Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Grik1 (glutamate ionotropic receptor kainate type subunit 1) Rattus norvegicus
Symbol: Grik1
Name: glutamate ionotropic receptor kainate type subunit 1
Description: Exhibits several functions, including glutamate binding activity; ion gated channel activity; and protein homodimerization activity. Involved in ionotropic glutamate receptor signaling pathway; modulation of chemical synaptic transmission; and nervous system development. Localizes to several cellular components, including the glutamatergic synapse; integral component of plasma membrane; and neuron projection. Used to study status epilepticus. Human ortholog(s) of this gene implicated in childhood absence epilepsy. Orthologous to human GRIK1 (glutamate ionotropic receptor kainate type subunit 1); PARTICIPATES IN long term potentiation; glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GluK1; GluR-5; GluR5; glutamate receptor 5; glutamate receptor ionotropic kainate 1; glutamate receptor ionotropic, kainate 1; glutamate receptor, ionotropic kainate 1; glutamate receptor, ionotropic, kainate 1
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01127,811,954 - 28,213,940 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01131,426,627 - 31,828,737 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41127,703,874 - 28,106,450 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11127,703,874 - 28,106,450 (-)NCBI
Celera1126,906,345 - 27,304,585 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Grik1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2732
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.