Gene: Yars2 (tyrosyl-tRNA synthetase 2) Rattus norvegicus
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Symbol: Yars2
Name: tyrosyl-tRNA synthetase 2
Description: ENCODES a protein that exhibits protein homodimerization activity (ortholog); tRNA binding (ortholog); tyrosine binding (ortholog); INVOLVED IN mitochondrial tyrosyl-tRNA aminoacylation (ortholog); tRNA aminoacylation (ortholog); PARTICIPATES IN aminoacyl-tRNA biosynthetic pathway; ASSOCIATED WITH arrhythmogenic right ventricular dysplasia 9 (ortholog); genetic disease (ortholog); Lethal Encephalopathy due to Defective Mitochondrial and Peroxisomal Fission 1 (ortholog); FOUND IN mitochondrion (ortholog); nuclear body (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene
AGR Description: Predicted to have several functions, including protein homodimerization activity, tRNA binding activity, and tyrosine binding activity; predicted to be involved in mitochondrial tyrosyl-tRNA aminoacylation; predicted to localize to the cytosol, mitochondrion, and nuclear body; orthologous to human YARS2 (tyrosyl-tRNA synthetase 2).
Merged Description: Predicted to have several functions, including protein homodimerization activity, tRNA binding activity, and tyrosine binding activity; predicted to be involved in mitochondrial tyrosyl-tRNA aminoacylation; predicted to localize to the cytosol, mitochondrion, and nuclear body; orthologous to human YARS2 (tyrosyl-tRNA synthetase 2); PARTICIPATES IN aminoacyl-tRNA biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CGI-04; LOC287924; RGD1311696; similar to CGI-04 protein; tyrosine--tRNA ligase; tyrosine--tRNA ligase, mitochondrial; tyrosyl-tRNA synthetase 2 (mitochondrial); tyrosyl-tRNA synthetase 2, mitochondrial; tyrosyl-tRNA synthetase, mitochondrial; tyrRS
Orthologs:
Homo sapiens (human) : YARS2 (tyrosyl-tRNA synthetase 2)  HGNC  Alliance
Mus musculus (house mouse) : Yars2 (tyrosyl-tRNA synthetase 2 (mitochondrial))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Yars2 (tyrosyl-tRNA synthetase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : YARS2 (tyrosyl-tRNA synthetase 2)
Canis lupus familiaris (dog) : YARS2 (tyrosyl-tRNA synthetase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Yars2 (tyrosyl-tRNA synthetase 2)
Sus scrofa (pig) : YARS2 (tyrosyl-tRNA synthetase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01188,882,615 - 88,888,377 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01191,936,942 - 91,942,704 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,609,037 - 86,614,799 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11186,649,633 - 86,655,395 (+)NCBI
Celera1183,377,810 - 83,383,571 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated
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Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Yars2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1311696
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.