Grik1 (glutamate ionotropic receptor kainate type subunit 1) - Rat Genome Database

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Gene: Grik1 (glutamate ionotropic receptor kainate type subunit 1) Rattus norvegicus
Analyze
Symbol: Grik1
Name: glutamate ionotropic receptor kainate type subunit 1
RGD ID: 2732
Description: Enables several functions, including glutamate binding activity; ligand-gated monoatomic ion channel activity; and scaffold protein binding activity. Contributes to heterocyclic compound binding activity. Involved in ionotropic glutamate receptor signaling pathway; modulation of chemical synaptic transmission; and nervous system development. Located in dendrite; neuronal cell body; and terminal bouton. Part of ionotropic glutamate receptor complex. Is active in glutamatergic synapse and presynaptic membrane. Used to study status epilepticus. Human ortholog(s) of this gene implicated in childhood absence epilepsy. Orthologous to human GRIK1 (glutamate ionotropic receptor kainate type subunit 1); PARTICIPATES IN long term potentiation; glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: GluK1; GluR-5; GluR5; glutamate receptor 5; glutamate receptor ionotropic kainate 1; glutamate receptor ionotropic, kainate 1; glutamate receptor, ionotropic kainate 1; glutamate receptor, ionotropic, kainate 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21127,169,739 - 27,571,131 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1127,169,740 - 27,570,645 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1135,873,718 - 36,274,020 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01128,573,961 - 28,974,261 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01127,741,791 - 28,141,806 (-)NCBIRnor_WKY
Rnor_6.01127,811,954 - 28,213,940 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1127,811,957 - 27,971,359 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01131,426,627 - 31,828,737 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41127,703,874 - 28,106,450 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11127,703,874 - 28,106,450 (-)NCBI
Celera1126,906,345 - 27,304,585 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development. Bettler B, etal., Neuron 1990 Nov;5(5):583-95.
2. Kainate receptors are involved in synaptic plasticity. Bortolotto ZA, etal., Nature. 1999 Nov 18;402(6759):297-301.
3. Bidirectional modulation of GABA release by presynaptic glutamate receptor 5 kainate receptors in the basolateral amygdala. Braga MF, etal., J Neurosci. 2003 Jan 15;23(2):442-52.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons. Gryder DS and Rogawski MA, J Neurosci 2003 Aug 6;23(18):7069-74.
7. Activation of spinal kainate receptors after inflammation: behavioral hyperalgesia and subunit gene expression. Guo W, etal., Eur J Pharmacol 2002 Oct 11;452(3):309-18.
8. Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. Hirbec H, etal., Neuron. 2003 Feb 20;37(4):625-38. doi: 10.1016/s0896-6273(02)01191-1.
9. Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn. Lu CR, etal., J Comp Neurol. 2005 May 30;486(2):169-78.
10. Presynaptic low- and high-affinity kainate receptors in nociceptive spinal afferents. Lucifora S, etal., Pain. 2006 Jan;120(1-2):97-105. Epub 2005 Dec 15.
11. Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists. Mayer ML, etal., J Neurosci. 2006 Mar 15;26(11):2852-61.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
15. GluR5 and GluR6 kainate receptor subunits coexist in hippocampal neurons and coassemble to form functional receptors. Paternain AV, etal., J Neurosci. 2000 Jan 1;20(1):196-205.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. GluR5 kainate receptors, seizures, and the amygdala. Rogawski MA, etal., Ann N Y Acad Sci. 2003 Apr;985:150-62.
20. Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway. Salinas GD, etal., J Biol Chem. 2006 Dec 29;281(52):40164-73. Epub 2006 Oct 24.
21. Effects of the kainate receptor agonist ATPA on glutamatergic synaptic transmission and plasticity during early postnatal development. Sallert M, etal., Neuropharmacology. 2007 May;52(6):1354-65. Epub 2007 Feb 4.
22. Allelic association of juvenile absence epilepsy with a GluR5 kainate receptor gene (GRIK1) polymorphism. Sander T, etal., Am J Med Genet 1997 Jul 25;74(4):416-21.
23. Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia. Shibata H, etal., Psychiatr Genet. 2001 Sep;11(3):139-44.
24. A glutamate receptor channel with high affinity for domoate and kainate. Sommer B, etal., EMBO J. 1992 Apr;11(4):1651-6. doi: 10.1002/j.1460-2075.1992.tb05211.x.
25. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1322826   PMID:8889548   PMID:9069287   PMID:9335499   PMID:10516295   PMID:11069933   PMID:11144357   PMID:11985817   PMID:12223554   PMID:14715943   PMID:14724198   PMID:15014126  
PMID:15458844   PMID:15483117   PMID:15509753   PMID:15513934   PMID:15537878   PMID:15673679   PMID:15928066   PMID:17174564   PMID:17245443   PMID:17569736   PMID:18046310   PMID:18678878  
PMID:19043593   PMID:19123252   PMID:20848775   PMID:21734292   PMID:22279215   PMID:24069373   PMID:28100490   PMID:30421168   PMID:30451858  


Genomics

Comparative Map Data
Grik1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21127,169,739 - 27,571,131 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1127,169,740 - 27,570,645 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1135,873,718 - 36,274,020 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01128,573,961 - 28,974,261 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01127,741,791 - 28,141,806 (-)NCBIRnor_WKY
Rnor_6.01127,811,954 - 28,213,940 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1127,811,957 - 27,971,359 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01131,426,627 - 31,828,737 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41127,703,874 - 28,106,450 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11127,703,874 - 28,106,450 (-)NCBI
Celera1126,906,345 - 27,304,585 (-)NCBICelera
Cytogenetic Map11q11NCBI
GRIK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382129,536,933 - 29,939,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2129,536,933 - 29,940,033 (-)EnsemblGRCh38hg38GRCh38
GRCh372130,909,254 - 31,312,314 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362129,831,125 - 30,234,153 (-)NCBINCBI36Build 36hg18NCBI36
Build 342129,831,126 - 30,234,153NCBI
Celera2116,092,373 - 16,495,412 (-)NCBICelera
Cytogenetic Map21q21.3NCBI
HuRef2116,317,387 - 16,721,110 (-)NCBIHuRef
CHM1_12130,470,770 - 30,873,809 (-)NCBICHM1_1
T2T-CHM13v2.02127,902,775 - 28,305,893 (-)NCBIT2T-CHM13v2.0
Grik1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391687,692,789 - 88,087,751 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1687,692,788 - 88,087,153 (-)EnsemblGRCm39 Ensembl
GRCm381687,895,901 - 88,290,863 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1687,895,900 - 88,290,265 (-)EnsemblGRCm38mm10GRCm38
MGSCv371687,896,142 - 88,290,503 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361687,784,754 - 88,179,102 (-)NCBIMGSCv36mm8
Celera1688,093,673 - 88,486,750 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1650.23NCBI
Grik1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540728,899,899 - 29,308,470 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540728,899,643 - 29,308,936 (-)NCBIChiLan1.0ChiLan1.0
GRIK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12120,585,887 - 20,966,267 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02115,976,931 - 16,357,578 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12129,363,972 - 29,743,940 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2129,364,269 - 29,743,379 (-)Ensemblpanpan1.1panPan2
GRIK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13124,477,319 - 24,839,502 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3124,478,696 - 24,839,434 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3124,471,425 - 24,648,177 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03124,592,133 - 24,768,924 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3124,592,138 - 24,953,198 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13124,542,198 - 24,719,018 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03124,544,158 - 24,720,948 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03125,015,707 - 25,192,582 (-)NCBIUU_Cfam_GSD_1.0
