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Gene: Or5h22 (olfactory receptor family 5 subfamily H member 22) Mus musculus

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No known orthologs.

Symbol:

Or5h22

Name:

olfactory receptor family 5 subfamily H member 22

RGD ID:

1616480

MGI Page

MGI

Description:

Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and sensory perception of smell. Predicted to be located in membrane. Orthologous to several human genes including OR5H1 (olfactory receptor family 5 subfamily H member 1); OR5H14 (olfactory receptor family 5 subfamily H member 14); and OR5H15 (olfactory receptor family 5 subfamily H member 15).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

GA_x54KRFPKG5P-55303207-55302284; MGC123481; MGC123482; MOR183; MOR183-4; olfactory receptor 190; olfactory receptor MOR183-4; Olfr190

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	58,894,518 - 58,895,441 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	58,887,503 - 58,898,368 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	59,074,155 - 59,075,078 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	59,067,140 - 59,078,005 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	59,073,981 - 59,074,904 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	59,016,425 - 59,017,334 (-)	NCBI		MGSCv36	mm8
Celera	16	59,423,673 - 59,424,596 (-)	NCBI		Celera
Cytogenetic Map	16	C1.3	NCBI
cM Map	16	34.83	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Or5h22	Mouse	1,2-dichloroethane	increases expression	EXP		6480464	ethylene dichloride results in increased expression of OR5H22 mRNA	CTD	PMID:28189721\|PMID:28960355
Or5h22	Mouse	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of OR5H22 mRNA	CTD	PMID:21354282
Or5h22	Mouse	Azoxymethane	multiple interactions	EXP		6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] affects the expression of OR5H22 mRNA	CTD	PMID:29950665
Or5h22	Mouse	dextran sulfate	multiple interactions	EXP		6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] affects the expression of OR5H22 mRNA	CTD	PMID:29950665
Or5h22	Mouse	titanium dioxide	multiple interactions	EXP		6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] affects the expression of OR5H22 mRNA	CTD	PMID:29950665

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Or5h22	Mouse	G protein-coupled receptor signaling pathway	acts_upstream_of_or_within	ISA	protein_id:AAF20365	2290270	PMID:14611657	MGI	PMID:14611657
Or5h22	Mouse	sensory perception of smell	acts_upstream_of_or_within	ISA	protein_id:AAF20365	2290270	PMID:14611657	MGI	PMID:14611657

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Or5h22	Mouse	membrane	located_in	ISA	protein_id:AAF20365	2290270	PMID:14611657	MGI	PMID:14611657

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Or5h22	Mouse	odorant binding	enables	IBA	PANTHER:PTN001241937\|UniProtKB:Q8NGI8\|MGI:3030853	2290270		GO_Central	GO_REF:0000033
Or5h22	Mouse	olfactory receptor activity	enables	IBA	PANTHER:PTN001241937\|UniProtKB:Q8NGI8\|MGI:3031274\|MGI:3030069\|MGI:3030853	2290270		GO_Central	GO_REF:0000033
Or5h22	Mouse	olfactory receptor activity	enables	ISA	protein_id:AAF20365	2290270	PMID:14611657	MGI	PMID:14611657

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:11802173	PMID:11875048	PMID:12477932	PMID:14611657	PMID:21873635	PMID:32061665	PMID:32295537

Variants in Or5h22
38 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	13
Count of miRNA genes:	12
Interacting mature miRNAs:	12
Transcripts:	ENSMUST00000071243
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
11059560	Lmr12b_m	leishmaniasis resistance 12b (mouse)					16	28792813	62792952	Mouse
1300915	Lmr12_m	leishmaniasis resistance 12 (mouse)			Not determined		16	28792813	62792952	Mouse
1301138	Pcd4ts3_m	p-glycoprotein positive CD4 T cell subset 3 (mouse)			Not determined		16	40593923	74594076	Mouse
1301394	Eae11_m	susceptibility to experimental allergic encephalomyelitis 11 (mouse)			Not determined		16	53561891	87562035	Mouse
26884376	Skwq4_m	skull length QTL 4, 5 week (mouse)					16	8417864	90896888	Mouse
1302096	Aod1a_m	autoimmune ovarian dysgenesis 1a (mouse)			Not determined		16	35446643	92573008	Mouse
4141212	Imraq3_m	immune response to AAV2 QTL 3 (mouse)			Not determined		16	44383350	78383506	Mouse
1558836	Dice1b_m	determination of interleukin 4 commitment 1b (mouse)			Not determined		16	45511000	72274485	Mouse
1301719	Remslp3_m	rapid eye movement sleep 3 (mouse)			Not determined		16	44383350	78383506	Mouse
1357778	Diobq_m	diet-induced obesity QTL (mouse)			Not determined		16	42197817	82331174	Mouse
1301364	Lith14_m	lithogenic gene 14 (mouse)			Not determined		16	55661846	89661961	Mouse
26884432	Zlq7_m	zygomatic length QTL 7, 10 week (mouse)					16	3817864	64620363	Mouse
11049571	Lmr12c_m	leishmaniasis resistance 12c (mouse)					16	28792813	62792952	Mouse
11059559	Lmr12a_m	leishmaniasis resistance 12a (mouse)					16	28792813	62792952	Mouse
4142187	Arrd3_m	age-related retinal degeneration 3 (mouse)			Not determined			32522909	65466552	Mouse
11522747	Eae41_m	experimental allergic encephalomyelitis susceptibility 41 (mouse)					16	40399134	78015472	Mouse
14928310	Manh80_m	mandible shape 80 (mouse)					16	48219841	82219841	Mouse
1357763	Lp1_m	lymphocyte proliferation 1 (mouse)			Not determined		16	6542979	65466552	Mouse
1357517	Bwtn1_m	body weight at necropsy 1 (mouse)			Not determined		16	20019329	85600826	Mouse
26884416	Bzwq5_m	bi-zygomatic width QTL 5, 5 week (mouse)					16	37320362	84696888	Mouse
1301070	Cypr1_m	cytokine production 1 (mouse)			Not determined		16	32312795	66312933	Mouse
27226785	Feml12_m	femur length 12, 5 week (mouse)					16	3317864	64620363	Mouse
4142112	Skts-fp3_m	skin tumor susceptibility in FVB and PWK 3 (mouse)			Not determined		16	40053881	72924385	Mouse

UniSTS:489338

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	16	59,074,170 - 59,075,078	UniSTS	GRCm38
MGSCv37	16	59,073,996 - 59,074,904	UniSTS	GRCm37
Celera	16	59,423,688 - 59,424,596	UniSTS
Cytogenetic Map	16	C1.3	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	NM_146397	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC121290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY073698	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY317275	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC104050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC104051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000071243 ⟹ ENSMUSP00000071224

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	16	58,894,518 - 58,895,441 (-)	Ensembl
GRCm38.p6 Ensembl	16	59,074,155 - 59,075,078 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000215687 ⟹ ENSMUSP00000150190

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	16	58,887,503 - 58,898,324 (-)	Ensembl
GRCm38.p6 Ensembl	16	59,067,140 - 59,077,961 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000216495 ⟹ ENSMUSP00000148991

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	16	58,887,503 - 58,898,368 (-)	Ensembl
GRCm38.p6 Ensembl	16	59,067,140 - 59,078,005 (-)	Ensembl

RefSeq Acc Id:

NM_146397 ⟹ NP_666509

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	16	58,894,518 - 58,895,441 (-)	NCBI
GRCm38	16	59,074,155 - 59,075,078 (-)	ENTREZGENE
MGSCv37	16	59,073,981 - 59,074,904 (-)	RGD
Celera	16	59,423,673 - 59,424,596 (-)	RGD
cM Map	16		ENTREZGENE

Sequence:

show sequence

ATGAAAAATTCAACTGTGCTGACAGAGTTTGTGCTTACAGGGCTCACAGAGTCTCCAGAGCTACAGGTGCCCTTGTTCTTGTTTTTTCTGGTGATCTATCTCATTACTATTGTAGGGAACCTTGGTCT
AATTGCTCTTATCTGGAATGACCCTCACTTACATATCCCTATGTACTTCTTTCTTGGCCATCTGGCTTTTGTGGATGCTTCCCTATCATCCACAGTGGCACCAAAGATGTTACTCGATTTCTTACAGA
TGAATAAGATGATTTCCTACTCTGAATGCATGACACAATTCTTTATCTTTGCAATCTGTGCTACTACAGAATGTTTCTTGTTGGGAGCTATGGCATATGATCGCTATGTAGCCATATGCAAACCTTTA
CTTTATCCAATGATTATGACTAAGAGACTATGTATATGTCTCTTAGTCCTGTCTTTTGTAGGTGGAATTCTTCATTCTTCAATACATGAGGGATTTCTATTACTACTAAACTTCTGTAATTCCAATAT
AGTACATCACTTTTTCTGTGACATCGTTCCATTGCTAAAGATTTCCTGTACTGACACTACTCTTAATTTTCAACTGATATTTGTTTTAGCTGGAATAATTCAAGTCCTCACCGTTGTGATTGTTCTTG
TGTCCTATACACTAGTGCTATTGACGATTTTGCAAAGGAAGTCTGTCCAAAGCATGAAGAAGGCTTTCTCTACCTGTGGTGCCCATCTCTTATCTGTGTCTCTGTACTATGGGCCTCTTCTCATCATG
TATATTTTCCCCGTGTCCCAAGAAGCAGATGGTCAAGATATCATAGACTCTCTGTTTTACACGGTAATAATTCCTGTGTTAAATCCAATTATCTACAGCCTGAGAAACAAGCAAGTAATGGATTCTCT
GAAAAAGGTGTTAAAGAAAAAGGCTTAG

hide sequence


Protein RefSeqs	NP_666509	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI04051	(Get FASTA)	NCBI Sequence Viewer
	AAI04052	(Get FASTA)	NCBI Sequence Viewer
	AAL61361	(Get FASTA)	NCBI Sequence Viewer
	AAP70778	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000071224
	ENSMUSP00000071224.4
	ENSMUSP00000145941
	ENSMUSP00000148991.2
	ENSMUSP00000150190.2

RefSeq Acc Id:

NP_666509 ⟸ NM_146397

- UniProtKB:

K7N5T5 (UniProtKB/TrEMBL), Q7TS46 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKNSTVLTEFVLTGLTESPELQVPLFLFFLVIYLITIVGNLGLIALIWNDPHLHIPMYFFLGHLAFVDASLSSTVAPKMLLDFLQMNKMISYSECMTQFFIFAICATTECFLLGAMAYDRYVAICKPL
LYPMIMTKRLCICLLVLSFVGGILHSSIHEGFLLLLNFCNSNIVHHFFCDIVPLLKISCTDTTLNFQLIFVLAGIIQVLTVVIVLVSYTLVLLTILQRKSVQSMKKAFSTCGAHLLSVSLYYGPLLIM
YIFPVSQEADGQDIIDSLFYTVIIPVLNPIIYSLRNKQVMDSLKKVLKKKA

hide sequence

Ensembl Acc Id:

ENSMUSP00000071224 ⟸ ENSMUST00000071243

Ensembl Acc Id:

ENSMUSP00000148991 ⟸ ENSMUST00000216495

Ensembl Acc Id:

ENSMUSP00000150190 ⟸ ENSMUST00000215687

Protein Domains

G-protein coupled receptors family 1 profile

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-K7N5T5-F1-model_v2	AlphaFold	K7N5T5	1-307	view protein structure

Database	Acc Id	Source(s)
Ensembl Genes	ENSMUSG00000064006	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000071243	ENTREZGENE
	ENSMUST00000071243.4	UniProtKB/TrEMBL
	ENSMUST00000206214	UniProtKB/TrEMBL
	ENSMUST00000215687.3	UniProtKB/TrEMBL
	ENSMUST00000216495.3	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	Olfact_rcpt	UniProtKB/TrEMBL
KEGG Report	mmu:258392	UniProtKB/TrEMBL
MGD	MGI:3030024	ENTREZGENE
NCBI Gene	258392	ENTREZGENE
PANTHER	OLFACTORY RECEPTOR	UniProtKB/TrEMBL
Pfam	7tm_4	UniProtKB/TrEMBL
PhenoGen	Or5h22	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
	OLFACTORYR	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	K7N5T5	ENTREZGENE, UniProtKB/TrEMBL
	Q3SXX4_MOUSE	UniProtKB/TrEMBL
	Q7TS46	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-05-24	Or5h22	olfactory receptor family 5 subfamily H member 22	Olfr190	olfactory receptor 190	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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