OR5H15 (olfactory receptor family 5 subfamily H member 15) - Rat Genome Database

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Gene: OR5H15 (olfactory receptor family 5 subfamily H member 15) Homo sapiens
Analyze
Symbol: OR5H15
Name: olfactory receptor family 5 subfamily H member 15
RGD ID: 1344642
HGNC Page HGNC:31287
Description: Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: olfactory receptor 5H15; olfactory receptor, family 5, subfamily H, member 15
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38398,166,696 - 98,169,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl398,166,696 - 98,169,774 (+)EnsemblGRCh38hg38GRCh38
GRCh37397,885,540 - 97,888,618 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36399,370,234 - 99,371,175 (+)NCBINCBI36Build 36hg18NCBI36
Build 34399,370,233 - 99,371,175NCBI
Celera396,277,330 - 96,278,271 (+)NCBICelera
Cytogenetic Map3q11.2NCBI
HuRef395,257,464 - 95,258,405 (+)NCBIHuRef
CHM1_1397,850,566 - 97,851,507 (+)NCBICHM1_1
T2T-CHM13v2.03100,870,429 - 100,873,507 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21873635   PMID:32126975  


Genomics

Comparative Map Data
OR5H15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38398,166,696 - 98,169,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl398,166,696 - 98,169,774 (+)EnsemblGRCh38hg38GRCh38
GRCh37397,885,540 - 97,888,618 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36399,370,234 - 99,371,175 (+)NCBINCBI36Build 36hg18NCBI36
Build 34399,370,233 - 99,371,175NCBI
Celera396,277,330 - 96,278,271 (+)NCBICelera
Cytogenetic Map3q11.2NCBI
HuRef395,257,464 - 95,258,405 (+)NCBIHuRef
CHM1_1397,850,566 - 97,851,507 (+)NCBICHM1_1
T2T-CHM13v2.03100,870,429 - 100,873,507 (+)NCBIT2T-CHM13v2.0
Or5h17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391658,749,781 - 58,820,979 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1658,815,720 - 58,821,804 (+)EnsemblGRCm39 Ensembl
GRCm381658,929,418 - 59,000,616 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1658,995,357 - 59,001,441 (+)EnsemblGRCm38mm10GRCm38
MGSCv371658,995,230 - 59,000,442 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361658,941,943 - 58,942,872 (+)NCBIMGSCv36mm8
Celera1659,346,271 - 59,351,476 (+)NCBICelera
Cytogenetic Map16C1.2- C1.3NCBI
cM Map1634.83NCBI

Variants

.
Variants in OR5H15
29 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q11.1-21.1(chr3:93886671-123216683)x1 copy number loss See cases [RCV000051543] Chr3:93886671..123216683 [GRCh38]
Chr3:93605515..122935530 [GRCh37]
Chr3:95088205..124418220 [NCBI36]
Chr3:3q11.1-21.1
pathogenic
NM_001005515.1(OR5H15):c.69G>A (p.Trp23Ter) single nucleotide variant Malignant melanoma [RCV000066217] Chr3:98168768 [GRCh38]
Chr3:97887612 [GRCh37]
Chr3:99370302 [NCBI36]
Chr3:3q11.2
not provided
NM_001005515.1(OR5H15):c.691G>A (p.Asp231Asn) single nucleotide variant Malignant melanoma [RCV000066219] Chr3:98169390 [GRCh38]
Chr3:97888234 [GRCh37]
Chr3:99370924 [NCBI36]
Chr3:3q11.2
not provided
NM_001005515.1(OR5H15):c.548C>T (p.Pro183Leu) single nucleotide variant Malignant melanoma [RCV000060881] Chr3:98169247 [GRCh38]
Chr3:97888091 [GRCh37]
Chr3:99370781 [NCBI36]
Chr3:3q11.2
not provided
GRCh38/hg38 3q11.1-13.31(chr3:93819623-116887056)x1 copy number loss See cases [RCV000135320] Chr3:93819623..116887056 [GRCh38]
Chr3:93538467..116605903 [GRCh37]
Chr3:95021157..118088593 [NCBI36]
Chr3:3q11.1-13.31
pathogenic
GRCh38/hg38 3q11.2-13.31(chr3:97795369-115663349)x1 copy number loss See cases [RCV000138186] Chr3:97795369..115663349 [GRCh38]
Chr3:97514213..115382196 [GRCh37]
Chr3:98996903..116864886 [NCBI36]
Chr3:3q11.2-13.31
pathogenic|uncertain significance
GRCh38/hg38 3q11.2(chr3:98023760-98332789)x1 copy number loss See cases [RCV000138146] Chr3:98023760..98332789 [GRCh38]
Chr3:97742604..98051633 [GRCh37]
Chr3:99225294..99534323 [NCBI36]
Chr3:3q11.2
likely benign
GRCh38/hg38 3q11.1-24(chr3:93800620-145695381)x3 copy number gain See cases [RCV000142340] Chr3:93800620..145695381 [GRCh38]
Chr3:93519464..145413168 [GRCh37]
Chr3:95002154..146895858 [NCBI36]
Chr3:3q11.1-24
pathogenic
GRCh38/hg38 3q11.1-13.11(chr3:93819623-103888749)x3 copy number gain See cases [RCV000143259] Chr3:93819623..103888749 [GRCh38]
Chr3:93538467..103607593 [GRCh37]
Chr3:95021157..105090283 [NCBI36]
Chr3:3q11.1-13.11
likely pathogenic|uncertain significance
GRCh37/hg19 3q11.2(chr3:96575117-98212517)x3 copy number gain See cases [RCV000448437] Chr3:96575117..98212517 [GRCh37]
Chr3:3q11.2
uncertain significance
GRCh37/hg19 3q11.2(chr3:96579273-98216225)x3 copy number gain See cases [RCV000510411] Chr3:96579273..98216225 [GRCh37]
Chr3:3q11.2
uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_001005515.2(OR5H15):c.898T>G (p.Ser300Ala) single nucleotide variant not specified [RCV004298593] Chr3:98169597 [GRCh38]
Chr3:97888441 [GRCh37]
Chr3:3q11.2
uncertain significance
GRCh37/hg19 3q11.2(chr3:97650137-98174233)x3 copy number gain See cases [RCV000512476] Chr3:97650137..98174233 [GRCh37]
Chr3:3q11.2
uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3q11.2(chr3:97866177-97888337)x3 copy number gain not provided [RCV000742636] Chr3:97866177..97888337 [GRCh37]
Chr3:3q11.2
benign
GRCh37/hg19 3q11.2(chr3:96850456-97974150)x3 copy number gain not provided [RCV001005454] Chr3:96850456..97974150 [GRCh37]
Chr3:3q11.2
uncertain significance
GRCh37/hg19 3q11.2-12.1(chr3:97606054-98499715)x3 copy number gain not provided [RCV001005456] Chr3:97606054..98499715 [GRCh37]
Chr3:3q11.2-12.1
uncertain significance
GRCh37/hg19 3q11.2-12.3(chr3:95563096-102371126)x1 copy number loss not provided [RCV001259224] Chr3:95563096..102371126 [GRCh37]
Chr3:3q11.2-12.3
likely pathogenic
GRCh37/hg19 3p13-q12.1(chr3:72488757-99614758)x3 copy number gain not provided [RCV002221455] Chr3:72488757..99614758 [GRCh37]
Chr3:3p13-q12.1
likely pathogenic
GRCh37/hg19 3q11.2(chr3:97283117-98218677)x3 copy number gain not provided [RCV002475836] Chr3:97283117..98218677 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.410C>T (p.Thr137Ile) single nucleotide variant not provided [RCV004695337]|not specified [RCV004079266] Chr3:98169109 [GRCh38]
Chr3:97887953 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.931G>C (p.Val311Leu) single nucleotide variant not specified [RCV004235852] Chr3:98169630 [GRCh38]
Chr3:97888474 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.314C>T (p.Ala105Val) single nucleotide variant not specified [RCV004239504] Chr3:98169013 [GRCh38]
Chr3:97887857 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.98T>C (p.Val33Ala) single nucleotide variant not specified [RCV004157127] Chr3:98168797 [GRCh38]
Chr3:97887641 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.17C>A (p.Ala6Glu) single nucleotide variant not specified [RCV004160861] Chr3:98168716 [GRCh38]
Chr3:97887560 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.364C>T (p.Arg122Cys) single nucleotide variant not specified [RCV004124884] Chr3:98169063 [GRCh38]
Chr3:97887907 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.320G>C (p.Gly107Ala) single nucleotide variant not specified [RCV004092968] Chr3:98169019 [GRCh38]
Chr3:97887863 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.774G>A (p.Met258Ile) single nucleotide variant not specified [RCV004262879] Chr3:98169473 [GRCh38]
Chr3:97888317 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.457A>C (p.Ile153Leu) single nucleotide variant not specified [RCV004258125] Chr3:98169156 [GRCh38]
Chr3:97888000 [GRCh37]
Chr3:3q11.2
likely benign
NM_001005515.2(OR5H15):c.740C>G (p.Ser247Cys) single nucleotide variant not specified [RCV004297084] Chr3:98169439 [GRCh38]
Chr3:97888283 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.209A>G (p.Asp70Gly) single nucleotide variant not specified [RCV004327725] Chr3:98168908 [GRCh38]
Chr3:97887752 [GRCh37]
Chr3:3q11.2
uncertain significance
GRCh38/hg38 3q11.1-21.2(chr3:93979547-124774010)x1 copy number loss Chromosome 3q13.31 deletion syndrome [RCV003327614] Chr3:93979547..124774010 [GRCh38]
Chr3:3q11.1-21.2
pathogenic
NM_001005515.2(OR5H15):c.335G>A (p.Cys112Tyr) single nucleotide variant not specified [RCV004355706] Chr3:98169034 [GRCh38]
Chr3:97887878 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.286G>C (p.Glu96Gln) single nucleotide variant not specified [RCV004339343] Chr3:98168985 [GRCh38]
Chr3:97887829 [GRCh37]
Chr3:3q11.2
uncertain significance
GRCh37/hg19 3q11.2(chr3:97542156-98076080)x1 copy number loss not provided [RCV003485395] Chr3:97542156..98076080 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.598T>C (p.Phe200Leu) single nucleotide variant not provided [RCV003437927] Chr3:98169297 [GRCh38]
Chr3:97888141 [GRCh37]
Chr3:3q11.2
likely benign
GRCh37/hg19 3q11.1-12.3(chr3:93519465-101464485)x3 copy number gain not specified [RCV003986472] Chr3:93519465..101464485 [GRCh37]
Chr3:3q11.1-12.3
uncertain significance
GRCh37/hg19 3q11.2(chr3:96308168-98033912)x1 copy number loss See cases [RCV004442802] Chr3:96308168..98033912 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.700G>A (p.Val234Ile) single nucleotide variant not specified [RCV004499628] Chr3:98169399 [GRCh38]
Chr3:97888243 [GRCh37]
Chr3:3q11.2
likely benign
NM_001005515.2(OR5H15):c.235C>T (p.Pro79Ser) single nucleotide variant not specified [RCV004499621] Chr3:98168934 [GRCh38]
Chr3:97887778 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.649T>C (p.Ser217Pro) single nucleotide variant not specified [RCV004499626] Chr3:98169348 [GRCh38]
Chr3:97888192 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.899C>T (p.Ser300Leu) single nucleotide variant not specified [RCV004499630] Chr3:98169598 [GRCh38]
Chr3:97888442 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.521T>C (p.Val174Ala) single nucleotide variant not specified [RCV004499624] Chr3:98169220 [GRCh38]
Chr3:97888064 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.589C>G (p.Leu197Val) single nucleotide variant not specified [RCV004499625] Chr3:98169288 [GRCh38]
Chr3:97888132 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.658T>C (p.Phe220Leu) single nucleotide variant not specified [RCV004499627] Chr3:98169357 [GRCh38]
Chr3:97888201 [GRCh37]
Chr3:3q11.2
likely benign
NM_001005515.2(OR5H15):c.82T>C (p.Phe28Leu) single nucleotide variant not specified [RCV004499629] Chr3:98168781 [GRCh38]
Chr3:97887625 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.508A>G (p.Asn170Asp) single nucleotide variant not specified [RCV004499623] Chr3:98169207 [GRCh38]
Chr3:97888051 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.905T>C (p.Ile302Thr) single nucleotide variant not specified [RCV004499631] Chr3:98169604 [GRCh38]
Chr3:97888448 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.480A>T (p.Glu160Asp) single nucleotide variant not specified [RCV004499622] Chr3:98169179 [GRCh38]
Chr3:97888023 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.115A>G (p.Ile39Val) single nucleotide variant not specified [RCV004647789] Chr3:98168814 [GRCh38]
Chr3:97887658 [GRCh37]
Chr3:3q11.2
uncertain significance
NM_001005515.2(OR5H15):c.689C>G (p.Ser230Cys) single nucleotide variant not specified [RCV004646517] Chr3:98169388 [GRCh38]
Chr3:97888232 [GRCh37]
Chr3:3q11.2
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:61
Interacting mature miRNAs:61
Transcripts:ENST00000356526
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
9 43 38 31 42 14 20 5 28 5 23 110 92 1 30 9 89 12

Sequence


Ensembl Acc Id: ENST00000383696   ⟹   ENSP00000373196
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl398,168,700 - 98,169,733 (+)Ensembl
Ensembl Acc Id: ENST00000641450   ⟹   ENSP00000493082
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl398,166,696 - 98,169,774 (+)Ensembl
RefSeq Acc Id: NM_001005515   ⟹   NP_001005515
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38398,166,696 - 98,169,774 (+)NCBI
GRCh37397,887,544 - 97,888,485 (+)RGD
Build 36399,370,234 - 99,371,175 (+)NCBI Archive
Celera396,277,330 - 96,278,271 (+)RGD
HuRef395,257,464 - 95,258,405 (+)ENTREZGENE
CHM1_1397,850,566 - 97,851,507 (+)NCBI
T2T-CHM13v2.03100,870,429 - 100,873,507 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001005515 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A6NDH6 (Get FASTA)   NCBI Sequence Viewer  
  EAW79867 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000493082
  ENSP00000493082.1
RefSeq Acc Id: NP_001005515   ⟸   NM_001005515
- UniProtKB: A6NDH6 (UniProtKB/Swiss-Prot),   A0A126GW64 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000493082   ⟸   ENST00000641450
Ensembl Acc Id: ENSP00000373196   ⟸   ENST00000383696
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A6NDH6-F1-model_v2 AlphaFold A6NDH6 1-313 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31287 AgrOrtholog
COSMIC OR5H15 COSMIC
Ensembl Genes ENSG00000233412 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000641450 ENTREZGENE
  ENST00000641450.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000233412 GTEx
HGNC ID HGNC:31287 ENTREZGENE
Human Proteome Map OR5H15 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Olfactory_GPCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:403274 UniProtKB/Swiss-Prot
NCBI Gene 403274 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 5H1 UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 5H15 UniProtKB/Swiss-Prot
Pfam 7tm_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134956122 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A126GW64 ENTREZGENE, UniProtKB/TrEMBL
  A6NDH6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-15 OR5H15  olfactory receptor family 5 subfamily H member 15    olfactory receptor, family 5, subfamily H, member 15  Symbol and/or name change 5135510 APPROVED