Mir185 (microRNA 185) - Rat Genome Database

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Gene: Mir185 (microRNA 185) Rattus norvegicus
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Symbol: Mir185
Name: microRNA 185
RGD ID: 2325380
Description: Predicted to enable lncRNA binding activity; mRNA 3'-UTR binding activity; and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including cellular response to cholesterol; cholesterol homeostasis; and negative regulation of biosynthetic process. Predicted to act upstream of or within cellular response to leukemia inhibitory factor and regulation of SMAD protein signal transduction. Orthologous to human MIR185 (microRNA 185); INTERACTS WITH 2-acetamidofluorene; bleomycin A2; cisplatin.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-185; rno-mir-185
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,169,028 - 96,169,107 (+)NCBIGRCr8
mRatBN7.21182,664,716 - 82,664,795 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,664,716 - 82,664,795 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,393,107 - 91,393,186 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,054,335 - 84,054,414 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,107,847 - 83,107,926 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,812,702 - 86,812,781 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,812,702 - 86,812,781 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,906,640 - 89,906,719 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1181,441,729 - 81,441,808 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to cholesterol  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cholesterol homeostasis  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of (R)-mevalonic acid biosynthetic process  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of B cell activation  (ISO)
negative regulation of B cell proliferation  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cholesterol biosynthetic process  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of fatty acid biosynthetic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of high-density lipoprotein particle clearance  (ISO)
negative regulation of low-density lipoprotein particle clearance  (ISO)
negative regulation of receptor-mediated endocytosis involved in cholesterol transport  (ISO)
negative regulation of response to drug  (ISO)
negative regulation of signal transduction  (ISO)
negative regulation of transmembrane transport  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane  (ISO)
positive regulation of macrophage derived foam cell differentiation  (ISO)
regulation of SMAD protein signal transduction  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15345052   PMID:16381832   PMID:16766679   PMID:17604727   PMID:20403161   PMID:20439489   PMID:23390484   PMID:25767890   PMID:26036598   PMID:26521941   PMID:30201694   PMID:31814881  
PMID:32090685   PMID:32300942   PMID:33560148   PMID:34647243   PMID:34999395   PMID:36481751   PMID:38168094  


Genomics

Comparative Map Data
Mir185
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,169,028 - 96,169,107 (+)NCBIGRCr8
mRatBN7.21182,664,716 - 82,664,795 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,664,716 - 82,664,795 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,393,107 - 91,393,186 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,054,335 - 84,054,414 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,107,847 - 83,107,926 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,812,702 - 86,812,781 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,812,702 - 86,812,781 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,906,640 - 89,906,719 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1181,441,729 - 81,441,808 (+)NCBICelera
Cytogenetic Map11q23NCBI
MIR185
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,033,139 - 20,033,220 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2220,033,139 - 20,033,220 (+)EnsemblGRCh38hg38GRCh38
GRCh372220,020,662 - 20,020,743 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,400,661 - 18,400,742 (+)NCBINCBI36Build 36hg18NCBI36
Celera223,871,865 - 3,871,946 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef223,641,080 - 3,641,161 (+)NCBIHuRef
CHM1_12220,020,370 - 20,020,451 (+)NCBICHM1_1
T2T-CHM13v2.02220,410,752 - 20,410,833 (+)NCBIT2T-CHM13v2.0
Mir185
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,145,265 - 18,145,329 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,145,265 - 18,145,329 (-)EnsemblGRCm39 Ensembl
GRCm381618,327,401 - 18,327,465 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,327,401 - 18,327,465 (-)EnsemblGRCm38mm10GRCm38
MGSCv371618,327,494 - 18,327,558 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1618,900,146 - 18,900,210 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.35NCBI
MIR185
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,296,014 - 29,296,069 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,296,004 - 29,296,079 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2629,254,692 - 29,254,747 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,699,896 - 30,699,951 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12628,747,758 - 28,747,813 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,373,121 - 28,373,176 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,458,129 - 29,458,184 (-)NCBIUU_Cfam_GSD_1.0
MIR185
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,449,903 - 51,449,978 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,449,903 - 51,449,978 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21455,086,524 - 55,086,599 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Vimrno-miR-185-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Targets
Summary Value
Count of predictions:19487
Count of gene targets:9287
Count of transcripts:10070
Interacting mature miRNAs:rno-miR-185-3p, rno-miR-185-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
2302043Pia27Pristane induced arthritis QTL 2718.60.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)118256654583440803Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 3 7 22 15 10 1 8 1 1 36 23 13 8 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000053708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,664,716 - 82,664,795 (+)Ensembl
Rnor_6.0 Ensembl1186,812,702 - 86,812,781 (+)Ensembl
RefSeq Acc Id: NR_031903
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,169,028 - 96,169,107 (+)NCBI
mRatBN7.21182,664,716 - 82,664,795 (+)NCBI
Rnor_6.01186,812,702 - 86,812,781 (+)NCBI
Rnor_5.01189,906,640 - 89,906,719 (+)NCBI
Celera1181,441,729 - 81,441,808 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325380 AgrOrtholog
BioCyc Gene G2FUF-20653 BioCyc
Ensembl Genes ENSRNOG00000035585 Ensembl
miRBase MI0000930 ENTREZGENE
NCBI Gene 100314243 ENTREZGENE
PhenoGen Mir185 PhenoGen
RatGTEx ENSRNOG00000035585 RatGTEx
RNAcentral URS00004176D4 RNACentral
  URS00006449B1 RNACentral
  URS000075C761 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir185  microRNA 185  Mir185  microRNA mir-185  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir185  microRNA mir-185      Symbol and Name status set to provisional 70820 PROVISIONAL