Adcy5 (adenylate cyclase 5) - Rat Genome Database

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Gene: Adcy5 (adenylate cyclase 5) Rattus norvegicus
Analyze
Symbol: Adcy5
Name: adenylate cyclase 5
RGD ID: 71014
Description: Exhibits calcium- and calmodulin-responsive adenylate cyclase activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and response to morphine. Localizes to endosome; membrane raft; and plasma membrane. Colocalizes with sarcolemma. Biomarker of hypertension and type 2 diabetes mellitus. Orthologous to human ADCY5 (adenylate cyclase 5); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; 7,12-dimethyltetraphene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: adenylate cyclase type 5; adenylate cyclase type V; adenylyl cyclase 5; adenylyl cyclase type V; ATP pyrophosphate-lyase 5
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21165,471,612 - 65,618,877 (-)NCBI
Rnor_6.0 Ensembl1168,695,839 - 68,842,320 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01168,695,839 - 68,842,452 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01171,787,104 - 71,933,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41167,290,968 - 67,437,468 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11167,348,556 - 67,495,057 (-)NCBI
Celera1164,930,432 - 65,076,790 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acetylcholine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
atrazine  (EXP)
atropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
carbachol  (ISO)
carbon nanotube  (ISO)
CGS-21680  (ISO)
clozapine  (ISO)
colforsin daropate hydrochloride  (ISO)
crocidolite asbestos  (ISO)
decabromodiphenyl ether  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
endosulfan  (EXP)
ethanol  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (EXP)
genistein  (EXP,ISO)
haloperidol  (ISO)
isoprenaline  (ISO)
lipopolysaccharide  (ISO)
magnesium atom  (ISO)
methapyrilene  (ISO)
monosodium L-glutamate  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ozone  (EXP)
paraquat  (EXP)
phenylephrine  (ISO)
PhIP  (EXP)
pioglitazone  (ISO)
progesterone  (EXP)
quinpirole  (ISO)
SCH 23390  (ISO)
silicon dioxide  (ISO)
SKF 38393  (ISO)
sodium arsenite  (ISO)
sulpiride  (ISO)
sunitinib  (ISO)
triclosan  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
valproic acid  (EXP,ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Desjardins S, etal., Neuropharmacology. 2008 Dec;55(8):1347-54. doi: 10.1016/j.neuropharm.2008.08.027. Epub 2008 Aug 30.
2. Fan P, etal., Mol Pharmacol. 2009 Sep;76(3):526-33. Epub 2009 Jun 23.
3. Fujino T, etal., J Cardiovasc Pharmacol. 2003 May;41(5):720-5.
4. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Head BP, etal., J Biol Chem. 2005 Sep 2;280(35):31036-44. Epub 2005 Jun 16.
6. Helies-Toussaint C, etal., Am J Physiol Renal Physiol. 2000 Jul;279(1):F185-94.
7. Hu CL, etal., Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1776-82. doi: 10.1152/ajpheart.00050.2009. Epub 2009 Sep 4.
8. Ivanov A, etal., J Physiol. 2006 Jan 1;570(Pt 1):73-84. Epub 2005 Nov 10.
9. Jourdan KB, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1359-69.
10. KEGG
11. Matsuoka I, etal., J Neurochem. 1997 Feb;68(2):498-506.
12. Merlen C, etal., FEBS Lett. 2006 Oct 16;580(24):5697-704. Epub 2006 Sep 20.
13. MGD Curation, June 12, 2002
14. MGD data from the GO Consortium
15. Nair AG, etal., J Neurosci. 2015 Oct 14;35(41):14017-30. doi: 10.1523/JNEUROSCI.0730-15.2015.
16. NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Noyama K and Maekawa S, Neurosci Res. 2003 Feb;45(2):141-8.
18. OMIM Disease Annotation Pipeline
19. Ostrom RS, etal., J Biol Chem. 2003 Jul 4;278(27):24461-8. Epub 2003 Apr 23.
20. Pipeline to import KEGG annotations from KEGG into RGD
21. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. Portela-Gomes GM, etal., Appl Immunohistochem Mol Morphol. 2002 Dec;10(4):387-92.
