Adcy5 (adenylate cyclase 5) - Rat Genome Database

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Gene: Adcy5 (adenylate cyclase 5) Rattus norvegicus
Symbol: Adcy5
Name: adenylate cyclase 5
RGD ID: 71014
Description: Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and heart development. Located in endosome. Colocalizes with sarcolemma. Biomarker of hypertension and type 2 diabetes mellitus. Orthologous to human ADCY5 (adenylate cyclase 5); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
Previously known as: adenylate cyclase type 5; adenylate cyclase type V; adenylyl cyclase 5; adenylyl cyclase type V; ATP pyrophosphate-lyase 5
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21165,471,612 - 65,618,877 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1165,471,612 - 65,618,974 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1174,293,894 - 74,441,081 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01166,956,169 - 67,103,380 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01165,987,453 - 66,134,656 (-)NCBIRnor_WKY
Rnor_6.01168,695,839 - 68,842,452 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1168,695,839 - 68,842,320 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01171,787,104 - 71,933,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41167,290,968 - 67,437,468 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11167,348,556 - 67,495,057 (-)NCBI
Celera1164,930,432 - 65,076,790 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acetylcholine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
atropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
carbachol  (ISO)
carbon nanotube  (ISO)
CGS-21680  (ISO)
chlordecone  (ISO)
clozapine  (ISO)
colforsin daropate hydrochloride  (ISO)
crocidolite asbestos  (ISO)
decabromodiphenyl ether  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
endosulfan  (EXP)
ethanol  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
genistein  (EXP,ISO)
haloperidol  (ISO)
isoprenaline  (ISO)
lipopolysaccharide  (ISO)
magnesium atom  (ISO)
methapyrilene  (ISO)
monosodium L-glutamate  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ozone  (EXP)
paraquat  (EXP)
phenylephrine  (ISO)
pioglitazone  (ISO)
progesterone  (EXP)
quinpirole  (ISO)
SCH 23390  (ISO)
silicon dioxide  (ISO)
SKF 38393  (ISO)
sodium arsenite  (ISO)
sulpiride  (ISO)
sunitinib  (ISO)
triclosan  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
valproic acid  (EXP,ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cilium  (IEA,ISO,ISS)
endosome  (IDA)
membrane  (ISO,ISS)
plasma membrane  (IEA,ISO)
sarcolemma  (IDA)

Molecular Function


References - curated
# Reference Title Reference Citation
1. Effects of chronic morphine and morphine withdrawal on gene expression in rat peripheral blood mononuclear cells. Desjardins S, etal., Neuropharmacology. 2008 Dec;55(8):1347-54. doi: 10.1016/j.neuropharm.2008.08.027. Epub 2008 Aug 30.
2. Up-regulation of AGS3 during morphine withdrawal promotes cAMP superactivation via adenylyl cyclase 5 and 7 in rat nucleus accumbens/striatal neurons. Fan P, etal., Mol Pharmacol. 2009 Sep;76(3):526-33. Epub 2009 Jun 23.
3. Effect of beta-adrenoceptor antagonist and angiotensin-converting enzyme inhibitor on hypertension-associated changes in adenylyl cyclase type V messenger RNA expression in spontaneously hypertensive rats. Fujino T, etal., J Cardiovasc Pharmacol. 2003 May;41(5):720-5.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. Head BP, etal., J Biol Chem. 2005 Sep 2;280(35):31036-44. Epub 2005 Jun 16.
6. Cellular localization of type 5 and type 6 ACs in collecting duct and regulation of cAMP synthesis. Helies-Toussaint C, etal., Am J Physiol Renal Physiol. 2000 Jul;279(1):F185-94.
7. Adenylyl cyclase type 5 protein expression during cardiac development and stress. Hu CL, etal., Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1776-82. doi: 10.1152/ajpheart.00050.2009. Epub 2009 Sep 4.
8. Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle. Ivanov A, etal., J Physiol. 2006 Jan 1;570(Pt 1):73-84. Epub 2005 Nov 10.
9. Characterization of adenylyl cyclase isoforms in rat peripheral pulmonary arteries. Jourdan KB, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1359-69.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Differential expression of type I, II, and V adenylyl cyclase gene in the postnatal developing rat brain. Matsuoka I, etal., J Neurochem. 1997 Feb;68(2):498-506.
12. Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver. Merlen C, etal., FEBS Lett. 2006 Oct 16;580(24):5697-704. Epub 2006 Sep 20.
13. Gene Data Set MGD Curation, June 12, 2002
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Sensing Positive versus Negative Reward Signals through Adenylyl Cyclase-Coupled GPCRs in Direct and Indirect Pathway Striatal Medium Spiny Neurons. Nair AG, etal., J Neurosci. 2015 Oct 14;35(41):14017-30. doi: 10.1523/JNEUROSCI.0730-15.2015.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Localization of cyclic nucleotide phosphodiesterase 2 in the brain-derived Triton-insoluble low-density fraction (raft). Noyama K and Maekawa S, Neurosci Res. 2003 Feb;45(2):141-8.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. Ostrom RS, etal., J Biol Chem. 2003 Jul 4;278(27):24461-8. Epub 2003 Apr 23.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. Increased expression of adenylyl cyclase isoforms in the adrenal gland of diabetic Goto-Kakizaki rat. Portela-Gomes GM, etal., Appl Immunohistochem Mol Morphol. 2002 Dec;10(4):387-92.
23. Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases. Premont RT, etal., Proc Natl Acad Sci U S A 1992 Oct 15;89(20):9809-13.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
28. Differences in type II, IV, V and VI adenylyl cyclase isoform expression between rat preadipocytes and adipocytes. Serazin-Leroy V, etal., Biochim Biophys Acta. 2001 Nov 26;1550(1):37-51.
29. Type VI adenylyl cyclase regulates neurite extension by binding to Snapin and Snap25. Wu CS, etal., Mol Cell Biol. 2011 Dec;31(24):4874-86. doi: 10.1128/MCB.05593-11. Epub 2011 Oct 10.
Additional References at PubMed
PMID:12223546   PMID:12665504   PMID:15385642   PMID:15499025   PMID:17593019   PMID:18164588   PMID:18673448   PMID:19574217   PMID:19913519   PMID:20736067   PMID:21131397   PMID:21670265  
PMID:22871113   PMID:24700542   PMID:24740569  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21165,471,612 - 65,618,877 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1165,471,612 - 65,618,974 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1174,293,894 - 74,441,081 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01166,956,169 - 67,103,380 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01165,987,453 - 66,134,656 (-)NCBIRnor_WKY
Rnor_6.01168,695,839 - 68,842,452 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1168,695,839 - 68,842,320 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01171,787,104 - 71,933,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41167,290,968 - 67,437,468 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11167,348,556 - 67,495,057 (-)NCBI
Celera1164,930,432 - 65,076,790 (-)NCBICelera
Cytogenetic Map11q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh383123,282,296 - 123,449,090 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3123,282,296 - 123,449,090 (-)EnsemblGRCh38hg38GRCh38
GRCh373123,001,143 - 123,167,937 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363124,486,089 - 124,650,082 (-)NCBINCBI36Build 36hg18NCBI36
Build 343124,486,088 - 124,650,082NCBI
Celera3121,410,492 - 121,574,947 (-)NCBICelera
Cytogenetic Map3q21.1ENTREZGENE
HuRef3120,374,350 - 120,540,687 (-)NCBIHuRef
CHM1_13122,964,827 - 123,131,019 (-)NCBICHM1_1
T2T-CHM13v2.03126,002,377 - 126,169,667 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391634,974,933 - 35,126,108 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1634,975,247 - 35,126,108 (+)EnsemblGRCm39 Ensembl
GRCm381635,154,494 - 35,305,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1635,154,877 - 35,305,738 (+)EnsemblGRCm38mm10GRCm38
MGSCv371635,155,722 - 35,304,635 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361635,074,624 - 35,225,482 (+)NCBIMGSCv36mm8
Celera1635,623,764 - 35,773,605 (+)NCBICelera
Cytogenetic Map16B3NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan13121,241,907 - 121,406,967 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03120,380,094 - 120,545,725 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13127,281,603 - 127,446,504 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3127,283,921 - 127,446,508 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13326,345,617 - 26,490,120 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3326,345,617 - 26,504,616 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3326,367,988 - 26,513,164 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03326,577,319 - 26,724,145 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3326,578,830 - 26,724,145 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13326,374,397 - 26,519,530 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03326,418,883 - 26,564,205 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03326,977,815 - 27,020,671 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405602127,842,824 - 127,989,489 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367251,751,266 - 1,897,946 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049367251,751,272 - 1,897,937 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl13136,972,801 - 137,135,347 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113136,965,746 - 137,133,795 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213146,590,223 - 146,680,465 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12257,427,711 - 57,589,440 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041108,759,225 - 108,922,808 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046249121,632,107 - 1,768,462 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249121,632,469 - 1,767,885 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Adcy5
849 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:89
Interacting mature miRNAs:101
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,497,303 - 65,497,453 (+)MAPPERmRatBN7.2
Rnor_6.01168,721,529 - 68,721,678NCBIRnor6.0
Rnor_5.01171,812,987 - 71,813,136UniSTSRnor5.0
RGSC_v3.41167,316,657 - 67,316,807RGDRGSC3.4
RGSC_v3.41167,316,658 - 67,316,807UniSTSRGSC3.4
RGSC_v3.11167,374,246 - 67,374,396RGD
Celera1164,955,907 - 64,956,024UniSTS
SHRSP x BN Map1129.8399RGD
SHRSP x BN Map1129.8399UniSTS
Cytogenetic Map11q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,482,671 - 65,482,887 (+)MAPPERmRatBN7.2
Rnor_6.01168,706,899 - 68,707,114NCBIRnor6.0
Rnor_5.01171,798,164 - 71,798,379UniSTSRnor5.0
RGSC_v3.41167,302,028 - 67,302,243UniSTSRGSC3.4
Celera1164,941,288 - 64,941,503UniSTS
Cytogenetic Map11q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,471,141 - 65,471,326 (+)MAPPERmRatBN7.2
Rnor_6.01168,695,369 - 68,695,553NCBIRnor6.0
Rnor_5.01171,786,634 - 71,786,818UniSTSRnor5.0
RGSC_v3.41167,290,498 - 67,290,682UniSTSRGSC3.4
Celera1164,929,962 - 64,930,146UniSTS
RH 3.4 Map11436.1UniSTS
Cytogenetic Map11q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,602,077 - 65,602,281 (+)MAPPERmRatBN7.2
Rnor_6.01168,826,297 - 68,826,500NCBIRnor6.0
Rnor_5.01171,917,746 - 71,917,949UniSTSRnor5.0
RGSC_v3.41167,421,458 - 67,421,661UniSTSRGSC3.4
Celera1165,060,832 - 65,061,035UniSTS
RH 3.4 Map11436.5UniSTS
Cytogenetic Map11q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,479,758 - 65,479,951 (+)MAPPERmRatBN7.2
Rnor_6.01168,703,986 - 68,704,178NCBIRnor6.0
Rnor_5.01171,795,251 - 71,795,443UniSTSRnor5.0
RGSC_v3.41167,299,115 - 67,299,307UniSTSRGSC3.4
Celera1164,938,375 - 64,938,567UniSTS
RH 3.4 Map11436.6UniSTS
Cytogenetic Map11q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,471,665 - 65,471,815 (+)MAPPERmRatBN7.2
Rnor_6.01168,695,893 - 68,696,042NCBIRnor6.0
Rnor_5.01171,787,158 - 71,787,307UniSTSRnor5.0
RGSC_v3.41167,291,022 - 67,291,171UniSTSRGSC3.4
Celera1164,930,486 - 64,930,635UniSTS
Cytogenetic Map11q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21165,563,203 - 65,563,526 (+)MAPPERmRatBN7.2
mRatBN7.21165,563,223 - 65,563,526 (+)MAPPERmRatBN7.2
Rnor_6.01168,787,450 - 68,787,752NCBIRnor6.0
Rnor_6.01168,787,430 - 68,787,752NCBIRnor6.0
Rnor_5.01171,878,899 - 71,879,201UniSTSRnor5.0
Rnor_5.01171,878,879 - 71,879,201UniSTSRnor5.0
RGSC_v3.41167,382,560 - 67,382,882UniSTSRGSC3.4
RGSC_v3.41167,382,580 - 67,382,882UniSTSRGSC3.4
Celera1165,021,988 - 65,022,290UniSTS
Celera1165,021,968 - 65,022,290UniSTS
Cytogenetic Map11q22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 43 1 64 4 15 8
Low 3 57 41 18 41 8 11 10 31 26 3 8
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000049180   ⟹   ENSRNOP00000046488
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1165,471,612 - 65,618,974 (-)Ensembl
Rnor_6.0 Ensembl1168,695,839 - 68,842,320 (-)Ensembl
RefSeq Acc Id: NM_022600   ⟹   NP_072122
Rat AssemblyChrPosition (strand)Source
mRatBN7.21165,471,612 - 65,618,101 (-)NCBI
Rnor_6.01168,695,839 - 68,842,320 (-)NCBI
Rnor_5.01171,787,104 - 71,933,971 (-)NCBI
RGSC_v3.41167,290,968 - 67,437,468 (-)RGD
Celera1164,930,432 - 65,076,790 (-)RGD
RefSeq Acc Id: XM_017598068   ⟹   XP_017453557
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21165,480,165 - 65,618,876 (-)NCBI
Rnor_6.01168,701,675 - 68,842,452 (-)NCBI
RefSeq Acc Id: XM_039088613   ⟹   XP_038944541
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21165,479,756 - 65,618,877 (-)NCBI
Protein Sequences
Protein RefSeqs NP_072122 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453557 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944541 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB39764 (Get FASTA)   NCBI Sequence Viewer  
  EDM11326 (Get FASTA)   NCBI Sequence Viewer  
  Q04400 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_072122   ⟸   NM_022600
- Sequence:
RefSeq Acc Id: XP_017453557   ⟸   XM_017598068
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000046488   ⟸   ENSRNOT00000049180
RefSeq Acc Id: XP_038944541   ⟸   XM_039088613
- Peptide Label: isoform X1
Protein Domains
Guanylate cyclase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q04400-F1-model_v2 AlphaFold Q04400 1-1262 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71014 AgrOrtholog
BioCyc Gene G2FUF-21161 BioCyc
Ensembl Genes ENSRNOG00000002229 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000046488 ENTREZGENE
  ENSRNOP00000046488.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049180 ENTREZGENE
  ENSRNOT00000049180.3 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adcy UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adcy_conserved_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64532 UniProtKB/Swiss-Prot
Pfam AC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1053 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adcy5 PhenoGen
PIRSF Ade_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ADCY5_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Adcy5  adenylate cyclase 5      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation membrane-bound, calcium-inhibitable adenylyl cyclase 724707
gene_regulation activity is stimulated by forskolin, guanosine 5'-[gamma-thio]triphosphate, and isoproterenol plus GTP 69740