Dync1i2 (dynein cytoplasmic 1 intermediate chain 2) - Rat Genome Database

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Gene: Dync1i2 (dynein cytoplasmic 1 intermediate chain 2) Rattus norvegicus
Analyze
Symbol: Dync1i2
Name: dynein cytoplasmic 1 intermediate chain 2
RGD ID: 620174
Description: Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in cellular response to nerve growth factor stimulus and negative regulation of neuron projection development. Predicted to be located in centrosome; microtubule; and vesicle. Predicted to be part of cytoplasmic dynein complex and outer dynein arm. Orthologous to human DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2); PARTICIPATES IN mitochondria transport pathway; phagocytosis pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytoplasmic dynein 1 intermediate chain 2; cytoplasmic dynein intermediate chain 2; DH IC-2; Dnci2; Dncic2; dynein intermediate chain 2, cytosolic; dynein, cytoplasmic, intermediate chain 2; dynein, cytoplasmic, intermediate polypeptide 2; MGC93277; oncofetal protein (OFP)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8376,441,621 - 76,492,782 (+)NCBIGRCr8
mRatBN7.2356,033,882 - 56,085,080 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl356,033,917 - 56,085,080 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx359,431,604 - 59,482,847 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0368,015,213 - 68,066,454 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0365,777,439 - 65,828,519 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0357,817,677 - 57,868,854 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl357,817,693 - 57,868,854 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0364,314,254 - 64,364,653 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4353,480,918 - 53,533,222 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1353,377,289 - 53,429,594 (+)NCBI
Celera355,581,617 - 55,633,089 (+)NCBICelera
Cytogenetic Map3q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA,ISO)
cytoplasm  (IEA)
cytoplasmic dynein complex  (IBA,IEA)
dynein complex  (ISO)
microtubule  (IEA,ISO)
outer dynein arm  (ISO)
vesicle  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cytoplasmic dynein. Allan VJ, Biochem Soc Trans. 2011 Oct;39(5):1169-78. doi: 10.1042/BST0391169.
2. Live cell imaging reveals differential modifications to cytoplasmic dynein properties by phospho- and dephosphomimic mutations of the intermediate chain 2C S84. Blasier KR, etal., J Neurosci Res. 2014 Sep;92(9):1143-54. doi: 10.1002/jnr.23388. Epub 2014 May 5.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Integrated proteomics identified novel activation of dynein IC2-GR-COX-1 signaling in neurofibromatosis type I (NF1) disease model cells. Hirayama M, etal., Mol Cell Proteomics. 2013 May;12(5):1377-94. doi: 10.1074/mcp.M112.024802. Epub 2013 Jan 28.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Identification and developmental regulation of a neuron-specific subunit of cytoplasmic dynein. Pfister KK, etal., Mol Biol Cell. 1996 Feb;7(2):331-43.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Growth factor regulation of cytoplasmic dynein intermediate chain subunit expression preceding neurite extension. Salata MW, etal., J Neurosci Res. 2001 Sep 1;65(5):408-16.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued. Vaughan KT and Vallee RB, J Cell Biol 1995 Dec;131(6 Pt 1):1507-16.
Additional References at PubMed
PMID:20682791   PMID:21399614   PMID:21525035   PMID:23836931   PMID:25002582   PMID:27353389  


Genomics

Comparative Map Data
Dync1i2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8376,441,621 - 76,492,782 (+)NCBIGRCr8
mRatBN7.2356,033,882 - 56,085,080 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl356,033,917 - 56,085,080 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx359,431,604 - 59,482,847 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0368,015,213 - 68,066,454 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0365,777,439 - 65,828,519 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0357,817,677 - 57,868,854 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl357,817,693 - 57,868,854 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0364,314,254 - 64,364,653 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4353,480,918 - 53,533,222 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1353,377,289 - 53,429,594 (+)NCBI
Celera355,581,617 - 55,633,089 (+)NCBICelera
Cytogenetic Map3q22NCBI
DYNC1I2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382171,687,469 - 171,750,158 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2171,687,409 - 171,750,158 (+)EnsemblGRCh38hg38GRCh38
GRCh372172,543,979 - 172,606,668 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362172,252,228 - 172,313,165 (+)NCBINCBI36Build 36hg18NCBI36
Build 342172,369,488 - 172,430,426NCBI
Celera2166,160,554 - 166,221,488 (+)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2164,429,292 - 164,492,025 (+)NCBIHuRef
CHM1_12172,550,676 - 172,613,534 (+)NCBICHM1_1
T2T-CHM13v2.02172,164,878 - 172,227,564 (+)NCBIT2T-CHM13v2.0
Dync1i2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39271,041,999 - 71,093,647 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl271,042,050 - 71,093,647 (+)EnsemblGRCm39 Ensembl
GRCm38271,211,676 - 71,263,303 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl271,211,706 - 71,263,303 (+)EnsemblGRCm38mm10GRCm38
MGSCv37271,050,070 - 71,101,351 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36271,012,852 - 71,064,133 (+)NCBIMGSCv36mm8
Celera272,870,734 - 72,922,164 (+)NCBICelera
Cytogenetic Map2C2NCBI
cM Map242.38NCBI
Dync1i2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554493,204,839 - 3,256,059 (-)NCBIChiLan1.0ChiLan1.0
DYNC1I2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21374,364,029 - 74,424,938 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B74,379,007 - 74,441,659 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B58,977,379 - 59,039,514 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B176,436,442 - 176,498,638 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B176,436,471 - 176,498,638 (+)Ensemblpanpan1.1panPan2
DYNC1I2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13616,103,480 - 16,163,232 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3616,103,751 - 16,162,215 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3616,113,452 - 16,173,236 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03616,224,349 - 16,284,203 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3616,224,362 - 16,284,112 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13616,311,937 - 16,372,018 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03616,311,893 - 16,371,695 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03616,414,689 - 16,474,496 (+)NCBIUU_Cfam_GSD_1.0
Dync1i2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303133,361,095 - 133,415,960 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365091,914,893 - 1,973,943 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365091,915,006 - 1,969,857 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYNC1I2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1577,803,350 - 77,860,041 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11577,803,601 - 77,859,559 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21587,190,717 - 87,246,863 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DYNC1I2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11057,182,245 - 57,242,359 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1057,182,220 - 57,244,510 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040142,304,754 - 142,365,418 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dync1i2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247879,103,271 - 9,167,043 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247879,103,392 - 9,164,695 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dync1i2
205 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:723
Count of miRNA genes:157
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000013400, ENSRNOT00000047243, ENSRNOT00000067729
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35318459364655484Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat

Markers in Region
RH134802  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2356,084,688 - 56,084,897 (+)MAPPERmRatBN7.2
Rnor_6.0357,868,463 - 57,868,671NCBIRnor6.0
Rnor_5.0364,364,262 - 64,364,470UniSTSRnor5.0
RGSC_v3.4353,532,841 - 53,533,049UniSTSRGSC3.4
Celera355,632,698 - 55,632,906UniSTS
Cytogenetic Map3q21UniSTS
RH135346  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2356,084,461 - 56,084,675 (+)MAPPERmRatBN7.2
Rnor_6.0357,868,236 - 57,868,449NCBIRnor6.0
Rnor_5.0364,364,035 - 64,364,248UniSTSRnor5.0
RGSC_v3.4353,532,614 - 53,532,827UniSTSRGSC3.4
Celera355,632,471 - 55,632,684UniSTS
Cytogenetic Map3q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB733957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM076575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM110655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U39044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U39045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U39046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000013400   ⟹   ENSRNOP00000013400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl356,033,926 - 56,085,058 (+)Ensembl
Rnor_6.0 Ensembl357,817,693 - 57,868,854 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000047243   ⟹   ENSRNOP00000042414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl356,033,917 - 56,085,080 (+)Ensembl
Rnor_6.0 Ensembl357,817,693 - 57,868,854 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000067729   ⟹   ENSRNOP00000060919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl356,033,917 - 56,085,080 (+)Ensembl
Rnor_6.0 Ensembl357,817,693 - 57,868,854 (+)Ensembl
RefSeq Acc Id: NM_001270624   ⟹   NP_001257553
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,621 - 76,492,782 (+)NCBI