23. Premont RT, etal., Proc Natl Acad Sci U S A 1992 Oct 15;89(20):9809-13.
24. RGD automated data pipeline
25. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. RGD automated import pipeline for gene-chemical interactions
27. Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
28. Serazin-Leroy V, etal., Biochim Biophys Acta. 2001 Nov 26;1550(1):37-51.
29. Wu CS, etal., Mol Cell Biol. 2011 Dec;31(24):4874-86. doi: 10.1128/MCB.05593-11. Epub 2011 Oct 10.
Additional References at PubMed
PMID:12223546   PMID:12665504   PMID:15385642   PMID:15499025   PMID:17593019   PMID:18164588   PMID:18673448   PMID:19574217   PMID:19913519   PMID:20736067   PMID:21131397   PMID:21670265  
PMID:22871113   PMID:24700542   PMID:24740569  


Genomics

Comparative Map Data
Adcy5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21165,471,612 - 65,618,877 (-)NCBI
Rnor_6.0 Ensembl1168,695,839 - 68,842,320 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01168,695,839 - 68,842,452 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01171,787,104 - 71,933,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41167,290,968 - 67,437,468 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11167,348,556 - 67,495,057 (-)NCBI
Celera1164,930,432 - 65,076,790 (-)NCBICelera
Cytogenetic Map11q22NCBI
ADCY5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3123,282,296 - 123,449,758 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl3123,282,296 - 123,449,090 (-)EnsemblGRCh38hg38GRCh38
GRCh383123,282,296 - 123,449,090 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373123,001,143 - 123,167,937 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363124,486,089 - 124,650,082 (-)NCBINCBI36hg18NCBI36
Build 343124,486,088 - 124,650,082NCBI
Celera3121,410,492 - 121,574,947 (-)NCBI
Cytogenetic Map3q21.1ENTREZGENE
HuRef3120,374,350 - 120,540,687 (-)NCBIHuRef
CHM1_13122,964,827 - 123,131,019 (-)NCBICHM1_1
Adcy5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391634,974,863 - 35,126,113 (+)NCBIGRCm39mm39
GRCm39 Ensembl1634,975,247 - 35,126,108 (+)Ensembl
GRCm381635,154,494 - 35,305,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1635,154,877 - 35,305,738 (+)EnsemblGRCm38mm10GRCm38
MGSCv371635,155,722 - 35,304,635 (+)NCBIGRCm37mm9NCBIm37
MGSCv361635,074,624 - 35,225,482 (+)NCBImm8
Celera1635,623,764 - 35,773,605 (+)NCBICelera
Cytogenetic Map16B3NCBI
ADCY5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13127,281,603 - 127,446,504 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3127,283,921 - 127,446,508 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03120,380,094 - 120,545,725 (-)NCBIMhudiblu_PPA_v0panPan3
ADCY5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13326,345,617 - 26,490,120 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3326,345,617 - 26,504,616 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3326,367,988 - 26,513,164 (-)NCBI
ROS_Cfam_1.03326,577,319 - 26,724,145 (-)NCBI
UMICH_Zoey_3.13326,374,397 - 26,519,530 (-)NCBI
UNSW_CanFamBas_1.03326,418,883 - 26,564,205 (-)NCBI
UU_Cfam_GSD_1.03326,977,815 - 27,020,671 (-)NCBI
Adcy5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602127,842,824 - 127,989,489 (+)NCBI
SpeTri2.0NW_0049367251,751,272 - 1,897,937 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13136,973,000 - 137,135,349 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113136,965,746 - 137,133,795 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213146,590,223 - 146,680,465 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12257,427,711 - 57,589,440 (+)NCBI
Adcy5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249121,632,469 - 1,767,885 (-)NCBI

Position Markers
D11Rat107  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,497,303 - 65,497,453 (+)MAPPER
Rnor_6.01168,721,529 - 68,721,678NCBIRnor6.0
Rnor_5.01171,812,987 - 71,813,136UniSTSRnor5.0
RGSC_v3.41167,316,657 - 67,316,807RGDRGSC3.4
RGSC_v3.41167,316,658 - 67,316,807UniSTSRGSC3.4
RGSC_v3.11167,374,246 - 67,374,396RGD
Celera1164,955,907 - 64,956,024UniSTS
SHRSP x BN Map1129.8399RGD
SHRSP x BN Map1129.8399UniSTS
Cytogenetic Map11q22UniSTS
RH128707  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,482,671 - 65,482,887 (+)MAPPER
Rnor_6.01168,706,899 - 68,707,114NCBIRnor6.0
Rnor_5.01171,798,164 - 71,798,379UniSTSRnor5.0
RGSC_v3.41167,302,028 - 67,302,243UniSTSRGSC3.4
Celera1164,941,288 - 64,941,503UniSTS
Cytogenetic Map11q22UniSTS
RH143365  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,471,141 - 65,471,326 (+)MAPPER
Rnor_6.01168,695,369 - 68,695,553NCBIRnor6.0
Rnor_5.01171,786,634 - 71,786,818UniSTSRnor5.0
RGSC_v3.41167,290,498 - 67,290,682UniSTSRGSC3.4
Celera1164,929,962 - 64,930,146UniSTS
RH 3.4 Map11436.1UniSTS
Cytogenetic Map11q22UniSTS
BE114258  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,602,077 - 65,602,281 (+)MAPPER
Rnor_6.01168,826,297 - 68,826,500NCBIRnor6.0
Rnor_5.01171,917,746 - 71,917,949UniSTSRnor5.0
RGSC_v3.41167,421,458 - 67,421,661UniSTSRGSC3.4
Celera1165,060,832 - 65,061,035UniSTS
RH 3.4 Map11436.5UniSTS
Cytogenetic Map11q22UniSTS
BF406340  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,479,758 - 65,479,951 (+)MAPPER
Rnor_6.01168,703,986 - 68,704,178NCBIRnor6.0
Rnor_5.01171,795,251 - 71,795,443UniSTSRnor5.0
RGSC_v3.41167,299,115 - 67,299,307UniSTSRGSC3.4
Celera1164,938,375 - 64,938,567UniSTS
RH 3.4 Map11436.6UniSTS
Cytogenetic Map11q22UniSTS
Adcy5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,471,665 - 65,471,815 (+)MAPPER
Rnor_6.01168,695,893 - 68,696,042NCBIRnor6.0
Rnor_5.01171,787,158 - 71,787,307UniSTSRnor5.0
RGSC_v3.41167,291,022 - 67,291,171UniSTSRGSC3.4
Celera1164,930,486 - 64,930,635UniSTS
Cytogenetic Map11q22UniSTS
stSG602571  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,563,203 - 65,563,526 (+)MAPPER
mRatBN7.21165,563,223 - 65,563,526 (+)MAPPER
Rnor_6.01168,787,450 - 68,787,752NCBIRnor6.0
Rnor_6.01168,787,430 - 68,787,752NCBIRnor6.0
Rnor_5.01171,878,899 - 71,879,201UniSTSRnor5.0
Rnor_5.01171,878,879 - 71,879,201UniSTSRnor5.0
RGSC_v3.41167,382,560 - 67,382,882UniSTSRGSC3.4
RGSC_v3.41167,382,580 - 67,382,882UniSTSRGSC3.4
Celera1165,021,988 - 65,022,290UniSTS
Celera1165,021,968 - 65,022,290UniSTS
Cytogenetic Map11q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11172720192Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)1132503169342559Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111947517979734728Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112540112970401129Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112572003870720038Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112572003870720038Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112572003870720038Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112572003870720038Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112831466586994795Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)113043533986714631Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113215552082443118Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113590063480900634Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114309033886714631Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)114444434769649708Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114658320986714631Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
4889859Pur28Proteinuria QTL 2819.50.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114790104978471527Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115785881090463843Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115994302390463843Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116010984287141948Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)116265336586714475Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116265336586714483Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116449467190463843Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:89
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000049180
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 1 64 4 15 8
Low 3 57 41 18 41 8 11 10 31 26 3 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000049180   ⟹   ENSRNOP00000046488
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1168,695,839 - 68,842,320 (-)Ensembl
RefSeq Acc Id: NM_022600   ⟹   NP_072122
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21165,471,612 - 65,618,101 (-)NCBI
Rnor_6.01168,695,839 - 68,842,320 (-)NCBI
Rnor_5.01171,787,104 - 71,933,971 (-)NCBI
RGSC_v3.41167,290,968 - 67,437,468 (-)RGD
Celera1164,930,432 - 65,076,790 (-)RGD
Sequence:
RefSeq Acc Id: XM_017598068   ⟹   XP_017453557
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21165,480,165 - 65,618,876 (-)NCBI
Rnor_6.01168,701,675 - 68,842,452 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088613   ⟹   XP_038944541
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21165,479,756 - 65,618,877 (-)NCBI
Protein Sequences
Protein RefSeqs NP_072122 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453557 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944541 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB39764 (Get FASTA)   NCBI Sequence Viewer  
  EDM11326 (Get FASTA)   NCBI Sequence Viewer  
  Q04400 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_072122   ⟸   NM_022600
- Sequence:
RefSeq Acc Id: XP_017453557   ⟸   XM_017598068
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000046488   ⟸   ENSRNOT00000049180
RefSeq Acc Id: XP_038944541   ⟸   XM_039088613
- Peptide Label: isoform X1
Protein Domains
Guanylate cyclase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71014 AgrOrtholog
Ensembl Genes ENSRNOG00000002229 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000046488 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049180 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adcy UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adcy_conserved_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64532 UniProtKB/Swiss-Prot
NCBI Gene 64532 ENTREZGENE
Pfam AC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1053 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adcy5 PhenoGen
PIRSF Ade_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ADCY5_RAT UniProtKB/Swiss-Prot
  G3V9G1_RAT UniProtKB/TrEMBL
  Q04400 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Adcy5  adenylate cyclase 5      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation membrane-bound, calcium-inhibitable adenylyl cyclase 724707
gene_regulation activity is stimulated by forskolin, guanosine 5'-[gamma-thio]triphosphate, and isoproterenol plus GTP 69740