Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in decreased expression of IGSF11 mRNA | CTD | PMID:27840820 | 17beta-estradiol | multiple interactions | ISO | IGSF11 (Homo sapiens) | 6480464 | [Estradiol binds to ESR2 protein] which results in increased expression of IGSF11 mRNA | CTD | PMID:20404318 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Igsf11 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of IGSF11 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of IGSF11 mRNA | CTD | PMID:32109520 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 3,7-dihydropurine-6-thione | increases expression | EXP | | 6480464 | Mercaptopurine results in increased expression of IGSF11 mRNA | CTD | PMID:23358152 | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of IGSF11 mRNA | CTD | PMID:28522335 | 4,4'-sulfonyldiphenol | increases expression | ISO | Igsf11 (Mus musculus) | 6480464 | bisphenol S results in increased expression of IGSF11 mRNA | CTD | PMID:30951980 | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of IGSF11 mRNA | CTD | PMID:36041667 | 4-hydroxyphenyl retinamide | increases expression | ISO | Igsf11 (Mus musculus) | 6480464 | Fenretinide results in increased expression of IGSF11 mRNA | CTD | PMID:28973697 | 5-aza-2'-deoxycytidine | affects expression | ISO | IGSF11 (Homo sapiens) | 6480464 | Decitabine affects the expression of IGSF11 mRNA | CTD | PMID:23300844 | aflatoxin B1 | decreases methylation | ISO | IGSF11 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of IGSF11 gene | CTD | PMID:27153756 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of IGSF11 mRNA | CTD | PMID:33354967 | aflatoxin B1 | increases methylation | ISO | IGSF11 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of IGSF11 gene | CTD | PMID:28458013 | all-trans-retinoic acid | increases expression | ISO | IGSF11 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of IGSF11 mRNA | CTD | PMID:23724009 | all-trans-retinoic acid | multiple interactions | ISO | Igsf11 (Mus musculus) | 6480464 | [bisphenol F co-treated with Tretinoin] results in increased expression of IGSF11 mRNA | CTD | PMID:30951980 | arsane | affects methylation | ISO | IGSF11 (Homo sapiens) | 6480464 | Arsenic affects the methylation of IGSF11 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | IGSF11 (Homo sapiens) | 6480464 | Arsenic affects the methylation of IGSF11 gene | CTD | PMID:25304211 | benzo[a]pyrene | decreases expression | ISO | Igsf11 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of IGSF11 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | decreases methylation | ISO | IGSF11 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of IGSF11 3' UTR | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | IGSF11 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of IGSF11 promoter | CTD | PMID:27901495 | benzo[e]pyrene | increases methylation | ISO | IGSF11 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of IGSF11 exon and benzo(e)pyrene results in increased methylation of IGSF11 intron | CTD | PMID:30157460 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of IGSF11 mRNA more ... | CTD | PMID:26496021 more ... | bisphenol A | multiple interactions | ISO | IGSF11 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of IGSF11 gene | CTD | PMID:31601247 | bisphenol A | decreases methylation | ISO | IGSF11 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of IGSF11 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | ISO | Igsf11 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of IGSF11 mRNA | CTD | PMID:32156529 and PMID:33221593 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of IGSF11 mRNA | CTD | PMID:34947998 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of IGSF11 gene | CTD | PMID:28505145 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of IGSF11 mRNA | CTD | PMID:25181051 | bisphenol F | increases expression | ISO | Igsf11 (Mus musculus) | 6480464 | bisphenol F results in increased expression of IGSF11 mRNA | CTD | PMID:30951980 | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of IGSF11 mRNA | CTD | PMID:36041667 | bisphenol F | multiple interactions | ISO | Igsf11 (Mus musculus) | 6480464 | [bisphenol F co-treated with Tretinoin] results in increased expression of IGSF11 mRNA | CTD | PMID:30951980 | butanal | decreases expression | ISO | IGSF11 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of IGSF11 mRNA | CTD | PMID:26079696 | carbon nanotube | increases expression | ISO | Igsf11 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25620056 | CGP 52608 | multiple interactions | ISO | IGSF11 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to IGSF11 gene] | CTD | PMID:28238834 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of IGSF11 mRNA | CTD | PMID:18668222 | chlorpyrifos | decreases expression | ISO | Igsf11 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of IGSF11 mRNA | CTD | PMID:37019170 | choline | multiple interactions | ISO | Igsf11 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IGSF11 mRNA | CTD | PMID:20938992 | cisplatin | affects expression | ISO | IGSF11 (Homo sapiens) | 6480464 | Cisplatin affects the expression of IGSF11 mRNA | CTD | PMID:23300844 | clofibric acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of IGSF11 mRNA | CTD | PMID:17602206 | cyclosporin A | increases expression | ISO | IGSF11 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of IGSF11 mRNA | CTD | PMID:20106945 | dorsomorphin | multiple interactions | ISO | IGSF11 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | emodin | increases expression | ISO | Igsf11 (Mus musculus) | 6480464 | Emodin results in increased expression of IGSF11 mRNA | CTD | PMID:21319176 | entinostat | multiple interactions | ISO | IGSF11 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGSF11 mRNA | CTD | PMID:27188386 | entinostat | decreases expression | ISO | IGSF11 (Homo sapiens) | 6480464 | entinostat results in decreased expression of IGSF11 mRNA | CTD | PMID:26272509 | epoxiconazole | increases expression | ISO | Igsf11 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of IGSF11 mRNA | CTD | PMID:35436446 | etoposide | decreases expression | ISO | Igsf11 (Mus musculus) | 6480464 | Etoposide results in decreased expression of IGSF11 mRNA | CTD | PMID:25270620 | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of IGSF11 mRNA | CTD | PMID:24136188 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of IGSF11 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Igsf11 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IGSF11 mRNA | CTD | PMID:20938992 | folic acid | decreases expression | ISO | Igsf11 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of IGSF11 mRNA | CTD | PMID:25629700 | FR900359 | increases phosphorylation | ISO | IGSF11 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of IGSF11 protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | IGSF11 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of IGSF11 gene | CTD | PMID:31601247 | furan | decreases expression | EXP | | 6480464 | furan results in decreased expression of IGSF11 mRNA | CTD | PMID:27387713 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of IGSF11 mRNA | CTD | PMID:33387578 | glyphosate | decreases expression | EXP | | 6480464 | Glyphosate results in decreased expression of IGSF11 mRNA | CTD | PMID:26302742 | glyphosate | increases methylation | EXP | | 6480464 | Glyphosate results in increased methylation of IGSF11 gene | CTD | PMID:31011160 | L-methionine | multiple interactions | ISO | Igsf11 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IGSF11 mRNA | CTD | PMID:20938992 | lead(0) | affects expression | ISO | IGSF11 (Homo sapiens) | 6480464 | Lead affects the expression of IGSF11 mRNA | CTD | PMID:28903495 | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of IGSF11 mRNA | CTD | PMID:24136188 | Licochalcone B | increases expression | ISO | IGSF11 (Homo sapiens) | 6480464 | licochalcone B results in increased expression of IGSF11 mRNA | CTD | PMID:33647349 | lipopolysaccharide | increases expression | ISO | IGSF11 (Homo sapiens) | 6480464 | Lipopolysaccharides results in increased expression of IGSF11 mRNA | CTD | PMID:35811015 | lipopolysaccharide | multiple interactions | ISO | IGSF11 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of IGSF11 mRNA | CTD | PMID:35811015 | mercaptopurine | increases expression | EXP | | 6480464 | Mercaptopurine results in increased expression of IGSF11 mRNA | CTD | PMID:23358152 | methapyrilene | increases methylation | ISO | IGSF11 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of IGSF11 exon and Methapyrilene results in increased methylation of IGSF11 intron | CTD | PMID:30157460 | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of IGSF11 mRNA | CTD | PMID:30467583 | methylmercury chloride | decreases expression | ISO | IGSF11 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of IGSF11 mRNA | CTD | PMID:28001369 | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of IGSF11 gene | CTD | PMID:33148267 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of IGSF11 mRNA | CTD | PMID:17602206 | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of IGSF11 mRNA | CTD | PMID:24136188 | nickel atom | decreases expression | ISO | IGSF11 (Homo sapiens) | 6480464 | Nickel results in decreased expression of IGSF11 mRNA | CTD | PMID:25583101 | ozone | multiple interactions | ISO | Igsf11 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of IGSF11 mRNA | CTD | PMID:34911549 | paracetamol | affects expression | ISO | Igsf11 (Mus musculus) | 6480464 | Acetaminophen affects the expression of IGSF11 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of IGSF11 mRNA | CTD | PMID:33387578 | perfluorooctane-1-sulfonic acid | increases expression | ISO | IGSF11 (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in increased expression of IGSF11 mRNA | CTD | PMID:25812627 | perfluorooctanoic acid | increases expression | ISO | IGSF11 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in increased expression of IGSF11 mRNA | CTD | PMID:25812627 | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of IGSF11 gene | CTD | PMID:33148267 | phenylmercury acetate | increases expression | ISO | IGSF11 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of IGSF11 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | IGSF11 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IGSF11 mRNA | CTD | PMID:27188386 | pirinixic acid | multiple interactions | ISO | Igsf11 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of IGSF11 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | ISO | Igsf11 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of IGSF11 mRNA | CTD | PMID:18301758 and PMID:23811191 | purine-6-thiol | increases expression | EXP | | 6480464 | Mercaptopurine results in increased expression of IGSF11 mRNA | CTD | PMID:23358152 | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of IGSF11 mRNA | CTD | PMID:28374803 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | IGSF11 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of IGSF11 mRNA | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | IGSF11 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | IGSF11 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of IGSF11 mRNA | CTD | PMID:25895662 | sodium dichromate | affects expression | EXP | | 6480464 | sodium bichromate affects the expression of IGSF11 mRNA | CTD | PMID:22110744 | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of IGSF11 mRNA | CTD | PMID:19281266 | sunitinib | increases expression | ISO | IGSF11 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of IGSF11 mRNA | CTD | PMID:31533062 | testosterone | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of IGSF11 mRNA | CTD | PMID:26496021 | tetrachloromethane | increases expression | ISO | Igsf11 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of IGSF11 mRNA | CTD | PMID:27339419 and PMID:31919559 | tributylstannane | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with tributyltin] results in increased expression of IGSF11 mRNA | CTD | PMID:31129395 | trichostatin A | increases expression | ISO | IGSF11 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of IGSF11 mRNA | CTD | PMID:24935251 | valproic acid | increases methylation | ISO | IGSF11 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of IGSF11 gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | IGSF11 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of IGSF11 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | IGSF11 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IGSF11 mRNA | CTD | PMID:27188386 | valproic acid | affects expression | ISO | IGSF11 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of IGSF11 mRNA | CTD | PMID:25979313 | vancomycin | increases expression | ISO | Igsf11 (Mus musculus) | 6480464 | Vancomycin results in increased expression of IGSF11 mRNA | CTD | PMID:18930951 | |