Or6c76b (olfactory receptor family 6 subfamily C member 76B) - Rat Genome Database

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Gene: Or6c76b (olfactory receptor family 6 subfamily C member 76B) Rattus norvegicus
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Symbol: Or6c76b
Name: olfactory receptor family 6 subfamily C member 76B
RGD ID: 1334198
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Orthologous to human OR6C76 (olfactory receptor family 6 subfamily C member 76); INTERACTS WITH bisphenol A; C60 fullerene; cadmium dichloride.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 932; olfactory receptor gene Olr932; olfactory receptor Olr932; olfactory receptor pseudogene 1056; olfactory receptor pseudogene Olr1056-ps; Olr1056-ps; Olr932
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr873,765,256 - 3,771,688 (-)NCBIGRCr8
mRatBN7.273,121,741 - 3,122,676 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.273,121,741 - 3,122,676 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl73,121,741 - 3,122,676 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx75,984,853 - 5,985,788 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.077,860,525 - 7,861,460 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.079,026,959 - 9,027,893 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0716,431,803 - 16,432,738 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0716,596,143 - 16,597,078 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.474,386,212 - 4,387,147 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.174,386,211 - 4,387,147 (-)NCBI
Celera74,676,745 - 4,677,679 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or6c76bRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOOr6c76b (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of OR6C76 mRNACTDPMID:21570461
Or6c76bRat4,4'-sulfonyldiphenol increases methylationISOOR6C76 (Homo sapiens)6480464bisphenol S results in increased methylation of OR6C76 geneCTDPMID:31601247
Or6c76bRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of OR6C76 mRNA and bisphenol A results in decreased expression of OR6C76B mRNACTDPMID:25181051
Or6c76bRatbisphenol A decreases methylationISOOR6C76 (Homo sapiens)6480464bisphenol A results in decreased methylation of OR6C76 geneCTDPMID:31601247
Or6c76bRatbisphenol A decreases methylationISOOr6c76b (Mus musculus)6480464bisphenol A results in decreased methylation of OR6C76 promoterCTDPMID:27312807
Or6c76bRatC60 fullerene decreases expressionEXP 6480464fullerene C60 results in decreased expression of OR6C76B mRNACTDPMID:19167457
Or6c76bRatcadmium dichloride affects methylationEXP 6480464Cadmium Chloride affects the methylation of OR6C76B promoterCTDPMID:22457795


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or6c76bRatdetection of chemical stimulus involved in sensory perception of smell involved_inIEAGO:00049841600115GO_REF:0000108GOCGO_REF:0000108
Or6c76bRatdetection of chemical stimulus involved in sensory perception of smell  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or6c76bRatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or6c76bRatG protein-coupled receptor signaling pathway  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or6c76bRatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 and InterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or6c76bRatsensory perception of smell involved_inIEAUniProtKB-KW:KW-05521600115GO_REF:0000043UniProtGO_REF:0000043
Or6c76bRatsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or6c76bRatmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Or6c76bRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Or6c76bRatplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Or6c76bRatplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or6c76bRatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or6c76bRatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Or6c76bRatolfactory receptor activity enablesIBAMGI:1333764 and PANTHER:PTN0012458721600115GO_REF:0000033GO_CentralGO_REF:0000033
Or6c76bRatolfactory receptor activity  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or6c76bRatolfactory receptor activity enablesIEAInterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or6c76bRattaste/olfaction phenotype  IEA 1303377 RGD 

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Or6c76b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr873,765,256 - 3,771,688 (-)NCBIGRCr8
mRatBN7.273,121,741 - 3,122,676 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.273,121,741 - 3,122,676 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl73,121,741 - 3,122,676 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx75,984,853 - 5,985,788 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.077,860,525 - 7,861,460 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.079,026,959 - 9,027,893 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0716,431,803 - 16,432,738 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0716,596,143 - 16,597,078 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.474,386,212 - 4,387,147 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.174,386,211 - 4,387,147 (-)NCBI
Celera74,676,745 - 4,677,679 (+)NCBICelera
Cytogenetic Map7q11NCBI
OR6C76
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381255,426,254 - 55,427,192 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1255,426,254 - 55,427,192 (+)EnsemblGRCh38hg38GRCh38
GRCh371255,820,038 - 55,820,976 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,106,305 - 54,107,243 (+)NCBINCBI36Build 36hg18NCBI36
Build 341254,106,304 - 54,107,243NCBI
Celera1255,472,093 - 55,473,030 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1252,858,811 - 52,859,748 (+)NCBIHuRef
CHM1_11255,786,836 - 55,787,773 (+)NCBICHM1_1
T2T-CHM13v2.01255,392,802 - 55,393,761 (+)NCBIT2T-CHM13v2.0
Or6c76b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910129,692,389 - 129,693,321 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10129,691,236 - 129,694,591 (+)EnsemblGRCm39 Ensembl
GRCm3810129,856,520 - 129,857,452 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10129,855,367 - 129,858,722 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710129,293,576 - 129,294,508 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610129,259,469 - 129,260,401 (+)NCBIMGSCv36mm8
Celera10132,242,169 - 132,243,101 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.57NCBI
LOC100683141
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1331,338,984 - 31,339,918 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha333,331,088 - 33,332,022 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0331,488,907 - 31,489,844 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1331,337,436 - 31,338,370 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0331,263,408 - 31,264,342 (+)NCBIUNSW_CanFamBas_1.0
LOC100620182
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.2521,692,500 - 21,693,441 (+)NCBISscrofa10.2Sscrofa10.2susScr3

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Variants in Or6c76b
4 total Variants


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
7 4386837 4386838 A G snv SS/JrHsdMcwi (MCW), FHH/EurMcwi (MDC), F344/NCrl (ICL), SS/Jr (ICL), HCR/2Mco (UMich), LCR/1Mco (UMich), LEW/NCrl (ICL), SR/JrHsd (ICL), WAG/Rij (ICL), WKY/NHsd (ICL), HCR/1Mco (UMich), LEW/Crl (ICL) View more Information

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:122
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000049493
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 9 of 9 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

1 to 9 of 9 rows



alimentary part of gastrointestinal system
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
reproductive system
respiratory system
1 1 1 3 4 3 2 1



Ensembl Acc Id: ENSRNOT00000049493   ⟹   ENSRNOP00000049336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl716,431,592 - 16,432,738 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105744   ⟹   ENSRNOP00000080166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl73,121,741 - 3,122,676 (-)Ensembl
RefSeq Acc Id: NM_001001386   ⟹   NP_001001386
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr873,770,753 - 3,771,688 (-)NCBI
mRatBN7.273,121,741 - 3,122,676 (-)NCBI
RGSC_v3.474,386,212 - 4,387,147 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264022   ⟹   XP_063120092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr873,765,256 - 3,771,688 (-)NCBI
Protein RefSeqs NP_001001386 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120092 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89102 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080166
  ENSRNOP00000080166.1
RefSeq Acc Id: NP_001001386   ⟸   NM_001001386
- UniProtKB: A0A8I5ZP76 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049336   ⟸   ENSRNOT00000049493
Ensembl Acc Id: ENSRNOP00000080166   ⟸   ENSRNOT00000105744
RefSeq Acc Id: XP_063120092   ⟸   XM_063264022
- Peptide Label: isoform X1
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWI5-F1-model_v2 AlphaFold D3ZWI5 1-313 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-35251 BioCyc
Ensembl Genes ENSRNOG00000033400 Ensembl
  ENSRNOG00000066966 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000105744 ENTREZGENE
  ENSRNOT00000105744.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfact_rcpt_6C-like UniProtKB/TrEMBL
KEGG Report rno:366802 UniProtKB/TrEMBL
NCBI Gene 366802 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 6C76 UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or6c76b PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033400 RatGTEx
  ENSRNOG00000066966 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I5ZP76 ENTREZGENE, UniProtKB/TrEMBL
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-06 Or6c76b  olfactory receptor family 6 subfamily C member 76B  Olr1056-ps  olfactory receptor pseudogene 1056  Data merged from RGD:1332917 737654 PROVISIONAL
2022-08-16 Or6c76b  olfactory receptor family 6 subfamily C member 76B  Olr932  olfactory receptor 932  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr932  olfactory receptor 932   Olr932_predicted  olfactory receptor 932 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr932_predicted  olfactory receptor 932 (predicted)      Symbol and Name status set to approved 70820 APPROVED
2005-02-04 Olr1056-ps  olfactory receptor pseudogene 1056      Symbol and Name status set to approved 70820 APPROVED