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Gene: Smpd4 (sphingomyelin phosphodiesterase 4) Rattus norvegicus
Symbol: Smpd4
Name: sphingomyelin phosphodiesterase 4
Description: Predicted to have sphingomyelin phosphodiesterase D activity. Predicted to be involved in several processes, including cellular response to tumor necrosis factor; ceramide biosynthetic process; and phospholipid catabolic process. Predicted to localize to endoplasmic reticulum; nuclear outer membrane; and trans-Golgi network. Orthologous to human SMPD4 (sphingomyelin phosphodiesterase 4); PARTICIPATES IN sphingolipid metabolic pathway; INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC303790; RGD1310674; similar to RIKEN cDNA 4122402O22; sphingomyelin phosphodiesterase 4, neutral membrane
Homo sapiens (human) : SMPD4 (sphingomyelin phosphodiesterase 4)  HGNC  Alliance
Mus musculus (house mouse) : Smpd4 (sphingomyelin phosphodiesterase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smpd4 (sphingomyelin phosphodiesterase 4)
Canis lupus familiaris (dog) : SMPD4 (sphingomyelin phosphodiesterase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smpd4 (sphingomyelin phosphodiesterase 4)
Sus scrofa (pig) : SMPD4 (sphingomyelin phosphodiesterase 4)
Chlorocebus sabaeus (African green monkey) : SMPD4 (sphingomyelin phosphodiesterase 4)
Heterocephalus glaber (naked mole-rat) : Smpd4 (sphingomyelin phosphodiesterase 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01187,522,971 - 87,546,687 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,522,971 - 87,546,687 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,575,599 - 90,599,309 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,352,180 - 85,375,918 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15169,511,693 - 169,512,094 (+)NCBI
Celera1182,134,192 - 82,157,831 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Smpd4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1310674
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.