Symbol:
Ccdc80
Name:
coiled-coil domain containing 80
Description:
Predicted to have fibronectin binding activity and heparin binding activity. Predicted to be involved in extracellular matrix organization; positive regulation of cell-substrate adhesion; and response to bacterium. Predicted to localize to the basement membrane and interstitial matrix. Orthologous to human CCDC80 (coiled-coil domain containing 80); INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2-dimethylhydrazine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
CL2; coiled-coil domain-containing protein 80; down-regulated by oncogenes 1 protein; Dro1; SSG-1; Ssg1; steroid sensitive gene 1; steroid sensitive gene-1 protein; steroid-sensitive gene 1 protein
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CCDC80 (coiled-coil domain containing 80) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, PhylomeDB, Treefam
Mus musculus (house mouse):
Ccdc80 (coiled-coil domain containing 80) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ccdc80 (coiled-coil domain containing 80) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CCDC80 (coiled-coil domain containing 80) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CCDC80 (coiled-coil domain containing 80) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ccdc80 (coiled-coil domain containing 80) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CCDC80 (coiled-coil domain containing 80) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Ccdc80 (coiled-coil domain containing 80)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
CCDC80 (coiled-coil domain containing 80)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
ccdc80l1 (coiled-coil domain containing 80 like 1)
Alliance
DIOPT (OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
ccdc80 (coiled-coil domain containing 80)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 11 60,645,660 - 60,679,249 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 11 60,645,086 - 60,679,555 (-) Ensembl Rnor_5.0 11 64,747,815 - 64,781,404 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 11 57,222,551 - 57,257,162 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 11 57,280,642 - 57,314,846 (-) NCBI Celera 11 55,250,971 - 55,284,620 (-) NCBI Celera Cytogenetic Map 11 q21 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
(RS)-amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of CCDC80 mRNA CTD PMID:30779732 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE increases expression EXP 6480464 Topotecan results in increased expression of CCDC80 mRNA CTD PMID:25729387 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of CCDC80 mRNA CTD PMID:25729387 1,2-dimethylhydrazine multiple interactions EXP 6480464 [APC protein affects the susceptibility to 1, 2-Dimethylhydrazine] which results in increased expression of CCDC80 mRNA CTD PMID:27840820 17alpha-ethynylestradiol affects expression ISO RGD:731978 6480464 Ethinyl Estradiol affects the expression of CCDC80 mRNA CTD PMID:17555576 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of CCDC80 mRNA CTD PMID:17557909 17beta-estradiol affects expression ISO RGD:736330 6480464 Estradiol affects the expression of CCDC80 mRNA CTD PMID:22574217 17beta-estradiol multiple interactions ISO RGD:736330 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of CCDC80 mRNA CTD PMID:30165855 17beta-estradiol increases expression ISO RGD:731978 6480464 Estradiol results in increased expression of CCDC80 mRNA CTD PMID:19484750 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:731978 6480464 Tetrachlorodibenzodioxin results in decreased expression of CCDC80 mRNA CTD PMID:23994337 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:731978 6480464 Tetrachlorodibenzodioxin affects the expression of CCDC80 mRNA CTD PMID:21570461 , PMID:26377647 2-hydroxypropanoic acid decreases expression ISO RGD:736330 6480464 Lactic Acid results in decreased expression of CCDC80 mRNA CTD PMID:30851411 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:23196670 3,3',4,4',5-pentachlorobiphenyl decreases expression ISO RGD:731978 6480464 3 more ... CTD PMID:23994337 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of CCDC80 mRNA CTD PMID:28522335 4-hydroxyphenyl retinamide decreases expression ISO RGD:731978 6480464 Fenretinide results in decreased expression of CCDC80 mRNA CTD PMID:28973697 8-bromo-3',5'-cyclic AMP decreases expression ISO RGD:736330 6480464 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of CCDC80 mRNA CTD PMID:22079614 all-trans-retinoic acid increases expression ISO RGD:736330 6480464 Tretinoin results in increased expression of CCDC80 mRNA CTD PMID:21934132 aristolochic acid multiple interactions EXP 6480464 [aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of CCDC80 mRNA CTD PMID:23912714 benzo[a]pyrene decreases expression ISO RGD:731978 6480464 Benzo(a)pyrene results in decreased expression of CCDC80 mRNA CTD PMID:21569818 benzo[a]pyrene decreases expression ISO RGD:736330 6480464 Benzo(a)pyrene results in decreased expression of CCDC80 mRNA CTD PMID:22178795 beta-naphthoflavone decreases expression ISO RGD:731978 6480464 beta-Naphthoflavone results in decreased expression of CCDC80 mRNA CTD PMID:23994337 bilirubin IXalpha decreases expression ISO RGD:736330 6480464 Bilirubin results in decreased expression of CCDC80 mRNA CTD PMID:20196124 bisphenol A decreases methylation ISO RGD:736330 6480464 bisphenol A results in decreased methylation of CCDC80 gene CTD PMID:22576693 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of CCDC80 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:736330 6480464 bisphenol A results in increased expression of CCDC80 mRNA CTD PMID:22576693 buspirone decreases expression EXP 6480464 Buspirone results in decreased expression of CCDC80 mRNA CTD PMID:24136188 butanal decreases expression ISO RGD:736330 6480464 butyraldehyde results in decreased expression of CCDC80 mRNA CTD PMID:26079696 calcitriol decreases expression ISO RGD:736330 6480464 Calcitriol results in decreased expression of CCDC80 mRNA CTD PMID:26485663 carbon nanotube affects expression ISO RGD:731978 6480464 Nanotubes, Carbon analog affects the expression of CCDC80 mRNA CTD PMID:25554681 carbon nanotube decreases expression ISO RGD:731978 6480464 Nanotubes, Carbon analog results in decreased expression of CCDC80 mRNA CTD PMID:25620056 carbon nanotube increases expression ISO RGD:731978 6480464 Nanotubes, Carbon results in increased expression of CCDC80 mRNA CTD PMID:25554681 choline multiple interactions ISO RGD:731978 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCDC80 mRNA CTD PMID:20938992 cisplatin multiple interactions ISO RGD:736330 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of CCDC80 mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:736330 6480464 Cisplatin results in decreased expression of CCDC80 mRNA CTD PMID:27392435 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CCDC80 mRNA CTD PMID:17602206 copper atom multiple interactions ISO RGD:736330 6480464 [NSC 689534 binds to Copper] which results in increased expression of CCDC80 mRNA CTD PMID:20971185 copper atom multiple interactions ISO RGD:731978 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CCDC80 mRNA CTD PMID:15467011 copper(0) multiple interactions ISO RGD:736330 6480464 [NSC 689534 binds to Copper] which results in increased expression of CCDC80 mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:731978 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CCDC80 mRNA CTD PMID:15467011 copper(2+) multiple interactions ISO RGD:731978 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CCDC80 mRNA CTD PMID:15467011 copper(2+) multiple interactions ISO RGD:736330 6480464 [NSC 689534 binds to Copper] which results in increased expression of CCDC80 mRNA CTD PMID:20971185 CU-O LINKAGE decreases expression ISO RGD:736330 6480464 cupric oxide results in decreased expression of CCDC80 mRNA CTD PMID:22077320 dioxygen increases expression ISO RGD:736330 6480464 Oxygen deficiency results in increased expression of CCDC80 mRNA CTD PMID:20042640 diuron decreases expression EXP 6480464 Diuron results in decreased expression of CCDC80 mRNA CTD PMID:21551480 , PMID:25152437 dorsomorphin multiple interactions ISO RGD:736330 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin affects expression ISO RGD:736330 6480464 Doxorubicin affects the expression of CCDC80 mRNA CTD PMID:29803840 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of CCDC80 mRNA CTD PMID:29391264 entinostat multiple interactions ISO RGD:736330 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCDC80 mRNA CTD PMID:27188386 entinostat decreases expression ISO RGD:736330 6480464 entinostat results in decreased expression of CCDC80 mRNA CTD PMID:26272509 ethanol increases expression ISO RGD:731978 6480464 Ethanol results in increased expression of CCDC80 mRNA CTD PMID:30319688 fipronil increases expression EXP 6480464 fipronil results in increased expression of CCDC80 mRNA CTD PMID:23962444 flavonoids increases expression EXP 6480464 Flavonoids results in increased expression of CCDC80 mRNA CTD PMID:18035473 folic acid multiple interactions ISO RGD:731978 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCDC80 mRNA CTD PMID:20938992 formaldehyde increases expression ISO RGD:736330 6480464 Formaldehyde results in increased expression of CCDC80 mRNA CTD PMID:23649840 furan increases expression EXP 6480464 furan results in increased expression of CCDC80 mRNA CTD PMID:27387713 Indeno[1,2,3-cd]pyrene decreases expression ISO RGD:731978 6480464 indeno(1 more ... CTD PMID:26377693 isoprenaline increases expression ISO RGD:731978 6480464 Isoproterenol results in increased expression of CCDC80 mRNA CTD PMID:20003209 L-methionine multiple interactions ISO RGD:731978 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCDC80 mRNA CTD PMID:20938992 lead diacetate decreases expression ISO RGD:731978 6480464 lead acetate results in decreased expression of CCDC80 mRNA CTD PMID:20542052 levofloxacin decreases expression EXP 6480464 Levofloxacin results in decreased expression of CCDC80 mRNA CTD PMID:24136188 mifepristone decreases expression EXP 6480464 Mifepristone results in decreased expression of CCDC80 mRNA CTD PMID:25972201 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CCDC80 mRNA CTD PMID:17602206 nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of CCDC80 mRNA CTD PMID:24136188 nickel sulfate decreases expression ISO RGD:736330 6480464 nickel sulfate results in decreased expression of CCDC80 mRNA CTD PMID:22714537 nimesulide decreases expression EXP 6480464 nimesulide results in decreased expression of CCDC80 mRNA CTD PMID:24136188 oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of CCDC80 mRNA CTD PMID:25729387 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of CCDC80 mRNA CTD PMID:25729387 paracetamol affects expression ISO RGD:731978 6480464 Acetaminophen affects the expression of CCDC80 mRNA CTD PMID:17562736 rac-lactic acid decreases expression ISO RGD:736330 6480464 Lactic Acid results in decreased expression of CCDC80 mRNA CTD PMID:30851411 SB 431542 multiple interactions ISO RGD:736330 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide decreases expression ISO RGD:736330 6480464 Silicon Dioxide analog results in decreased expression of CCDC80 mRNA CTD PMID:25895662 sodium arsenite decreases expression ISO RGD:736330 6480464 sodium arsenite results in decreased expression of CCDC80 mRNA CTD PMID:22714537 sulforaphane increases expression ISO RGD:731978 6480464 sulforafan results in increased expression of CCDC80 mRNA CTD PMID:30529165 tamoxifen affects expression ISO RGD:731978 6480464 Tamoxifen affects the expression of CCDC80 mRNA CTD PMID:17555576 tetrachloromethane affects expression ISO RGD:731978 6480464 Carbon Tetrachloride affects the expression of CCDC80 mRNA CTD PMID:17484886 tetrachloromethane increases expression ISO RGD:731978 6480464 Carbon Tetrachloride results in increased expression of CCDC80 mRNA CTD PMID:29987408 titanium dioxide decreases expression ISO RGD:731978 6480464 titanium dioxide results in decreased expression of CCDC80 mRNA CTD PMID:23557971 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of CCDC80 mRNA CTD PMID:25729387 topotecan increases expression EXP 6480464 Topotecan results in increased expression of CCDC80 mRNA CTD PMID:25729387 trichostatin A decreases expression ISO RGD:736330 6480464 trichostatin A results in decreased expression of CCDC80 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:736330 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCDC80 mRNA CTD PMID:27188386 valproic acid affects expression ISO RGD:736330 6480464 Valproic Acid affects the expression of CCDC80 mRNA CTD PMID:25979313 valproic acid multiple interactions ISO RGD:736330 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCDC80 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:736330 6480464 Valproic Acid results in increased expression of CCDC80 mRNA CTD PMID:23179753 , PMID:27188386 valproic acid decreases expression ISO RGD:736330 6480464 Valproic Acid results in decreased expression of CCDC80 mRNA CTD PMID:26272509 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of CCDC80 mRNA CTD PMID:19015723 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of CCDC80 mRNA CTD PMID:23034163 
Gene-Chemical Interaction Annotations
