Hrg l1 (histidine-rich glycoprotein like 1) - Rat Genome Database

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Gene: Hrg l1 (histidine-rich glycoprotein like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Hrg l1 (Ensembl: LOC681544)
Name: histidine-rich glycoprotein like 1 (Ensembl:similar to histidine-rich glycoprotein)
RGD ID: 1594092
Description: Predicted to enable several functions, including heme binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to be involved in several processes, including negative regulation of endothelial cell migration; negative regulation of lamellipodium assembly; and negative regulation of vascular endothelial growth factor signaling pathway. Human ortholog(s) of this gene implicated in thrombophilia due to HRG deficiency and thrombosis. Orthologous to human HRG (histidine rich glycoprotein).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: histidine-rich glycoprotein 2; histidine-rich glycoprotein-like; Hrg; LOC681544; RNHRG2; similar to histidine-rich glycoprotein; ubiquitin specific peptidase 17 like family member 8; Usp17l8
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,543,964 - 91,553,946 (-)NCBIGRCr8
mRatBN7.21178,039,371 - 78,049,353 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1178,039,376 - 78,049,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1186,789,838 - 86,799,820 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01179,448,130 - 79,458,076 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,504,148 - 78,514,132 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0 Ensembl1181,621,283 - 81,639,952 (-)EnsemblRnor6.0rn6Rnor6.0
Celera1176,911,947 - 76,921,941 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
Additional References at PubMed
PMID:10849117  


Genomics

Variants

.
Variants in Hrg l1
102 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat

Markers in Region
RH130910  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21178,054,621 - 78,054,822 (+)MAPPERmRatBN7.2
Rnor_6.01181,621,402 - 81,621,602NCBIRnor6.0
Rnor_5.01184,718,354 - 84,718,554UniSTSRnor5.0
RGSC_v3.41180,248,706 - 80,248,906UniSTSRGSC3.4
RGSC_v3.41180,230,715 - 80,230,915UniSTSRGSC3.4
Celera1176,927,186 - 76,927,386UniSTS
Celera1176,912,075 - 76,912,275UniSTS
RH 3.4 Map11642.2UniSTS
Cytogenetic Map11q23UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000081864   ⟹   ENSRNOP00000072623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1178,054,498 - 78,069,389 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090031   ⟹   ENSRNOP00000075182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1178,039,376 - 78,049,353 (-)Ensembl
RefSeq Acc Id: NM_001329900   ⟹   NP_001316829
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,543,964 - 91,553,946 (-)NCBI
mRatBN7.21178,039,371 - 78,049,353 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001316829 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG28417 (Get FASTA)   NCBI Sequence Viewer  
  BAB33093 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075182
  ENSRNOP00000075182.2
Reference Protein Sequences
RefSeq Acc Id: NP_001316829   ⟸   NM_001329900
- Peptide Label: precursor
- UniProtKB: A0A0G2K9Y5 (UniProtKB/TrEMBL),   A6JS41 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000075182   ⟸   ENSRNOT00000090031
RefSeq Acc Id: ENSRNOP00000072623   ⟸   ENSRNOT00000081864
Protein Domains
Cystatin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99PS8-F1-model_v2 AlphaFold Q99PS8 1-525 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594092 AgrOrtholog
BioCyc Gene G2FUF-20832 BioCyc
Ensembl Genes ENSRNOG00000001809 Ensembl
  ENSRNOG00000070559 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090031 ENTREZGENE
  ENSRNOT00000090031.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystatin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171016 UniProtKB/Swiss-Prot
  rno:681544 UniProtKB/Swiss-Prot
NCBI Gene 681544 ENTREZGENE
PANTHER FETUIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTIDINE-RICH GLYCOPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hrg l1 PhenoGen
RatGTEx ENSRNOG00000001809 RatGTEx
  ENSRNOG00000070559 RatGTEx
SMART SM00043 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K9Y5 ENTREZGENE, UniProtKB/TrEMBL
  A6JS41 ENTREZGENE, UniProtKB/TrEMBL
  HRG_RAT UniProtKB/Swiss-Prot
UniProt Secondary D3ZJN0 UniProtKB/Swiss-Prot
  Q99PS7 UniProtKB/Swiss-Prot
  Q9ESB2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Hrg l1  histidine-rich glycoprotein like 1  Usp17l8  ubiquitin specific peptidase 17 like family member 8  Name and Symbol changed 629549 APPROVED
2023-09-19 Usp17l8  ubiquitin specific peptidase 17 like family member 8  LOC681544  similar to histidine-rich glycoprotein  Symbol and Name Changed 1299863 APPROVED
2006-11-20 LOC681544  similar to histidine-rich glycoprotein      Symbol and Name status set to provisional 70820 PROVISIONAL