Hira (histone cell cycle regulator) - Rat Genome Database

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Gene: Hira (histone cell cycle regulator) Rattus norvegicus
Analyze
Symbol: Hira
Name: histone cell cycle regulator
RGD ID: 1584950
Description: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and histone binding activity. Predicted to contribute to nucleosome binding activity. Predicted to be involved in nucleosome assembly. Predicted to act upstream of or within gastrulation; muscle cell differentiation; and osteoblast differentiation. Predicted to be located in nucleoplasm. Predicted to be part of HIR complex. Predicted to be active in chromatin. Orthologous to human HIRA (histone cell cycle regulator); PARTICIPATES IN histone modification pathway; INTERACTS WITH 3-chloropropane-1,2-diol; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: HIR histone cell cycle regulation defective homolog A; HIR histone cell cycle regulation defective homolog A (S. cerevisiae); histone cell cycle regulation defective homolog A; LOC100911837; LOC363849; protein HIRA-like; similar to histone cell cycle regulation defective homolog A isoform 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,528,831 - 95,637,565 (-)NCBIGRCr8
mRatBN7.21182,024,469 - 82,133,212 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,024,469 - 82,133,529 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,753,636 - 90,862,674 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,414,851 - 83,523,894 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,468,120 - 82,577,162 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,168,196 - 86,276,430 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,168,196 - 86,276,430 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,270,162 - 89,378,396 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1180,805,603 - 80,913,841 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HiraRatCardiac Fibrosis disease_progressionISOHira (Mus musculus)11354650 RGD 
HiraRattetralogy of Fallot  ISOHIRA (Homo sapiens)401851914mRNA and protein:decreased expression: myocardium :RGD 
1 to 16 of 16 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HiraRatautism spectrum disorder  ISOHIRA (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:25741868 and PMID:27569545
HiraRatautistic disorder  ISOHIRA (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
HiraRatchromosome 22q11.2 deletion syndrome, distal  ISOHIRA (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 22q11.2 deletion syndrome and distalClinVarPMID:31690835
HiraRatchromosome 22q11.2 microduplication syndrome  ISOHIRA (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 22q11.2 microduplication syndromeClinVarPMID:25741868 and PMID:31690835
HiraRatDiGeorge syndrome  ISOHIRA (Homo sapiens)8554872ClinVar more ...ClinVarPMID:21921585 more ...
HiraRatepilepsy  ISOHIRA (Homo sapiens)8554872ClinVar Annotator: match by term: EpilepsyClinVar 
HiraRatFanconi anemia complementation group T  ISOHIRA (Homo sapiens)8554872ClinVar Annotator: match by term: Fanconi anemia complementation group TClinVarPMID:25741868
HiraRatimmunodeficiency 51  ISOHIRA (Homo sapiens)8554872ClinVar Annotator: match by term: CANDIDIASIS more ...ClinVarPMID:24552284 more ...
HiraRatintellectual disability  ISOHIRA (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
HiraRatmegacolon  ISOHIRA (Homo sapiens)8554872ClinVar Annotator: match by term: MegacolonClinVarPMID:21681106
HiraRatNeurodevelopmental Disorders  ISOHIRA (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
HiraRatPolyarteritis Nodosa, Childhood-Onset  ISOHIRA (Homo sapiens)8554872ClinVar Annotator: match by term: VASCULITIS more ...ClinVarPMID:24552284 more ...
HiraRatprimary immunodeficiency disease  ISOHIRA (Homo sapiens)8554872ClinVar Annotator: match by term: Inherited Immunodeficiency DiseasesClinVarPMID:25741868
HiraRatprostate cancer  ISOHIRA (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383
HiraRatschizophrenia  ISOHIRA (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
HiraRatvelocardiofacial syndrome  ISOHIRA (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868
1 to 16 of 16 rows

1 to 20 of 67 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HiraRat1,2-dimethylhydrazine affects expressionISOHira (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of HIRA mRNACTDPMID:22206623
HiraRat17beta-estradiol increases expressionISOHIRA (Homo sapiens)6480464Estradiol results in increased expression of HIRA mRNACTDPMID:15223131 more ...
HiraRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOHIRA (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of HIRA mRNACTDPMID:17101203
HiraRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOHira (Mus musculus)6480464Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HIRA promoter]CTDPMID:19654925
HiraRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOHira (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of HIRA mRNACTDPMID:21570461
HiraRat3,3',5-triiodo-L-thyronine increases expressionISOHIRA (Homo sapiens)6480464Triiodothyronine results in increased expression of HIRA mRNACTDPMID:23397585
HiraRat3-chloropropane-1,2-diol decreases expressionEXP 6480464alpha-Chlorohydrin results in decreased expression of HIRA proteinCTDPMID:34915118
HiraRat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOHIRA (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HIRA mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of HIRA mRNACTDPMID:28628672
HiraRat4,4'-sulfonyldiphenol multiple interactionsISOHIRA (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of HIRA mRNACTDPMID:28628672
HiraRat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of HIRA mRNACTDPMID:36041667
HiraRataflatoxin B1 increases expressionISOHira (Mus musculus)6480464Aflatoxin B1 results in increased expression of HIRA mRNACTDPMID:19770486
HiraRatall-trans-retinoic acid decreases expressionISOHIRA (Homo sapiens)6480464Tretinoin results in decreased expression of HIRA mRNACTDPMID:15498508
HiraRatamiodarone increases expressionISOHIRA (Homo sapiens)6480464Amiodarone results in increased expression of HIRA mRNACTDPMID:19774075
HiraRatantirheumatic drug decreases expressionISOHIRA (Homo sapiens)6480464Antirheumatic Agents results in decreased expression of HIRA mRNACTDPMID:24449571
HiraRatarsenous acid increases expressionISOHira (Mus musculus)6480464Arsenic Trioxide results in increased expression of HIRA mRNACTDPMID:35676786
HiraRatbenzo[a]pyrene decreases expressionISOHIRA (Homo sapiens)6480464Benzo(a)pyrene results in decreased expression of HIRA mRNACTDPMID:20498004
HiraRatbenzo[a]pyrene diol epoxide I decreases expressionISOHIRA (Homo sapiens)64804647 more ...CTDPMID:19150397
HiraRatbiotin decreases expressionISOHIRA (Homo sapiens)6480464Biotin results in decreased expression of HIRA mRNACTDPMID:15219929
HiraRatbisphenol A increases expressionISOHira (Mus musculus)6480464bisphenol A results in increased expression of HIRA mRNACTDPMID:26063408
HiraRatbisphenol A multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of HIRA mRNACTDPMID:36041667

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Biological Process
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HiraRatbiological_process  ND 159840710/2014: no relevant rat dataRGD 
HiraRatchromatin organization involved_inIEAUniProtKB-KW:KW-01561600115GO_REF:0000043UniProtGO_REF:0000043
HiraRatchromatin organization involved_inIEAInterPro:IPR0311201600115GO_REF:0000002InterProGO_REF:0000002
HiraRatchromatin remodeling involved_inIBACGD:CAL0000197832 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
HiraRatchromatin remodeling involved_inIEAInterPro:IPR0114941600115GO_REF:0000002InterProGO_REF:0000002
HiraRatDNA-templated transcription involved_inIEAInterPro:IPR0311201600115GO_REF:0000002InterProGO_REF:0000002
HiraRatgastrulation acts_upstream_of_or_withinISOHira (Mus musculus)1624291MGI:2178130 PMID:11884616RGDPMID:11884616
HiraRatmuscle cell differentiation acts_upstream_of_or_withinISOHira (Mus musculus)1624291MGI:1097686 more ...RGDPMID:22705305
HiraRatnucleosome assembly involved_inISOHIRA (Homo sapiens)1624291 PMID:14718166RGDPMID:14718166
HiraRatosteoblast differentiation acts_upstream_of_or_withinISOHira (Mus musculus)1624291MGI:1097686 more ...RGDPMID:22705305
HiraRatregulation of DNA-templated transcription involved_inIEAInterPro:IPR0114941600115GO_REF:0000002InterProGO_REF:0000002
1 to 11 of 11 rows

Cellular Component
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HiraRatchromatin located_inISOHIRA (Homo sapiens)1624291 PMID:14718166RGDPMID:14718166
HiraRatchromatin is_active_inIBAMGI:99430 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
HiraRatchromatin located_inISOHira (Mus musculus)1624291 PMID:15922569RGDPMID:15922569
HiraRatHIR complex part_ofIBACGD:CAL0000197832 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
HiraRatnucleoplasm located_inISOHIRA (Homo sapiens) more ...1624291 RGDGO_REF:0000052
HiraRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
HiraRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
HiraRatnucleus located_inIEAInterPro:IPR0311201600115GO_REF:0000002InterProGO_REF:0000002
HiraRatprotein-containing complex part_ofISOHIRA (Homo sapiens)1624291 PMID:14718166RGDPMID:14718166
1 to 9 of 9 rows

Molecular Function

  

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HiraRathistone modification pathway   ISOHIRA (Homo sapiens)9068945 RGD 

#
Reference Title
Reference Citation
1. Histone chaperones in nucleosome assembly and human disease. Burgess RJ and Zhang Z, Nat Struct Mol Biol. 2013 Jan;20(1):14-22. doi: 10.1038/nsmb.2461.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. HIRA Gene is Lower Expressed in the Myocardium of Patients with Tetralogy of Fallot. Ju ZR, etal., Chin Med J (Engl). 2016 Oct 20;129(20):2403-2408. doi: 10.4103/0366-6999.191745.
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis. Valenzuela N, etal., Dis Model Mech. 2016 Mar;9(3):335-45. doi: 10.1242/dmm.022889.
PMID:11884616   PMID:14718166   PMID:15922569   PMID:18570454   PMID:22705305  



