Ccdc80 (coiled-coil domain containing 80) - Rat Genome Database

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Gene: Ccdc80 (coiled-coil domain containing 80) Rattus norvegicus
Analyze
Symbol: Ccdc80
Name: coiled-coil domain containing 80
RGD ID: 69421
Description: Predicted to enable fibronectin binding activity and heparin binding activity. Predicted to be involved in extracellular matrix organization and positive regulation of cell-substrate adhesion. Predicted to act upstream of or within response to bacterium. Predicted to be located in interstitial matrix. Predicted to be active in basement membrane. Orthologous to human CCDC80 (coiled-coil domain containing 80); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CL2; coiled-coil domain-containing protein 80; down-regulated by oncogenes 1 protein; Dro1; SSG-1; Ssg1; steroid sensitive gene 1; steroid sensitive gene-1 protein; steroid-sensitive gene 1 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21155,685,165 - 55,718,827 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,685,872 - 55,719,137 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,498,843 - 64,532,488 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01157,160,702 - 57,194,361 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01156,230,920 - 56,264,579 (-)NCBIRnor_WKY
Rnor_6.01160,645,660 - 60,679,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1160,645,086 - 60,679,555 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01164,747,815 - 64,781,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,222,551 - 57,257,162 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,280,642 - 57,314,846 (-)NCBI
Celera1155,250,971 - 55,284,620 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
8-Br-cAMP  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
aristolochic acid A  (EXP,ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
CU-O LINKAGE  (ISO)
Didecyldimethylammonium  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
mifepristone  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning and characterization of a novel gene that is regulated by estrogen and is associated with mammary gland carcinogenesis. Marcantonio D, etal., Endocrinology 2001 Jun;142(6):2409-18.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:12592395   PMID:15489334   PMID:15563452   PMID:18757743   PMID:23012479   PMID:23449887   PMID:24006456  


Genomics

Comparative Map Data
Ccdc80
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21155,685,165 - 55,718,827 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,685,872 - 55,719,137 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,498,843 - 64,532,488 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01157,160,702 - 57,194,361 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01156,230,920 - 56,264,579 (-)NCBIRnor_WKY
Rnor_6.01160,645,660 - 60,679,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1160,645,086 - 60,679,555 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01164,747,815 - 64,781,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,222,551 - 57,257,162 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,280,642 - 57,314,846 (-)NCBI
Celera1155,250,971 - 55,284,620 (-)NCBICelera
Cytogenetic Map11q21NCBI
CCDC80
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383112,596,797 - 112,641,143 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3112,596,797 - 112,649,530 (-)EnsemblGRCh38hg38GRCh38
GRCh373112,315,644 - 112,359,990 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363113,806,097 - 113,842,667 (-)NCBINCBI36Build 36hg18NCBI36
Build 343113,806,100 - 113,842,667NCBI
Celera3110,732,063 - 110,768,628 (-)NCBICelera
Cytogenetic Map3q13.2NCBI
HuRef3109,706,775 - 109,743,319 (-)NCBIHuRef
CHM1_13112,287,318 - 112,323,877 (-)NCBICHM1_1
T2T-CHM13v2.03115,317,839 - 115,362,183 (-)NCBIT2T-CHM13v2.0
Ccdc80
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391644,913,770 - 44,948,287 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1644,913,765 - 44,948,440 (+)EnsemblGRCm39 Ensembl
GRCm381645,093,407 - 45,127,924 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1645,093,402 - 45,128,077 (+)EnsemblGRCm38mm10GRCm38
MGSCv371645,094,166 - 45,128,037 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361645,013,496 - 45,046,996 (+)NCBIMGSCv36mm8
Celera1645,485,370 - 45,521,051 (+)NCBICelera
Cytogenetic Map16B5NCBI
Ccdc80
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542712,945,230 - 12,975,114 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542712,945,230 - 12,975,020 (-)NCBIChiLan1.0ChiLan1.0
CCDC80
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13116,678,009 - 116,714,001 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3116,678,161 - 116,712,611 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03109,753,743 - 109,789,769 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CCDC80
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13317,105,086 - 17,141,380 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3317,105,086 - 17,139,896 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3317,208,232 - 17,244,374 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03317,348,918 - 17,385,073 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3317,348,924 - 17,383,880 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13317,153,695 - 17,189,794 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03317,201,117 - 17,237,246 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03317,750,713 - 17,786,844 (-)NCBIUU_Cfam_GSD_1.0
Ccdc80
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602137,191,030 - 137,227,449 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936536293,549 - 330,998 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936536294,650 - 330,875 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCDC80
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13147,207,598 - 147,245,994 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113147,203,333 - 147,244,753 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213156,787,502 - 156,825,938 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103228317
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12268,168,159 - 68,182,818 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605087,161,904 - 87,198,049 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccdc80
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473135,891,184 - 35,929,936 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473135,891,180 - 35,928,497 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccdc80
90 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:82
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000059735
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 7 10 24 35 38 11 7
Low 1 1 50 3 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000059735   ⟹   ENSRNOP00000056490
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,685,872 - 55,719,137 (-)Ensembl
Rnor_6.0 Ensembl1160,645,086 - 60,679,555 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093233
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1160,646,402 - 60,650,293 (-)Ensembl
RefSeq Acc Id: NM_022543   ⟹   NP_071988
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21155,685,165 - 55,718,827 (-)NCBI
Rnor_6.01160,645,660 - 60,679,249 (-)NCBI
Rnor_5.01164,747,815 - 64,781,404 (-)NCBI
RGSC_v3.41157,222,551 - 57,257,162 (-)RGD
Celera1155,250,971 - 55,284,620 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_071988 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF35351 (Get FASTA)   NCBI Sequence Viewer  
  AAH70926 (Get FASTA)   NCBI Sequence Viewer  
  AAS66670 (Get FASTA)   NCBI Sequence Viewer  
  EDM11148 (Get FASTA)   NCBI Sequence Viewer  
  Q6QD51 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_071988   ⟸   NM_022543
- Peptide Label: precursor
- UniProtKB: Q9JKW4 (UniProtKB/Swiss-Prot),   Q6QD51 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000056490   ⟸   ENSRNOT00000059735

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6QD51-F1-model_v2 AlphaFold Q6QD51 1-949 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698144
Promoter ID:EPDNEW_R8668
Type:multiple initiation site
Name:Ccdc80_1
Description:coiled-coil domain containing 80
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8669  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01160,679,394 - 60,679,454EPDNEW
RGD ID:13698145
Promoter ID:EPDNEW_R8669
Type:multiple initiation site
Name:Ccdc80_2
Description:coiled-coil domain containing 80
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8668  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01160,679,555 - 60,679,615EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69421 AgrOrtholog
BioCyc Gene G2FUF-21372 BioCyc
Ensembl Genes ENSRNOG00000002052 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000056490 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000059735 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7096530 IMAGE-MGC_LOAD
InterPro DUF4174 UniProtKB/Swiss-Prot
KEGG Report rno:64387 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91686 IMAGE-MGC_LOAD
NCBI Gene 64387 ENTREZGENE
Pfam DUF4174 UniProtKB/Swiss-Prot
PhenoGen Ccdc80 PhenoGen
TIGR TC205354
UniProt CCD80_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9JKW4 ENTREZGENE
UniProt Secondary Q6IRG8 UniProtKB/Swiss-Prot
  Q9JKW4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Ccdc80  coiled-coil domain containing 80  Ssg1  steroid sensitive gene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ssg1  steroid sensitive gene 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to the cytoplasm and nucleus 1299213
gene_disease overexpression is correlated with mammary carcinogensis 68732
gene_expression protein expressed in uterus, liver, lung, spleen, kidney, heart, bladder, skeletal muscle, and brain 68732
gene_process may play a role in estrogen functions 68732
gene_protein 949 amino-acid protein 1299213
gene_regulation tightly regulated by 17 beta-estradiol (E2) in the normal mammary gland 68732