Hrg l1 (histidine-rich glycoprotein like 1)

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Gene: Hrg l1 (histidine-rich glycoprotein like 1) Rattus norvegicus

Analyze

No known orthologs.

Symbol:

Hrg l1 (Ensembl: LOC681544)

Name:

histidine-rich glycoprotein like 1 (Ensembl:similar to histidine-rich glycoprotein)

RGD ID:

1594092

Description:

Predicted to enable several functions, including heme binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to be involved in several processes, including negative regulation of endothelial cell migration; negative regulation of lamellipodium assembly; and negative regulation of vascular endothelial growth factor signaling pathway. Human ortholog(s) of this gene implicated in thrombophilia due to HRG deficiency and thrombosis. Orthologous to human HRG (histidine rich glycoprotein).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

histidine-rich glycoprotein 2; histidine-rich glycoprotein-like; Hrg; LOC681544; RNHRG2; similar to histidine-rich glycoprotein; ubiquitin specific peptidase 17 like family member 8; Usp17l8

RGD Orthologs

Alliance Genes

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Other homologs ²				less info ...
Homo sapiens (human):	HRG (histidine rich glycoprotein)	HGNC	Ensembl
Alliance orthologs ³
Homo sapiens (human):	HRG (histidine rich glycoprotein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Hrg (histidine-rich glycoprotein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fetub (fetuin B)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	78,039,371 - 78,049,353 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	78,039,376 - 78,049,353 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	86,789,838 - 86,799,820 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	79,448,130 - 79,458,076 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	78,504,148 - 78,514,132 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0 Ensembl	11	81,621,283 - 81,639,952 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Celera	11	76,911,947 - 76,921,941 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

defense response to fungus (ISS)

heme transport (IBA)

negative regulation of angiogenesis (ISS)

negative regulation of blood vessel endothelial cell migration (ISS)

negative regulation of cell adhesion (ISS)

negative regulation of cell adhesion mediated by integrin (ISS)

negative regulation of cell growth (ISS)

negative regulation of cell population proliferation (ISS)

negative regulation of endothelial cell chemotaxis (ISS)

negative regulation of fibrinolysis (IBA)

negative regulation of lamellipodium assembly (ISS)

negative regulation of vascular endothelial growth factor signaling pathway (ISS)

platelet activation (ISS)

positive regulation of apoptotic process (ISS)

positive regulation of blood vessel remodeling (ISS)

positive regulation of focal adhesion assembly (ISS)

positive regulation of immune response to tumor cell (ISS)

regulation of actin cytoskeleton organization (ISS)

regulation of blood coagulation (ISS)

regulation of gene expression (ISS)

regulation of peptidyl-tyrosine phosphorylation (ISS)

regulation of platelet activation (IBA,ISS)

regulation of protein-containing complex assembly (ISS)

Cellular Component

endolysosome (IBA)

extracellular region (IBA)

Molecular Function

cysteine-type endopeptidase inhibitor activity (IEA)

heme binding (ISS)

heparan sulfate proteoglycan binding (ISS)

heparin binding (IBA,ISS)

immunoglobulin binding (ISS)

metal ion binding (ISS)

serine-type endopeptidase inhibitor activity (IBA)

signaling receptor binding (ISS)

zinc ion binding (IBA,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline

Additional References at PubMed

PMID:10849117

Genomics

Variants

Variants in Hrg l1
82 total Variants

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	29528418	82566702	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	31239134	78851519	Rat
70180	BpQTLcluster10	Blood pressure QTL cluster 10	3.19		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	11	34918041	79918041	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	40946188	82566702	Rat
2312566	Glom20	Glomerulus QTL 20	3.6	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	44285759	82566702	Rat
1581565	Pur10	Proteinuria QTL 10		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
1581572	Uae35	Urinary albumin excretion QTL 35		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	54457534	86241447	Rat
4889521	Gluco62	Glucose level QTL 62	2.82	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	55136729	82993457	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	56351424	86241447	Rat
631506	Bp104	Blood pressure QTL 104	2.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	59802794	82566545	Rat
70208	Niddm22	Non-insulin dependent diabetes mellitus QTL 22	3.61		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	59802794	82566553	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	60346590	86241447	Rat
1549848	Bvd6	Brain ventricular dilatation QTL 6	3.1	0.0001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	66113321	82169223	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	66422148	86241447	Rat
1354593	Stl12	Serum triglyceride level QTL 12	3.36		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	11	66422148	86241447	Rat
1354656	Bvd3	Brain ventricular dilatation QTL 3	3.64	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	69446070	82846715	Rat
10450831	Scl80	Serum cholesterol level QTL 80	4.7	0.01	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	11	76957131	83051965	Rat

Markers in Region

RH130910

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	78,054,621 - 78,054,822 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	81,621,402 - 81,621,602	NCBI	Rnor6.0
Rnor_5.0	11	84,718,354 - 84,718,554	UniSTS	Rnor5.0
RGSC_v3.4	11	80,248,706 - 80,248,906	UniSTS	RGSC3.4
RGSC_v3.4	11	80,230,715 - 80,230,915	UniSTS	RGSC3.4
Celera	11	76,927,186 - 76,927,386	UniSTS
Celera	11	76,912,075 - 76,912,275	UniSTS
RH 3.4 Map	11	642.2	UniSTS
Cytogenetic Map	11	q23	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001329900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001057320	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB055896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF194029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000081864 ⟹ ENSRNOP00000072623

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	78,054,498 - 78,069,389 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000090031 ⟹ ENSRNOP00000075182

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	78,039,376 - 78,049,353 (-)	Ensembl

RefSeq Acc Id:

NM_001329900 ⟹ NP_001316829

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	78,039,371 - 78,049,353 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001316829	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG28417	(Get FASTA)	NCBI Sequence Viewer
	BAB33093	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000075182
	ENSRNOP00000075182.2

RefSeq Acc Id:	NP_001316829 ⟸ NM_001329900
- Peptide Label:	precursor
- UniProtKB:	A0A0G2K9Y5 (UniProtKB/TrEMBL), A6JS41 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000075182 ⟸ ENSRNOT00000090031

RefSeq Acc Id:

ENSRNOP00000072623 ⟸ ENSRNOT00000081864

Protein Domains

Cystatin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q99PS8-F1-model_v2	AlphaFold	Q99PS8	1-525	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1594092	AgrOrtholog
BioCyc Gene	G2FUF-20832	BioCyc
Ensembl Genes	ENSRNOG00000001809	Ensembl
	ENSRNOG00000070559	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000090031	ENTREZGENE
	ENSRNOT00000090031.2	UniProtKB/TrEMBL
Gene3D-CATH	3.10.450.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Cystatin_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cystatin_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:171016	UniProtKB/Swiss-Prot
	rno:681544	UniProtKB/Swiss-Prot
NCBI Gene	681544	ENTREZGENE
PANTHER	FETUIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HISTIDINE-RICH GLYCOPROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Hrg l1	PhenoGen
RatGTEx	ENSRNOG00000001809	RatGTEx
	ENSRNOG00000070559	RatGTEx
SMART	SM00043	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF54403	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K9Y5	ENTREZGENE, UniProtKB/TrEMBL
	A6JS41	ENTREZGENE, UniProtKB/TrEMBL
	HRG_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	D3ZJN0	UniProtKB/Swiss-Prot
	Q99PS7	UniProtKB/Swiss-Prot
	Q9ESB2	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-09-19	Hrg l1	histidine-rich glycoprotein like 1	Usp17l8	ubiquitin specific peptidase 17 like family member 8	Name and Symbol changed	629549	APPROVED
2023-09-19	Usp17l8	ubiquitin specific peptidase 17 like family member 8	LOC681544	similar to histidine-rich glycoprotein	Symbol and Name Changed	1299863	APPROVED
2006-11-20	LOC681544	similar to histidine-rich glycoprotein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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