Or10z1 (olfactory receptor family 10 subfamily Z member 1) - Rat Genome Database

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Gene: Or10z1 (olfactory receptor family 10 subfamily Z member 1) Rattus norvegicus
Analyze
Symbol: Or10z1
Name: olfactory receptor family 10 subfamily Z member 1
RGD ID: 1333906
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to be active in plasma membrane. Orthologous to human OR10Z1 (olfactory receptor family 10 subfamily Z member 1); INTERACTS WITH bisphenol A; 1,2-dimethylhydrazine (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1597; olfactory receptor gene Olr1597; olfactory receptor Olr1597; Olr1597
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81388,813,861 - 88,814,802 (-)NCBIGRCr8
mRatBN7.21386,281,535 - 86,282,476 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1386,278,626 - 86,283,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1388,788,717 - 88,789,658 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01390,188,991 - 90,189,932 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01387,373,732 - 87,374,673 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01392,342,255 - 92,343,196 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1392,342,255 - 92,343,196 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01396,862,491 - 96,863,432 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41390,030,756 - 90,031,697 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11390,219,639 - 90,220,581 (-)NCBI
Celera1385,884,542 - 85,885,483 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
aflatoxin B1  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
CGP 52608  (ISO)
heptanal  (ISO)
hexanal  (ISO)
nonanal  (ISO)
octanal  (ISO)
pentanal  (ISO)
propanal  (ISO)
resveratrol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or10z1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81388,813,861 - 88,814,802 (-)NCBIGRCr8
mRatBN7.21386,281,535 - 86,282,476 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1386,278,626 - 86,283,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1388,788,717 - 88,789,658 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01390,188,991 - 90,189,932 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01387,373,732 - 87,374,673 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01392,342,255 - 92,343,196 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1392,342,255 - 92,343,196 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01396,862,491 - 96,863,432 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41390,030,756 - 90,031,697 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11390,219,639 - 90,220,581 (-)NCBI
Celera1385,884,542 - 85,885,483 (-)NCBICelera
Cytogenetic Map13q24NCBI
OR10Z1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381158,605,268 - 158,612,514 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1158,605,268 - 158,612,514 (+)EnsemblGRCh38hg38GRCh38
GRCh371158,575,058 - 158,582,304 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361156,842,853 - 156,843,794 (+)NCBINCBI36Build 36hg18NCBI36
Build 341155,389,301 - 155,390,243NCBI
Celera1131,647,280 - 131,648,221 (+)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1129,933,995 - 129,934,936 (+)NCBIHuRef
CHM1_11159,972,583 - 159,973,524 (+)NCBICHM1_1
T2T-CHM13v2.01157,742,367 - 157,749,617 (+)NCBIT2T-CHM13v2.0
Or10z1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391174,077,455 - 174,078,542 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1174,076,080 - 174,079,627 (-)EnsemblGRCm39 Ensembl
GRCm381174,249,889 - 174,250,976 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1174,248,514 - 174,252,061 (-)EnsemblGRCm38mm10GRCm38
MGSCv371176,180,020 - 176,181,107 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361176,086,659 - 176,087,600 (-)NCBIMGSCv36mm8
Celera1181,364,753 - 181,365,840 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map181.01NCBI
LOC100981887
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2191,235,238 - 91,242,451 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1190,978,795 - 90,986,009 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01133,965,449 - 133,966,390 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11137,756,134 - 137,757,075 (+)NCBIpanpan1.1PanPan1.1panPan2
OR10Z1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13823,122,339 - 23,123,280 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3823,122,339 - 23,123,280 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3823,144,871 - 23,145,812 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03823,254,394 - 23,255,335 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3823,254,394 - 23,255,335 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13823,017,074 - 23,018,015 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03823,551,865 - 23,552,806 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03823,983,334 - 23,984,275 (-)NCBIUU_Cfam_GSD_1.0
LOC101973775
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050584,988,107 - 4,989,048 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367401,765,462 - 1,766,403 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367401,765,462 - 1,766,403 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100154445
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl491,643,676 - 91,644,614 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1491,643,676 - 91,644,614 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2499,637,788 - 99,639,244 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103223780
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1205,316,506 - 5,318,741 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660384,482,301 - 4,488,389 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Or10z1
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:64
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000004719
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1302791Stl29Serum triglyceride level QTL 293.30.0011blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)138473078886800898Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat


Expression

RNA-SEQ Expression

circulatory system
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
renal system
reproductive system
respiratory system
8 5 6 12 28 20 8 3 6

Sequence


Ensembl Acc Id: ENSRNOT00000004719   ⟹   ENSRNOP00000004719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1392,342,255 - 92,343,196 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118869   ⟹   ENSRNOP00000091356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1386,278,626 - 86,283,642 (-)Ensembl
RefSeq Acc Id: NM_001000911   ⟹   NP_001000911
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81388,813,861 - 88,814,802 (-)NCBI
mRatBN7.21386,281,535 - 86,282,476 (-)NCBI
Rnor_6.01392,342,255 - 92,343,196 (-)NCBI
Rnor_5.01396,862,491 - 96,863,432 (-)NCBI
RGSC_v3.41390,030,756 - 90,031,697 (-)RGD
Celera1385,884,542 - 85,885,483 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000911 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94761 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091356.1
RefSeq Acc Id: NP_001000911   ⟸   NM_001000911
- UniProtKB: D4A0C2 (UniProtKB/TrEMBL),   A6JGA5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004719   ⟸   ENSRNOT00000004719
Ensembl Acc Id: ENSRNOP00000091356   ⟸   ENSRNOT00000118869
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A0C2-F1-model_v2 AlphaFold D4A0C2 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333906 AgrOrtholog
BioCyc Gene G2FUF-17255 BioCyc
Ensembl Genes ENSRNOG00000003555 Ensembl
  ENSRNOG00000068466 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000118869.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfactory_GPCR UniProtKB/TrEMBL
KEGG Report rno:405222 UniProtKB/TrEMBL
NCBI Gene 405222 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 1358 UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or10z1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003555 RatGTEx
  ENSRNOG00000068466 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6JGA5 ENTREZGENE, UniProtKB/TrEMBL
  D4A0C2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or10z1  olfactory receptor family 10 subfamily Z member 1  Olr1597  olfactory receptor 1597  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1597  olfactory receptor 1597   Olr1597_predicted  olfactory receptor 1597 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1597_predicted  olfactory receptor 1597 (predicted)      Symbol and Name status set to approved 70820 APPROVED