Or56b2b (olfactory receptor family 56 subfamily B member 2B) - Rat Genome Database

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Gene: Or56b2b (olfactory receptor family 56 subfamily B member 2B) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Or56b2b
Name: olfactory receptor family 56 subfamily B member 2B
RGD ID: 1333452
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be active in plasma membrane. Orthologous to human OR56B2 (olfactory receptor family 56 subfamily B member 2); INTERACTS WITH Cuprizon.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: LOC100910716; olfactory receptor 162; olfactory receptor gene Olr162; olfactory receptor Olr162; Olr162; putative olfactory receptor 56B2-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81168,368,859 - 168,369,818 (+)NCBIGRCr8
mRatBN7.21158,956,989 - 158,957,948 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1158,954,795 - 158,958,503 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1166,957,619 - 166,958,577 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01174,137,635 - 174,138,593 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01167,015,895 - 167,016,854 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01169,683,311 - 169,684,270 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1169,683,311 - 169,684,270 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01175,820,754 - 175,821,713 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41162,332,962 - 162,333,921 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11162,429,776 - 162,430,736 (+)NCBI
Celera1156,942,065 - 156,943,024 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or56b2bRatCuprizon decreases expressionEXP 6480464Cuprizone results in decreased expression of OR56B2B mRNACTDPMID:27523638


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or56b2bRatdetection of chemical stimulus involved in sensory perception of smell involved_inIEAGO:00049841600115GO_REF:0000108GOCGO_REF:0000108
Or56b2bRatdetection of chemical stimulus involved in sensory perception of smell  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or56b2bRatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or56b2bRatG protein-coupled receptor signaling pathway  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or56b2bRatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 and InterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or56b2bRatsensory perception of smell involved_inIEAUniProtKB-KW:KW-05521600115GO_REF:0000043UniProtGO_REF:0000043
Or56b2bRatsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or56b2bRatmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Or56b2bRatmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Or56b2bRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Or56b2bRatplasma membrane is_active_inIBAMGI:2157548 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or56b2bRatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or56b2bRatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Or56b2bRatolfactory receptor activity enablesIBAPANTHER:PTN002816874 and UniProtKB:Q9H2551600115GO_REF:0000033GO_CentralGO_REF:0000033
Or56b2bRatolfactory receptor activity  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or56b2bRatolfactory receptor activity enablesIEAInterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or56b2bRattaste/olfaction phenotype  IEA 1303377 RGD 

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


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Variants in Or56b2b
9 total Variants


Assembly: mRatBN7.2
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
1 158957883 158957884 C T snv PVG/Seac (2019) View more Information


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
1 162333509 162333510 G A snv FHL/EurMcwi (MCW), FHH/EurMcwi (MCW) View more Information


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
1 169683858 169683859 G A snv COP/CrCrl (MCW & UW), FHH/EurMcwi (MCW), FHL/EurMcwi (MCW) View more Information
1 169684205 169684206 C T snv PVG/Seac (2019) View more Information

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:92
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000075826, ENSRNOT00000075828
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 78 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat

1 to 10 of 78 rows



ectoderm
endocrine system
mesenchyme
mesoderm
nervous system
reproductive system
5 1 1 1 4 3


RefSeq Transcripts NM_001000950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC130613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000073194   ⟹   ENSRNOP00000064206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1158,954,795 - 158,958,503 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075826   ⟹   ENSRNOP00000066317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1169,683,311 - 169,684,270 (+)Ensembl
RefSeq Acc Id: NM_001000950   ⟹   NP_001000950
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,368,859 - 168,369,818 (+)NCBI
mRatBN7.21158,956,989 - 158,957,948 (+)NCBI
Rnor_6.01169,683,311 - 169,684,270 (+)NCBI
Rnor_5.01175,820,754 - 175,821,713 (+)NCBI
RGSC_v3.41162,332,962 - 162,333,921 (+)RGD
Celera1156,942,065 - 156,943,024 (+)RGD
Sequence:
Protein RefSeqs NP_001000950 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064206
  ENSRNOP00000064206.2
RefSeq Acc Id: NP_001000950   ⟸   NM_001000950
- UniProtKB: D3ZXX1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066317   ⟸   ENSRNOT00000075826
Ensembl Acc Id: ENSRNOP00000064206   ⟸   ENSRNOT00000073194
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-M0RB85-F1-model_v2 AlphaFold M0RB85 1-319 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-58078 BioCyc
Ensembl Genes ENSRNOG00000047589 Ensembl
  ENSRNOG00000065831 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000075923 ENTREZGENE
Ensembl Transcript ENSRNOT00000073194 ENTREZGENE
  ENSRNOT00000073194.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfactory_rcpt UniProtKB/TrEMBL
KEGG Report rno:405295 UniProtKB/TrEMBL
NCBI Gene 405295 ENTREZGENE
PANTHER OLFACTORY RECEPTOR 56B1-RELATED UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 56B2-RELATED UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or56b2b PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047589 RatGTEx
  ENSRNOG00000065831 RatGTEx
  ENSRNOG00000075923 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt D3ZXX1 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or56b2b  olfactory receptor family 56 subfamily B member 2B  Olr162  olfactory receptor 162  Symbol and Name Changed 1299863 APPROVED
2015-07-29 Olr162  olfactory receptor 162  LOC100910716  putative olfactory receptor 56B2-like  Data merged from RGD:6496982 737654 PROVISIONAL
2012-07-05 LOC100910716  putative olfactory receptor 56B2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Olr162  olfactory receptor 162   Olr162_predicted  olfactory receptor 162 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr162_predicted  olfactory receptor 162 (predicted)      Symbol and Name status set to approved 70820 APPROVED