Grik1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497124,931,282 - 25,310,559 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650012,157,765 - 12,536,224 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493650012,157,215 - 12,536,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13192,877,606 - 193,294,952 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113192,877,707 - 193,296,954 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213203,411,219 - 203,897,606 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRIK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1262,286,828 - 62,692,061 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660714,856,919 - 5,276,564 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grik1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474517,592,874 - 17,986,759 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474517,592,587 - 17,986,863 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grik1
2861 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:67
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000042581, ENSRNOT00000050073, ENSRNOT00000051060
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat

Markers in Region
RH132302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21127,169,788 - 27,169,979 (+)MAPPERmRatBN7.2
Rnor_6.01127,812,004 - 27,812,194NCBIRnor6.0
Rnor_5.01131,426,677 - 31,426,867UniSTSRnor5.0
RGSC_v3.41127,703,924 - 27,704,114UniSTSRGSC3.4
Celera1126,906,395 - 26,906,585UniSTS
RH 3.4 Map11137.5UniSTS
Cytogenetic Map11q11UniSTS
D10S224  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21127,188,185 - 27,189,584 (+)MAPPERmRatBN7.2
Rnor_6.01127,830,716 - 27,832,114NCBIRnor6.0
Rnor_5.01131,445,389 - 31,446,787UniSTSRnor5.0
RGSC_v3.41127,722,321 - 27,723,719UniSTSRGSC3.4
Celera1126,924,740 - 26,926,138UniSTS
Cytogenetic Map11q11UniSTS
UniSTS:478959  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21127,413,001 - 27,413,216 (+)MAPPERmRatBN7.2
Rnor_6.01128,056,384 - 28,056,598NCBIRnor6.0
Rnor_5.01131,671,205 - 31,671,419UniSTSRnor5.0
RGSC_v3.41127,948,442 - 27,948,656UniSTSRGSC3.4
Celera1127,149,365 - 27,149,579UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map11q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 46 2
Low 8 2 2 2 22 18 29
Below cutoff 1 14 9 6 10 6 3 3 6 5 7 1 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001111114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001111117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AI145540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z11712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z11713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z11714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000042581   ⟹   ENSRNOP00000050263
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1127,169,742 - 27,570,645 (-)Ensembl
Rnor_6.0 Ensembl1127,811,957 - 27,971,359 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000050073   ⟹   ENSRNOP00000045594
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1127,169,742 - 27,570,645 (-)Ensembl
Rnor_6.0 Ensembl1127,812,235 - 27,971,359 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000051060   ⟹   ENSRNOP00000046164
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1127,169,740 - 27,570,645 (-)Ensembl
Rnor_6.0 Ensembl1127,811,957 - 27,971,359 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081066   ⟹   ENSRNOP00000074448
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1127,170,536 - 27,570,645 (-)Ensembl
Rnor_6.0 Ensembl1127,812,751 - 27,971,359 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085629   ⟹   ENSRNOP00000069424
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1127,169,742 - 27,328,359 (-)Ensembl
Rnor_6.0 Ensembl1127,811,957 - 27,971,359 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100916   ⟹   ENSRNOP00000078137
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1127,187,235 - 27,570,645 (-)Ensembl
RefSeq Acc Id: NM_001111114   ⟹   NP_001104584
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21127,169,739 - 27,570,273 (-)NCBI
Rnor_6.01127,811,954 - 28,213,539 (-)NCBI
Rnor_5.01131,426,627 - 31,828,737 (-)NCBI
RGSC_v3.41127,703,874 - 28,106,450 (-)RGD
Celera1126,906,345 - 27,304,585 (-)RGD
Sequence:
RefSeq Acc Id: NM_001111117   ⟹   NP_001104587
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21127,169,739 - 27,570,273 (-)NCBI
Rnor_6.01127,811,954 - 28,213,539 (-)NCBI
Rnor_5.01131,426,627 - 31,828,737 (-)NCBI
RGSC_v3.41127,703,874 - 28,106,450 (-)RGD
Celera1126,906,345 - 27,304,585 (-)RGD
Sequence:
RefSeq Acc Id: NM_017241   ⟹   NP_058937
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21127,169,739 - 27,570,273 (-)NCBI
Rnor_6.01127,811,954 - 28,213,539 (-)NCBI
Rnor_5.01131,426,627 - 31,828,737 (-)NCBI
RGSC_v3.41127,703,874 - 28,106,450 (-)RGD
Celera1126,906,345 - 27,304,585 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248053   ⟹   XP_006248115
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21127,170,020 - 27,570,088 (-)NCBI
Rnor_6.01127,811,954 - 28,213,940 (-)NCBI
Rnor_5.01131,426,627 - 31,828,737 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248054   ⟹   XP_006248116
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21127,187,281 - 27,570,119 (-)NCBI
Rnor_6.01127,828,400 - 28,213,940 (-)NCBI
Rnor_5.01131,426,627 - 31,828,737 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597947   ⟹   XP_017453436
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21127,169,739 - 27,341,648 (-)NCBI
Rnor_6.01127,811,954 - 27,984,741 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088252   ⟹   XP_038944180
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21127,187,370 - 27,570,088 (-)NCBI
RefSeq Acc Id: XM_039088253   ⟹   XP_038944181
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21127,200,581 - 27,571,131 (-)NCBI
RefSeq Acc Id: XR_005491017
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21127,170,034 - 27,570,119 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058937   ⟸   NM_017241
- Peptide Label: isoform 2
- UniProtKB: P22756 (UniProtKB/Swiss-Prot),   A0A140TAF9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001104584   ⟸   NM_001111114
- Peptide Label: isoform 3
- UniProtKB: P22756 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001104587   ⟸   NM_001111117
- Peptide Label: isoform 1 precursor
- UniProtKB: P22756 (UniProtKB/Swiss-Prot),   F1M7M9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248115   ⟸   XM_006248053
- Peptide Label: isoform X1
- UniProtKB: A0A140TAG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248116   ⟸   XM_006248054
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017453436   ⟸   XM_017597947
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000069424   ⟸   ENSRNOT00000085629
RefSeq Acc Id: ENSRNOP00000046164   ⟸   ENSRNOT00000051060
RefSeq Acc Id: ENSRNOP00000050263   ⟸   ENSRNOT00000042581
RefSeq Acc Id: ENSRNOP00000074448   ⟸   ENSRNOT00000081066
RefSeq Acc Id: ENSRNOP00000045594   ⟸   ENSRNOT00000050073
RefSeq Acc Id: XP_038944180   ⟸   XM_039088252
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y1Z7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944181   ⟸   XM_039088253
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000078137   ⟸   ENSRNOT00000100916
Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22756-F1-model_v2 AlphaFold P22756 1-949 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2732 AgrOrtholog
BioCyc Gene G2FUF-22035 BioCyc
Ensembl Genes ENSRNOG00000001575 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000045594 ENTREZGENE
  ENSRNOP00000045594.5 UniProtKB/TrEMBL
  ENSRNOP00000046164 ENTREZGENE
  ENSRNOP00000046164.5 UniProtKB/TrEMBL
  ENSRNOP00000050263 ENTREZGENE
  ENSRNOP00000050263.6 UniProtKB/TrEMBL
  ENSRNOP00000069424 ENTREZGENE
  ENSRNOP00000069424.2 UniProtKB/TrEMBL
  ENSRNOP00000074448 ENTREZGENE
  ENSRNOP00000074448.2 UniProtKB/TrEMBL
  ENSRNOP00000078137 ENTREZGENE
  ENSRNOP00000078137.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042581 ENTREZGENE
  ENSRNOT00000042581.6 UniProtKB/TrEMBL
  ENSRNOT00000050073 ENTREZGENE
  ENSRNOT00000050073.6 UniProtKB/TrEMBL
  ENSRNOT00000051060 ENTREZGENE
  ENSRNOT00000051060.6 UniProtKB/TrEMBL
  ENSRNOT00000081066 ENTREZGENE
  ENSRNOT00000081066.2 UniProtKB/TrEMBL
  ENSRNOT00000085629 ENTREZGENE
  ENSRNOT00000085629.2 UniProtKB/TrEMBL
  ENSRNOT00000100916 ENTREZGENE
  ENSRNOT00000100916.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29559 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29559 ENTREZGENE
PANTHER GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grik1 PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBPe UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC221180
UniProt A0A0G2JVC0_RAT UniProtKB/TrEMBL
  A0A0G2K830_RAT UniProtKB/TrEMBL
  A0A140TAF9 ENTREZGENE, UniProtKB/TrEMBL
  A0A140TAG6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y1Z7 ENTREZGENE, UniProtKB/TrEMBL
  F1M7M9 ENTREZGENE, UniProtKB/TrEMBL
  GRIK1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grik1  glutamate ionotropic receptor kainate type subunit 1  Grik1  glutamate receptor, ionotropic, kainate 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Grik1  Glutamate receptor, ionotropic, kainate 1      Symbol and Name status set to approved 70586 APPROVED