Ext2 (exostosin glycosyltransferase 2)

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Gene: Ext2 (exostosin glycosyltransferase 2) Rattus norvegicus

Analyze

Symbol:

Ext2

Name:

exostosin glycosyltransferase 2

RGD ID:

1307707

Description:

Predicted to enable UDP-glycosyltransferase activity and protein dimerization activity. Predicted to be involved in glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; and ossification. Predicted to act upstream of or within with a positive effect on gene expression; protein N-linked glycosylation; and sulfation. Predicted to act upstream of or within several processes, including heparin biosynthetic process; multicellular organismal-level water homeostasis; and skeletal system development. Predicted to be located in endoplasmic reticulum. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Predicted to be active in Golgi apparatus. Orthologous to human EXT2 (exostosin glycosyltransferase 2); PARTICIPATES IN heparan sulfate biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; acrylamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

exostoses (multiple) 2; exostosin 2; exostosin-2; LOC311215

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EXT2 (exostosin glycosyltransferase 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ext2 (exostosin glycosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ext2 (exostosin glycosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EXT2 (exostosin glycosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EXT2 (exostosin glycosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ext2 (exostosin glycosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EXT2 (exostosin glycosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EXT2 (exostosin glycosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SAP130 (Sin3A associated protein 130)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	EXT2 (exostosin glycosyltransferase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ext2 (exostosin glycosyltransferase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ext2 (exostosin glycosyltransferase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	sotv	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ext2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	79,665,414 - 79,798,077 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	79,665,415 - 79,798,059 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	83,139,349 - 83,272,515 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	91,738,418 - 91,871,601 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	89,590,230 - 89,720,226 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	82,602,784 - 82,734,557 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	82,602,785 - 82,734,533 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	89,303,367 - 89,435,124 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	78,111,436 - 78,244,444 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	78,008,379 - 78,140,888 (-)	NCBI
Celera	3	78,867,721 - 79,000,170 (-)	NCBI		Celera
Cytogenetic Map	3	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

hepatoblastoma (ISO)

hereditary multiple exostoses (ISO,ISS)

Hereditary Neoplastic Syndromes (ISO)

intellectual disability (ISO)

Multiple Exostoses Type I (ISO)

Multiple Exostoses Type II (ISO)

Ollier disease (ISO)

Osteochondromatosis (ISO)

ovarian cancer (ISO)

SEIZURES, SCOLIOSIS, AND MACROCEPHALY SYNDROME (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cycloheximide (ISO)

cytarabine (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

dioxygen (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

fenthion (ISO)

folic acid (ISO)

indometacin (ISO)

methidathion (ISO)

paracetamol (EXP,ISO)

perfluorooctanoic acid (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulforaphane (ISO)

tamoxifen (ISO)

thapsigargin (ISO)

titanium dioxide (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to fibroblast growth factor stimulus (ISO)

chondrocyte differentiation (ISO)

endochondral bone morphogenesis (ISO)

fluid transport (ISO)

gene expression (ISO)

glycosaminoglycan biosynthetic process (ISO)

heart contraction (ISO)

heparan sulfate proteoglycan biosynthetic process (ISO)

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process (ISO)

heparin biosynthetic process (ISO)

mesoderm formation (ISO)

multicellular organismal-level water homeostasis (ISO)

ossification (ISO)

polysaccharide biosynthetic process (ISO)

protein N-linked glycosylation (ISO)

regulation of blood pressure (ISO)

sodium ion homeostasis (ISO)

sulfation (ISO)

vasodilation (ISO)

Cellular Component

catalytic complex (ISO)

endoplasmic reticulum (ISO)

Golgi apparatus (IBA,ISO)

UDP-N-acetylglucosamine transferase complex (ISO)

Molecular Function

acetylglucosaminyltransferase activity (IBA,ISO)

glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity (ISO)

glucuronosyltransferase activity (ISO)

glycosyltransferase activity (ISO)

N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity (IBA,ISO)

protein binding (ISO)

protein heterodimerization activity (ISO)

protein homodimerization activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

heparan sulfate biosynthetic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9326317	PMID:10639137	PMID:12477932	PMID:12907669	PMID:16236767	PMID:17761672	PMID:18337501	PMID:19199708	PMID:19946888	PMID:22339633

Genomics

Comparative Map Data

Ext2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	79,665,414 - 79,798,077 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	79,665,415 - 79,798,059 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	83,139,349 - 83,272,515 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	91,738,418 - 91,871,601 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	89,590,230 - 89,720,226 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	82,602,784 - 82,734,557 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	82,602,785 - 82,734,533 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	89,303,367 - 89,435,124 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	78,111,436 - 78,244,444 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	78,008,379 - 78,140,888 (-)	NCBI
Celera	3	78,867,721 - 79,000,170 (-)	NCBI		Celera
Cytogenetic Map	3	q31	NCBI

EXT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	44,095,678 - 44,251,962 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	44,095,648 - 44,251,962 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	44,117,228 - 44,273,512 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	44,073,675 - 44,223,556 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	44,073,674 - 44,223,555	NCBI
Celera	11	44,264,389 - 44,414,268 (+)	NCBI		Celera
Cytogenetic Map	11	p11.2	NCBI
HuRef	11	43,826,189 - 43,975,955 (+)	NCBI		HuRef
CHM1_1	11	44,116,142 - 44,266,006 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	44,251,025 - 44,407,303 (+)	NCBI		T2T-CHM13v2.0

Ext2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	93,525,978 - 93,652,913 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	93,491,373 - 93,652,913 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	93,695,631 - 93,822,568 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	93,661,028 - 93,822,568 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	93,535,788 - 93,662,725 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	93,496,472 - 93,623,384 (-)	NCBI		MGSCv36	mm8
Celera	2	95,099,313 - 95,226,251 (-)	NCBI		Celera
Cytogenetic Map	2	E1	NCBI
cM Map	2	51.62	NCBI

Ext2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	3,304,842 - 3,447,908 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	3,303,948 - 3,438,381 (-)	NCBI	ChiLan1.0	ChiLan1.0

EXT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	11	46,316,398 - 46,464,742 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	44,055,670 - 44,204,055 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	44,551,242 - 44,699,447 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	44,522,797 - 44,699,447 (+)	Ensembl	panpan1.1		panPan2

EXT2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	44,987,310 - 45,122,339 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	44,987,748 - 45,129,974 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	43,655,617 - 43,798,860 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	45,647,570 - 45,796,802 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	45,646,913 - 45,823,492 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	45,130,584 - 45,263,356 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	44,684,085 - 44,826,126 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	45,420,394 - 45,563,983 (-)	NCBI		UU_Cfam_GSD_1.0

Ext2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	22,233,504 - 22,377,538 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936562	4,342,874 - 4,489,180 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936562	4,345,146 - 4,489,180 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EXT2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	18,209,102 - 18,232,025 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	18,099,790 - 18,239,229 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	19,709,056 - 19,849,479 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EXT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	21,077,159 - 21,282,317 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	21,119,987 - 21,281,635 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	118,305,404 - 118,502,345 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Ext2
1031 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	86
Count of miRNA genes:	66
Interacting mature miRNAs:	76
Transcripts:	ENSRNOT00000012161
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	30356773	98535386	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	104104347	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	38517803	83517803	Rat
1331777	Bw24	Body weight QTL 24	3.503		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	89115240	Rat
1331795	Rf30	Renal function QTL 30	3.708		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	3	39454637	89115240	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	41874578	104104347	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	43827364	90905114	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	53184692	89878207	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	53781112	91609953	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
631200	Cm25	Cardiac mass QTL 25	4.8	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	3	61134348	89115068	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat

Markers in Region

D3Got227

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	79,711,874 - 79,712,004 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	82,648,687 - 82,648,816	NCBI	Rnor6.0
Rnor_5.0	3	89,349,269 - 89,349,398	UniSTS	Rnor5.0
RGSC_v3.4	3	78,157,963 - 78,158,092	UniSTS	RGSC3.4
Celera	3	78,913,947 - 78,914,076	UniSTS
Cytogenetic Map	3	q24	UniSTS

RH128252

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	79,665,467 - 79,665,672 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	82,602,838 - 82,603,042	NCBI	Rnor6.0
Rnor_5.0	3	89,303,420 - 89,303,624	UniSTS	Rnor5.0
RGSC_v3.4	3	78,111,489 - 78,111,693	UniSTS	RGSC3.4
Celera	3	78,867,774 - 78,867,978	UniSTS
RH 3.4 Map	3	686.8	UniSTS
Cytogenetic Map	3	q24	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	6	9	74	35	36	11	6
Low							2	2			5		2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001399506	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104913	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104914	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000012161 ⟹ ENSRNOP00000012161

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	79,665,415 - 79,798,059 (-)	Ensembl
Rnor_6.0 Ensembl	3	82,602,785 - 82,734,533 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000083743 ⟹ ENSRNOP00000075401

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	79,665,425 - 79,798,053 (-)	Ensembl
Rnor_6.0 Ensembl	3	82,602,786 - 82,734,520 (-)	Ensembl

RefSeq Acc Id:

NM_001107751 ⟹ NP_001101221

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	79,665,414 - 79,798,069 (-)	NCBI
Rnor_6.0	3	82,602,785 - 82,734,533 (-)	NCBI
Rnor_5.0	3	89,303,367 - 89,435,124 (-)	NCBI
RGSC_v3.4	3	78,111,436 - 78,244,444 (-)	RGD
Celera	3	78,867,721 - 79,000,170 (-)	RGD

Sequence:

