Gene: CLCN2 (chloride voltage-gated channel 2) Homo sapiens
Symbol: CLCN2
Name: chloride voltage-gated channel 2
Description: This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: chloride channel 2; chloride channel protein 2; chloride channel, voltage-sensitive 2; CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11; EGI3; EGMA; EJM6; EJM8; LKPAT; OTTHUMP00000210513; OTTHUMP00000210514; OTTHUMP00000210515; OTTHUMP00000210516
Mus musculus (house mouse) : Clcn2 (chloride channel, voltage-sensitive 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Clcn2 (chloride voltage-gated channel 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clcn2 (chloride voltage-gated channel 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CLCN2 (chloride voltage-gated channel 2)
Canis lupus familiaris (dog) : CLCN2 (chloride voltage-gated channel 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clcn2 (chloride voltage-gated channel 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh383184,346,185 - 184,361,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373184,063,973 - 184,079,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,547,034 - 185,562,085 (-)NCBINCBI36hg18NCBI36
Build 343185,547,095 - 185,561,969NCBI
Celera3182,504,875 - 182,520,290 (-)NCBI
Cytogenetic Map3q27.1NCBI
HuRef3181,470,404 - 181,485,871 (-)NCBIHuRef
CHM1_13184,028,432 - 184,043,898 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CLCN2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733366
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2018-03-13
Status: ACTIVE