERmRatBN7.2
Rnor_6.01182,852,507 - 82,852,653NCBIRnor6.0
Rnor_6.01183,873,738 - 83,873,884NCBIRnor6.0
Rnor_5.01186,945,656 - 86,945,802UniSTSRnor5.0
Rnor_5.01185,931,600 - 85,931,746UniSTSRnor5.0
RGSC_v3.41182,417,635 - 82,417,781UniSTSRGSC3.4
Celera1179,027,736 - 79,027,882UniSTS
RH 3.4 Map11658.0UniSTS
Cytogenetic Map11q23UniSTS




alimentary part of gastrointestinal system
ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
nervous system
renal system
reproductive system
2 8 3 3 3 3 8 8 3 10



Ensembl Acc Id: ENSRNOT00000002376   ⟹   ENSRNOP00000002376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,198,153 - 80,211,653 (+)Ensembl
Rnor_6.0 Ensembl1183,884,048 - 83,897,084 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000050927   ⟹   ENSRNOP00000050925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,198,153 - 80,211,653 (+)Ensembl
Rnor_6.0 Ensembl1183,883,879 - 83,897,394 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071707   ⟹   ENSRNOP00000066524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,198,153 - 80,211,653 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000073435   ⟹   ENSRNOP00000065970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,199,817 - 80,211,657 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119058   ⟹   ENSRNOP00000089386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,199,817 - 80,211,657 (+)Ensembl
RefSeq Acc Id: NM_017137   ⟹   NP_058833
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,594 - 93,716,059 (+)NCBI
mRatBN7.21180,198,190 - 80,211,657 (+)NCBI
Rnor_6.01182,862,664 - 82,876,165 (+)NCBI
Rnor_5.01186,935,748 - 86,969,314 (+)NCBI
RGSC_v3.41182,427,792 - 82,441,293 (+)RGD
Celera1179,037,893 - 79,051,394 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248563   ⟹   XP_006248625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,382 - 93,716,059 (+)NCBI
mRatBN7.21180,197,741 - 80,211,648 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088239   ⟹   XP_038944167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,382 - 93,716,059 (+)NCBI
mRatBN7.21180,197,741 - 80,211,648 (+)NCBI
RefSeq Acc Id: XM_039088240   ⟹   XP_038944168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,706,129 - 93,716,059 (+)NCBI
mRatBN7.21180,201,724 - 80,211,648 (+)NCBI
RefSeq Acc Id: XM_039088243   ⟹   XP_038944171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,382 - 93,709,819 (+)NCBI
mRatBN7.21180,197,741 - 80,205,414 (+)NCBI
RefSeq Acc Id: XM_039088244   ⟹   XP_038944172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,708,699 - 93,716,059 (+)NCBI
mRatBN7.21180,204,364 - 80,211,648 (+)NCBI
RefSeq Acc Id: XM_063270437   ⟹   XP_063126507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,382 - 93,711,386 (+)NCBI
RefSeq Acc Id: XM_063270438   ⟹   XP_063126508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,382 - 93,711,844 (+)NCBI
RefSeq Acc Id: XR_358402
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,382 - 93,711,841 (+)NCBI
mRatBN7.21180,197,741 - 80,207,443 (+)NCBI
Sequence:
RefSeq Acc Id: XR_595156
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,382 - 93,711,792 (+)NCBI
mRatBN7.21180,197,741 - 80,207,391 (+)NCBI
Sequence:
RefSeq Acc Id: XR_595157
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,702,382 - 93,711,841 (+)NCBI
mRatBN7.21180,197,741 - 80,211,637 (+)NCBI
Sequence:
1 to 5 of 13 rows
1 to 5 of 13 rows
RefSeq Acc Id: NP_058833   ⟸   NM_017137
- UniProtKB: P35525 (UniProtKB/Swiss-Prot),   A6JS86 (UniProtKB/TrEMBL),   O54821 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248625   ⟸   XM_006248563
- Peptide Label: isoform X1
- UniProtKB: A0A0A0MXT6 (UniProtKB/TrEMBL),   O54822 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038944167   ⟸   XM_039088239
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QXG3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944171   ⟸   XM_039088243
- Peptide Label: isoform X6
- UniProtKB: O54823 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944168   ⟸   XM_039088240
- Peptide Label: isoform X5
CBS

Name Modeler Protein Id AA Range Protein Structure
AF-P35525-F1-model_v2 AlphaFold P35525 1-907 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 34 of 34 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-20754 BioCyc
Ensembl Genes ENSRNOG00000001742 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002376 ENTREZGENE
  ENSRNOT00000050927 ENTREZGENE
  ENSRNOT00000050927.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.580.10 UniProtKB/Swiss-Prot
  Clc chloride channel UniProtKB/Swiss-Prot
InterPro CBS_dom_sf UniProtKB/Swiss-Prot
  Cl-channel-2 UniProtKB/Swiss-Prot
  Cl-channel_core UniProtKB/Swiss-Prot
  Cl-channel_volt-gated UniProtKB/Swiss-Prot
  Cl_channel_volt-gated UniProtKB/Swiss-Prot
KEGG Report rno:29232 UniProtKB/Swiss-Prot
NCBI Gene 29232 ENTREZGENE
PANTHER CHLORIDE CHANNEL PROTEIN 2 UniProtKB/Swiss-Prot
  CHLORIDE CHANNEL PROTEIN 2 UniProtKB/Swiss-Prot
Pfam Voltage_CLC UniProtKB/Swiss-Prot
PhenoGen Clcn2 PhenoGen
PRINTS CLCHANNEL UniProtKB/Swiss-Prot
  CLCHANNEL2 UniProtKB/Swiss-Prot
PROSITE CBS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001742 RatGTEx
Superfamily-SCOP SSF54631 UniProtKB/Swiss-Prot
  SSF81340 UniProtKB/Swiss-Prot
UniProt A0A0A0MXT6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ABL4_RAT UniProtKB/TrEMBL
  A0A8L2QXG3 ENTREZGENE, UniProtKB/TrEMBL
  A6JS86 ENTREZGENE, UniProtKB/TrEMBL
  CLCN2_RAT UniProtKB/Swiss-Prot
  E9PU32_RAT UniProtKB/TrEMBL
  O54821 ENTREZGENE, UniProtKB/TrEMBL
  O54822 ENTREZGENE, UniProtKB/TrEMBL
  O54823 ENTREZGENE, UniProtKB/TrEMBL
  P35525 ENTREZGENE
1 to 34 of 34 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Clcn2  chloride voltage-gated channel 2  LOC108348101  chloride channel protein 2  Data merged from RGD:11384925 737654 PROVISIONAL
2016-08-02 LOC108348101  chloride channel protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2016-02-11 Clcn2  chloride voltage-gated channel 2  Clcn2  chloride channel, voltage-sensitive 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Clcn2  chloride channel, voltage-sensitive 2  Clcn2  chloride channel 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Clcn2  chloride channel 2      Symbol and Name status set to approved 70586 APPROVED