Mrap (melanocortin 2 receptor accessory protein) - Rat Genome Database

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Gene: Mrap (melanocortin 2 receptor accessory protein) Rattus norvegicus
Analyze
Symbol: Mrap
Name: melanocortin 2 receptor accessory protein
RGD ID: 1310648
Description: Predicted to enable identical protein binding activity; melanocortin receptor binding activity; and signaling receptor regulator activity. Predicted to be involved in negative regulation of protein localization to plasma membrane; protein localization to plasma membrane; and regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within brown fat cell differentiation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum and plasma membrane. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human MRAP (melanocortin 2 receptor accessory protein); PARTICIPATES IN melanocortin system pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC288271; melanocortin-2 receptor accessory protein; RGD1310648; similar to Fat cell-specific low molecular weight protein (Fat tissue-specific low MW protein)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,477,382 - 43,489,118 (+)NCBIGRCr8
mRatBN7.21129,991,974 - 30,003,024 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1129,992,034 - 30,003,024 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1138,678,088 - 38,688,589 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01131,349,499 - 31,360,000 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01130,524,188 - 30,534,681 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01130,904,733 - 30,915,225 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1130,904,733 - 30,915,225 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01134,516,208 - 34,526,700 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41130,720,783 - 30,731,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11130,720,699 - 30,731,228 (+)NCBI
Celera1129,660,355 - 29,670,822 (+)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
alpha-Zearalanol  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
clofibrate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diethylstilbestrol  (EXP)
endosulfan  (EXP)
fenofibrate  (ISO)
fructose  (ISO)
glucose  (ISO)
glycidol  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indinavir  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
lamivudine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
saquinavir  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Melanocortin receptors and their accessory proteins. Cooray SN and Clark AJ, Mol Cell Endocrinol. 2011 Jan 15;331(2):215-21. Epub 2010 Jul 21.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:18077336   PMID:18492766   PMID:19329486   PMID:20371771  


Genomics

Comparative Map Data
Mrap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,477,382 - 43,489,118 (+)NCBIGRCr8
mRatBN7.21129,991,974 - 30,003,024 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1129,992,034 - 30,003,024 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1138,678,088 - 38,688,589 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01131,349,499 - 31,360,000 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01130,524,188 - 30,534,681 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01130,904,733 - 30,915,225 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1130,904,733 - 30,915,225 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01134,516,208 - 34,526,700 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41130,720,783 - 30,731,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11130,720,699 - 30,731,228 (+)NCBI
Celera1129,660,355 - 29,670,822 (+)NCBICelera
Cytogenetic Map11q11NCBI
MRAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382132,291,813 - 32,314,784 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2132,291,813 - 32,314,784 (+)EnsemblGRCh38hg38GRCh38
GRCh372133,664,124 - 33,687,095 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362132,585,995 - 32,608,966 (+)NCBINCBI36Build 36hg18NCBI36
Celera2118,847,645 - 18,870,696 (+)NCBICelera
Cytogenetic Map21q22.11NCBI
HuRef2119,073,352 - 19,095,865 (+)NCBIHuRef
CHM1_12133,225,857 - 33,248,911 (+)NCBICHM1_1
T2T-CHM13v2.02130,661,493 - 30,684,541 (+)NCBIT2T-CHM13v2.0
Mrap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391690,535,095 - 90,546,673 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1690,535,095 - 90,546,673 (+)EnsemblGRCm39 Ensembl
GRCm381690,738,207 - 90,749,785 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1690,738,207 - 90,749,785 (+)EnsemblGRCm38mm10GRCm38
MGSCv371690,738,569 - 90,750,021 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361690,627,183 - 90,638,635 (+)NCBIMGSCv36mm8
Celera1691,820,337 - 91,831,258 (+)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1651.9NCBI
Mrap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540731,833,469 - 31,847,043 (+)NCBIChiLan1.0ChiLan1.0
MRAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22228,415,811 - 28,430,731 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12123,275,995 - 23,291,524 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02118,665,550 - 18,679,537 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12132,047,269 - 32,060,786 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2132,047,269 - 32,063,104 (+)Ensemblpanpan1.1panPan2
MRAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13127,058,469 - 27,085,704 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3127,058,366 - 27,087,573 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3127,052,020 - 27,079,039 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03127,179,197 - 27,206,163 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13127,124,124 - 27,151,129 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03127,136,091 - 27,162,850 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03127,643,853 - 27,670,882 (+)NCBIUU_Cfam_GSD_1.0
Mrap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497127,660,538 - 27,677,388 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365009,790,435 - 9,807,101 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.113195,950,949 - 195,973,501 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MRAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1259,815,547 - 59,834,674 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl259,814,095 - 59,834,610 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660712,356,881 - 2,375,959 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474520,620,807 - 20,642,688 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mrap
58 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:38
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000036027
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat

Markers in Region
RH137574  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21130,002,691 - 30,002,891 (+)MAPPERmRatBN7.2
Rnor_6.01130,914,893 - 30,915,092NCBIRnor6.0
Rnor_5.01134,526,368 - 34,526,567UniSTSRnor5.0
RGSC_v3.41130,730,943 - 30,731,142UniSTSRGSC3.4
Celera1129,670,490 - 29,670,689UniSTS
Cytogenetic Map11q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 103 87 86 55 24 55 6 213 96 83 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000036027   ⟹   ENSRNOP00000030039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1129,992,034 - 30,003,024 (+)Ensembl
Rnor_6.0 Ensembl1130,904,733 - 30,915,225 (+)Ensembl
RefSeq Acc Id: NM_001135834   ⟹   NP_001129306
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,478,628 - 43,489,118 (+)NCBI
mRatBN7.21129,992,529 - 30,003,024 (+)NCBI
Rnor_6.01130,904,733 - 30,915,225 (+)NCBI
Rnor_5.01134,516,208 - 34,526,700 (+)NCBI
RGSC_v3.41130,720,783 - 30,731,275 (+)RGD
Celera1129,660,355 - 29,670,822 (+)RGD
Sequence:
RefSeq Acc Id: XM_039088214   ⟹   XP_038944142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,477,384 - 43,489,118 (+)NCBI
mRatBN7.21129,991,974 - 30,002,767 (+)NCBI
RefSeq Acc Id: XM_039088215   ⟹   XP_038944143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,477,395 - 43,489,118 (+)NCBI
mRatBN7.21129,991,979 - 30,002,829 (+)NCBI
RefSeq Acc Id: XM_063270431   ⟹   XP_063126501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,477,382 - 43,489,118 (+)NCBI
RefSeq Acc Id: NP_001129306   ⟸   NM_001135834
- UniProtKB: D4A897 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000030039   ⟸   ENSRNOT00000036027
RefSeq Acc Id: XP_038944142   ⟸   XM_039088214
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038944143   ⟸   XM_039088215
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063126501   ⟸   XM_063270431
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A897-F1-model_v2 AlphaFold D4A897 1-127 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698046
Promoter ID:EPDNEW_R8571
Type:single initiation site
Name:Mrap_1
Description:melanocortin 2 receptor accessory protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01130,904,800 - 30,904,860EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310648 AgrOrtholog
BioCyc Gene G2FUF-21933 BioCyc
Ensembl Genes ENSRNOG00000021524 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036027.5 UniProtKB/TrEMBL
InterPro MRAP UniProtKB/TrEMBL
NCBI Gene 288271 ENTREZGENE
PANTHER MELANOCORTIN-2 RECEPTOR ACCESSORY PROTEIN UniProtKB/TrEMBL
  PTHR28675 UniProtKB/TrEMBL
Pfam MRAP UniProtKB/TrEMBL
PhenoGen Mrap PhenoGen
RatGTEx ENSRNOG00000021524 RatGTEx
UniProt A6JLC7_RAT UniProtKB/TrEMBL
  D4A897 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Mrap  melanocortin 2 receptor accessory protein   Mrap_predicted  melanocortin 2 receptor accessory protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Mrap_predicted  melanocortin 2 receptor accessory protein (predicted)  RGD1310648_predicted  similar to Fat cell-specific low molecular weight protein (Fat tissue-specific low MW protein) (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1310648_predicted  similar to Fat cell-specific low molecular weight protein (Fat tissue-specific low MW protein) (predicted)  LOC288271_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC288271_predicted  similar to Fat cell-specific low molecular weight protein (Fat tissue-specific low MW protein) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL