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Gene: Olr1057 (olfactory receptor 1057) Rattus norvegicus

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Symbol:

Olr1057

Name:

olfactory receptor 1057

RGD ID:

1333363

Description:

Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Orthologous to human OR6C70 (olfactory receptor family 6 subfamily C member 70); INTERACTS WITH cadmium dichloride; 2,3',4,4',5-Pentachlorobiphenyl (ortholog); bisphenol A (ortholog).

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

olfactory receptor gene Olr1057; olfactory receptor Olr1057; ratchr7-7913797-7912859_ORF

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

NCBI Annotation Information:

Note: This locus was incorrectly placed in this location on Rnor_6.0. It is missing from Rnor_6.0 but is present in the alternate assembly Rn_Celera. [10 Dec 2014]

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	7,125,807 - 7,126,745 (-)	NCBI		GRCr8
mRatBN7.2	7	6,474,994 - 6,475,932 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	3,102,570 - 3,103,508 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	9,366,702 - 9,367,640 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	11,242,363 - 11,243,301 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	9,050,574 - 9,051,512 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	16,404,763 - 16,405,701 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	16,404,755 - 16,405,751 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	16,571,902 - 16,572,840 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	7,912,859 - 7,913,797 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	7,912,858 - 7,913,797 (-)	NCBI
Celera	7	4,699,018 - 4,699,956 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3',4,4',5-Pentachlorobiphenyl (ISO)

bisphenol A (ISO)

cadmium dichloride (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

detection of chemical stimulus involved in sensory perception of smell (IEA)

G protein-coupled receptor signaling pathway (IEA)

Molecular Function

olfactory receptor activity (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

taste/olfaction phenotype (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Genome sequence of the Brown Norway rat yields insights into mammalian evolution.	Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Olr1057
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	7,125,807 - 7,126,745 (-)	NCBI		GRCr8
mRatBN7.2	7	6,474,994 - 6,475,932 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	3,102,570 - 3,103,508 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	9,366,702 - 9,367,640 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	11,242,363 - 11,243,301 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	9,050,574 - 9,051,512 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	16,404,763 - 16,405,701 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	16,404,755 - 16,405,751 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	16,571,902 - 16,572,840 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	7,912,859 - 7,913,797 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	7,912,858 - 7,913,797 (-)	NCBI
Celera	7	4,699,018 - 4,699,956 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

OR6C70
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	55,469,200 - 55,470,138 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	55,469,200 - 55,470,138 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	55,862,984 - 55,863,922 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	54,149,251 - 54,150,189 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	54,149,250 - 54,150,189	NCBI
Celera	12	55,515,181 - 55,516,119 (-)	NCBI		Celera
Cytogenetic Map	12	q13.2	NCBI
HuRef	12	52,901,748 - 52,902,686 (-)	NCBI		HuRef
CHM1_1	12	55,829,771 - 55,830,709 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	55,435,752 - 55,436,690 (-)	NCBI		T2T-CHM13v2.0

Or6c70
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	129,709,692 - 129,710,624 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	129,707,342 - 129,715,720 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	129,873,823 - 129,874,755 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	129,871,473 - 129,879,851 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	129,310,879 - 129,311,811 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	129,276,772 - 129,277,704 (-)	NCBI		MGSCv36	mm8
Celera	10	132,259,472 - 132,260,404 (-)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	77.58	NCBI

OR6C69
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	68,503 - 69,441 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	68,503 - 69,441 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	46,210,888 - 46,211,826 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	73,593 - 74,531 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	73,593 - 74,531 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	67,839 - 68,773 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	69,468 - 70,406 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	46,592,146 - 46,593,084 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101971896
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	59,640,773 - 59,641,714 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004937074	119,519 - 120,451 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004937074	119,506 - 120,467 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC100513710
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa10.2	X	142,540,005 - 142,540,904 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103238470
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	51,459,901 - 51,461,782 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	194,546,124 - 194,547,180 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Olr1057
1 total Variants

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	664270	26029351	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	5329019	50329019	Rat
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	27829089	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
10755438	Coatc9	Coat color QTL 9		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	3529280	48529280	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
5	5	6	16	39	39	21	22	21	3	72	40	3	2	8	18

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001000072	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000044977 ⟹ ENSRNOP00000043977

