Fap (fibroblast activation protein, alpha) - Rat Genome Database

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Gene: Fap (fibroblast activation protein, alpha) Rattus norvegicus
Analyze
Symbol: Fap
Name: fibroblast activation protein, alpha
RGD ID: 621253
Description: Predicted to enable several functions, including integrin binding activity; peptidase activity; and protein homodimerization activity. Predicted to be involved in several processes, including melanocyte apoptotic process; melanocyte proliferation; and negative regulation of cell proliferation involved in contact inhibition. Predicted to be located in several cellular components, including basal part of cell; cell surface; and lamellipodium. Predicted to be part of peptidase complex. Orthologous to human FAP (fibroblast activation protein alpha); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: fibroblast activation protein; prolyl endopeptidase FAP; seprase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2347,138,823 - 47,207,671 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl347,138,813 - 47,225,545 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx350,493,843 - 50,562,306 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0359,077,377 - 59,145,833 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0356,850,389 - 56,919,037 (-)NCBIRnor_WKY
Rnor_6.0348,467,781 - 48,536,242 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl348,467,781 - 48,536,235 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0355,133,418 - 55,201,844 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4344,457,151 - 44,525,602 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1344,353,522 - 44,421,639 (-)NCBI
Celera346,780,390 - 46,848,693 (-)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Structural requirements for catalysis, expression, and dimerization in the CD26/DPIV gene family. Ajami K, etal., Biochemistry 2003 Jan 28;42(3):694-701.
2. Upregulated expression and activation of membrane‚ÄĎassociated proteases in esophageal squamous cell carcinoma. Augoff K, etal., Oncol Rep. 2014 Jun;31(6):2820-6. doi: 10.3892/or.2014.3162. Epub 2014 Apr 29.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic Impact and Their Correlations with Tumor Molecular Markers. Kilvaer TK, etal., PLoS One. 2015 Aug 7;10(8):e0134965. doi: 10.1371/journal.pone.0134965. eCollection 2015.
6. Tissue analyses reveal a potential immune-adjuvant function of FAP-1 positive fibroblasts in non-small cell lung cancer. Kilvaer TK, etal., PLoS One. 2018 Feb 7;13(2):e0192157. doi: 10.1371/journal.pone.0192157. eCollection 2018.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9065413   PMID:9688278   PMID:10455171   PMID:10593948   PMID:12477932   PMID:15133496   PMID:16651416   PMID:17317851   PMID:19219682   PMID:21423176   PMID:24038871   PMID:26319660  


Genomics

Comparative Map Data
Fap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2347,138,823 - 47,207,671 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl347,138,813 - 47,225,545 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx350,493,843 - 50,562,306 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0359,077,377 - 59,145,833 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0356,850,389 - 56,919,037 (-)NCBIRnor_WKY
Rnor_6.0348,467,781 - 48,536,242 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl348,467,781 - 48,536,235 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0355,133,418 - 55,201,844 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4344,457,151 - 44,525,602 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1344,353,522 - 44,421,639 (-)NCBI
Celera346,780,390 - 46,848,693 (-)NCBICelera
Cytogenetic Map3q21NCBI
FAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382162,170,684 - 162,243,445 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2162,170,684 - 162,245,151 (-)EnsemblGRCh38hg38GRCh38
GRCh372163,027,194 - 163,099,955 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362162,735,446 - 162,808,291 (-)NCBINCBI36Build 36hg18NCBI36
Build 342162,852,708 - 162,925,552NCBI
Celera2156,637,516 - 156,710,361 (-)NCBICelera
Cytogenetic Map2q24.2NCBI
HuRef2154,909,562 - 154,982,406 (-)NCBIHuRef
CHM1_12163,033,090 - 163,105,931 (-)NCBICHM1_1
T2T-CHM13v2.02162,627,338 - 162,700,099 (-)NCBIT2T-CHM13v2.0
Fap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39262,331,280 - 62,404,365 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl262,331,287 - 62,404,419 (-)EnsemblGRCm39 Ensembl
GRCm38262,500,936 - 62,575,509 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl262,500,943 - 62,574,075 (-)EnsemblGRCm38mm10GRCm38
MGSCv37262,339,002 - 62,412,078 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36262,301,784 - 62,374,860 (-)NCBIMGSCv36mm8
Celera264,191,101 - 64,264,176 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map235.85NCBI
Fap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544911,623,741 - 11,694,335 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544911,623,838 - 11,694,256 (+)NCBIChiLan1.0ChiLan1.0
FAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B166,832,669 - 166,905,515 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B166,832,963 - 166,904,950 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B49,464,199 - 49,537,284 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1367,574,364 - 7,647,448 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl367,575,161 - 7,647,226 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha367,718,907 - 7,791,280 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0367,706,897 - 7,779,228 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl367,706,899 - 7,778,929 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1367,725,598 - 7,797,918 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0367,766,525 - 7,838,827 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0367,874,009 - 7,946,310 (-)NCBIUU_Cfam_GSD_1.0
Fap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303124,728,654 - 124,802,072 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646916,817,232 - 16,888,773 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493646916,817,000 - 16,889,066 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1568,830,730 - 68,902,379 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11568,831,281 - 68,902,416 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21576,323,040 - 76,394,182 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11047,578,164 - 47,652,179 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1047,577,888 - 47,652,689 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040151,875,647 - 151,947,663 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247323,275,025 - 3,345,977 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247323,273,339 - 3,346,207 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fap
471 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:191
Count of miRNA genes:137
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000008148
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)32749462150302886Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)33819223350749747Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)33871036550302886Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)33945463753296578Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat

Markers in Region
RH143611  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2347,138,850 - 47,138,974 (+)MAPPERmRatBN7.2
Rnor_6.0348,467,569 - 48,467,692NCBIRnor6.0
Rnor_5.0355,133,206 - 55,133,329UniSTSRnor5.0
RGSC_v3.4344,456,939 - 44,457,062UniSTSRGSC3.4
Celera346,780,178 - 46,780,301UniSTS
RH 3.4 Map3605.0UniSTS
Cytogenetic Map3q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 4 4 23 4
Low 3 26 13 2 19 2 4 7 72 25 18 10 4
Below cutoff 2 39 34 34 2 9 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008148   ⟹   ENSRNOP00000008148
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl347,138,813 - 47,225,545 (-)Ensembl
Rnor_6.0 Ensembl348,467,781 - 48,535,909 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083536   ⟹   ENSRNOP00000070543
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl347,177,592 - 47,207,193 (-)Ensembl
Rnor_6.0 Ensembl348,503,525 - 48,536,235 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096836   ⟹   ENSRNOP00000091534
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl347,138,813 - 47,207,193 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104439   ⟹   ENSRNOP00000078725
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl347,138,813 - 47,225,545 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106269   ⟹   ENSRNOP00000082041
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl347,138,813 - 47,225,545 (-)Ensembl
RefSeq Acc Id: NM_138850   ⟹   NP_620205
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2347,139,063 - 47,207,526 (-)NCBI
Rnor_6.0348,467,781 - 48,536,242 (-)NCBI
Rnor_5.0355,133,418 - 55,201,844 (-)NCBI
RGSC_v3.4344,457,151 - 44,525,602 (-)RGD
Celera346,780,390 - 46,848,693 (-)RGD
Sequence:
RefSeq Acc Id: XM_039104225   ⟹   XP_038960153
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2347,138,823 - 47,207,671 (-)NCBI
RefSeq Acc Id: XM_039104226   ⟹   XP_038960154
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2347,138,823 - 47,207,671 (-)NCBI
Protein Sequences
Protein RefSeqs NP_620205 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960153 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960154 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61713 (Get FASTA)   NCBI Sequence Viewer  
  AAM11677 (Get FASTA)   NCBI Sequence Viewer  
  EDL79010 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_620205   ⟸   NM_138850
- UniProtKB: Q8R492 (UniProtKB/TrEMBL),   F1LMH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008148   ⟸   ENSRNOT00000008148
RefSeq Acc Id: ENSRNOP00000070543   ⟸   ENSRNOT00000083536
RefSeq Acc Id: XP_038960154   ⟸   XM_039104226
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038960153   ⟸   XM_039104225
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000078725   ⟸   ENSRNOT00000104439
RefSeq Acc Id: ENSRNOP00000091534   ⟸   ENSRNOT00000096836
RefSeq Acc Id: ENSRNOP00000082041   ⟸   ENSRNOT00000106269
Protein Domains
DPPIV_N   Peptidase_S9

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LMH7-F1-model_v2 AlphaFold F1LMH7 1-760 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692104
Promoter ID:EPDNEW_R2625
Type:initiation region
Name:Fap_1
Description:fibroblast activation protein, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0348,536,316 - 48,536,376EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621253 AgrOrtholog
BioCyc Gene G2FUF-49586 BioCyc
Ensembl Genes ENSRNOG00000005679 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008148 ENTREZGENE
  ENSRNOP00000008148.7 UniProtKB/TrEMBL
  ENSRNOP00000070543.2 UniProtKB/TrEMBL
  ENSRNOP00000078725.1 UniProtKB/TrEMBL
  ENSRNOP00000082041.1 UniProtKB/TrEMBL
  ENSRNOP00000091534.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008148 ENTREZGENE
  ENSRNOT00000008148.7 UniProtKB/TrEMBL
  ENSRNOT00000083536.2 UniProtKB/TrEMBL
  ENSRNOT00000096836.1 UniProtKB/TrEMBL
  ENSRNOT00000104439.1 UniProtKB/TrEMBL
  ENSRNOT00000106269.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  FAP/Dpf2 UniProtKB/TrEMBL
  Pept_S9_AS UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/TrEMBL
  Peptidase_S9B UniProtKB/TrEMBL
KEGG Report rno:192203 UniProtKB/TrEMBL
NCBI Gene 192203 ENTREZGENE
PANTHER PTHR11731:SF136 UniProtKB/TrEMBL
Pfam DPPIV_N UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/TrEMBL
PhenoGen Fap PhenoGen
PROSITE PRO_ENDOPEP_SER UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A0G2JY72_RAT UniProtKB/TrEMBL
  A0A8I5ZX00_RAT UniProtKB/TrEMBL
  A0A8I6AEN0_RAT UniProtKB/TrEMBL
  A0A8I6G286_RAT UniProtKB/TrEMBL
  F1LMH7 ENTREZGENE
  Q6P7D6_RAT UniProtKB/TrEMBL
  Q8R492 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LMH7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Fap  fibroblast activation protein, alpha  Fap  fibroblast activation protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Fap  fibroblast activation protein      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Fap  fibroblast activation protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein substrates include the glucagonlike peptides, neuropeptide Y, and the chemokines CCL3, CCL5, CCL11, CCL22, and CXCL12 708321