LOC681544 (similar to histidine-rich glycoprotein)

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Gene: LOC681544 (similar to histidine-rich glycoprotein) Rattus norvegicus

Analyze

Symbol:

LOC681544

Name:

similar to histidine-rich glycoprotein

RGD ID:

1594092

Description:

ENCODES a protein that exhibits heme binding (ortholog); heparan sulfate proteoglycan binding (ortholog); heparin binding (ortholog); INVOLVED IN defense response to fungus (ortholog); negative regulation of angiogenesis (ortholog); negative regulation of blood vessel endothelial cell migration (ortholog)

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

histidine-rich glycoprotein 2; histidine-rich glycoprotein-like; Hrg; RNHRG2

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	78,039,371 - 78,049,353 (-)	NCBI
Rnor_6.0 Ensembl	11	81,621,283 - 81,639,952 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Celera	11	76,911,947 - 76,921,941 (-)	NCBI		Celera
Cytogenetic Map	11		NCBI

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

defense response to fungus (ISS)

fibrinolysis (IEA)

heme transport (IBA)

negative regulation of angiogenesis (ISS)

negative regulation of blood vessel endothelial cell migration (ISS)

negative regulation of cell adhesion (ISS)

negative regulation of cell adhesion mediated by integrin (ISS)

negative regulation of cell growth (ISS)

negative regulation of cell population proliferation (ISS)

negative regulation of endopeptidase activity (IBA)

negative regulation of endothelial cell chemotaxis (ISS)

negative regulation of fibrinolysis (IBA)

negative regulation of lamellipodium assembly (ISS)

negative regulation of vascular endothelial growth factor signaling pathway (ISS)

platelet activation (ISS)

positive regulation of apoptotic process (ISS)

positive regulation of blood vessel remodeling (ISS)

positive regulation of focal adhesion assembly (ISS)

positive regulation of immune response to tumor cell (ISS)

regulation of actin cytoskeleton organization (ISS)

regulation of blood coagulation (ISS)

regulation of gene expression (ISS)

regulation of peptidyl-tyrosine phosphorylation (ISS)

regulation of platelet activation (IBA,ISS)

regulation of protein-containing complex assembly (ISS)

Cellular Component

endolysosome (IBA)

extracellular region (IBA)

Molecular Function

cysteine-type endopeptidase inhibitor activity (IEA)

endopeptidase inhibitor activity (IBA)

heme binding (ISS)

heparan sulfate proteoglycan binding (ISS)

heparin binding (IBA,ISS)

immunoglobulin binding (ISS)

metal ion binding (ISS)

serine-type endopeptidase inhibitor activity (IBA)

signaling receptor binding (ISS)

zinc ion binding (IBA,ISS)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	RGD automated data pipeline

Additional References at PubMed

PMID:10849117

Genomics

Position Markers

RH130910

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	11	81,621,402 - 81,621,602	NCBI	Rnor6.0
Rnor_5.0	11	84,718,354 - 84,718,554	UniSTS	Rnor5.0
RGSC_v3.4	11	80,248,706 - 80,248,906	UniSTS	RGSC3.4
RGSC_v3.4	11	80,230,715 - 80,230,915	UniSTS	RGSC3.4
Celera	11	76,912,075 - 76,912,275	UniSTS
Celera	11	76,927,186 - 76,927,386	UniSTS
RH 3.4 Map	11	642.2	UniSTS
Cytogenetic Map	11	q23	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001329900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB055896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF194029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

NM_001329900 ⟹ NP_001316829

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	78,039,371 - 78,049,353 (-)	NCBI

RefSeq Acc Id:

XM_001057320 ⟹ XP_001057320

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Celera	11	76,911,947 - 76,921,941 (-)	NCBI

Sequence:

