Dvl3 (dishevelled segment polarity protein 3)

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Gene: Dvl3 (dishevelled segment polarity protein 3) Rattus norvegicus

Analyze

Symbol:

Dvl3

Name:

dishevelled segment polarity protein 3

RGD ID:

1308834

Description:

Enables signaling receptor binding activity. Involved in positive regulation of neuron projection arborization and response to xenobiotic stimulus. Predicted to be located in cytoplasm. Predicted to be part of Wnt signalosome and chromatin. Predicted to be active in cytosol and glutamatergic synapse. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 3 and lung cancer. Orthologous to human DVL3 (dishevelled segment polarity protein 3); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; Wnt signaling, non-canonical pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; clozapine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

dishevelled 3, dsh homolog; dishevelled 3, dsh homolog (Drosophila) ; dishevelled, dsh homolog 3; dishevelled, dsh homolog 3 (Drosophila); LOC303811; segment polarity protein dishevelled homolog DVL-3

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DVL3 (dishevelled segment polarity protein 3)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Dvl3 (dishevelled segment polarity protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dvl3 (dishevelled segment polarity protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DVL3 (dishevelled segment polarity protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DVL3 (dishevelled segment polarity protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dvl3 (dishevelled segment polarity protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DVL3 (dishevelled segment polarity protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DVL3 (dishevelled segment polarity protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dvl3 (dishevelled segment polarity protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DVL3 (dishevelled segment polarity protein 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dvl3 (dishevelled segment polarity protein 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dvl3a (dishevelled segment polarity protein 3a)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	dsh	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dsh-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	dvl3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	80,365,446 - 80,382,641 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	80,366,117 - 80,382,462 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	89,090,200 - 89,104,688 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	81,743,619 - 81,758,109 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	80,804,686 - 80,819,179 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	84,051,177 - 84,068,479 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	84,051,078 - 84,068,302 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	87,123,483 - 87,139,802 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	82,597,654 - 82,622,175 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	82,654,389 - 82,679,764 (-)	NCBI
Celera	11	79,207,145 - 79,222,292 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-Methylcrotonyl-CoA carboxylase 1 deficiency (ISO)

autosomal dominant Robinow syndrome 1 (ISO)

autosomal dominant Robinow syndrome 2 (ISO)

autosomal dominant Robinow syndrome 3 (ISO)

congenital disorder of glycosylation Id (ISO)

Currarino syndrome (ISO)

Dwarfism (ISO)

genetic disease (ISO)

lung cancer (ISO)

Robinow syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

5-aza-2'-deoxycytidine (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP)

buta-1,3-diene (ISO)

caffeine (ISO)

carbon nanotube (ISO)

chrysene (ISO)

clobetasol (ISO)

clozapine (EXP)

copper atom (EXP)

copper(0) (EXP)

crocidolite asbestos (ISO)

diazinon (EXP)

dicrotophos (ISO)

diethylstilbestrol (EXP)

ethanol (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

gentamycin (EXP)

glyphosate (ISO)

haloperidol (EXP)

Indeno[1,2,3-cd]pyrene (ISO)

methyl methanesulfonate (ISO)

methylseleninic acid (ISO)

N-ethyl-N-nitrosourea (ISO)

niclosamide (ISO)

Nor-9-carboxy-delta9-THC (ISO)

oxaliplatin (ISO)

ozone (ISO)

paracetamol (ISO)

PCB138 (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

risperidone (EXP)

Salinomycin (ISO)

sodium arsenite (ISO)

tert-butyl hydroperoxide (ISO)

tetraphene (ISO)

thioacetamide (EXP)

tremolite asbestos (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

canonical Wnt signaling pathway (IBA,ISO)

cochlea morphogenesis (ISO)

heart morphogenesis (ISO)

intracellular signal transduction (IEA)

non-canonical Wnt signaling pathway (ISO)

outflow tract septum morphogenesis (ISO)

planar cell polarity pathway involved in neural tube closure (IBA,ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of JNK cascade (IEA,ISO)

positive regulation of neuron projection arborization (IGI)

positive regulation of protein phosphorylation (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

protein stabilization (ISO)

regulation of protein localization (ISO)

response to xenobiotic stimulus (IEP)

Wnt signaling pathway, planar cell polarity pathway (ISO)

Cellular Component

chromatin (ISO)

cytoplasm (ISO)

cytosol (IBA,ISO,TAS)

glutamatergic synapse (ISO)

synapse (ISO)

Wnt signalosome (ISO)

Molecular Function

beta-catenin binding (ISO)

frizzled binding (IBA,ISO)

protease binding (ISO)

protein binding (IPI,ISO)

protein-macromolecule adaptor activity (ISO)

signaling receptor binding (IPI,ISO)

small GTPase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

basal cell carcinoma pathway (IEA)

Notch signaling pathway (IEA)

Wnt signaling pathway (IEA,ISO)

Wnt signaling, canonical pathway (ISO)

Wnt signaling, non-canonical pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.	Bian WJ, etal., Dev Neurobiol. 2015 Aug;75(8):805-22. doi: 10.1002/dneu.22250. Epub 2014 Dec 1.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.	Kishida S, etal., Mol Cell Biol. 1999 Jun;19(6):4414-22.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation
12.	The Wnt Homepage	Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
13.	Activation of the canonical Wnt pathway by the antipsychotics haloperidol and clozapine involves dishevelled-3.	Sutton LP, etal., J Neurochem. 2007 Jul;102(1):153-69. Epub 2007 May 1.
14.	Integrating expression-related SNPs into genome-wide gene- and pathway-based analyses identified novel lung cancer susceptibility genes.	Wang Y, etal., Int J Cancer. 2018 Apr 15;142(8):1602-1610. doi: 10.1002/ijc.31182. Epub 2017 Dec 12.

