Ostn (osteocrin) - Rat Genome Database

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Gene: Ostn (osteocrin) Rattus norvegicus
Analyze
Symbol: Ostn
Name: osteocrin
RGD ID: 1303110
Description: Predicted to enable signaling receptor binding activity. Predicted to be involved in hormone-mediated signaling pathway and negative regulation of dendrite extension. Predicted to act upstream of or within several processes, including endochondral bone growth; negative regulation of D-glucose import; and negative regulation of osteoblast differentiation. Predicted to be active in extracellular space. Orthologous to human OSTN (osteocrin); INTERACTS WITH bisphenol A; Muraglitazar; paraquat.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: musclin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81186,947,023 - 86,983,322 (-)NCBIGRCr8
mRatBN7.21173,442,167 - 73,478,498 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,442,487 - 73,468,603 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1182,285,131 - 82,307,232 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01174,920,161 - 74,942,266 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01173,951,063 - 73,973,200 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01176,851,923 - 76,888,140 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1176,851,322 - 76,888,178 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01183,841,994 - 83,873,314 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41175,432,572 - 75,455,380 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11175,486,189 - 75,512,971 (-)NCBI
Celera1172,377,886 - 72,400,027 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Training objectives of a well developed geriatrics program. Pattee JJ J Am Geriatr Soc 1978 Apr;26(4):167-9.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype. Thomas G, etal., J Biol Chem 2003 Dec 12;278(50):50563-71. Epub 2003 Oct 01.
Additional References at PubMed
PMID:15044443   PMID:17189616   PMID:17951249   PMID:23940802   PMID:27830782   PMID:33955191  


Genomics

Comparative Map Data
Ostn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81186,947,023 - 86,983,322 (-)NCBIGRCr8
mRatBN7.21173,442,167 - 73,478,498 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,442,487 - 73,468,603 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1182,285,131 - 82,307,232 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01174,920,161 - 74,942,266 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01173,951,063 - 73,973,200 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01176,851,923 - 76,888,140 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1176,851,322 - 76,888,178 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01183,841,994 - 83,873,314 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41175,432,572 - 75,455,380 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11175,486,189 - 75,512,971 (-)NCBI
Celera1172,377,886 - 72,400,027 (-)NCBICelera
Cytogenetic Map11q22NCBI
OSTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383191,199,241 - 191,265,615 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3191,199,241 - 191,265,615 (+)EnsemblGRCh38hg38GRCh38
GRCh373190,917,030 - 190,983,404 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363192,413,016 - 192,450,604 (+)NCBINCBI36Build 36hg18NCBI36
Build 343192,413,023 - 192,450,612NCBI
Celera3189,359,164 - 189,396,700 (+)NCBICelera
Cytogenetic Map3q28NCBI
HuRef3188,329,884 - 188,367,558 (+)NCBIHuRef
CHM1_13190,893,879 - 190,931,478 (+)NCBICHM1_1
T2T-CHM13v2.03194,014,945 - 194,081,320 (+)NCBIT2T-CHM13v2.0
Ostn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391627,125,733 - 27,169,959 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1627,126,239 - 27,169,962 (+)EnsemblGRCm39 Ensembl
GRCm381627,307,641 - 27,351,209 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1627,307,489 - 27,351,212 (+)EnsemblGRCm38mm10GRCm38
MGSCv371627,307,727 - 27,351,295 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361627,222,874 - 27,266,442 (+)NCBIMGSCv36mm8
Celera1627,846,676 - 27,890,160 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1618.88NCBI
Ostn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542016,991,576 - 17,035,981 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542016,994,447 - 17,035,576 (-)NCBIChiLan1.0ChiLan1.0
OSTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22189,138,390 - 189,207,557 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13189,143,151 - 189,212,269 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03188,491,237 - 188,557,000 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13196,839,501 - 196,905,696 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3196,852,828 - 196,902,960 (+)Ensemblpanpan1.1panPan2
OSTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13423,064,973 - 23,106,223 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3423,076,910 - 23,104,912 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3427,157,210 - 27,198,723 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03422,999,202 - 23,040,728 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3423,011,258 - 23,041,462 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13423,019,670 - 23,061,162 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03423,006,318 - 23,047,835 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03423,248,710 - 23,290,215 (+)NCBIUU_Cfam_GSD_1.0
Ostn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602120,934,914 - 120,975,322 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936900396,821 - 435,911 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936900396,772 - 437,130 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OSTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13128,546,915 - 128,574,989 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113128,530,911 - 128,574,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213137,735,950 - 137,970,646 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OSTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11585,372,077 - 85,432,769 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1585,386,221 - 85,416,224 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604159,035,972 - 59,066,337 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ostn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473066,006,315 - 66,048,434 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473066,009,048 - 66,047,963 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ostn
382 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:37
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000049841
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 16 54 49 48 17 25 17 6 120 64 34 22 44 31

Sequence


Ensembl Acc Id: ENSRNOT00000049841   ⟹   ENSRNOP00000043654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1173,442,487 - 73,468,603 (-)Ensembl
Rnor_6.0 Ensembl1176,851,322 - 76,888,178 (-)Ensembl
RefSeq Acc Id: NM_207612   ⟹   NP_997495
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,947,023 - 86,983,322 (-)NCBI
mRatBN7.21173,442,197 - 73,478,498 (-)NCBI
Rnor_6.01176,855,895 - 76,878,036 (-)NCBI
Rnor_5.01183,841,994 - 83,873,314 (+)NCBI
RGSC_v3.41175,432,572 - 75,455,380 (-)RGD
Celera1172,377,886 - 72,400,027 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088499   ⟹   XP_038944427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,947,312 - 86,978,149 (-)NCBI
mRatBN7.21173,442,167 - 73,473,326 (-)NCBI
Protein Sequences
Protein RefSeqs NP_997495 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944427 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ94967 (Get FASTA)   NCBI Sequence Viewer  
  AAS87600 (Get FASTA)   NCBI Sequence Viewer  
  EDL78125 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043654
  ENSRNOP00000043654.2
GenBank Protein P61365 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_997495   ⟸   NM_207612
- Peptide Label: precursor
- UniProtKB: P61365 (UniProtKB/Swiss-Prot),   A6JRY2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043654   ⟸   ENSRNOT00000049841
RefSeq Acc Id: XP_038944427   ⟸   XM_039088499
- Peptide Label: isoform X1
- UniProtKB: P61365 (UniProtKB/Swiss-Prot),   A6JRY2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61365-F1-model_v2 AlphaFold P61365 1-132 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303110 AgrOrtholog
BioCyc Gene G2FUF-20950 BioCyc
Ensembl Genes ENSRNOG00000030462 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000049841 ENTREZGENE
  ENSRNOT00000049841.4 UniProtKB/Swiss-Prot
InterPro Osteocrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:360730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 360730 ENTREZGENE
PANTHER OSTEOCRIN UniProtKB/Swiss-Prot
  OSTEOCRIN UniProtKB/TrEMBL
  OSTEOCRIN UniProtKB/TrEMBL
  PTHR35353 UniProtKB/Swiss-Prot
Pfam Musclin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ostn PhenoGen
RatGTEx ENSRNOG00000030462 RatGTEx
UniProt A6JRY2 ENTREZGENE, UniProtKB/TrEMBL
  OSTN_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Ostn  osteocrin      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Ostn  osteocrin      Symbol and Name status set to provisional 70820 PROVISIONAL