Ehhadh (enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase) - Rat Genome Database

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Gene: Ehhadh (enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase) Rattus norvegicus
Analyze
Symbol: Ehhadh
Name: enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
RGD ID: 621441
Description: Enables several functions, including 3-hydroxyacyl-CoA dehydrogenase activity; delta(3)-delta(2)-enoyl-CoA isomerase activity; and enoyl-CoA hydratase activity. Involved in fatty acid beta-oxidation. Located in cytosol and peroxisome. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 3. Orthologous to human EHHADH (enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase); PARTICIPATES IN valproic acid pharmacokinetics pathway; beta-alanine metabolic pathway; butanoate metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase; L-specific bifunctional protein; LBP; MEF; Mfe; Mfe1; MFP1; multifunctional enzyme 1; multifunctional enzyme type 1; multifunctional protein 1; PBE; PBFE; pe-CoA; perMFE-1; peroxisomal bifunctional enzyme; peroxisomal bifunctional enzyme type 1; peroxisomal enoyl-CoA/hydrotase-3-hydroxyacyl-CoA
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,746,409 - 92,779,647 (+)NCBIGRCr8
mRatBN7.21179,241,927 - 79,275,173 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1179,241,938 - 79,275,188 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1187,978,647 - 88,012,122 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01180,632,293 - 80,665,765 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01179,692,993 - 79,726,464 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01182,945,104 - 82,978,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1182,945,104 - 82,978,364 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01186,024,803 - 86,057,811 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,474,161 - 81,507,645 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11181,531,749 - 81,565,234 (+)NCBI
Celera1178,098,443 - 78,131,686 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
Acetyl tributyl citrate  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
aspartame  (ISO)
azathioprine  (ISO)
benoxaprofen  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
cerium trichloride  (ISO)
chlorpyrifos  (ISO)
ciprofibrate  (EXP,ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (EXP)
D-glucose  (ISO)
dehydroepiandrosterone  (EXP)
dehydroepiandrosterone sulfate  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
fenofibrate  (EXP,ISO)
fenthion  (ISO)
flavonoids  (EXP)
fluoranthene  (EXP)
flutamide  (EXP,ISO)
FR900359  (ISO)
fructose  (ISO)
furan  (EXP)
gemfibrozil  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
indometacin  (EXP)
isoflavones  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
mercury dichloride  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP,ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
nafenopin  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perflubutane  (ISO)
perfluorobutanesulfonic acid  (EXP,ISO)
perfluorobutyric acid  (EXP,ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (EXP,ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
Propiverine  (EXP)
quercetin  (ISO)
ritonavir  (EXP)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulfluramid  (ISO)
tamoxifen  (EXP,ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (EXP)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
withaferin A  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP)
zinc oxide  (ISO)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
fatty acid beta-oxidation  (IBA,IDA,IEA,ISO)

Cellular Component
cytosol  (IDA)
peroxisome  (IBA,IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Organization of the multifunctional enzyme type 1: interaction between N- and C-terminal domains is required for the hydratase-1/isomerase activity. Kiema TR, etal., Biochem J. 2002 Oct 15;367(Pt 2):433-41. doi: 10.1042/BJ20020292.
3. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
4. Molecular organization of peroxisomal enzymes: protein-protein interactions in the membrane and in the matrix. Makkar RS, etal., Arch Biochem Biophys. 2006 Jul 15;451(2):128-40. Epub 2006 May 24.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Molecular cloning and nucleotide sequence of the cDNA for rat peroxisomal enoyl-CoA: hydratase-3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme. Osumi T, etal., J Biol Chem 1985 Jul 25;260(15):8905-10.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Functional characterization of Delta3,Delta2-enoyl-CoA isomerases from rat liver. Zhang D, etal., J Biol Chem. 2002 Mar 15;277(11):9127-32. Epub 2002 Jan 7.
Additional References at PubMed
PMID:1651711   PMID:2303409   PMID:2895531   PMID:3036802   PMID:8856068   PMID:9053548   PMID:12477932   PMID:14651853   PMID:15060085   PMID:16330050   PMID:17442273   PMID:18614015  
PMID:20167786   PMID:20178365   PMID:20463028   PMID:23351063   PMID:38458818  


Genomics

Comparative Map Data
Ehhadh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,746,409 - 92,779,647 (+)NCBIGRCr8
mRatBN7.21179,241,927 - 79,275,173 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1179,241,938 - 79,275,188 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1187,978,647 - 88,012,122 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01180,632,293 - 80,665,765 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01179,692,993 - 79,726,464 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01182,945,104 - 82,978,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1182,945,104 - 82,978,364 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01186,024,803 - 86,057,811 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,474,161 - 81,507,645 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11181,531,749 - 81,565,234 (+)NCBI
Celera1178,098,443 - 78,131,686 (+)NCBICelera
Cytogenetic Map11q23NCBI
EHHADH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383185,190,624 - 185,254,049 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3185,190,624 - 185,281,990 (-)EnsemblGRCh38hg38GRCh38
GRCh373184,908,412 - 184,971,837 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363186,391,106 - 186,454,531 (-)NCBINCBI36Build 36hg18NCBI36
Build 343186,391,115 - 186,454,518NCBI
Celera3183,355,409 - 183,418,245 (-)NCBICelera
Cytogenetic Map3q27.2NCBI
HuRef3182,318,813 - 182,381,574 (-)NCBIHuRef
CHM1_13184,871,265 - 184,934,558 (-)NCBICHM1_1
T2T-CHM13v2.03188,006,637 - 188,069,581 (-)NCBIT2T-CHM13v2.0
Ehhadh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391621,580,035 - 21,606,589 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1621,580,037 - 21,606,557 (-)EnsemblGRCm39 Ensembl
GRCm381621,761,285 - 21,787,834 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1621,761,287 - 21,787,807 (-)EnsemblGRCm38mm10GRCm38
MGSCv371621,761,358 - 21,787,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361621,675,273 - 21,701,779 (-)NCBIMGSCv36mm8
Celera1622,329,681 - 22,356,230 (-)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1612.86NCBI
EHHADH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22183,067,115 - 183,158,228 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13183,071,836 - 183,162,948 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03182,228,520 - 182,319,339 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13190,705,412 - 190,796,075 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3190,704,695 - 190,796,075 (-)Ensemblpanpan1.1panPan2
EHHADH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13418,021,047 - 18,080,993 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3418,022,353 - 18,080,903 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3422,106,718 - 22,155,425 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03417,929,829 - 17,978,525 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3417,929,617 - 17,990,012 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13417,965,901 - 18,014,608 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03417,961,931 - 18,010,564 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03418,191,518 - 18,240,177 (-)NCBIUU_Cfam_GSD_1.0
LOC101954746
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602118,462,099 - 118,574,573 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365784,554,113 - 4,666,428 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365784,554,164 - 4,666,427 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EHHADH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13123,104,101 - 123,176,086 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113123,104,085 - 123,162,119 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213132,800,915 - 132,803,789 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EHHADH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1154,164,795 - 4,228,593 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl154,164,838 - 4,228,651 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606312,921,353 - 12,985,087 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ehhadh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473071,323,484 - 71,357,109 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473071,323,713 - 71,354,805 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ehhadh
207 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:94
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000002410
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat

Markers in Region
RH140177  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21179,274,617 - 79,274,821 (+)MAPPERmRatBN7.2
Rnor_6.01182,977,807 - 82,978,010NCBIRnor6.0
Rnor_5.01186,057,254 - 86,057,457UniSTSRnor5.0
RGSC_v3.41181,507,088 - 81,507,291UniSTSRGSC3.4
Celera1178,131,129 - 78,131,332UniSTS
RH 3.4 Map11653.8UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002410   ⟹   ENSRNOP00000002410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1179,241,938 - 79,275,188 (+)Ensembl
Rnor_6.0 Ensembl1182,945,104 - 82,978,364 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098835   ⟹   ENSRNOP00000079506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1179,253,325 - 79,275,188 (+)Ensembl
RefSeq Acc Id: NM_133606   ⟹   NP_598290
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,746,409 - 92,779,647 (+)NCBI
mRatBN7.21179,241,927 - 79,275,173 (+)NCBI
Rnor_6.01182,945,104 - 82,978,364 (+)NCBI
Rnor_5.01186,024,803 - 86,057,811 (+)NCBI
RGSC_v3.41181,474,161 - 81,507,645 (+)RGD
Celera1178,098,443 - 78,131,686 (+)RGD
Sequence:
RefSeq Acc Id: NP_598290   ⟸   NM_133606
- UniProtKB: Q5EBD2 (UniProtKB/Swiss-Prot),   P07896 (UniProtKB/Swiss-Prot),   A6JS69 (UniProtKB/TrEMBL),   A0A8I5ZNC3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002410   ⟸   ENSRNOT00000002410
Ensembl Acc Id: ENSRNOP00000079506   ⟸   ENSRNOT00000098835
Protein Domains
3-hydroxyacyl-CoA dehydrogenase C-terminal   3-hydroxyacyl-CoA dehydrogenase NAD binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07896-F1-model_v2 AlphaFold P07896 1-722 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698263
Promoter ID:EPDNEW_R8788
Type:multiple initiation site
Name:Ehhadh_1
Description:enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01182,945,101 - 82,945,161EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621441 AgrOrtholog
BioCyc Gene G2FUF-20790 BioCyc
Ensembl Genes ENSRNOG00000001770 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002410.5 UniProtKB/Swiss-Prot
  ENSRNOT00000098835.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1040.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7321434 IMAGE-MGC_LOAD
InterPro 3-OHacyl-CoA_DH_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3-OHacyl-CoA_DH_NAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3HC_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6-PGluconate_DH-like_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ClpP/crotonase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Enoyl-CoA_hyd/isom_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Enoyl-CoA_hydra/iso UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171142 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108601 IMAGE-MGC_LOAD
NCBI Gene 171142 ENTREZGENE
PANTHER 3-HYDROXYACYL-COA DEHYROGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEROXISOMAL BIFUNCTIONAL ENZYME UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 3HCDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3HCDH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ECH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ehhadh PhenoGen
PROSITE 3HCDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENOYL_COA_HYDRATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001770 RatGTEx
Superfamily-SCOP SSF48179 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZNC3 ENTREZGENE, UniProtKB/TrEMBL
  A6JS69 ENTREZGENE, UniProtKB/TrEMBL
  ECHP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5EBD2 ENTREZGENE
UniProt Secondary Q5EBD2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 Ehhadh  enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase  Ehhadh  enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Ehhadh  enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase  Ehhadh  enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ehhadh  enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ehhadh  enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 722 amino acids; 78.5 kDa 632622
gene_regulation induced by di-(2-ethylhexyl)phthalate 632622