Additional References at PubMed

PMID:10644691	PMID:11274398	PMID:12805222	PMID:16501258	PMID:17005174	PMID:17030191	PMID:17593335	PMID:18093802	PMID:19008950	PMID:19137009	PMID:19388021	PMID:19625296
PMID:20137080	PMID:20227366	PMID:21718540	PMID:21880741	PMID:22899650	PMID:23109420	PMID:26359454	PMID:30808893

Genomics

Comparative Map Data

Dvl3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	80,365,446 - 80,382,641 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	80,366,117 - 80,382,462 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	89,090,200 - 89,104,688 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	81,743,619 - 81,758,109 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	80,804,686 - 80,819,179 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	84,051,177 - 84,068,479 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	84,051,078 - 84,068,302 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	87,123,483 - 87,139,802 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	82,597,654 - 82,622,175 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	82,654,389 - 82,679,764 (-)	NCBI
Celera	11	79,207,145 - 79,222,292 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

DVL3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	184,155,377 - 184,173,614 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	184,155,377 - 184,173,614 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	183,873,165 - 183,891,402 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	185,355,978 - 185,374,008 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	185,355,985 - 185,374,016	NCBI
Celera	3	182,315,580 - 182,333,025 (+)	NCBI		Celera
Cytogenetic Map	3	q27.1	NCBI
HuRef	3	181,280,976 - 181,298,206 (+)	NCBI		HuRef
CHM1_1	3	183,837,689 - 183,855,719 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	186,964,902 - 186,982,556 (+)	NCBI		T2T-CHM13v2.0

Dvl3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	20,335,694 - 20,352,763 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	20,335,732 - 20,352,760 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	20,516,949 - 20,534,013 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	20,516,982 - 20,534,010 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	20,517,137 - 20,532,260 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	20,430,525 - 20,445,193 (+)	NCBI		MGSCv36	mm8
Celera	16	21,081,348 - 21,096,276 (+)	NCBI		Celera
Cytogenetic Map	16	A3	NCBI
cM Map	16	12.46	NCBI

Dvl3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	23,293,222 - 23,301,694 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	23,291,650 - 23,301,695 (-)	NCBI	ChiLan1.0	ChiLan1.0

DVL3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	3	182,031,934 - 182,049,695 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	181,190,961 - 181,207,831 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	189,674,405 - 189,691,749 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	189,674,399 - 189,693,130 (+)	Ensembl	panpan1.1		panPan2

DVL3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	17,053,534 - 17,069,965 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	17,053,343 - 17,068,389 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	21,140,844 - 21,154,943 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	16,961,718 - 16,975,817 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	16,961,342 - 16,976,564 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	16,999,057 - 17,013,143 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	16,995,018 - 17,011,464 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	17,225,218 - 17,241,675 (+)	NCBI		UU_Cfam_GSD_1.0

Dvl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	119,602,013 - 119,618,283 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936578	5,693,342 - 5,710,143 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936578	5,693,433 - 5,710,137 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DVL3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	122,076,003 - 122,092,971 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	122,075,851 - 122,092,975 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	131,521,353 - 131,532,563 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DVL3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	5,254,764 - 5,270,661 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	5,254,661 - 5,270,403 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	14,033,307 - 14,049,218 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dvl3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	72,396,343 - 72,413,175 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	72,396,437 - 72,412,260 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dvl3
73 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	40
Count of miRNA genes:	40
Interacting mature miRNAs:	40
Transcripts:	ENSRNOT00000002323
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	29528418	82566702	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	40946188	82566702	Rat
2312566	Glom20	Glomerulus QTL 20	3.6	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	44285759	82566702	Rat
1581565	Pur10	Proteinuria QTL 10		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
1581572	Uae35	Urinary albumin excretion QTL 35		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	54457534	86241447	Rat
4889521	Gluco62	Glucose level QTL 62	2.82	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	55136729	82993457	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	56351424	86241447	Rat
631506	Bp104	Blood pressure QTL 104	2.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	59802794	82566545	Rat
70208	Niddm22	Non-insulin dependent diabetes mellitus QTL 22	3.61		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	59802794	82566553	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	60346590	86241447	Rat
1549848	Bvd6	Brain ventricular dilatation QTL 6	3.1	0.0001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	66113321	82169223	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	66422148	86241447	Rat
1354593	Stl12	Serum triglyceride level QTL 12	3.36		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	11	66422148	86241447	Rat
1354656	Bvd3	Brain ventricular dilatation QTL 3	3.64	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	69446070	82846715	Rat
10450831	Scl80	Serum cholesterol level QTL 80	4.7	0.01	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	11	76957131	83051965	Rat

Markers in Region

RH127970

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	80,365,547 - 80,365,733 (+)	MAPPER	mRatBN7.2
mRatBN7.2	7	110,707,666 - 110,707,852 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	120,375,647 - 120,375,832	NCBI	Rnor6.0
Rnor_6.0	11	84,051,273 - 84,051,458	NCBI	Rnor6.0
Rnor_5.0	11	87,123,585 - 87,123,770	UniSTS	Rnor5.0
Rnor_5.0	7	120,369,726 - 120,369,911	UniSTS	Rnor5.0
RGSC_v3.4	7	117,117,919 - 117,118,104	UniSTS	RGSC3.4
RGSC_v3.4	11	82,595,563 - 82,595,748	UniSTS	RGSC3.4
Celera	11	79,204,941 - 79,205,126	UniSTS
Celera	7	107,042,159 - 107,042,344	UniSTS
RH 3.4 Map	11	654.01	UniSTS
Cytogenetic Map	11	q23	UniSTS
Cytogenetic Map	7	q34	UniSTS

UniSTS:532277

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	80,367,808 - 80,368,299 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	84,053,534 - 84,054,024	NCBI	Rnor6.0
Rnor_5.0	11	87,125,846 - 87,126,336	UniSTS	Rnor5.0
Celera	11	79,207,202 - 79,207,692	UniSTS
Cytogenetic Map	11	q23	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	34	31	31	5	31		3	66	27	33	3
Low		9	26	10	14	10	8	8	8	8	8	8	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248564	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248566	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC110855	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000002323 ⟹ ENSRNOP00000002323

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	80,366,117 - 80,382,462 (-)	Ensembl
Rnor_6.0 Ensembl	11	84,051,078 - 84,068,302 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000101876 ⟹ ENSRNOP00000094862

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	80,367,624 - 80,382,391 (-)	Ensembl

RefSeq Acc Id:

NM_001107081 ⟹ NP_001100551

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	80,365,452 - 80,382,522 (-)	NCBI
Rnor_6.0	11	84,053,477 - 84,068,087 (-)	NCBI
Rnor_5.0	11	87,123,483 - 87,139,802 (-)	NCBI
RGSC_v3.4	11	82,597,654 - 82,622,175 (-)	RGD
Celera	11	79,207,145 - 79,222,292 (-)	NCBI

Sequence:

show sequence

ATGGACGACGATTTTGGAGTGGTGAAGGAAGAGATCTCGGATGACAATGCCAAGCTGCCCTGCT
TCAATGGCCGGGTGGTGTCCTGGCTGGTATCGGCCGAGGGCTCACACCCAGAGCCAGCCCCTTT
CTGTGCTGACAACCCCTCAGAGCTGCCTCCTTCAATGGAACGCACAGGAGGCATCGGTGACTCT
CGGCCCCCGTCCTTCCACCCTCATGCTAGTGGGGGCAGCCAGGAGAACTTGGACAATGACACAG
AGACCGACTCCTTGGTATCTGCCCAACGAGAGCGGCCCAGACGGAGGGATGGCCCTGAGCACGC
AGCCCGCCTCAATGGAACCACAAAGGGCGAGCGGCGACGGGAGCCAGGTGGCTATGACAGTTCA
TCTACCCTCATGAGCAGCGAGCTGGAGACTACCAGTTTCTTTGATTCAGATGAGGATGACTCCA
CCAGCAGGTTCAGCAGCTCCACAGAACAGAGCAGTGCCTCACGCCTAATGAGAAGACACAAGCG
GCGGCGACGGAAGCAGAAGGTCTCCCGGATTGAGCGGTCCTCCTCCTTCAGCAGCATCACAGAC
TCCACTATGTCTCTCAACATCATCACAGTGACTCTCAACATGGAAAAGTATAACTTCTTGGGCA
TCTCCATTGTGGGCCAGAGCAATGAGCGAGGTGATGGGGGCATCTACATTGGCTCCATCATGAA
GGGTGGGGCAGTGGCGGCTGATGGACGCATTGAGCCGGGAGATATGCTGTTGCAGGTAAATGAG
ATCAACTTCGAGAACATGAGTAATGATGACGCAGTCAGAGTGCTTCGGGAGATCGTGCACAAAC
CAGGGCCCATCACTCTGACTGTAGCCAAGTGCTGGGACCCAAGTCCTCGTGGCTGCTTCACATT
ACCCCGGAGTGAGCCCATCCGTCCCATTGACCCTGCAGCCTGGGTCTCCCACACTGCAGCCATG
ACAGGAACCTTCCCTGCCTATGGCATGAGCCCCTCCTTAAGCACCATCACCTCCACCAGCTCCT
CCATCACCAGCTCCATCCCCGACACAGAACGCCTAGATGATTTCCACCTCTCCATCCACAGTGA
CATGGCGGCCATCGTAAAAGCCATGGCCTCCCCCGAGTCAGGGCTGGAGGTCCGAGACCGCATG
TGGCTCAAGATTACCATTCCCAATGCTTTCATCGGCTCAGATGTGGTGGACTGGCTGTATCACA
ATGTGGAAGGATTCACCGACCGGCGGGAGGCCCGCAAGTACGCTAGCAACCTGCTGAAGGCTGG
ATTCATCCGCCACACGGTCAACAAGATCACGTTCTCTGAGCAGTGCTACTACATCTTTGGTGAC
CTCTGTGGCAACATGGCCAACCTATCGCTGCACGACCATGATGGCTCCAGTGGTGCCTCTGACC
AGGACACACTGGCTCCTCTGCCGCACCCAGGGGCTGCCCCTTGGCCTATGGCTTTCCCTTACCA
GTACCCACCACCTCCGCACCCGTACAACCCACACCCAGGCTTCCCGGAGCTGGGCTACAGCTAC
GCTGGGGGCAGCGCCAGCAGTCAGCACAGTGAAGGTAGTAGGAGCAGTGGCTCCAACCGAAGTG
GCAGCGACCGGCGCAAGGAGAAGGACCCAAAAGCTGGGGACTCAAAGTCAGGTGGTAGCGGCAG
CGAGTCAGACCACACTACACGCAGCAGTCTGCGGGGGCCACGGGAGCGGGCACCAAGCGAGCGC
TCAGGCCCAGCGGCCAGCGAGCACAGCCACCGCAGTCATCATTCACTGACCAGTAGCCTGCGCA
GCCACCACACACACCCAAGCTATGGCCCACCCGGAGTGCCCCCTCTCTATGGTCCCCCGATGCT
GATGATGACCCCACCGCCTGCAGCCATGGGGCCCCCAGGAGCCCCTCCAGGGCGTGACCTGGCC
TCGGTGCCCCCGGAACTGACGGCCAGCAGACAGTCCTTCCGCATGGCAATGGGAAACCCCAGTG
AGTTCTTTGTGGATGTGATGTGA

hide sequence

RefSeq Acc Id:

XM_006248564 ⟹ XP_006248626

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	80,365,446 - 80,382,641 (-)	NCBI
Rnor_6.0	11	84,051,177 - 84,068,479 (-)	NCBI
Rnor_5.0	11	87,123,483 - 87,139,802 (-)	NCBI

Sequence:

show sequence

GGCCCAGAGCCGGGAGGGCCGAGGCCACCGGAAGAGTCGCGGTCGCCAGCCGAGCGCTGTGAGT
GGGGAGCGGAAGCGGTGGCGGGCGGCGCTGGGACCCGGGAGCGGCCGGAGAACAAGGGAGCTGG
CGCCCCGGCCGGCGGCTGAGCGGGGCTAAGCAGCGGGCCTCGCCGAGCGCCGAGCTCTGTCGGA
GAGGCCCGGCCCCGCTGCCCAAGCAGGCCGCACGCCGCGGGGCCGAGGCCGGAGCCATGGGCGA
GACTAAGATCATCTACCACTTGGACGGCCAGGAGACGCCGTACCTAGTGAAGCTGCCCCTGCCC
GCCGAGCGCGTCACCTTGGCGGACTTTAAGGGCGTTTTGCAGCGGCCCAGCTATAAGTTCTTCT
TCAAGTCTATGGACGACGATTTTGGAGTGGTGAAGGAAGAGATCTCGGATGACAATGCCAAGCT
GCCCTGCTTCAATGGCCGGGTGGTGTCCTGGCTGGTATCGGCCGAGGGCTCACACCCAGAGCCA
GCCCCTTTCTGTGCTGACAACCCCTCAGAGCTGCCTCCTTCAATGGAACGCACAGGAGGCATCG
GTGACTCTCGGCCCCCGTCCTTCCACCCTCATGCTAGTGGGGGCAGCCAGGAGAACTTGGACAA
TGACACAGAGACCGACTCCTTGGTATCTGCCCAACGAGAGCGGCCCAGACGGAGGGATGGCCCT
GAGCACGCAGCCCGCCTCAATGGAACCACAAAGGGCGAGCGGCGACGGGAGCCAGGTGGCTATG
ACAGTTCATCTACCCTCATGAGCAGCGAGCTGGAGACTACCAGTTTCTTTGATTCAGATGAGGA
TGACTCCACCAGCAGGTTCAGCAGCTCCACAGAACAGAGCAGTGCCTCACGCCTAATGAGAAGA
CACAAGCGGCGGCGACGGAAGCAGAAGGTCTCCCGGATTGAGCGGTCCTCCTCCTTCAGCAGCA
TCACAGACTCCACTATGTCTCTCAACATCATCACAGTGACTCTCAACATGGAAAAGTATAACTT
CTTGGGCATCTCCATTGTGGGCCAGAGCAATGAGCGAGGTGATGGGGGCATCTACATTGGCTCC
ATCATGAAGGGTGGGGCAGTGGCGGCTGATGGACGCATTGAGCCGGGAGATATGCTGTTGCAGG
TAAATGAGATCAACTTCGAGAACATGAGTAATGATGACGCAGTCAGAGTGCTTCGGGAGATCGT
GCACAAACCAGGGCCCATCACTCTGACTGTAGCCAAGTGCTGGGACCCAAGTCCTCGTGGCTGC
TTCACATTACCCCGGAGTGAGCCCATCCGTCCCATTGACCCTGCAGCCTGGGTCTCCCACACTG
CAGCCATGACAGGAACCTTCCCTGCCTATGGCATGAGCCCCTCCTTAAGCACCATCACCTCCAC
CAGCTCCTCCATCACCAGCTCCATCCCCGACACAGAACGCCTAGATGATTTCCACCTCTCCATC
CACAGTGACATGGCGGCCATCGTAAAAGCCATGGCCTCCCCCGAGTCAGGGCTGGAGGTCCGAG
ACCGCATGTGGCTCAAGATTACCATTCCCAATGCTTTCATCGGCTCAGATGTGGTGGACTGGCT
GTATCACAATGTGGAAGGATTCACCGACCGGCGGGAGGCCCGCAAGTACGCTAGCAACCTGCTG
AAGGCTGGATTCATCCGCCACACGGTCAACAAGATCACGTTCTCTGAGCAGTGCTACTACATCT
TTGGTGACCTCTGTGGCAACATGGCCAACCTATCGCTGCACGACCATGATGGCTCCAGTGGTGC
CTCTGACCAGGACACACTGGCTCCTCTGCCGCACCCAGGGGCTGCCCCTTGGCCTATGGCTTTC
CCTTACCAGTACCCACCACCTCCGCACCCGTACAACCCACACCCAGGCTTCCCGGAGCTGGGCT
ACAGCTACGCTGGGGGCAGCGCCAGCAGTCAGCACAGTGAAGGTAGTAGGAGCAGTGGCTCCAA
CCGAAGTGGCAGCGACCGGCGCAAGGAGAAGGACCCAAAAGCTGGGGACTCAAAGTCAGGTGGT
AGCGGCAGCGAGTCAGACCACACTACACGCAGCAGTCTGCGGGGGCCACGGGAGCGGGCACCAA
GCGAGCGCTCAGGCCCAGCGGCCAGCGAGCACAGCCACCGCAGTCATCATTCACTGACCAGTAG
CCTGCGCAGCCACCACACACACCCAAGCTATGGCCCACCCGGAGTGCCCCCTCTCTATGGTCCC
CCGATGCTGATGATGACCCCACCGCCTGCAGCCATGGGGCCCCCAGGAGCCCCTCCAGGGCGTG
ACCTGGCCTCGGTGCCCCCGGAACTGACGGCCAGCAGACAGTCCTTCCGCATGGCAATGGGAAA
CCCCACCAAGAATTTCGGGCTCTTTGACTTTCTGTGAGTCCCCAGGAAAGGGAGGCCCAGCCTC
CAAGGAGACCAGGAACTCTGCTTCAGCTCCCTCAGGGCTTCCCAAGGATGTCCAGCCCCCACAG
GACCCACACTTCAAGGTCACTAGGCTTTTGGGAAGGGCCTCAGCTTCCCCCATGCATAACTGAC
TACTCTTTTCAGAGAGAAGTAGAGAAGTTCGCTCCCCTCCACCTCATACACATAGATATACATA
CACATGTGAGTCTCTCCCCCCAACCCCTGGTCTCTGTCTCTCTGTCTCTGTCTCTGTCTCTCTC
TCACGCCTATGCAAGTTTACAGAAGCCTCAGGGCTGGTCCCTGGCCAGAGGGCTGGACCCTTTT
TCCAAGTCATCTCCTAGATAGTAGGGCTGGTCCCTGACGTCCTCTTCCCTTCAGCTAGCCCTTA
AGCTTCCCTTACATGTTCCCAACATCTTTGTACTTAGATAAAAGTCCAAAAGCTGGGGCTCACC
AGAGGGCTCTCCGGTAACTGACAGATCATTCTCTACTTCCCTTCTGCCCCACATCTCTGGGTAC
CTGCTCTGTTTCATCTTCCCCATGAACCCTGGGGACACAGGCCAGTTGAAGCTATACGAGCAGA
CAACTGGGGCTTCCAGACCGTTCCAGTTAACTGTTTTCTACCTTAAATCATAATTTCCTCCTTA
AAACACCGCTATAAACTCTGACTTATCCAGACTCTTTAAATTTTCAGTCAAGGGTGTCAGCTGA
GGAAATAGCTGTGTAGTGCTTGCCTAGCATGCCCCAGCAAATGTCTCCCCCATCAAGATGTCCT
TAGCCCAGGTTTGGGGGCAACCTGAGGTAGGGATATTTTGACATTCATTTAACATATTTCCAGG
GACTTTAATGAACAAAGGGCTATGTTAGAAGCATGACTTGATCTTCGCTGTCTTCAGTTCTCTC
TGACTCTGCCTTTTCCTGTTCTCTTGAGAATCCCTCACCAGTGCTCCCATTATCCTGCCTTTGG
CTCATGTCCCTTTCTTCCCCCCTTTCCCCCATAGTGTCAGCCACTCTCTTCTTAAGCTGTTGAT
GTGCTGGCCACTTCTAAATCTGGATCTCCCACCCCAGCTTCCCCTCTCTTTAGATCTGTTTTTA
TTCCCCACTGGACATCTCCCCAGGCTTGTCCATATGTCCCCAGCCAAGTATTATTCCTCTCGAA
TTCCTGCCCTTGTGACCTTCATTACAAGCCACACCTACACGGGCTTAGTCAGCATCTCACACCC
TTATACTCAGACACTCTGAAGTTCAGCTGTTCCTCTCCCTTCCTTACATTACAGAGCATGGGAT
TTGGAGTCAGGTTGGTTTGGGCTTGATTTCCAGCTCTATCATTTTTGATTGTGTAATAGAGTTA
TTTAACCTCTCTGGAGCCTCAGTCCTCCCATATGTAAAATGATGATAATAATACCTACCTCACA
GGGTTGTTGTGAGGATTTAAATTAGATATTGTACGAAAAGTGCCTAGCACAGTGCCTGGCACAT
AATAGAGTAGGTGCTCAATAAATGGTAGCTATTATTATTACTA

hide sequence

RefSeq Acc Id:

XM_006248565 ⟹ XP_006248627

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	80,365,446 - 80,382,641 (-)	NCBI
Rnor_6.0	11	84,051,177 - 84,068,479 (-)	NCBI
Rnor_5.0	11	87,123,483 - 87,139,802 (-)	NCBI

Sequence:

show sequence

GGCCCAGAGCCGGGAGGGCCGAGGCCACCGGAAGAGTCGCGGTCGCCAGCCGAGCGCTGTGAGT
GGGGAGCGGAAGCGGTGGCGGGCGGCGCTGGGACCCGGGAGCGGCCGGAGAACAAGGGAGCTGG
CGCCCCGGCCGGCGGCTGAGCGGGGCTAAGCAGCGGGCCTCGCCGAGCGCCGAGCTCTGTCGGA
GAGGCCCGGCCCCGCTGCCCAAGCAGGCCGCACGCCGCGGGGCCGAGGCCGGAGCCATGGGCGA
GACTAAGATCATCTACCACTTGGACGGCCAGGAGACGCCGTACCTAGTGAAGCTGCCCCTGCCC
GCCGAGCGCGTCACCTTGGCGGACTTTAAGGGCGTTTTGCAGCGGCCCAGCTATAAGTTCTTCT
TCAAGTCTATGGACGACGATTTTGGAGTGGTGAAGGAAGAGATCTCGGATGACAATGCCAAGCT
GCCCTGCTTCAATGGCCGGGTGGTGTCCTGGCTGGTATCGGCCGAGGGCTCACACCCAGAGCCA
GCCCCTTTCTGTGCTGACAACCCCTCAGAGCTGCCTCCTTCAATGGAACGCACAGGAGGCATCG
GTGACTCTCGGCCCCCGTCCTTCCACCCTCATGCTAGTGGGGGCAGCCAGGAGAACTTGGACAA
TGACACAGAGACCGACTCCTTGGTATCTGCCCAACGAGAGCGGCCCAGACGGAGGGATGGCCCT
GAGCACGCCCGCCTCAATGGAACCACAAAGGGCGAGCGGCGACGGGAGCCAGGTGGCTATGACA
GTTCATCTACCCTCATGAGCAGCGAGCTGGAGACTACCAGTTTCTTTGATTCAGATGAGGATGA
CTCCACCAGCAGGTTCAGCAGCTCCACAGAACAGAGCAGTGCCTCACGCCTAATGAGAAGACAC
AAGCGGCGGCGACGGAAGCAGAAGGTCTCCCGGATTGAGCGGTCCTCCTCCTTCAGCAGCATCA
CAGACTCCACTATGTCTCTCAACATCATCACAGTGACTCTCAACATGGAAAAGTATAACTTCTT
GGGCATCTCCATTGTGGGCCAGAGCAATGAGCGAGGTGATGGGGGCATCTACATTGGCTCCATC
ATGAAGGGTGGGGCAGTGGCGGCTGATGGACGCATTGAGCCGGGAGATATGCTGTTGCAGGTAA
ATGAGATCAACTTCGAGAACATGAGTAATGATGACGCAGTCAGAGTGCTTCGGGAGATCGTGCA
CAAACCAGGGCCCATCACTCTGACTGTAGCCAAGTGCTGGGACCCAAGTCCTCGTGGCTGCTTC
ACATTACCCCGGAGTGAGCCCATCCGTCCCATTGACCCTGCAGCCTGGGTCTCCCACACTGCAG
CCATGACAGGAACCTTCCCTGCCTATGGCATGAGCCCCTCCTTAAGCACCATCACCTCCACCAG
CTCCTCCATCACCAGCTCCATCCCCGACACAGAACGCCTAGATGATTTCCACCTCTCCATCCAC
AGTGACATGGCGGCCATCGTAAAAGCCATGGCCTCCCCCGAGTCAGGGCTGGAGGTCCGAGACC
GCATGTGGCTCAAGATTACCATTCCCAATGCTTTCATCGGCTCAGATGTGGTGGACTGGCTGTA
TCACAATGTGGAAGGATTCACCGACCGGCGGGAGGCCCGCAAGTACGCTAGCAACCTGCTGAAG
GCTGGATTCATCCGCCACACGGTCAACAAGATCACGTTCTCTGAGCAGTGCTACTACATCTTTG
GTGACCTCTGTGGCAACATGGCCAACCTATCGCTGCACGACCATGATGGCTCCAGTGGTGCCTC
TGACCAGGACACACTGGCTCCTCTGCCGCACCCAGGGGCTGCCCCTTGGCCTATGGCTTTCCCT
TACCAGTACCCACCACCTCCGCACCCGTACAACCCACACCCAGGCTTCCCGGAGCTGGGCTACA
GCTACGCTGGGGGCAGCGCCAGCAGTCAGCACAGTGAAGGTAGTAGGAGCAGTGGCTCCAACCG
AAGTGGCAGCGACCGGCGCAAGGAGAAGGACCCAAAAGCTGGGGACTCAAAGTCAGGTGGTAGC
GGCAGCGAGTCAGACCACACTACACGCAGCAGTCTGCGGGGGCCACGGGAGCGGGCACCAAGCG
AGCGCTCAGGCCCAGCGGCCAGCGAGCACAGCCACCGCAGTCATCATTCACTGACCAGTAGCCT
GCGCAGCCACCACACACACCCAAGCTATGGCCCACCCGGAGTGCCCCCTCTCTATGGTCCCCCG
ATGCTGATGATGACCCCACCGCCTGCAGCCATGGGGCCCCCAGGAGCCCCTCCAGGGCGTGACC
TGGCCTCGGTGCCCCCGGAACTGACGGCCAGCAGACAGTCCTTCCGCATGGCAATGGGAAACCC
CACCAAGAATTTCGGGCTCTTTGACTTTCTGTGAGTCCCCAGGAAAGGGAGGCCCAGCCTCCAA
GGAGACCAGGAACTCTGCTTCAGCTCCCTCAGGGCTTCCCAAGGATGTCCAGCCCCCACAGGAC
CCACACTTCAAGGTCACTAGGCTTTTGGGAAGGGCCTCAGCTTCCCCCATGCATAACTGACTAC
TCTTTTCAGAGAGAAGTAGAGAAGTTCGCTCCCCTCCACCTCATACACATAGATATACATACAC
ATGTGAGTCTCTCCCCCCAACCCCTGGTCTCTGTCTCTCTGTCTCTGTCTCTGTCTCTCTCTCA
CGCCTATGCAAGTTTACAGAAGCCTCAGGGCTGGTCCCTGGCCAGAGGGCTGGACCCTTTTTCC
AAGTCATCTCCTAGATAGTAGGGCTGGTCCCTGACGTCCTCTTCCCTTCAGCTAGCCCTTAAGC
TTCCCTTACATGTTCCCAACATCTTTGTACTTAGATAAAAGTCCAAAAGCTGGGGCTCACCAGA
GGGCTCTCCGGTAACTGACAGATCATTCTCTACTTCCCTTCTGCCCCACATCTCTGGGTACCTG
CTCTGTTTCATCTTCCCCATGAACCCTGGGGACACAGGCCAGTTGAAGCTATACGAGCAGACAA
CTGGGGCTTCCAGACCGTTCCAGTTAACTGTTTTCTACCTTAAATCATAATTTCCTCCTTAAAA
CACCGCTATAAACTCTGACTTATCCAGACTCTTTAAATTTTCAGTCAAGGGTGTCAGCTGAGGA
AATAGCTGTGTAGTGCTTGCCTAGCATGCCCCAGCAAATGTCTCCCCCATCAAGATGTCCTTAG
CCCAGGTTTGGGGGCAACCTGAGGTAGGGATATTTTGACATTCATTTAACATATTTCCAGGGAC
TTTAATGAACAAAGGGCTATGTTAGAAGCATGACTTGATCTTCGCTGTCTTCAGTTCTCTCTGA
CTCTGCCTTTTCCTGTTCTCTTGAGAATCCCTCACCAGTGCTCCCATTATCCTGCCTTTGGCTC
ATGTCCCTTTCTTCCCCCCTTTCCCCCATAGTGTCAGCCACTCTCTTCTTAAGCTGTTGATGTG
CTGGCCACTTCTAAATCTGGATCTCCCACCCCAGCTTCCCCTCTCTTTAGATCTGTTTTTATTC
CCCACTGGACATCTCCCCAGGCTTGTCCATATGTCCCCAGCCAAGTATTATTCCTCTCGAATTC
CTGCCCTTGTGACCTTCATTACAAGCCACACCTACACGGGCTTAGTCAGCATCTCACACCCTTA
TACTCAGACACTCTGAAGTTCAGCTGTTCCTCTCCCTTCCTTACATTACAGAGCATGGGATTTG
GAGTCAGGTTGGTTTGGGCTTGATTTCCAGCTCTATCATTTTTGATTGTGTAATAGAGTTATTT
AACCTCTCTGGAGCCTCAGTCCTCCCATATGTAAAATGATGATAATAATACCTACCTCACAGGG
TTGTTGTGAGGATTTAAATTAGATATTGTACGAAAAGTGCCTAGCACAGTGCCTGGCACATAAT
AGAGTAGGTGCTCAATAAATGGTAGCTATTATTATTACTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100551	(Get FASTA)	NCBI Sequence Viewer
	XP_006248626	(Get FASTA)	NCBI Sequence Viewer
	XP_006248627	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL77996	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002323
	ENSRNOP00000002323.6
	ENSRNOP00000094862
	ENSRNOP00000094862.1

RefSeq Acc Id:

NP_001100551 ⟸ NM_001107081

- UniProtKB:

A6JSB1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPEPAPFCADNPSELPPSMERTGGIGDS
RPPSFHPHASGGSQENLDNDTETDSLVSAQRERPRRRDGPEHAARLNGTTKGERRREPGGYDSS
STLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITD
STMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNE
INFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAM
TGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRM
WLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGD
LCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSY
AGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSER
SGPAASEHSHRSHHSLTSSLRSHHTHPSYGPPGVPPLYGPPMLMMTPPPAAMGPPGAPPGRDLA
SVPPELTASRQSFRMAMGNPSEFFVDVM

hide sequence

RefSeq Acc Id:	XP_006248627 ⟸ XM_006248565
- Peptide Label:	isoform X2
- UniProtKB:	A6JSB1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDN AKLPCFNGRVVSWLVSAEGSHPEPAPFCADNPSELPPSMERTGGIGDSRPPSFHPHASGGSQEN LDNDTETDSLVSAQRERPRRRDGPEHARLNGTTKGERRREPGGYDSSSTLMSSELETTSFFDSD EDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKY NFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLRE IVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTIT STSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVD WLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSS GASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYAGGSASSQHSEGSRSSG SNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLT SSLRSHHTHPSYGPPGVPPLYGPPMLMMTPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAM GNPTKNFGLFDFL hide sequence

RefSeq Acc Id:	XP_006248626 ⟸ XM_006248564
- Peptide Label:	isoform X1
- UniProtKB:	D4ADV8 (UniProtKB/TrEMBL), A6JSB1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDN AKLPCFNGRVVSWLVSAEGSHPEPAPFCADNPSELPPSMERTGGIGDSRPPSFHPHASGGSQEN LDNDTETDSLVSAQRERPRRRDGPEHAARLNGTTKGERRREPGGYDSSSTLMSSELETTSFFDS DEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEK YNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLR EIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTI TSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVV DWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGS SGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYAGGSASSQHSEGSRSS GSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSL TSSLRSHHTHPSYGPPGVPPLYGPPMLMMTPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMA MGNPTKNFGLFDFL hide sequence

RefSeq Acc Id:

ENSRNOP00000002323 ⟸ ENSRNOT00000002323

RefSeq Acc Id:

ENSRNOP00000094862 ⟸ ENSRNOT00000101876

Protein Domains

DEP DIX PDZ

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4ADV8-F1-model_v2	AlphaFold	D4ADV8	1-716	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698280

Promoter ID:

EPDNEW_R8804

Type:

initiation region

Name:

Dvl3_1

Description:

dishevelled segment polarity protein 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	84,068,362 - 84,068,422	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308834	AgrOrtholog
BioCyc Gene	G2FUF-20730	BioCyc
Ensembl Genes	ENSRNOG00000001708	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002323	ENTREZGENE
	ENSRNOT00000002323.7	UniProtKB/TrEMBL
	ENSRNOT00000101876	ENTREZGENE
	ENSRNOT00000101876.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	2.30.42.10	UniProtKB/TrEMBL
	2.40.240.130	UniProtKB/TrEMBL
InterPro	DEP_dom	UniProtKB/TrEMBL
	Dishevell	UniProtKB/TrEMBL
	Dishevelled_3	UniProtKB/TrEMBL
	Dishevelled_C-dom	UniProtKB/TrEMBL
	Dishevelled_protein	UniProtKB/TrEMBL
	DIX	UniProtKB/TrEMBL
	DIX_dom_sf	UniProtKB/TrEMBL
	Dsh	UniProtKB/TrEMBL
	PDZ/DHR/GLGF	UniProtKB/TrEMBL
	PDZ_sf	UniProtKB/TrEMBL
	Ubiquitin-rel_dom	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
NCBI Gene	303811	ENTREZGENE
PANTHER	Dsh	UniProtKB/TrEMBL
	PTHR10878:SF6	UniProtKB/TrEMBL
Pfam	DEP	UniProtKB/TrEMBL
	Dishevelled	UniProtKB/TrEMBL
	DIX	UniProtKB/TrEMBL
	Dsh_C	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
PhenoGen	Dvl3	PhenoGen
PRINTS	DISHEVELLED	UniProtKB/TrEMBL
	DISHEVELLED3	UniProtKB/TrEMBL
PROSITE	DEP	UniProtKB/TrEMBL
	DIX	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001708	RatGTEx
SMART	DAX	UniProtKB/TrEMBL
	DEP	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
Superfamily-SCOP	PDZ	UniProtKB/TrEMBL
	SSF46785	UniProtKB/TrEMBL
	SSF54236	UniProtKB/TrEMBL
UniProt	A0A8I6GKX7_RAT	UniProtKB/TrEMBL
	A6JSB1	ENTREZGENE, UniProtKB/TrEMBL
	D4ADV8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-06-05	Dvl3	dishevelled segment polarity protein 3	Dvl3	dishevelled, dsh homolog 3 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-24	Dvl3	dishevelled, dsh homolog 3 (Drosophila)	Dvl3	dishevelled 3, dsh homolog (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Dvl3	dishevelled 3, dsh homolog (Drosophila)	Dvl3_predicted	dishevelled 3, dsh homolog (Drosophila) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Dvl3_predicted	dishevelled 3, dsh homolog (Drosophila) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)