OR6C70 (olfactory receptor family 6 subfamily C member 70) - Rat Genome Database
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Gene: OR6C70 (olfactory receptor family 6 subfamily C member 70) Homo sapiens
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Symbol: OR6C70
Name: olfactory receptor family 6 subfamily C member 70
RGD ID: 1346205
HGNC Page HGNC
Description: Predicted to have olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to localize to plasma membrane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: olfactory receptor 6C70; olfactory receptor, family 6, subfamily C, member 70
RGD Orthologs
Mouse
Rat
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1255,469,200 - 55,470,138 (-)EnsemblGRCh38hg38GRCh38
GRCh381255,469,200 - 55,470,138 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371255,862,984 - 55,863,922 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,149,251 - 54,150,189 (-)NCBINCBI36hg18NCBI36
Build 341254,149,250 - 54,150,189NCBI
Celera1255,515,181 - 55,516,119 (-)NCBI
Cytogenetic Map12q13.2NCBI
HuRef1252,901,748 - 52,902,686 (-)NCBIHuRef
CHM1_11255,829,771 - 55,830,709 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:21873635   PMID:24152035   PMID:26186194   PMID:28514442  


Genomics

Comparative Map Data
OR6C70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1255,469,200 - 55,470,138 (-)EnsemblGRCh38hg38GRCh38
GRCh381255,469,200 - 55,470,138 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371255,862,984 - 55,863,922 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,149,251 - 54,150,189 (-)NCBINCBI36hg18NCBI36
Build 341254,149,250 - 54,150,189NCBI
Celera1255,515,181 - 55,516,119 (-)NCBI
Cytogenetic Map12q13.2NCBI
HuRef1252,901,748 - 52,902,686 (-)NCBIHuRef
CHM1_11255,829,771 - 55,830,709 (-)NCBICHM1_1
Olfr814
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910129,709,692 - 129,710,624 (-)NCBIGRCm39mm39
GRCm3810129,873,823 - 129,874,755 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10129,871,473 - 129,879,851 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710129,310,879 - 129,311,811 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610129,276,772 - 129,277,704 (-)NCBImm8
Celera10132,259,472 - 132,260,404 (-)NCBICelera
Cytogenetic Map10D3NCBI
Olr1057
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0716,404,763 - 16,405,701 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl716,404,755 - 16,405,751 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0716,571,902 - 16,572,840 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.477,912,859 - 7,913,797 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.177,912,858 - 7,913,797 (-)NCBI
Celera74,699,018 - 4,699,956 (-)NCBICelera
Cytogenetic Map7q11NCBI
OR6C69
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2768,503 - 69,441 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12768,503 - 69,441 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC101971896
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004937074119,506 - 120,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100513710
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.2X142,540,005 - 142,540,904 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103238470
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11151,459,901 - 51,461,782 (-)NCBI

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:28
Interacting mature miRNAs:28
Transcripts:ENST00000327335
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 1
Low 4 4 2 4 9 2 1 1 2 21 1 1
Below cutoff 166 446 93 54 95 7 356 239 201 18 242 109 47 75 242

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000327335   ⟹   ENSP00000329153
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1255,469,200 - 55,470,138 (-)Ensembl
RefSeq Acc Id: NM_001005499   ⟹   NP_001005499
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381255,469,200 - 55,470,138 (-)NCBI
GRCh371255,862,984 - 55,863,922 (-)RGD
Build 361254,149,251 - 54,150,189 (-)NCBI Archive
Celera1255,515,181 - 55,516,119 (-)RGD
HuRef1252,901,748 - 52,902,686 (-)RGD
CHM1_11255,829,771 - 55,830,709 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001005499 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A6NIJ9 (Get FASTA)   NCBI Sequence Viewer  
  ALI87620 (Get FASTA)   NCBI Sequence Viewer  
  EAW96813 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001005499   ⟸   NM_001005499
- UniProtKB: A6NIJ9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000329153   ⟸   ENST00000327335
Protein Domains
G_PROTEIN_RECEP_F1_2


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001005499.1(OR6C70):c.453C>T (p.Phe151=) single nucleotide variant Malignant melanoma [RCV000062555] Chr12:55469686 [GRCh38]
Chr12:55863470 [GRCh37]
Chr12:54149737 [NCBI36]
Chr12:12q13.2
not provided
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q13.13-13.3(chr12:53420606-56202942)x3 copy number gain See cases [RCV000141435] Chr12:53420606..56202942 [GRCh38]
Chr12:53814390..56596726 [GRCh37]
Chr12:52100657..54882993 [NCBI36]
Chr12:12q13.13-13.3
pathogenic
NM_001005519.2(OR6C68):c.667A>T (p.Ile223Phe) single nucleotide variant Malignant melanoma [RCV000062556] Chr12:55493044 [GRCh38]
Chr12:55886828 [GRCh37]
Chr12:54173095 [NCBI36]
Chr12:12q13.2
not provided
NM_001005494.1(OR6C4):c.112C>T (p.Leu38=) single nucleotide variant Malignant melanoma [RCV000070100] Chr12:55551338 [GRCh38]
Chr12:55945122 [GRCh37]
Chr12:54231389 [NCBI36]
Chr12:12q13.2
not provided
NM_206899.1(OR10P1):c.73G>A (p.Gly25Ser) single nucleotide variant Malignant melanoma [RCV000070101] Chr12:55636964 [GRCh38]
Chr12:56030748 [GRCh37]
Chr12:54317015 [NCBI36]
Chr12:12q13.2
not provided
NM_206899.1(OR10P1):c.901G>A (p.Ala301Thr) single nucleotide variant Malignant melanoma [RCV000070102] Chr12:55637792 [GRCh38]
Chr12:56031576 [GRCh37]
Chr12:54317843 [NCBI36]
Chr12:12q13.2
not provided
NC_000012.12:g.55480386G>T single nucleotide variant Lung cancer [RCV000111122] Chr12:55480386 [GRCh38]
Chr12:55874170 [GRCh37]
Chr12:12q13.2
uncertain significance
NC_000012.12:g.55519536C>A single nucleotide variant Lung cancer [RCV000111123] Chr12:55519536 [GRCh38]
Chr12:55913320 [GRCh37]
Chr12:12q13.2
uncertain significance
NM_206899.1(OR10P1):c.-1616T>C single nucleotide variant Lung cancer [RCV000111124] Chr12:55635276 [GRCh38]
Chr12:56029060 [GRCh37]
Chr12:12q13.2
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q13.2-14.1(chr12:55552371-62126304)x3 copy number gain not provided [RCV001006505] Chr12:55552371..62126304 [GRCh37]
Chr12:12q13.2-14.1
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31299 AgrOrtholog
COSMIC OR6C70 COSMIC
Ensembl Genes ENSG00000184954 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000329153 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000327335 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000184954 GTEx
HGNC ID HGNC:31299 ENTREZGENE
Human Proteome Map OR6C70 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:390327 UniProtKB/Swiss-Prot
NCBI Gene 390327 ENTREZGENE
Pfam 7tm_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134915898 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.632718 ENTREZGENE
UniProt A0A126GW26_HUMAN UniProtKB/TrEMBL
  A6NIJ9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-15 OR6C70  olfactory receptor family 6 subfamily C member 70    olfactory receptor, family 6, subfamily C, member 70  Symbol and/or name change 5135510 APPROVED
2011-09-01 OR6C70  olfactory receptor, family 6, subfamily C, member 70  OR6C70  olfactory receptor, family 6, subfamily C, member 70  Symbol and/or name change 5135510 APPROVED