show sequence

GTGTCAGACGTGGGGAACTGGAGGCCGGCGCAGCGTTCCCCGGCTGGCTCTGGCTTACCTGGTG
CTGGCGGCGGCCTCCCGTCACCGCGCGATCCGACACGGCCGTGGCTCGCGCCCCGCGCCCAAAG
CCGGTGGCGGAGCGCGGGGCCGAGCGGGAGGCGGCCGGTTCCGAGGTGTGTGAGGACGAGGACA
TCTGTGTCATTATGTGTGCGTCCGTCAAGTCCAACATCCGGGGTCCTGCCCTCATCCCAAGGAT
GAAGACCAAGCACCGGATCTACTACGTCACCCTGTTCTCCATCGTCCTCCTGGGCCTCATCGCC
ACTGGCATGTTTCAGTTCTGGCCTCACTCCATCGAGTCCTCCAGCGATGGGGGTGTGGAGAAAC
GCAGCATCCGGGAAGTGCCAGTGGTCAGGCTGACAGCTGACAGCCCTATCCCAGAGCGGGGGGA
TCTCAGCTGTAGAATGCACACGTGTTTCGATGTCTACCGCTGCGGCTTCAACCCAAAGAACAAA
ATCAAGGTGTACATCTACCCCCTAAAGAAGTACGTGGATGACGCCGGTGTTCCGGTGAGCAGCG
CCATCTCCCGGGAGTACAATGAACTGCTCACAGCCATCTCAGACAGTGACTACTACACAGATGA
CATCAGCCGAGCCTGTCTGTTCGTCCCCTCCATTGATGTGCTGAACCAGAACCCCCTTCGAATC
AAGGAGACAGCGCAAGCCCTGGCCCAGCTTCCCAGGTGGGATCGAGGGACAAATCACCTGCTGT
TCAACATGTTGCCTGGAGGTCCTCCAGATTACAACACTGCCCTGGATGTCCCCAGAGACAGGGC
ACTGCTGGCTGGTGGCGGCTTTTCTACCTGGACTTACCGGCAGGGCTACGATGTCAGCATTCCT
GTTTTCAGCCCACTGTCAGCCGAAGTGGCTCTCCCAGAGAAAGCACCAGGTTCCCGGCGATACT
TCCTGCTGTCCTCTCAGATGGCCATCCACCCTGAGTACAGAGAGGAACTAGAAGCCCTCCAGGC
CAAACACAGAGAGTCCGTGTTAGTCCTAGACAAATGCACCAATCTCTCAGAGGGCGTCCTTTCC
ATCCGAAAGCGCTGCCACCAGCACCAGGTCTTTGATTACCCCCAAGTACTGCAGGAGGCTACTT
TTTGTACGGTTCTTCGAGGAGCTCGGCTGGGCCAGGCAGTGCTGAGCGATGTCTTACAGGCTGG
CTGTGTCCCAGTTGTCATTGCAGACTCTTACATTCTGCCTTTCTCTGAAGTTCTGGACTGGAAG
AGGGCATCTGTGGTCATTCCAGAGGAGAAGATGTCAGATGTGTACAGCATCCTGCAGAACATCC
CACAGAGGCAGATTGAAGAGATGCAGAGACAGGCACGATGGTTCTGGGAGGCATACTTTCGGTC
CATTAAAGCCATCGCCCTGGCCACCCTACAGATCATCAATGACAGGATCTATCCATATGCAGCC
ATTTCCTATGAAGAGTGGAATGACCCTCCTGCTGTGAAGTGGGCTAGTGTGAGCAACCCGCTCT
TCCTCCCACTGATCCCACCACAGTCGCAAGGCTTCACTGCCATTGTCCTCACCTATGACCGTGT
GGAGAGCCTCTTCCGGGTCATCACCGAGGTGTCCAAGGTGCCCAGTCTGTCCAAGCTGCTGGTG
GTCTGGAATAATCAGAATAAAAACCCTCCAGAAGAATCTCTGTGGCCCAAAATCCGTGTTCCCC
TGAAGGTTGTGAGGACTGCAGAAAACAAGCTAAGTAATCGTTTCTTCCCTTACGATGAAATCGA
GACAGAGGCCGTGCTGGCCATCGATGATGATATCATCATGCTGACCTCTGATGAGCTGCAGTTT
GGTTATGAGTATTTTAATTACCTGTATACCTACAAAATGCCTGGGGACATCAAGAACTGGGTAG
ATGCTCACATGAACTGTGAAGATATTGCCATGAATTTCCTAGTGGCCAATGTCACAGGGAAAGC
TGTCATCAAGGTAACCCCAAGAAAGAAGTTCAAGTGTCCTGAGTGCACAGCCATCGACGGACTC
TCACTAGACCAGACTCACATGGTAGAGAGGTCTGAGTGCATCAATAAGTTTGCTTCCGTCTTCG
GAACGATGCCCCTCAAGGTGGTGGAGCACCGAGCAGACCCTGTACTCTACAAAGATGACTTCCC
TGAGAAACTGAAGAGTTTCCCCAACATCGGCAGCTTGTGAGCTCACCGGTTCCCAGGGCTGTGG
AGGAGCCCTACAACATTCACGGTGGGGGTGAGGAGGCCAGCCTGGCTCAGACTTCCCCAAACAC
ACTGGAGCCTCTTGAGCTATGAGCCCTGCTTTGTCCTCTCATCTCCGTGGACTCTGAAAATGCC
AAAGGAAGGGAGCCTCAGGGACAAGCTGCAGCTTGGAGCCCAGCCTATCGCTCTTGGGTTGCCA
ACCCAGCTCACCATCTCACTGACCCTGCAGCTGCCTCAGAGGGTCAGCTGTCCAGCTCCAGATC
CCAGGAGTCACAGCAGAGGCATGCGATTGTTTCACATCTGCAGACTCTGGGGAAATGGCAAACC
TCAAACGTGCTACAGATCCCAGTACCTCTGAGGGTTAGAACTGTGCTTGGGACCCGAGTCATGA
GCCCAAGTACACAGCAGAGCACACGCTGCCAAGATGTGTCCTGACAGTCCCTGAACAAGTCTTT
GTTTTGGCTTTTTGATATGGTTAAAATTATTTTTTACTCCTTTT

hide sequence

RefSeq Acc Id:

NM_001399506 ⟹ NP_001386435

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	79,665,414 - 79,798,069 (-)	NCBI

RefSeq Acc Id:

XM_039104913 ⟹ XP_038960841

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	79,665,415 - 79,798,073 (-)	NCBI

RefSeq Acc Id:

XM_039104914 ⟹ XP_038960842

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	79,733,247 - 79,798,077 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101221	(Get FASTA)	NCBI Sequence Viewer
	NP_001386435	(Get FASTA)	NCBI Sequence Viewer
	XP_038960841	(Get FASTA)	NCBI Sequence Viewer
	XP_038960842	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66748	(Get FASTA)	NCBI Sequence Viewer
	EDL79595	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001101221 ⟸ NM_001107751
- Peptide Label:	isoform 2
- UniProtKB:	E9PTT2 (UniProtKB/TrEMBL), A6HNJ4 (UniProtKB/TrEMBL), B2RYE4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MCASVKSNIRGPALIPRMKTKHRIYYVTLFSIVLLGLIATGMFQFWPHSIESSSDGGVEKRSIR EVPVVRLTADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYPLKKYVDDAGVPVSSAISR EYNELLTAISDSDYYTDDISRACLFVPSIDVLNQNPLRIKETAQALAQLPRWDRGTNHLLFNML PGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVFSPLSAEVALPEKAPGSRRYFLLS SQMAIHPEYREELEALQAKHRESVLVLDKCTNLSEGVLSIRKRCHQHQVFDYPQVLQEATFCTV LRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVIPEEKMSDVYSILQNIPQRQ IEEMQRQARWFWEAYFRSIKAIALATLQIINDRIYPYAAISYEEWNDPPAVKWASVSNPLFLPL IPPQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEESLWPKIRVPLKVV RTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEYFNYLYTYKMPGDIKNWVDAHM NCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMP LKVVEHRADPVLYKDDFPEKLKSFPNIGSL hide sequence

RefSeq Acc Id:

ENSRNOP00000012161 ⟸ ENSRNOT00000012161

RefSeq Acc Id:

ENSRNOP00000075401 ⟸ ENSRNOT00000083743

RefSeq Acc Id:	XP_038960841 ⟸ XM_039104913
- Peptide Label:	isoform X2
- UniProtKB:	A0A0G2KAH7 (UniProtKB/TrEMBL), B2RYE4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038960842 ⟸ XM_039104914
- Peptide Label:	isoform X3

RefSeq Acc Id:	NP_001386435 ⟸ NM_001399506
- Peptide Label:	isoform 1
- UniProtKB:	A0A0G2KAH7 (UniProtKB/TrEMBL), B2RYE4 (UniProtKB/TrEMBL)

Protein Domains

Exostosin GT47 Glycosyl transferase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2KAH7-F1-model_v2	AlphaFold	A0A0G2KAH7	1-718	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307707	AgrOrtholog
BioCyc Gene	G2FUF-48666	BioCyc
Ensembl Genes	ENSRNOG00000008944	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000012161	ENTREZGENE
	ENSRNOP00000012161.5	UniProtKB/TrEMBL
	ENSRNOP00000075401	ENTREZGENE
	ENSRNOP00000075401.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000012161	ENTREZGENE
	ENSRNOT00000012161.8	UniProtKB/TrEMBL
	ENSRNOT00000083743	ENTREZGENE
	ENSRNOT00000083743.2	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5599208	IMAGE-MGC_LOAD
InterPro	Exostosin	UniProtKB/TrEMBL
	Exostosin_GT47	UniProtKB/TrEMBL
	HexNAc_Trfase_a	UniProtKB/TrEMBL
	Nucleotide-diphossugar_trans	UniProtKB/TrEMBL
KEGG Report	rno:311215	UniProtKB/TrEMBL
MGC_CLONE	MGC:188484	IMAGE-MGC_LOAD
NCBI Gene	311215	ENTREZGENE
PANTHER	ACETYLGLUCOSAMINYLTRANSFERASE	UniProtKB/TrEMBL
	ACETYLGLUCOSAMINYLTRANSFERASE	UniProtKB/TrEMBL
Pfam	Exostosin	UniProtKB/TrEMBL
	Glyco_transf_64	UniProtKB/TrEMBL
PhenoGen	Ext2	PhenoGen
Superfamily-SCOP	SSF53448	UniProtKB/TrEMBL
UniProt	A0A0G2KAH7	ENTREZGENE, UniProtKB/TrEMBL
	A6HNJ4	ENTREZGENE, UniProtKB/TrEMBL
	B2RYE4	ENTREZGENE, UniProtKB/TrEMBL
	E9PTT2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-03-20	Ext2	exostosin glycosyltransferase 2	Ext2	exostosin 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-16	Ext2	exostosin 2	Ext2	exostoses (multiple) 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Ext2	exostoses (multiple) 2	Ext2_predicted	exostoses (multiple) 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Ext2_predicted	exostoses (multiple) 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)