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	3,102,570 - 3,103,508 (+)	Ensembl
Rnor_6.0 Ensembl	7	16,404,755 - 16,405,751 (+)	Ensembl

RefSeq Acc Id:

NM_001000072 ⟹ NP_001000072

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	7,125,807 - 7,126,745 (-)	NCBI
mRatBN7.2	7	6,474,994 - 6,475,932 (-)	NCBI
Rnor_6.0	7	16,404,763 - 16,405,701 (+)	NCBI
Rnor_5.0	7	16,571,902 - 16,572,840 (+)	NCBI
RGSC_v3.4	7	7,912,859 - 7,913,797 (-)	RGD
Celera	7	4,699,018 - 4,699,956 (-)	RGD

Sequence:

show sequence

ATGAAGAACCATACAAGACAGATAGAATTTATTCTTCTTGGACTGACAGATAATCCTCAGTTAC
AGATTGTGATTTTTGTATTTCTTTTACTAAATTACTTTCTGAGTATGATAGGGAACTTAACTAT
TATTGCCCTCACTCTGCTAGATCCCCTTCTCAAGACACCAATGTATTTTTTCCTCCGTAATTTC
TCTTTCTTGGAAATTTTATTTACAACAACCTGCATCCCCAGATTTTTAATCACCACTGTAACCC
AGGAAAAGACAATTTCCTATAATGGCTGTATTTGTCAATTATTCTTTTACATATTCTTGGGAGG
CACAGAGTTTTTCCTTTTGGCTACCATGTCCTATGACCGCTATATTGCCATTTGCAAACCCTTG
CACTATGCATCTATCATGAGCAGTAAAGTTTGTCATCAGCTTGTCCTAGGTTCTTGGGTAACTG
GATTCCTGGTTATTTTCCCCCCACTGATTATTGGCCTTGATTTAGATTTCTGTGCTTCAGATGT
CATTGACCACTTCCTTTGTGATGTTTCTCCTGTCCTACAACTGTCCTGCTCAGACACAAATTTA
CTAGAAGTGACTGCTTTCATCCTAGCTCTCATGACACTCATTGTCACATTAGTAATAGTCATCC
TTTCTTATGCTCACATTGTCAAGACAATTACAAAATTCCCTTCTGTTCAGCAAAAGAAAAAGGC
CTTTTCCACTTGTTCTTCTCACATGATTGTTGTTTCCCTCACTTATGGGAGTTGCATATTTATC
TATATAAAACCTTCAGCAAATGAAAGAGTGACTTTGAGCAAAGGAATAGCTGTGCTCAACACTT
CAGTTGCCCCTTTGTTGAACCCATTCATTTATACACTGAGGAATAAACAAGTAAAACAAGCCTT
TGGAGCCATGTGTAGAAAAATATTTTCTGCTTCACAAAGGTAA

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Protein Sequences


Protein RefSeqs	NP_001000072	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001000072 ⟸ NM_001000072

- Sequence:

show sequence

MKNHTRQIEFILLGLTDNPQLQIVIFVFLLLNYFLSMIGNLTIIALTLLDPLLKTPMYFFLRNF
SFLEILFTTTCIPRFLITTVTQEKTISYNGCICQLFFYIFLGGTEFFLLATMSYDRYIAICKPL
HYASIMSSKVCHQLVLGSWVTGFLVIFPPLIIGLDLDFCASDVIDHFLCDVSPVLQLSCSDTNL
LEVTAFILALMTLIVTLVIVILSYAHIVKTITKFPSVQQKKKAFSTCSSHMIVVSLTYGSCIFI
YIKPSANERVTLSKGIAVLNTSVAPLLNPFIYTLRNKQVKQAFGAMCRKIFSASQR

hide sequence

Ensembl Acc Id:

ENSRNOP00000043977 ⟸ ENSRNOT00000044977

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1333363	AgrOrtholog
BioCyc Gene	G2FUF-35099	BioCyc
Ensembl Genes	ENSRNOG00000047264	Ensembl
NCBI Gene	288866	ENTREZGENE
PhenoGen	Olr1057	PhenoGen
RatGTEx	ENSRNOG00000047264	RatGTEx

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Olr1057	olfactory receptor 1057	Olr1057_predicted	olfactory receptor 1057 (predicted)	'predicted' is removed	2292626	APPROVED
2005-02-04	Olr1057_predicted	olfactory receptor 1057 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype