Or10a48 (olfactory receptor family 10 subfamily A member 48B) - Rat Genome Database

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Gene: Or10a48 (olfactory receptor family 10 subfamily A member 48B) Rattus norvegicus
Analyze
Symbol: Or10a48
Name: olfactory receptor family 10 subfamily A member 48B
RGD ID: 1334387
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to be active in plasma membrane. Orthologous to human OR10A6 (olfactory receptor family 10 subfamily A member 6 (gene/pseudogene)); INTERACTS WITH acrylamide; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 285; olfactory receptor family 10 subfamily A member 48B, pseudogene 1; olfactory receptor gene Olr285; olfactory receptor Olr285; Olr285; ratchr1-166658959-166659894_ORF
RGD Orthologs
Human
Mouse
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81172,228,688 - 172,229,623 (-)NCBIGRCr8
mRatBN7.21162,793,841 - 162,794,776 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,793,610 - 162,797,017 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,121,781 - 171,122,716 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01178,307,802 - 178,308,737 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01170,986,699 - 170,987,634 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01173,392,455 - 173,393,390 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1173,392,455 - 173,393,390 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01180,378,259 - 180,379,194 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41166,548,296 - 166,549,231 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11166,658,958 - 166,659,894 (+)NCBI
Celera1160,700,521 - 160,701,456 (-)NCBICelera
Cytogenetic Map1q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or10a48Rat1,2-dimethylhydrazine decreases expressionISOOr10a48 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of OR10A48 mRNACTDPMID:22206623
Or10a48Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOOr10a48 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of OR10A48 mRNACTDPMID:21570461
Or10a48Rat2-hydroxypropanoic acid decreases expressionISOOR10A6 (Homo sapiens)6480464Lactic Acid results in decreased expression of OR10A6 mRNACTDPMID:30851411
Or10a48Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of OR10A48 mRNACTDPMID:28959563
Or10a48Rataflatoxin B1 decreases methylationISOOR10A6 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of OR10A6 geneCTDPMID:27153756
Or10a48Ratbenzo[a]pyrene increases methylationISOOR10A6 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of OR10A6 promoterCTDPMID:27901495
Or10a48Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of OR10A48 mRNACTDPMID:25181051
Or10a48Ratbisphenol A multiple interactionsEXP 6480464[bisphenol A co-treated with tributyltin] results in decreased expression of OR10A48 mRNACTDPMID:31129395
Or10a48Ratbisphenol A increases methylationISOOr10a48 (Mus musculus)6480464bisphenol A results in increased methylation of OR10A48 promoterCTDPMID:27312807
Or10a48RatCGP 52608 multiple interactionsISOOR10A6 (Homo sapiens)6480464CGP 52608 promotes the reaction [RORA protein binds to OR10A6 gene]CTDPMID:28238834
Or10a48Ratcopper atom increases expressionEXP 6480464Copper deficiency results in increased expression of OR10A48 mRNACTDPMID:26033743
Or10a48Ratcopper(0) increases expressionEXP 6480464Copper deficiency results in increased expression of OR10A48 mRNACTDPMID:26033743
Or10a48Ratfuran increases expressionEXP 6480464furan results in increased expression of OR10A48 mRNACTDPMID:25539665
Or10a48Ratlidocaine decreases expressionEXP 6480464Lidocaine results in decreased expression of OR10A48 mRNACTDPMID:35283115
Or10a48Ratpermethrin increases expressionISOOR10A6 (Homo sapiens)6480464Permethrin results in increased expression of OR10A6 mRNACTDPMID:37047231
Or10a48Ratrac-lactic acid decreases expressionISOOR10A6 (Homo sapiens)6480464Lactic Acid results in decreased expression of OR10A6 mRNACTDPMID:30851411
Or10a48Rattributylstannane multiple interactionsEXP 6480464[bisphenol A co-treated with tributyltin] results in decreased expression of OR10A48 mRNACTDPMID:31129395
Or10a48Ratvalproic acid decreases methylationISOOR10A6 (Homo sapiens)6480464Valproic Acid results in decreased methylation of OR10A6 geneCTDPMID:29154799

1 to 18 of 18 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or10a48Ratdetection of chemical stimulus involved in sensory perception of smell involved_inIBAMGI:106182 and PANTHER:PTN0028180001600115GO_REF:0000033GO_CentralGO_REF:0000033
Or10a48Ratdetection of chemical stimulus involved in sensory perception of smell  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or10a48RatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or10a48RatG protein-coupled receptor signaling pathway  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or10a48RatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 and InterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or10a48Ratsensory perception of smell involved_inIEAUniProtKB-KW:KW-05521600115GO_REF:0000043UniProtGO_REF:0000043
Or10a48Ratsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or10a48Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Or10a48Ratmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Or10a48Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Or10a48Ratplasma membrane is_active_inIBAMGI:106648 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Or10a48Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or10a48RatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or10a48RatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Or10a48Ratolfactory receptor activity enablesIBAMGI:106182 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Or10a48Ratolfactory receptor activity  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or10a48Ratolfactory receptor activity enablesIEAInterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or10a48Rattaste/olfaction phenotype  IEA 1303377 RGD 

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Or10a48
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81172,228,688 - 172,229,623 (-)NCBIGRCr8
mRatBN7.21162,793,841 - 162,794,776 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,793,610 - 162,797,017 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,121,781 - 171,122,716 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01178,307,802 - 178,308,737 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01170,986,699 - 170,987,634 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01173,392,455 - 173,393,390 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1173,392,455 - 173,393,390 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01180,378,259 - 180,379,194 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41166,548,296 - 166,549,231 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11166,658,958 - 166,659,894 (+)NCBI
Celera1160,700,521 - 160,701,456 (-)NCBICelera
Cytogenetic Map1q33NCBI
OR10A6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38117,924,592 - 7,931,268 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl117,924,592 - 7,931,268 (-)EnsemblGRCh38hg38GRCh38
GRCh37117,946,139 - 7,952,815 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36117,905,841 - 7,906,785 (-)NCBINCBI36Build 36hg18NCBI36
Build 34117,905,840 - 7,906,785NCBI
Celera118,064,777 - 8,065,721 (-)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef117,615,953 - 7,616,897 (-)NCBIHuRef
CHM1_1117,948,238 - 7,949,182 (-)NCBICHM1_1
T2T-CHM13v2.0118,003,727 - 8,010,438 (-)NCBIT2T-CHM13v2.0
Or10a48
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397108,424,272 - 108,425,204 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7108,424,272 - 108,425,204 (-)EnsemblGRCm39 Ensembl
GRCm387108,825,065 - 108,825,997 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7108,825,065 - 108,825,997 (-)EnsemblGRCm38mm10GRCm38
MGSCv377115,968,579 - 115,969,511 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367108,616,242 - 108,617,174 (-)NCBIMGSCv36mm8
Celera7108,801,683 - 108,802,615 (-)NCBICelera
Cytogenetic Map7E3NCBI
cM Map757.21NCBI
OR10A6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12131,460,828 - 31,468,750 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2131,460,892 - 31,461,833 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2131,030,429 - 31,038,351 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02132,325,141 - 32,333,063 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12131,595,149 - 31,603,039 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02131,761,173 - 31,769,094 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02132,054,988 - 32,062,956 (-)NCBIUU_Cfam_GSD_1.0
LOC103240946
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1156,890,130 - 56,893,478 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl156,891,311 - 56,892,255 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038154,620,874 - 154,621,824 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Or10a48
4 total Variants

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:140
Interacting mature miRNAs:148
Transcripts:ENSRNOT00000050657
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 76 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat

1 to 10 of 76 rows



ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
reproductive system
respiratory system
4 2 3 2 1 2 4 3 1 9 1



Ensembl Acc Id: ENSRNOT00000050657   ⟹   ENSRNOP00000042349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1173,392,455 - 173,393,390 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096722   ⟹   ENSRNOP00000093904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,793,610 - 162,797,017 (-)Ensembl
RefSeq Acc Id: NM_001000223   ⟹   NP_001000223
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,228,688 - 172,229,623 (-)NCBI
mRatBN7.21162,793,841 - 162,794,776 (-)NCBI
Rnor_6.01173,392,455 - 173,393,390 (-)NCBI
Rnor_5.01180,378,259 - 180,379,194 (-)NCBI
RGSC_v3.41166,548,296 - 166,549,231 (+)RGD
Celera1160,700,521 - 160,701,456 (-)RGD
Sequence:
Protein RefSeqs NP_001000223 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM17934 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000093904
  ENSRNOP00000093904.1
RefSeq Acc Id: NP_001000223   ⟸   NM_001000223
- UniProtKB: A0A8I6AIF4 (UniProtKB/TrEMBL),   A6I7U6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000042349   ⟸   ENSRNOT00000050657
Ensembl Acc Id: ENSRNOP00000093904   ⟸   ENSRNOT00000096722
Name Modeler Protein Id AA Range Protein Structure
AF-D4A4L3-F1-model_v2 AlphaFold D4A4L3 1-311 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 23 of 23 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-57898 BioCyc
Ensembl Genes ENSRNOG00000032092 Ensembl
  ENSRNOG00000069937 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000096722 ENTREZGENE
  ENSRNOT00000096722.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
KEGG Report rno:293421 UniProtKB/TrEMBL
NCBI Gene 293421 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or10a48 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032092 RatGTEx
  ENSRNOG00000069937 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I6AIF4 ENTREZGENE, UniProtKB/TrEMBL
  A6I7U6 ENTREZGENE, UniProtKB/TrEMBL
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-11-16 Or10a48  olfactory receptor family 10 subfamily A member 48B  Or10a48  olfactory receptor family 10 subfamily A member 48B, pseudogene 1  Name changed 629549 APPROVED
2022-08-16 Or10a48  olfactory receptor family 10 subfamily A member 48B, pseudogene 1  Olr285  olfactory receptor 285  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr285  olfactory receptor 285   Olr285_predicted  olfactory receptor 285 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr285_predicted  olfactory receptor 285 (predicted)      Symbol and Name status set to approved 70820 APPROVED