Cep97 (centrosomal protein 97) - Rat Genome Database

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Gene: Cep97 (centrosomal protein 97) Rattus norvegicus
Analyze
Symbol: Cep97
Name: centrosomal protein 97
RGD ID: 1307400
Description: Predicted to be involved in negative regulation of cilium assembly and regulation of mitotic spindle assembly. Predicted to be located in centriolar satellite; centriole; and cytosol. Predicted to be part of protein-containing complex. Predicted to be active in centrosome. Orthologous to human CEP97 (centrosomal protein 97); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: centrosomal protein 97kDa; centrosomal protein of 97 kDa; leucine-rich repeats and IQ motif containing 2; LOC304007; Lrriq2; RGD1307400; similar to RIKEN cDNA 2810403B08
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21144,683,503 - 44,711,471 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1144,683,506 - 44,711,471 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1153,460,034 - 53,487,994 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01146,121,663 - 46,149,623 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01145,245,827 - 45,273,786 (+)NCBIRnor_WKY
Rnor_6.01147,146,409 - 47,174,460 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1147,146,308 - 47,174,713 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01150,327,756 - 50,355,273 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41145,658,903 - 45,687,089 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11145,716,552 - 45,744,460 (+)NCBI
Celera1144,434,493 - 44,462,608 (+)NCBICelera
Cytogenetic Map11q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17719545   PMID:21399614   PMID:21700703   PMID:24421332  


Genomics

Comparative Map Data
Cep97
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21144,683,503 - 44,711,471 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1144,683,506 - 44,711,471 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1153,460,034 - 53,487,994 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01146,121,663 - 46,149,623 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01145,245,827 - 45,273,786 (+)NCBIRnor_WKY
Rnor_6.01147,146,409 - 47,174,460 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1147,146,308 - 47,174,713 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01150,327,756 - 50,355,273 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41145,658,903 - 45,687,089 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11145,716,552 - 45,744,460 (+)NCBI
Celera1144,434,493 - 44,462,608 (+)NCBICelera
Cytogenetic Map11q12NCBI
CEP97
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383101,724,614 - 101,770,562 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3101,724,534 - 101,770,562 (+)EnsemblGRCh38hg38GRCh38
GRCh373101,443,458 - 101,489,406 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363102,926,184 - 102,968,871 (+)NCBINCBI36Build 36hg18NCBI36
Build 343102,926,183 - 102,968,871NCBI
Celera399,836,584 - 99,879,276 (+)NCBICelera
Cytogenetic Map3q12.3NCBI
HuRef398,812,356 - 98,854,863 (+)NCBIHuRef
CHM1_13101,406,776 - 101,449,462 (+)NCBICHM1_1
T2T-CHM13v2.03104,437,398 - 104,483,348 (+)NCBIT2T-CHM13v2.0
Cep97
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391655,720,250 - 55,755,237 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1655,720,251 - 55,755,218 (-)EnsemblGRCm39 Ensembl
GRCm381655,899,888 - 55,934,848 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1655,899,888 - 55,934,855 (-)EnsemblGRCm38mm10GRCm38
MGSCv371655,900,001 - 55,934,961 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361655,827,214 - 55,859,799 (-)NCBIMGSCv36mm8
Celera1656,215,320 - 56,250,333 (-)NCBICelera
Cytogenetic Map16C1.1NCBI
Cep97
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554273,227,130 - 3,247,062 (+)NCBIChiLan1.0ChiLan1.0
CEP97
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13105,494,497 - 105,539,141 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3105,494,497 - 105,536,308 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0398,812,804 - 98,858,899 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CEP97
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1338,023,788 - 8,064,131 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl338,040,668 - 8,060,095 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha338,177,212 - 8,218,683 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0338,161,916 - 8,203,211 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl338,179,806 - 8,201,378 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1338,049,482 - 8,090,862 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0338,095,875 - 8,137,087 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0338,436,238 - 8,477,706 (+)NCBIUU_Cfam_GSD_1.0
Cep97
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602148,788,944 - 148,836,496 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366301,715,155 - 1,734,444 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366301,715,225 - 1,734,560 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CEP97
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13157,356,253 - 157,388,411 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113157,356,248 - 157,388,425 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213166,846,046 - 166,864,860 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CEP97
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12279,138,774 - 79,176,186 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2279,140,794 - 79,176,244 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604187,355,355 - 87,421,257 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cep97
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478915,508,484 - 15,532,599 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478915,508,271 - 15,532,494 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cep97
76 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:261
Count of miRNA genes:157
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000002191
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat

Markers in Region
D11Rat8  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01150,337,688 - 50,337,856NCBIRnor5.0
Rnor_5.01150,337,754 - 50,337,856NCBIRnor5.0
RGSC_v3.41145,668,787 - 45,669,106RGDRGSC3.4
RGSC_v3.41145,668,853 - 45,669,016UniSTSRGSC3.4
RGSC_v3.11145,726,442 - 45,726,605RGD
RH 3.4 Map11331.4UniSTS
RH 3.4 Map11331.4RGD
RH 2.0 Map11300.2RGD
SHRSP x BN Map1119.5499RGD
Cytogenetic Map11q12UniSTS
AW530468  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21144,711,232 - 44,711,382 (+)MAPPERmRatBN7.2
Rnor_6.01147,174,222 - 47,174,371NCBIRnor6.0
Rnor_5.01150,355,035 - 50,355,184UniSTSRnor5.0
RGSC_v3.41145,686,851 - 45,687,000UniSTSRGSC3.4
Celera1144,462,370 - 44,462,519UniSTS
RH 3.4 Map11332.5UniSTS
Cytogenetic Map11q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 8 2 8 2 47 10 16
Low 3 39 49 39 11 39 8 11 27 25 25 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002191   ⟹   ENSRNOP00000002191
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1144,683,517 - 44,711,471 (+)Ensembl
Rnor_6.0 Ensembl1147,146,308 - 47,174,713 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099594   ⟹   ENSRNOP00000082014
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1144,683,506 - 44,692,917 (+)Ensembl
RefSeq Acc Id: NM_001107096   ⟹   NP_001100566
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21144,683,517 - 44,711,471 (+)NCBI
Rnor_6.01147,146,465 - 47,174,460 (+)NCBI
Rnor_5.01150,327,756 - 50,355,273 (+)NCBI
RGSC_v3.41145,658,903 - 45,687,089 (+)RGD
Celera1144,434,493 - 44,462,608 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248250   ⟹   XP_006248312
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21144,690,593 - 44,711,464 (+)NCBI
Rnor_6.01147,153,592 - 47,174,453 (+)NCBI
Rnor_5.01150,327,756 - 50,355,273 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088372   ⟹   XP_038944300
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21144,683,503 - 44,706,189 (+)NCBI
RefSeq Acc Id: XM_039088373   ⟹   XP_038944301
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21144,683,503 - 44,701,506 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001100566   ⟸   NM_001107096
- UniProtKB: D4AC95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248312   ⟸   XM_006248250
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000002191   ⟸   ENSRNOT00000002191
RefSeq Acc Id: XP_038944300   ⟸   XM_039088372
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038944301   ⟸   XM_039088373
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000082014   ⟸   ENSRNOT00000099594

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AC95-F1-model_v2 AlphaFold D4AC95 1-845 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307400 AgrOrtholog
BioCyc Gene G2FUF-21504 BioCyc
Ensembl Genes ENSRNOG00000001609 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002191 ENTREZGENE
  ENSRNOP00000002191.2 UniProtKB/TrEMBL
  ENSRNOP00000082014.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002191 ENTREZGENE
  ENSRNOT00000002191.5 UniProtKB/TrEMBL
  ENSRNOT00000099594.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_4 UniProtKB/TrEMBL
KEGG Report rno:304007 UniProtKB/TrEMBL
NCBI Gene 304007 ENTREZGENE
Pfam LRR_4 UniProtKB/TrEMBL
PhenoGen Cep97 PhenoGen
PROSITE LRR UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
UniProt A0A8I5ZTA1_RAT UniProtKB/TrEMBL
  D4AC95 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-04-27 Cep97  centrosomal protein 97  Cep97  centrosomal protein 97kDa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-29 Cep97  centrosomal protein 97kDa  Cep97  centrosomal protein 97  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Cep97  centrosomal protein 97  Lrriq2_predicted  leucine-rich repeats and IQ motif containing 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Lrriq2_predicted  leucine-rich repeats and IQ motif containing 2 (predicted)  RGD1307400_predicted  similar to RIKEN cDNA 2810403B08 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1307400_predicted  similar to RIKEN cDNA 2810403B08 (predicted)  LOC304007_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC304007_predicted  similar to RIKEN cDNA 2810403B08 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL