Or2av10 (olfactory receptor family 2 subfamily AV member 10) - Rat Genome Database

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Gene: Or2av10 (olfactory receptor family 2 subfamily AV member 10) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Or2av10
Name: olfactory receptor family 2 subfamily AV member 10
RGD ID: 1333036
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to be active in plasma membrane; INTERACTS WITH bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1414; olfactory receptor gene Olr1414; olfactory receptor Olr1414; Olr1414
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81043,156,168 - 43,157,121 (-)NCBIGRCr8
mRatBN7.21042,655,750 - 42,656,703 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1042,655,750 - 42,656,703 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1047,318,478 - 47,319,431 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01046,808,922 - 46,809,875 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01042,312,430 - 42,313,383 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01043,911,947 - 43,912,900 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1043,911,947 - 43,912,900 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01043,704,241 - 43,705,194 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41044,113,403 - 44,114,356 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11044,127,025 - 44,127,979 (-)NCBI
Celera1041,952,688 - 41,953,641 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or2av10Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of OR2AV10 mRNACTDPMID:25181051
Or2av10RatCuprizon decreases expressionEXP 6480464Cuprizone results in decreased expression of OR2AV10 mRNACTDPMID:26577399
Or2av10RatCuprizon increases expressionEXP 6480464Cuprizone results in increased expression of OR2AV10 mRNACTDPMID:27523638


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or2av10Ratdetection of chemical stimulus involved in sensory perception of smell involved_inIBAMGI:106182 and PANTHER:PTN0028180001600115GO_REF:0000033GO_CentralGO_REF:0000033
Or2av10Ratdetection of chemical stimulus involved in sensory perception of smell  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or2av10RatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or2av10RatG protein-coupled receptor signaling pathway  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or2av10RatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 and InterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or2av10Ratsensory perception of smell involved_inIEAUniProtKB-KW:KW-05521600115GO_REF:0000043UniProtGO_REF:0000043
Or2av10Ratsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or2av10Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Or2av10Ratmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Or2av10Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Or2av10Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Or2av10Ratplasma membrane is_active_inIBAMGI:106648 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or2av10RatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or2av10RatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Or2av10Ratolfactory receptor activity enablesIBAMGI:106182 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Or2av10Ratolfactory receptor activity  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or2av10Ratolfactory receptor activity enablesIEAInterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or2av10Rattaste/olfaction phenotype  IEA 1303377 RGD 

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


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Variants in Or2av10
9 total Variants

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:28
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000029524
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 63 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat

1 to 10 of 63 rows



appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 4 13 9 8 3 8 16 3 4 4 37 1



Ensembl Acc Id: ENSRNOT00000029524   ⟹   ENSRNOP00000037309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1042,655,750 - 42,656,703 (-)Ensembl
Rnor_6.0 Ensembl1043,911,947 - 43,912,900 (-)Ensembl
RefSeq Acc Id: NM_001000782   ⟹   NP_001000782
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81043,156,168 - 43,157,121 (-)NCBI
mRatBN7.21042,655,750 - 42,656,703 (-)NCBI
Rnor_6.01043,911,947 - 43,912,900 (-)NCBI
Rnor_5.01043,704,241 - 43,705,194 (-)NCBI
RGSC_v3.41044,113,403 - 44,114,356 (-)RGD
Celera1041,952,688 - 41,953,641 (-)RGD
Sequence:
Protein RefSeqs NP_001000782 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM04547 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037309.2
RefSeq Acc Id: NP_001000782   ⟸   NM_001000782
- UniProtKB: D3ZX55 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000037309   ⟸   ENSRNOT00000029524
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZX55-F1-model_v2 AlphaFold D3ZX55 1-317 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 19 of 19 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-24982 BioCyc
Ensembl Genes ENSRNOG00000026714 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029524.3 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
KEGG Report rno:405060 UniProtKB/TrEMBL
NCBI Gene 405060 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or2av10 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026714 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt D3ZX55 ENTREZGENE, UniProtKB/TrEMBL
1 to 19 of 19 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or2av10  olfactory receptor family 2 subfamily AV member 10  Olr1414  olfactory receptor 1414  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1414  olfactory receptor 1414   Olr1414_predicted  olfactory receptor 1414 (predicted)  'predicted' is removed 2292626 APPROVED