Hrgl1 (histidine-rich glycoprotein like 1) - Rat Genome Database

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Gene: Hrgl1 (histidine-rich glycoprotein like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Hrgl1
Name: histidine-rich glycoprotein like 1
RGD ID: 1594092
Description: Predicted to enable several functions, including heme binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to be involved in several processes, including negative regulation of endothelial cell migration; negative regulation of lamellipodium assembly; and negative regulation of vascular endothelial growth factor signaling pathway. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in thrombophilia due to HRG deficiency and thrombosis. Orthologous to human HRG (histidine rich glycoprotein).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: histidine-rich glycoprotein 2; histidine-rich glycoprotein-like; Hrg; LOC681544; RNHRG2; similar to histidine-rich glycoprotein; ubiquitin specific peptidase 17 like family member 8; Usp17l8
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,543,964 - 91,553,946 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1191,543,969 - 91,553,946 (-)EnsemblGRCr8
mRatBN7.21178,039,371 - 78,049,353 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1178,039,376 - 78,049,353 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1186,789,838 - 86,799,820 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01179,448,130 - 79,458,076 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,504,148 - 78,514,132 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0 Ensembl1181,621,283 - 81,639,952 (-)Ensemblrn6Rnor6.0
Celera1176,911,947 - 76,921,941 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
Additional References at PubMed
PMID:10849117  


Genomics


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)119046178196556255Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat

Markers in Region
RH130910  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21178,054,621 - 78,054,822 (+)MAPPERmRatBN7.2
Rnor_6.01181,621,402 - 81,621,602NCBIRnor6.0
Rnor_5.01184,718,354 - 84,718,554UniSTSRnor5.0
RGSC_v3.41180,248,706 - 80,248,906UniSTSRGSC3.4
RGSC_v3.41180,230,715 - 80,230,915UniSTSRGSC3.4
Celera1176,927,186 - 76,927,386UniSTS
Celera1176,912,075 - 76,912,275UniSTS
RH 3.4 Map11642.2UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 5 20 25 24 18 4 18 5 75 15 13 41 11 6

Sequence


Ensembl Acc Id: ENSRNOT00000081864   ⟹   ENSRNOP00000072623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1191,559,091 - 91,573,982 (-)Ensembl
mRatBN7.2 Ensembl1178,054,498 - 78,069,389 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090031   ⟹   ENSRNOP00000075182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1191,543,969 - 91,553,946 (-)Ensembl
mRatBN7.2 Ensembl1178,039,376 - 78,049,353 (-)Ensembl
RefSeq Acc Id: NM_001329900   ⟹   NP_001316829
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,543,964 - 91,553,946 (-)NCBI
mRatBN7.21178,039,371 - 78,049,353 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001316829 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG28417 (Get FASTA)   NCBI Sequence Viewer  
  BAB33093 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075182
RefSeq Acc Id: NP_001316829   ⟸   NM_001329900
- Peptide Label: precursor
- UniProtKB: A0A0G2K9Y5 (UniProtKB/TrEMBL),   A6JS41 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000075182   ⟸   ENSRNOT00000090031
Ensembl Acc Id: ENSRNOP00000072623   ⟸   ENSRNOT00000081864
Protein Domains
Cystatin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99PS8-F1-model_v2 AlphaFold Q99PS8 1-525 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594092 AgrOrtholog
BioCyc Gene G2FUF-20832 BioCyc
Ensembl Genes ENSRNOG00000001809 Ensembl
  ENSRNOG00000070559 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000090031 ENTREZGENE
Gene3D-CATH 3.10.450.10 UniProtKB/Swiss-Prot
InterPro Cystatin_dom UniProtKB/Swiss-Prot
  Cystatin_sf UniProtKB/Swiss-Prot
  Kininogen_Fetuin_HRG UniProtKB/Swiss-Prot
KEGG Report rno:171016 UniProtKB/Swiss-Prot
  rno:681544 UniProtKB/Swiss-Prot
NCBI Gene 681544 ENTREZGENE
PANTHER FETUIN UniProtKB/Swiss-Prot
  HISTIDINE-RICH GLYCOPROTEIN UniProtKB/Swiss-Prot
PhenoGen Hrgl1 PhenoGen
RatGTEx ENSRNOG00000001809 RatGTEx
  ENSRNOG00000070559 RatGTEx
SMART SM00043 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54403 UniProtKB/Swiss-Prot
UniProt A0A0G2K9Y5 ENTREZGENE, UniProtKB/TrEMBL
  A6JS41 ENTREZGENE, UniProtKB/TrEMBL
  HRG_RAT UniProtKB/Swiss-Prot
UniProt Secondary D3ZJN0 UniProtKB/Swiss-Prot
  Q99PS7 UniProtKB/Swiss-Prot
  Q9ESB2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-09-14 Hrgl1  histidine-rich glycoprotein like 1  Hrg l1  histidine-rich glycoprotein like 1  Symbol changed 629549 APPROVED
2023-09-19 Hrg l1  histidine-rich glycoprotein like 1  Usp17l8  ubiquitin specific peptidase 17 like family member 8  Name and Symbol changed 629549 APPROVED
2023-09-19 Usp17l8  ubiquitin specific peptidase 17 like family member 8  LOC681544  similar to histidine-rich glycoprotein  Symbol and Name Changed 1299863 APPROVED
2006-11-20 LOC681544  similar to histidine-rich glycoprotein      Symbol and Name status set to provisional 70820 PROVISIONAL