Yars2 (tyrosyl-tRNA synthetase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Yars2 (tyrosyl-tRNA synthetase 2) Rattus norvegicus
Analyze
Symbol: Yars2
Name: tyrosyl-tRNA synthetase 2
RGD ID: 1311696
Description: Predicted to enable several functions, including L-tyrosine binding activity; protein homodimerization activity; and tyrosine-tRNA ligase activity. Predicted to be involved in mitochondrial tyrosyl-tRNA aminoacylation. Predicted to be located in mitochondrial matrix and nuclear body. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 2. Orthologous to human YARS2 (tyrosyl-tRNA synthetase 2); PARTICIPATES IN aminoacyl-tRNA biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CGI-04; LOC287924; RGD1311696; similar to CGI-04 protein; tyrosine--tRNA ligase; tyrosine--tRNA ligase, mitochondrial; tyrosyl-tRNA synthetase 2 (mitochondrial); tyrosyl-tRNA synthetase 2, mitochondrial; tyrosyl-tRNA synthetase, mitochondrial; tyrRS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,136,530 - 98,142,320 (-)NCBIGRCr8
mRatBN7.21184,632,350 - 84,638,138 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,624,369 - 84,638,125 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,364,537 - 93,370,276 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,025,678 - 86,031,417 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,079,277 - 85,085,016 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,882,615 - 88,888,377 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,882,616 - 88,888,377 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,936,942 - 91,942,704 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,609,037 - 86,614,799 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,649,633 - 86,655,395 (+)NCBI
Celera1183,377,810 - 83,383,571 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars2Ratarrhythmogenic right ventricular dysplasia 9  ISOYARS2 (Homo sapiens)8554872ClinVar Annotator: match by term: Arrhythmogenic right ventricular dysplasia 9ClinVarPMID:27066507 and PMID:28492532
Yars2Ratencephalopathy due to defective mitochondrial and peroxisomal fission 1  ISOYARS2 (Homo sapiens)8554872ClinVar Annotator: match by term: Encephalopathy due to defective mitochondrial and peroxisomal fission 1ClinVarPMID:25741868
Yars2Ratgenetic disease  ISOYARS2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
Yars2Ratmitochondrial metabolism disease  ISOYARS2 (Homo sapiens)8554872ClinVar Annotator: match by term: Mitochondrial diseaseClinVarPMID:28812649
Yars2Ratmyopathy, lactic acidosis, and sideroblastic anemia  ISOYARS2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:28492532
Yars2Ratmyopathy, lactic acidosis, and sideroblastic anemia 2  ISOYARS2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12075011 more ...
Yars2Ratoptic atrophy 5  ISOYARS2 (Homo sapiens)8554872ClinVar Annotator: match by term: Optic atrophy 5ClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars2Ratmyopathy, lactic acidosis, and sideroblastic anemia  ISOYARS2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars2Ratmyopathy, lactic acidosis, and sideroblastic anemia 2  ISOYARS2 (Homo sapiens)7240710 OMIM 

1 to 20 of 72 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars2Rat(+)-dexrazoxane multiple interactionsISOYars2 (Mus musculus)6480464[Doxorubicin co-treated with Dexrazoxane] results in increased expression of YARS2 mRNACTDPMID:26873546
Yars2Rat(-)-alpha-phellandrene decreases expressionISOYARS2 (Homo sapiens)6480464alpha phellandrene results in decreased expression of YARS2 mRNACTDPMID:25075043
Yars2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of YARS2 mRNACTDPMID:21215274 and PMID:33387578
Yars2Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of YARS2 mRNACTDPMID:21346803
Yars2Rat2-deoxy-D-glucose increases expressionISOYARS2 (Homo sapiens)6480464Deoxyglucose results in increased expression of YARS2 mRNACTDPMID:33770205
Yars2Rat4-amino-2,6-dinitrotoluene affects expressionEXP 64804644-amino-2 and 6-dinitrotoluene affects the expression of YARS2 mRNACTDPMID:21346803
Yars2Rat5-fluorouracil increases expressionISOYARS2 (Homo sapiens)6480464Fluorouracil results in increased expression of YARS2 mRNACTDPMID:33770205
Yars2Rataflatoxin B1 increases methylationISOYARS2 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of YARS2 geneCTDPMID:27153756
Yars2Ratalpha-phellandrene decreases expressionISOYARS2 (Homo sapiens)6480464alpha phellandrene results in decreased expression of YARS2 mRNACTDPMID:25075043
Yars2Ratarsenite(3-) increases methylationISOYARS2 (Homo sapiens)6480464arsenite results in increased methylation of YARS2 promoterCTDPMID:23974009
Yars2Ratatrazine decreases expressionISOYARS2 (Homo sapiens)6480464Atrazine results in decreased expression of YARS2 mRNACTDPMID:22378314
Yars2Ratbenzo[a]pyrene increases expressionISOYars2 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of YARS2 mRNACTDPMID:19770486
Yars2Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of YARS2 mRNACTDPMID:25181051
Yars2Ratbisphenol A decreases methylationISOYARS2 (Homo sapiens)6480464bisphenol A results in decreased methylation of YARS2 geneCTDPMID:31601247
Yars2Ratbisphenol A increases expressionISOYars2 (Mus musculus)6480464bisphenol A results in increased expression of YARS2 mRNACTDPMID:33221593
Yars2Ratbisphenol AF increases expressionISOYARS2 (Homo sapiens)6480464bisphenol AF results in increased expression of YARS2 proteinCTDPMID:34186270
Yars2RatBisphenol B increases expressionISOYARS2 (Homo sapiens)6480464bisphenol B results in increased expression of YARS2 proteinCTDPMID:34186270
Yars2Ratbisphenol F increases expressionISOYars2 (Mus musculus)6480464bisphenol F results in increased expression of YARS2 mRNACTDPMID:38685157
Yars2Ratbisphenol F increases expressionISOYARS2 (Homo sapiens)6480464bisphenol F results in increased expression of YARS2 proteinCTDPMID:34186270
Yars2Ratcamptothecin increases expressionISOYARS2 (Homo sapiens)6480464Camptothecin results in increased expression of YARS2 mRNACTDPMID:33770205

1 to 20 of 72 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars2Ratmitochondrial tyrosyl-tRNA aminoacylation involved_inISOYARS2 (Homo sapiens)1624291 PMID:20598274RGDPMID:20598274
Yars2Rattranslation involved_inIEAUniProtKB-KW:KW-06481600115GO_REF:0000043UniProtGO_REF:0000043
Yars2RattRNA aminoacylation involved_inISOYARS2 (Homo sapiens)1624291 PMID:15779907 more ...RGDPMID:15779907 more ...
Yars2RattRNA aminoacylation involved_inIBAPANTHER:PTN000205414 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Yars2RattRNA aminoacylation for protein translation involved_inIEAInterPro:IPR001412 and InterPro:IPR0023051600115GO_REF:0000002InterProGO_REF:0000002
Yars2Rattyrosyl-tRNA aminoacylation involved_inIEAInterPro:IPR0023071600115GO_REF:0000002InterProGO_REF:0000002

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars2Ratcytosol is_active_inIBAPANTHER:PTN000205414 and UniProtKB:P0AGJ91600115GO_REF:0000033GO_CentralGO_REF:0000033
Yars2Ratmitochondrial matrix located_inISOYARS2 (Homo sapiens)1624291 PMID:30006346RGDPMID:30006346
Yars2Ratmitochondrial matrix located_inIEAUniProtKB-SubCell:SL-01701600115GO_REF:0000044UniProtGO_REF:0000044
Yars2Ratmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
Yars2Ratmitochondrion is_active_inIBAPANTHER:PTN000205415 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Yars2Ratmitochondrion located_inISOYARS2 (Homo sapiens)1624291 RGDGO_REF:0000052
Yars2Ratnuclear body located_inISOYARS2 (Homo sapiens)1624291 RGDGO_REF:0000052

Molecular Function
1 to 17 of 17 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars2Rataminoacyl-tRNA ligase activity enablesIEAUniProtKB-KW:KW-00301600115GO_REF:0000043UniProtGO_REF:0000043
Yars2Rataminoacyl-tRNA ligase activity enablesIEAInterPro:IPR001412 and InterPro:IPR0023051600115GO_REF:0000002InterProGO_REF:0000002
Yars2RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Yars2RatATP binding enablesIEAInterPro:IPR001412 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Yars2RatL-tyrosine binding enablesISOYARS2 (Homo sapiens)1624291 PMID:17997975RGDPMID:17997975
Yars2Ratligase activity enablesIEAUniProtKB-KW:KW-04361600115GO_REF:0000043UniProtGO_REF:0000043
Yars2Ratnucleotide binding enablesIEAInterPro:IPR001412 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Yars2Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Yars2Ratprotein binding enablesISOYARS2 (Homo sapiens)1624291UniProtKB:Q6RW13-2 more ...RGDPMID:25416956 and PMID:32296183
Yars2Ratprotein homodimerization activity enablesISOYARS2 (Homo sapiens)1624291UniProtKB:Q6PI48 more ...RGDPMID:15779907 and PMID:17997975
Yars2RatRNA binding enablesIEAInterPro:IPR0369861600115GO_REF:0000002InterProGO_REF:0000002
Yars2RattRNA binding enablesISOYARS2 (Homo sapiens)1624291 PMID:20598274RGDPMID:20598274
Yars2Rattyrosine-tRNA ligase activity enablesISOYARS2 (Homo sapiens)1624291 PMID:15779907 more ...RGDPMID:15779907 more ...
Yars2Rattyrosine-tRNA ligase activity enablesIEAEC:6.1.1.11600115GO_REF:0000003UniProtGO_REF:0000003
Yars2Rattyrosine-tRNA ligase activity enablesIBAPANTHER:PTN000205414 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Yars2Rattyrosine-tRNA ligase activity enablesIEAInterPro:IPR002307 and InterPro:IPR0240881600115GO_REF:0000002InterProGO_REF:0000002
Yars2Rattyrosine-tRNA ligase activity enablesIEARHEA:102201600115GO_REF:0000116RHEAGO_REF:0000116
1 to 17 of 17 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Yars2Rataminoacyl-tRNA biosynthetic pathway  IEA 6907045 KEGGrno:00970

BioCyc Pathways


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12477932   PMID:15489334   PMID:15779907   PMID:15840810   PMID:17997975   PMID:18614015   PMID:20598274   PMID:22681889  



Yars2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,136,530 - 98,142,320 (-)NCBIGRCr8
mRatBN7.21184,632,350 - 84,638,138 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,624,369 - 84,638,125 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,364,537 - 93,370,276 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,025,678 - 86,031,417 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,079,277 - 85,085,016 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,882,615 - 88,888,377 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,882,616 - 88,888,377 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,936,942 - 91,942,704 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,609,037 - 86,614,799 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,649,633 - 86,655,395 (+)NCBI
Celera1183,377,810 - 83,383,571 (-)NCBICelera
Cytogenetic Map11q23NCBI
YARS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381232,746,544 - 32,755,897 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1232,727,490 - 32,755,897 (-)EnsemblGRCh38hg38GRCh38
GRCh371232,899,478 - 32,908,831 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361232,790,726 - 32,800,141 (-)NCBINCBI36Build 36hg18NCBI36
Celera1212,720,156 - 12,729,572 (-)NCBICelera
Cytogenetic Map12p11.21NCBI
HuRef1232,651,954 - 32,661,361 (-)NCBIHuRef
CHM1_11232,865,980 - 32,875,403 (-)NCBICHM1_1
T2T-CHM13v2.01232,601,526 - 32,632,178 (-)NCBIT2T-CHM13v2.0
Yars2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,120,829 - 16,127,504 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,120,829 - 16,127,504 (+)EnsemblGRCm39 Ensembl
GRCm381616,302,965 - 16,309,640 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,302,965 - 16,309,640 (+)EnsemblGRCm38mm10GRCm38
MGSCv371616,303,075 - 16,309,721 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361616,216,560 - 16,223,206 (+)NCBIMGSCv36mm8
Celera1616,874,023 - 16,880,669 (+)NCBICelera
Cytogenetic Map16A2NCBI
cM Map1610.11NCBI
Yars2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555053,004,146 - 3,010,735 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555053,004,084 - 3,011,003 (+)NCBIChiLan1.0ChiLan1.0
YARS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21063,989,046 - 64,002,439 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11263,987,793 - 63,998,835 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01253,463,086 - 53,493,352 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11256,065,505 - 56,076,026 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1256,065,505 - 56,076,026 (+)Ensemblpanpan1.1panPan2
YARS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12716,139,462 - 16,162,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2716,139,499 - 16,161,147 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2730,259,986 - 30,287,139 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02716,320,190 - 16,347,401 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2716,320,205 - 16,343,475 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12716,128,784 - 16,155,906 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02716,161,357 - 16,188,536 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02730,407,857 - 30,435,045 (-)NCBIUU_Cfam_GSD_1.0
Yars2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494576,731,948 - 76,747,507 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366073,565,295 - 3,574,846 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366073,565,333 - 3,590,499 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YARS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl541,561,626 - 41,584,818 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1541,561,563 - 41,584,534 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
YARS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11132,181,214 - 32,192,654 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1132,181,397 - 32,192,454 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660692,704,100 - 2,717,210 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Yars2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247783,383,017 - 3,390,036 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247783,382,993 - 3,390,357 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Yars2
22 total Variants

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:94
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000034902
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat

RH129946  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q23UniSTS
RH131679  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21184,632,091 - 84,632,307 (+)MAPPERmRatBN7.2
Rnor_6.01188,882,357 - 88,882,572NCBIRnor6.0
Rnor_5.01191,936,684 - 91,936,899UniSTSRnor5.0
RGSC_v3.41186,614,842 - 86,615,057UniSTSRGSC3.4
Celera1183,377,552 - 83,377,767UniSTS
Cytogenetic Map11q23UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000034902   ⟹   ENSRNOP00000037398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1184,624,369 - 84,638,125 (-)Ensembl
Rnor_6.0 Ensembl1188,882,616 - 88,888,377 (-)Ensembl
RefSeq Acc Id: NM_001009627   ⟹   NP_001009627
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81198,136,530 - 98,142,292 (-)NCBI
mRatBN7.21184,632,350 - 84,638,112 (-)NCBI
Rnor_6.01188,882,615 - 88,888,377 (-)NCBI
Rnor_5.01191,936,942 - 91,942,704 (-)NCBI
RGSC_v3.41186,609,037 - 86,614,799 (+)RGD
Celera1183,377,810 - 83,383,571 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088056   ⟹   XP_038943984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81198,139,158 - 98,142,320 (-)NCBI
mRatBN7.21184,634,978 - 84,638,138 (-)NCBI
Protein RefSeqs NP_001009627 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943984 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88224 (Get FASTA)   NCBI Sequence Viewer  
  EDL77848 (Get FASTA)   NCBI Sequence Viewer  
  Q5I0L3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001009627   ⟸   NM_001009627
- UniProtKB: Q5I0L3 (UniProtKB/Swiss-Prot),   A6JSQ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000037398   ⟸   ENSRNOT00000034902
RefSeq Acc Id: XP_038943984   ⟸   XM_039088056
- Peptide Label: isoform X1

Name Modeler Protein Id AA Range Protein Structure
AF-Q5I0L3-F1-model_v2 AlphaFold Q5I0L3 1-471 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698344
Promoter ID:EPDNEW_R8869
Type:multiple initiation site
Name:Yars2_1
Description:tyrosyl-tRNA synthetase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,888,390 - 88,888,450EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-20550 BioCyc
BioCyc Pathway TRNA-CHARGING-PWY [tRNA charging] BioCyc
BioCyc Pathway Image TRNA-CHARGING-PWY BioCyc
Ensembl Genes ENSRNOG00000025252 Ensembl
Gene3D-CATH 3.10.290.10 UniProtKB/Swiss-Prot
  3.40.50.620 UniProtKB/Swiss-Prot
  Tyrosyl-Transfer RNA Synthetase UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7322099 IMAGE-MGC_LOAD
InterPro aa-tRNA-synth_I_CS UniProtKB/Swiss-Prot
  aa-tRNA-synth_Ic UniProtKB/Swiss-Prot
  Rossmann-like_a/b/a_fold UniProtKB/Swiss-Prot
  S4_RNA-bd_sf UniProtKB/Swiss-Prot
  Tyr-tRNA-ligase UniProtKB/Swiss-Prot
  Tyr-tRNA-ligase_bac-type UniProtKB/Swiss-Prot
KEGG Report rno:287924 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108978 IMAGE-MGC_LOAD
NCBI Gene 287924 ENTREZGENE
PANTHER PTHR11766 UniProtKB/Swiss-Prot
  TYROSINE--TRNA LIGASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam tRNA-synt_1b UniProtKB/Swiss-Prot
PhenoGen Yars2 PhenoGen
PRINTS TRNASYNTHTYR UniProtKB/Swiss-Prot
PROSITE AA_TRNA_LIGASE_I UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000025252 RatGTEx
Superfamily-SCOP Alpha-L RNA-binding motif UniProtKB/Swiss-Prot
  Nucleotidylyl transferase UniProtKB/Swiss-Prot
UniProt A0A8L2ULB9_RAT UniProtKB/TrEMBL
  A6JSQ9 ENTREZGENE, UniProtKB/TrEMBL
  Q5I0L3 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Yars2  tyrosyl-tRNA synthetase 2  Yars2  tyrosyl-tRNA synthetase 2 (mitochondrial)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Yars2  tyrosyl-tRNA synthetase 2 (mitochondrial)  RGD1311696  similar to CGI-04 protein  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1311696  similar to CGI-04 protein  RGD1311696_predicted  similar to CGI-04 protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1311696_predicted  similar to CGI-04 protein (predicted)  LOC287924_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC287924_predicted  similar to CGI-04 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL