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Gene: LOC681544 (similar to histidine-rich glycoprotein) Rattus norvegicus
Analyze
Symbol:
LOC681544
Name:
similar to histidine-rich glycoprotein
RGD ID:
1594092
Description:
Predicted to enable several functions, including heme binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to be involved in several processes, including negative regulation of endothelial cell migration; negative regulation of lamellipodium assembly; and negative regulation of vascular endothelial growth factor signaling pathway. Human ortholog(s) of this gene implicated in thrombophilia due to HRG deficiency and thrombosis. Orthologous to human HRG (histidine rich glycoprotein).
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
histidine-rich glycoprotein 2; histidine-rich glycoprotein-like; Hrg; RNHRG2
RGD Orthologs
Alliance Genes
No known orthologs.
More Info
homologs ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Alliance orthologs 3
Homo sapiens (human):
HRG (histidine rich glycoprotein)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Mus musculus (house mouse):
Hrg (histidine-rich glycoprotein)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Latest Assembly:
mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl mRatBN7.2 11 78,039,371 - 78,049,353 (-) NCBI mRatBN7.2 mRatBN7.2 Ensembl 11 78,039,376 - 78,049,353 (-) Ensembl Rnor_6.0 Ensembl 11 81,621,283 - 81,639,952 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Celera 11 76,911,947 - 76,921,941 (-) NCBI Celera Cytogenetic Map 11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Biological Process
antimicrobial humoral immune response mediated by antimicrobial peptide involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytolysis by host of symbiont cells involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 defense response to fungus involved_in ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 defense response to fungus involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 fibrinolysis involved_in IEA UniProtKB-KW:KW-0280 1600115 GO_REF:0000043 UniProt GO_REF:0000043 heme transport involved_in IBA MGI:2146636 , PANTHER:PTN001418583 13792537 PMID:21873635 GO_Central negative regulation of angiogenesis involved_in ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of angiogenesis involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of angiogenesis involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of blood vessel endothelial cell migration involved_in ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of cell adhesion involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of cell adhesion mediated by integrin involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of cell adhesion mediated by integrin involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of cell growth involved_in ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of cell growth involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of cell growth involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of cell population proliferation involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of cell population proliferation involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of endopeptidase activity involved_in IBA MGI:1890221 , PANTHER:PTN002674770 13792537 PMID:21873635 GO_Central negative regulation of endopeptidase activity involved_in IEA GO:0004869 1600115 GO_REF:0000108 GOC GO_REF:0000108 negative regulation of endothelial cell chemotaxis involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of endothelial cell chemotaxis involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of fibrinolysis involved_in IBA MGI:2146636 , PANTHER:PTN001418583 13792537 PMID:21873635 GO_Central negative regulation of lamellipodium assembly involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of lamellipodium assembly involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of vascular endothelial growth factor signaling pathway involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of vascular endothelial growth factor signaling pathway involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 platelet activation involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 platelet activation involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of apoptotic process involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of apoptotic process involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of blood vessel remodeling involved_in ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of blood vessel remodeling involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of blood vessel remodeling involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of focal adhesion assembly involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of focal adhesion assembly involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of immune response to tumor cell involved_in ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of immune response to tumor cell involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of immune response to tumor cell involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of actin cytoskeleton organization involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of actin cytoskeleton organization involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of blood coagulation involved_in ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of blood coagulation involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of blood coagulation involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of gene expression involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of gene expression involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of gene expression involved_in ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of peptidyl-tyrosine phosphorylation involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of peptidyl-tyrosine phosphorylation involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of platelet activation involved_in ISS UniProtKB:Q9ESB3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of platelet activation involved_in IBA MGI:2146636 , PANTHER:PTN001418583 13792537 PMID:21873635 GO_Central regulation of protein-containing complex assembly involved_in IEA UniProtKB:P04196 , ensembl:ENSP000002320031600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of protein-containing complex assembly involved_in ISS UniProtKB:P04196 1600115 GO_REF:0000024 UniProt GO_REF:0000024
References
Additional References at PubMed
Genomics
QTLs in Region (mRatBN7.2)
724554 Iddm17 Insulin dependent diabetes mellitus QTL 17 0.001 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 11 18976208 86241447 Rat 724563 Uae10 Urinary albumin excretion QTL 10 6 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 11 27672410 82846715 Rat 1300110 Stl7 Serum triglyceride level QTL 7 4.64 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) 11 29528418 82566702 Rat 2298551 Neuinf10 Neuroinflammation QTL 10 3.7 nervous system integrity trait (VT:0010566) spinal cord beta-2 microglobulin mRNA level (CMO:0002125) 11 31239134 78851519 Rat 70180 BpQTLcluster10 Blood pressure QTL cluster 10 3.19 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 11 34918041 79918041 Rat 1300135 Rf19 Renal function QTL 19 3.38 blood creatinine amount (VT:0005328) creatinine clearance (CMO:0000765) 11 40946188 82566702 Rat 2312566 Glom20 Glomerulus QTL 20 3.6 0.001 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) 11 44285759 82566702 Rat 1581565 Pur10 Proteinuria QTL 10 0.0001 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 11 44803318 82846466 Rat 1581572 Uae35 Urinary albumin excretion QTL 35 0.0001 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 11 44803318 82846466 Rat 724561 Plsm4 Polydactyly-luxate syndrome (PLS) morphotypes QTL 4 0.0003 forelimb integrity trait (VT:0010562) front foot phalanges count (CMO:0001947) 11 54457534 86241447 Rat 4889521 Gluco62 Glucose level QTL 62 2.82 0.001 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 11 55136729 82993457 Rat 7411658 Foco27 Food consumption QTL 27 16.2 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 11 56351424 86241447 Rat 631506 Bp104 Blood pressure QTL 104 2.8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 11 59802794 82566545 Rat 70208 Niddm22 Non-insulin dependent diabetes mellitus QTL 22 3.61 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 11 59802794 82566553 Rat 10058954 Gmadr7 Adrenal mass QTL 7 2.49 0.0049 adrenal gland mass (VT:0010420) both adrenal glands wet weight to body weight ratio (CMO:0002411) 11 60346590 86241447 Rat 1549848 Bvd6 Brain ventricular dilatation QTL 6 3.1 0.0001 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) 11 66113321 82169223 Rat 634339 Niddm50 Non-insulin dependent diabetes mellitus QTL 50 3.32 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 11 66422148 86241447 Rat 1354593 Stl12 Serum triglyceride level QTL 12 3.36 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) 11 66422148 86241447 Rat 1354656 Bvd3 Brain ventricular dilatation QTL 3 3.64 0.001 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) 11 69446070 82846715 Rat 10450831 Scl80 Serum cholesterol level QTL 80 4.7 0.01 blood LDL cholesterol amount (VT:0000181) blood low density lipoprotein cholesterol level (CMO:0000053) 11 76957131 83051965 Rat