mRatBN7.2356,033,917 - 56,085,080 (+)NCBI
Rnor_6.0357,817,693 - 57,868,854 (+)NCBI
Rnor_5.0364,314,254 - 64,364,653 (+)NCBI
Celera355,581,617 - 55,633,089 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270625   ⟹   NP_001257554
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,621 - 76,492,782 (+)NCBI
mRatBN7.2356,033,917 - 56,085,080 (+)NCBI
Rnor_6.0357,817,693 - 57,868,854 (+)NCBI
Rnor_5.0364,314,254 - 64,364,653 (+)NCBI
Celera355,581,617 - 55,633,089 (+)NCBI
Sequence:
RefSeq Acc Id: NM_053880   ⟹   NP_446332
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,621 - 76,492,782 (+)NCBI
mRatBN7.2356,033,917 - 56,085,080 (+)NCBI
Rnor_6.0357,817,693 - 57,868,854 (+)NCBI
Rnor_5.0364,314,254 - 64,364,653 (+)NCBI
RGSC_v3.4353,480,918 - 53,533,222 (+)RGD
Celera355,581,617 - 55,633,089 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234344   ⟹   XP_006234406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,653 - 76,492,769 (+)NCBI
mRatBN7.2356,033,882 - 56,084,766 (+)NCBI
Rnor_6.0357,817,678 - 57,868,671 (+)NCBI
Rnor_5.0364,314,254 - 64,364,653 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234346   ⟹   XP_006234408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,651 - 76,492,769 (+)NCBI
mRatBN7.2356,033,883 - 56,084,766 (+)NCBI
Rnor_6.0357,817,679 - 57,868,671 (+)NCBI
Rnor_5.0364,314,254 - 64,364,653 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591432   ⟹   XP_017446921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,720 - 76,492,769 (+)NCBI
mRatBN7.2356,033,918 - 56,084,766 (+)NCBI
Rnor_6.0357,817,677 - 57,868,671 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104115   ⟹   XP_038960043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,653 - 76,492,769 (+)NCBI
mRatBN7.2356,033,882 - 56,084,766 (+)NCBI
RefSeq Acc Id: XM_063283000   ⟹   XP_063139070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,698 - 76,492,769 (+)NCBI
RefSeq Acc Id: XM_063283001   ⟹   XP_063139071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,720 - 76,492,769 (+)NCBI
RefSeq Acc Id: XM_063283002   ⟹   XP_063139072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,720 - 76,492,769 (+)NCBI
RefSeq Acc Id: XM_063283003   ⟹   XP_063139073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,720 - 76,492,769 (+)NCBI
RefSeq Acc Id: XM_063283004   ⟹   XP_063139074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,720 - 76,492,769 (+)NCBI
RefSeq Acc Id: XM_063283005   ⟹   XP_063139075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,720 - 76,492,769 (+)NCBI
RefSeq Acc Id: XM_063283006   ⟹   XP_063139076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,653 - 76,492,769 (+)NCBI
RefSeq Acc Id: XM_063283007   ⟹   XP_063139077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,653 - 76,492,769 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001257553 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257554 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416634 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416635 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416636 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416637 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416638 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416639 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416640 (Get FASTA)   NCBI Sequence Viewer  
  NP_446332 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234406 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234408 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446921 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960043 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139070 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139071 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139072 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139073 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139074 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139075 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139076 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139077 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA89163 (Get FASTA)   NCBI Sequence Viewer  
  AAA89164 (Get FASTA)   NCBI Sequence Viewer  
  AAA89165 (Get FASTA)   NCBI Sequence Viewer  
  AAH78764 (Get FASTA)   NCBI Sequence Viewer  
  CAA39610 (Get FASTA)   NCBI Sequence Viewer  
  EDL79094 (Get FASTA)   NCBI Sequence Viewer  
  EDL79095 (Get FASTA)   NCBI Sequence Viewer  
  EDL79096 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013400
  ENSRNOP00000013400.4
  ENSRNOP00000042414
  ENSRNOP00000042414.2
  ENSRNOP00000060919
  ENSRNOP00000060919.3
GenBank Protein Q62871 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446332   ⟸   NM_053880
- Peptide Label: isoform 1
- UniProtKB: Q62873 (UniProtKB/Swiss-Prot),   Q62872 (UniProtKB/Swiss-Prot),   Q62871 (UniProtKB/Swiss-Prot),   G3V9V3 (UniProtKB/TrEMBL),   A6HM43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257553   ⟸   NM_001270624
- Peptide Label: isoform 2