Hira
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,528,831 - 95,637,565 (-)NCBIGRCr8
mRatBN7.21182,024,469 - 82,133,212 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,024,469 - 82,133,529 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,753,636 - 90,862,674 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,414,851 - 83,523,894 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,468,120 - 82,577,162 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,168,196 - 86,276,430 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,168,196 - 86,276,430 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,270,162 - 89,378,396 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1180,805,603 - 80,913,841 (-)NCBICelera
Cytogenetic Map11q23NCBI
HIRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,330,698 - 19,431,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,330,698 - 19,447,450 (-)EnsemblGRCh38hg38GRCh38
GRCh372219,318,221 - 19,419,256 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,698,224 - 17,799,219 (-)NCBINCBI36Build 36hg18NCBI36
Build 342217,692,777 - 17,793,773NCBI
Celera223,170,348 - 3,271,476 (-)NCBICelera
Cytogenetic Map22q11.21ENTREZGENE
HuRef222,938,779 - 3,039,800 (-)NCBIHuRef
CHM1_12219,317,795 - 19,418,793 (-)NCBICHM1_1
T2T-CHM13v2.02219,707,409 - 19,808,564 (-)NCBIT2T-CHM13v2.0
Hira
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,695,500 - 18,789,059 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,695,787 - 18,789,059 (+)EnsemblGRCm39 Ensembl
GRCm381618,876,750 - 18,970,309 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,877,037 - 18,970,309 (+)EnsemblGRCm38mm10GRCm38
MGSCv371618,876,843 - 18,970,402 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361618,790,313 - 18,883,872 (+)NCBIMGSCv36mm8
Celera1619,450,807 - 19,544,362 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.69NCBI
LOC102009660
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544218,581,370 - 18,673,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544218,581,370 - 18,673,590 (+)NCBIChiLan1.0ChiLan1.0
LOC100977781
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22328,955,170 - 29,056,833 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12231,498,613 - 31,604,572 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0222,087,846 - 2,191,192 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12217,765,598 - 17,845,654 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2217,765,598 - 17,847,084 (-)Ensemblpanpan1.1panPan2
HIRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,777,984 - 29,867,992 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,778,086 - 29,867,559 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2629,733,351 - 29,822,268 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02631,179,782 - 31,268,951 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2631,179,884 - 31,268,655 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12629,227,072 - 29,316,422 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,852,492 - 28,941,149 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,939,424 - 30,028,570 (+)NCBIUU_Cfam_GSD_1.0
LOC101957075
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118139,372,372 - 139,471,877 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366193,282,173 - 3,380,151 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366193,282,170 - 3,380,151 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HIRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,029,126 - 51,102,409 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,029,117 - 51,102,409 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,596,123 - 54,669,440 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HIRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,324,050 - 6,424,999 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl196,324,253 - 6,425,641 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666085508,725 - 609,791 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101713307
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247479 - 95,643 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Hira
317 total Variants

Predicted Target Of
Summary Value
Count of predictions:325
Count of miRNA genes:206
Interacting mature miRNAs:241
Transcripts:ENSRNOT00000075164
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 18 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat

1 to 10 of 18 rows
D11Got81  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,126,584 - 82,126,804 (+)MAPPERmRatBN7.2
Rnor_6.01186,269,803 - 86,270,022NCBIRnor6.0
Rnor_5.01189,371,769 - 89,371,988UniSTSRnor5.0
Celera1180,907,218 - 80,907,437UniSTS
RH 3.4 Map11698.3RGD
RH 3.4 Map11698.3UniSTS
BE115254  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,091,728 - 82,091,892 (+)MAPPERmRatBN7.2
Rnor_6.01185,870,299 - 85,870,462NCBIRnor6.0
Rnor_6.01186,235,449 - 86,235,612NCBIRnor6.0
Rnor_5.01189,337,415 - 89,337,578UniSTSRnor5.0
Rnor_5.01188,970,630 - 88,970,793UniSTSRnor5.0
Celera1180,872,849 - 80,873,012UniSTS
RH 3.4 Map11694.1UniSTS
Hira  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,132,470 - 82,132,627 (+)MAPPERmRatBN7.2
Rnor_6.01186,275,689 - 86,275,845NCBIRnor6.0
Rnor_5.01189,377,655 - 89,377,811UniSTSRnor5.0
Celera1180,913,100 - 80,913,256UniSTS
Cytogenetic Map11p12UniSTS
D22S1095E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,024,581 - 82,024,683 (+)MAPPERmRatBN7.2
Rnor_6.01185,802,649 - 85,802,750NCBIRnor6.0
Rnor_6.01186,168,309 - 86,168,410NCBIRnor6.0
Rnor_5.01189,270,275 - 89,270,376UniSTSRnor5.0
Rnor_5.01188,902,980 - 88,903,081UniSTSRnor5.0
Celera1180,805,716 - 80,805,817UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 89 88 57 25 57 6 216 97 93 45 60 31


1 to 18 of 18 rows
RefSeq Transcripts NM_001135760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 18 of 18 rows

Ensembl Acc Id: ENSRNOT00000071462   ⟹   ENSRNOP00000065274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,024,469 - 82,133,529 (-)Ensembl
Rnor_6.0 Ensembl1185,802,605 - 85,895,613 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000075164   ⟹   ENSRNOP00000064357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,024,469 - 82,133,212 (-)Ensembl
Rnor_6.0 Ensembl1186,168,196 - 86,276,430 (-)Ensembl
RefSeq Acc Id: NM_001135760   ⟹   NP_001129232
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,528,831 - 95,637,565 (-)NCBI
mRatBN7.21182,024,469 - 82,133,212 (-)NCBI
Rnor_6.01186,168,196 - 86,276,430 (-)NCBI
Rnor_5.01189,270,162 - 89,378,396 (-)NCBI
Celera1180,805,603 - 80,913,841 (-)RGD
Sequence:
RefSeq Acc Id: XM_063270678   ⟹   XP_063126748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,528,831 - 95,636,962 (-)NCBI
RefSeq Acc Id: XM_063270679   ⟹   XP_063126749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,528,831 - 95,636,962 (-)NCBI
RefSeq Acc Id: XM_063270680   ⟹   XP_063126750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,528,831 - 95,633,644 (-)NCBI
RefSeq Acc Id: XM_063270681   ⟹   XP_063126751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,528,831 - 95,636,883 (-)NCBI
RefSeq Acc Id: XM_063270682   ⟹   XP_063126752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,528,831 - 95,619,827 (-)NCBI
RefSeq Acc Id: XM_063270683   ⟹   XP_063126753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,528,831 - 95,618,004 (-)NCBI
RefSeq Acc Id: XR_010055965
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,552,752 - 95,636,962 (-)NCBI
RefSeq Acc Id: NP_001129232   ⟸   NM_001135760
- UniProtKB: M0R4R2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064357   ⟸   ENSRNOT00000075164
Ensembl Acc Id: ENSRNOP00000065274   ⟸   ENSRNOT00000071462
RefSeq Acc Id: XP_063126749   ⟸   XM_063270679
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063126748   ⟸   XM_063270678
- Peptide Label: isoform X1
- UniProtKB: M0R756 (UniProtKB/TrEMBL)
Name Modeler Protein Id AA Range Protein Structure
AF-M0R756-F1-model_v2 AlphaFold M0R756 1-1010 view protein structure
AF-M0R4R2-F1-model_v2 AlphaFold M0R4R2 1-1015 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698294
Promoter ID:EPDNEW_R8817
Type:multiple initiation site
Name:Hira_1
Description:histone cell cycle regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01186,275,971 - 86,276,031EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-20678 BioCyc
Ensembl Genes ENSRNOG00000045770 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000049255 Ensembl
Ensembl Transcript ENSRNOT00000071462.3 UniProtKB/TrEMBL
  ENSRNOT00000075164 ENTREZGENE
  ENSRNOT00000075164.2 UniProtKB/TrEMBL
  ENSRNOT00000121679 ENTREZGENE
  ENSRNOT00000129451 ENTREZGENE
  ENSRNOT00000151189 ENTREZGENE
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro HIR1 UniProtKB/TrEMBL
  Hira UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report rno:363849 UniProtKB/TrEMBL
NCBI Gene 363849 ENTREZGENE
PANTHER PROTEIN HIRA UniProtKB/TrEMBL
  PTHR13831 UniProtKB/TrEMBL
Pfam Hira UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PhenoGen Hira PhenoGen
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045770 RatGTEx
  ENSRNOG00000049255 RatGTEx
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP WD40_like UniProtKB/TrEMBL
UniProt M0R4R2 ENTREZGENE, UniProtKB/TrEMBL
  M0R756 ENTREZGENE, UniProtKB/TrEMBL
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Hira  histone cell cycle regulator  LOC100911837  protein HIRA-like  Data merged from RGD:6490647 737654 PROVISIONAL
2013-09-16 Hira  histone cell cycle regulator  Hira  HIR histone cell cycle regulation defective homolog A (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100911837  protein HIRA-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-12-01 Hira  HIR histone cell cycle regulation defective homolog A (S. cerevisiae)  LOC363849  similar to histone cell cycle regulation defective homolog A isoform 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC363849  similar to histone cell cycle regulation defective homolog A isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL