Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Clcn2 (chloride channel, voltage-sensitive 2) Mus musculus
Symbol: Clcn2
Name: chloride channel, voltage-sensitive 2
RGD ID: 736064
Description: Exhibits voltage-gated chloride channel activity. Involved in cell differentiation involved in salivary gland development and retina development in camera-type eye. Predicted to localize to dendrite; integral component of plasma membrane; and perikaryon. Is expressed in several structures, including central nervous system; gonad; hindlimb phalanx; notochord; and visual system. Used to study leukodystrophy. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 11 and primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AL118368; chloride channel 2; chloride channel protein 2; Clc; ClC-; ClC-2; Clc2; nmf24; nmf240
Homo sapiens (human) : CLCN2 (chloride voltage-gated channel 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Clcn2 (chloride voltage-gated channel 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clcn2 (chloride voltage-gated channel 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CLCN2 (chloride voltage-gated channel 2)
Canis lupus familiaris (dog) : CLCN2 (chloride voltage-gated channel 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clcn2 (chloride voltage-gated channel 2)
Sus scrofa (pig) : CLCN2 (chloride voltage-gated channel 2)
Chlorocebus sabaeus (African green monkey) : CLCN2 (chloride voltage-gated channel 2)
Heterocephalus glaber (naked mole-rat) : Clcn2 (chloride voltage-gated channel 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391620,521,185 - 20,536,496 (-)NCBI
GRCm381620,702,435 - 20,717,746 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,702,964 - 20,717,746 (-)EnsemblGRCm38mm10GRCm38
MGSCv371620,703,039 - 20,716,709 (-)NCBIGRCm37mm9NCBIm37
MGSCv361620,616,509 - 20,629,657 (-)NCBImm8
Celera1621,268,322 - 21,281,991 (-)NCBICelera
Cytogenetic Map16A3- B1NCBI
cM Map1612.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Clcn2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736064
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-11-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.