- UniProtKB: Q62873 (UniProtKB/Swiss-Prot),   Q62872 (UniProtKB/Swiss-Prot),   Q62871 (UniProtKB/Swiss-Prot),   Q6AZ35 (UniProtKB/TrEMBL),   A6HM44 (UniProtKB/TrEMBL),   F7FJ03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257554   ⟸   NM_001270625
- Peptide Label: isoform 3
- UniProtKB: Q62873 (UniProtKB/Swiss-Prot),   Q62872 (UniProtKB/Swiss-Prot),   Q62871 (UniProtKB/Swiss-Prot),   D3ZU74 (UniProtKB/TrEMBL),   A6HM45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234406   ⟸   XM_006234344
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006234408   ⟸   XM_006234346
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017446921   ⟸   XM_017591432
- Peptide Label: isoform X1
- UniProtKB: Q62873 (UniProtKB/Swiss-Prot),   Q62872 (UniProtKB/Swiss-Prot),   Q62871 (UniProtKB/Swiss-Prot),   G3V9V3 (UniProtKB/TrEMBL),   A6HM43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060919   ⟸   ENSRNOT00000067729
RefSeq Acc Id: ENSRNOP00000013400   ⟸   ENSRNOT00000013400
RefSeq Acc Id: ENSRNOP00000042414   ⟸   ENSRNOT00000047243
RefSeq Acc Id: XP_038960043   ⟸   XM_039104115
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063139076   ⟸   XM_063283006
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063139077   ⟸   XM_063283007
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063139070   ⟸   XM_063283000
- Peptide Label: isoform X2
- UniProtKB: Q62873 (UniProtKB/Swiss-Prot),   Q62872 (UniProtKB/Swiss-Prot),   Q62871 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063139073   ⟸   XM_063283003
- Peptide Label: isoform X5
- UniProtKB: Q62873 (UniProtKB/Swiss-Prot),   Q62872 (UniProtKB/Swiss-Prot),   Q62871 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063139071   ⟸   XM_063283001
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063139072   ⟸   XM_063283002
- Peptide Label: isoform X4
- UniProtKB: Q62873 (UniProtKB/Swiss-Prot),   Q62872 (UniProtKB/Swiss-Prot),   Q62871 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063139074   ⟸   XM_063283004
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063139075   ⟸   XM_063283005
- Peptide Label: isoform X7
- UniProtKB: Q62873 (UniProtKB/Swiss-Prot),   Q62872 (UniProtKB/Swiss-Prot),   Q62871 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62871-F1-model_v2 AlphaFold Q62871 1-638 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692134
Promoter ID:EPDNEW_R2658
Type:initiation region
Name:Dync1i2_1
Description:dynein cytoplasmic 1 intermediate chain 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2659  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0357,817,745 - 57,817,805EPDNEW
RGD ID:13692135
Promoter ID:EPDNEW_R2659
Type:multiple initiation site
Name:Dync1i2_2
Description:dynein cytoplasmic 1 intermediate chain 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2658  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0357,817,939 - 57,817,999EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620174 AgrOrtholog
BioCyc Gene G2FUF-49473 BioCyc
Ensembl Genes ENSRNOG00000009781 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013400 ENTREZGENE
  ENSRNOT00000013400.7 UniProtKB/TrEMBL
  ENSRNOT00000047243 ENTREZGENE
  ENSRNOT00000047243.5 UniProtKB/TrEMBL
  ENSRNOT00000067729 ENTREZGENE
  ENSRNOT00000067729.5 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7113840 IMAGE-MGC_LOAD
InterPro DYNC1I1/DYNC1I2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116659 UniProtKB/TrEMBL
MGC_CLONE MGC:93277 IMAGE-MGC_LOAD
NCBI Gene 116659 ENTREZGENE
PANTHER CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DYNEIN INTERMEDIATE CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Dynein_IC2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dync1i2 PhenoGen
PROSITE WD_REPEATS_2 UniProtKB/Swiss-Prot
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009781 RatGTEx
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HM43 ENTREZGENE, UniProtKB/TrEMBL
  A6HM44 ENTREZGENE, UniProtKB/TrEMBL
  A6HM45 ENTREZGENE, UniProtKB/TrEMBL
  D3ZU74 ENTREZGENE, UniProtKB/TrEMBL
  DC1I2_RAT UniProtKB/Swiss-Prot
  F7FJ03 ENTREZGENE, UniProtKB/TrEMBL
  G3V9V3 ENTREZGENE, UniProtKB/TrEMBL
  Q62871 ENTREZGENE
  Q62872 ENTREZGENE
  Q62873 ENTREZGENE
  Q6AZ35 ENTREZGENE
UniProt Secondary Q62872 UniProtKB/Swiss-Prot
  Q62873 UniProtKB/Swiss-Prot
  Q6AZ35 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-19 Dync1i2  dynein cytoplasmic 1 intermediate chain 2  Dncic2  dynein, cytoplasmic, intermediate chain 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Dncic2  dynein, cytoplasmic, intermediate chain 2    dynein, cytoplasmic, intermediate polypeptide 2  Name updated 1299863 APPROVED
2004-01-09 Dncic2    Dnci2  dynein, cytoplasmic, intermediate polypeptide 2  Symbol updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 Dnci2  dynein, cytoplasmic, intermediate polypeptide 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function may bind organelles via interaction with the p150Glued doublet of the dynactic complex 728206
gene_physical_interaction binds with p150Glued via aa 1-123 of dncic2 and aa 200-811 of p150Glued 728206