show sequence

AACTGAGTGTGAGTCACTGTAGCATTCTCCACTATGGTGGACCACAGCCGAGGATGGTTTTGCA
CCATGAAGGTGCTCACCACAGCATTGCTTCTAGTCACCCTGCAGTGTTCCCATGCCCTGAGTCC
CACCAACTGTGATGCCTCCAAGCCTTTGGCTGAGAAAGTTCTAGACTTGATCAATAAAGGGCGG
AGGAGTGGCTATACTTTTCAGCTGCTGCGGGTCTCTGATGCCCACTTGGACAGAGTGGAAACTG
CCACCATCTACTACTTAGTTTTAGATGTGATAGAATCTGACTGTTGGGTCCTCTCCACAAAAGC
CCAGGATGAGTGTCTTCCAGCCAGGTGGACATCTGAGATAGTGATTGGACAGTGTAAGGTAATA
GCCACAAGATACTCAAATGAGTCTCAAGATCTTAGCGTGAATGGCTATAACTGCACCATGAGAT
CCGTCTCTTCAGCACTTAGCAACACCAAAGACAGTCCTGTACTCTTCGACTTCTTTGAGGATTC
CGAGCCCTACAGAAAGCTAGCCCGGAAAGCCCTCGACAAGTACAAAGAGGAGAATGGTGACTTT
GCCTCATTCAGAGTGGAACGAGCTGAAAGGGTTATAAGAGGGAGAGGAGGGGAAAGAACCAGCT
ACTTCATAGAATTCTCGGTGAGGAACTGTTCCACACAACACTTCCCCAGACACCCTCCGGTCTT
TGGATTCTGCAGAGCAGTTTTGTCCTACAGTATAGAAGCCTCTGACTTGGAAACCCCAGAATAC
ACTGACGTGACCTGTGAAGTTGTCAACACTGAGGATCTTAAAAACAGGAGTGACATGAAACCCC
ATCGGGGCCATGAGCATCCTCATTGTGACAAACATCTGTGTAAGCTCAGTGGACCCAGGGACCA
TCATCATACCCATAAGACACATGAAATTGGATGCCCACCACCACCAGAAGGAAAAGATAACTCA
GACAGACCACCACTTCAAGAAGGAGCCCTTCCACAAATGCTCCCTGGCCATTCTGGGCCTTCTG
GTACCAACAGGAGCCATAGACCCCCTCATAATCACAGTTGTAATGAGCATCCTTGCCATGGACA
GCATCCCCATGGACACCACCCTCATGGTCAGCATCCCCATGGACACCACCCTCATGGTCAGCAT
CCCCATGGACACCACCCTCATGGTCACCATCTTCACAGGCACCACCCCCATGGTCACCATCCTC
ATGGTGACCATCCCCATGGACACCACCCCCATGGACATGATTTCCTTGACTATGGACCTTGTGA
CCCACCCTCCAATAGCCAAGAACTCAAGGGTCAGTATCATCGGGGACATGGTCCACCACACGGA
CACTCAAGGAAAAGAGGGCCAGGTAAAGGACTCTTTCCTTTCCACCAACGACAAATCGGATATG
TCTACCGACTCCCTCCACTGAATGTAGGTGAAGTTCTCACTCCTCCTGAAGCCAATTTCCCCAG
CTTCTCCTTGCCAAATTGCAACAGACCCCCACAACCAGAGATTCAGCCCTTCCCTCAGACAGCC
TCAAAGTCCTGTCCAGGGAAATTTGAGAGTAAGTTTCCACAAGTTTCCAACTTTTTTGAACATA
CGCCTCCAAAATAAAACCTGATTTCTTGGTAGGGGAAAGAGTACAATATTCTGAATAAATAAAA
TATGACCAGTTAGAAATGAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001316829	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG28417	(Get FASTA)	NCBI Sequence Viewer
	BAB33093	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_001057320 ⟸ XM_001057320

- Sequence:

show sequence

MVDHSRGWFCTMKVLTTALLLVTLQCSHALSPTNCDASKPLAEKVLDLINKGRRSGYTFQLLRV
SDAHLDRVETATIYYLVLDVIESDCWVLSTKAQDECLPARWTSEIVIGQCKVIATRYSNESQDL
SVNGYNCTMRSVSSALSNTKDSPVLFDFFEDSEPYRKLARKALDKYKEENGDFASFRVERAERV
IRGRGGERTSYFIEFSVRNCSTQHFPRHPPVFGFCRAVLSYSIEASDLETPEYTDVTCEVVNTE
DLKNRSDMKPHRGHEHPHCDKHLCKLSGPRDHHHTHKTHEIGCPPPPEGKDNSDRPPLQEGALP
QMLPGHSGPSGTNRSHRPPHNHSCNEHPCHGQHPHGHHPHGQHPHGHHPHGQHPHGHHPHGHHL
HRHHPHGHHPHGDHPHGHHPHGHDFLDYGPCDPPSNSQELKGQYHRGHGPPHGHSRKRGPGKGL
FPFHQRQIGYVYRLPPLNVGEVLTPPEANFPSFSLPNCNRPPQPEIQPFPQTASKSCPGKFESK
FPQVSNFFEHTPPK

hide sequence

RefSeq Acc Id:	NP_001316829 ⟸ NM_001329900
- Peptide Label:	precursor
- UniProtKB:	Q99PS8 (UniProtKB/Swiss-Prot)

Protein Domains

Cystatin

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSRNOG00000001809	Ensembl, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000049290	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000047595	UniProtKB/Swiss-Prot
InterPro	Cystatin_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:171016	UniProtKB/Swiss-Prot
	rno:681544	UniProtKB/Swiss-Prot
NCBI Gene	681544	ENTREZGENE
PhenoGen	LOC681544	PhenoGen
SMART	SM00043	UniProtKB/Swiss-Prot
UniProt	HRG_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	D3ZJN0	UniProtKB/Swiss-Prot
	Q99PS7	UniProtKB/Swiss-Prot
	Q9ESB2	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-11-20	LOC681544	similar to histidine-rich glycoprotein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)