Or12d2b (olfactory receptor family 12 subfamily D member 2B) - Rat Genome Database

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Gene: Or12d2b (olfactory receptor family 12 subfamily D member 2B) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Or12d2b
Name: olfactory receptor family 12 subfamily D member 2B
RGD ID: 1332623
Description: Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human OR12D1 (olfactory receptor family 12 subfamily D member 1 (gene/pseudogene)) and OR12D2 (olfactory receptor family 12 subfamily D member 2); INTERACTS WITH cadmium dichloride; copper atom; copper(0).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 14; olfactory receptor 1736; olfactory receptor gene Olr1736; Olr1736; Or14
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8201,279,401 - 1,280,327 (+)NCBIGRCr8
mRatBN7.2201,274,152 - 1,275,078 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl201,274,088 - 1,275,127 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx201,327,412 - 1,328,338 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0201,330,898 - 1,331,824 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0201,272,401 - 1,273,327 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0201,764,858 - 1,765,784 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl201,764,794 - 1,765,833 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0203,808,599 - 3,809,712 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4201,364,915 - 1,365,841 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1201,364,914 - 1,365,841 (+)NCBI
Celera201,987,674 - 1,988,600 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, etal., Genome Res 2004 Apr;14(4):631-9.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Or12d2b
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:64
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000065278
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2016693431Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2016693431Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013629303Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 1 3 30 29 22 2 20 2 1 43 35 17 2 6 20

Sequence


Ensembl Acc Id: ENSRNOT00000075084   ⟹   ENSRNOP00000067374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl201,274,088 - 1,275,127 (+)Ensembl
Rnor_6.0 Ensembl201,764,794 - 1,765,833 (+)Ensembl
RefSeq Acc Id: NM_001001421   ⟹   NP_001001421
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8201,279,401 - 1,280,327 (+)NCBI
mRatBN7.2201,274,152 - 1,275,078 (+)NCBI
Rnor_6.0201,764,858 - 1,765,784 (+)NCBI
Rnor_5.0203,808,599 - 3,809,712 (+)NCBI
RGSC_v3.4201,364,915 - 1,365,841 (+)RGD
Celera201,987,674 - 1,988,600 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001001421 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE84082 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067374.2
RefSeq Acc Id: NP_001001421   ⟸   NM_001001421
- UniProtKB: Q6MFW5 (UniProtKB/TrEMBL),   M0RCP8 (UniProtKB/TrEMBL),   D3ZW45 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067374   ⟸   ENSRNOT00000075084
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MFW5-F1-model_v2 AlphaFold Q6MFW5 1-308 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1332623 AgrOrtholog
BioCyc Gene G2FUF-5007 BioCyc
Ensembl Genes ENSRNOG00000061930 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075084.3 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfactory_GPCR UniProtKB/TrEMBL
KEGG Report rno:405203 UniProtKB/TrEMBL
NCBI Gene 405203 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or12d2b PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061930 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt D3ZW45 ENTREZGENE
  M0RCP8 ENTREZGENE
  Q6MFW5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D3ZW45 UniProtKB/TrEMBL
  M0RCP8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or12d2b  olfactory receptor family 12 subfamily D member 2B  Olr1736  olfactory receptor 1736  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1736  olfactory receptor 1736   Olr1736_predicted  olfactory receptor 1736 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1736_predicted  olfactory receptor 1736 (predicted)      Symbol and Name status set to approved 70820 APPROVED