Acp2 (acid phosphatase 2, lysosomal)

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Gene: Acp2 (acid phosphatase 2, lysosomal) Rattus norvegicus

Analyze

Symbol:

Acp2

Name:

acid phosphatase 2, lysosomal

RGD ID:

2021

Description:

Enables acid phosphatase activity; phosphoprotein phosphatase activity; and phosphotyrosine residue binding activity. Involved in autophagic cell death and response to organic substance. Predicted to be located in lysosomal lumen; lysosomal membrane; and synapse. Predicted to be active in lysosome. Orthologous to human ACP2 (acid phosphatase 2, lysosomal); PARTICIPATES IN autophagy pathway; riboflavin metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

acid phosphatase 2; Acid phosphatase 2 lysozymal; Acid phosphatase 2, lysozymal; LAP; LMW-PTP-II low molecular weight phosphotyrosine protein phosphatase isozyme 2; LMW-PTP-II, low molecular weight phosphotyrosine protein phosphatase isozyme 2; lysosomal acid phosphatase

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ACP2 (acid phosphatase 2, lysosomal)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Acp2 (acid phosphatase 2, lysosomal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Acp2 (acid phosphatase 2, lysosomal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ACP2 (acid phosphatase 2, lysosomal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ACP2 (acid phosphatase 2, lysosomal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Acp2 (acid phosphatase 2, lysosomal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ACP2 (acid phosphatase 2, lysosomal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ACP2 (acid phosphatase 2, lysosomal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Acp2 (acid phosphatase 2, lysosomal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Acp2 (acid phosphatase 2, lysosomal)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ACP2 (acid phosphatase 2, lysosomal)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	acp2 (acid phosphatase 2, lysosomal)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Acph-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6656	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	CG9449	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	CG9451	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	CG9452	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	pho-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	acp2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	77,175,022 - 77,185,180 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	77,175,895 - 77,185,680 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	80,654,465 - 80,663,379 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	89,253,472 - 89,262,386 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	87,104,531 - 87,113,457 (+)	NCBI	Rnor_WKY
Rnor_6.0	3	80,020,346 - 80,030,365 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	80,021,440 - 80,030,363 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	86,729,100 - 86,739,118 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	75,559,522 - 75,568,415 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	75,455,893 - 75,464,787 (+)	NCBI
Celera	3	76,384,458 - 76,393,383 (+)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acid Phosphatase Deficiency (ISO)

congenital disorder of glycosylation type IIc (ISO)

fetal akinesia deformation sequence syndrome 1 (ISO)

genetic disease (ISO)

hypertrophic cardiomyopathy (ISO)

intellectual disability (ISO)

visual epilepsy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

14-Deoxy-11,12-didehydroandrographolide (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3-dimethoxynaphthalene-1,4-dione (ISO)

2,6-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

anthracene (ISO)

antimony(0) (ISO)

antirheumatic drug (ISO)

Aroclor 1254 (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chromium atom (ISO)

cobalt dichloride (EXP)

cyclosporin A (ISO)

cyproconazole (ISO)

dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fipronil (EXP)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

inulin (ISO)

ivermectin (ISO)

leflunomide (EXP)

mercury atom (ISO)

mercury(0) (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodimethylamine (ISO)

naphthalene (ISO)

nefazodone (EXP)

p-toluidine (EXP)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenanthrene (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

propiconazole (ISO)

pyrene (ISO)

Soman (EXP)

sulindac (ISO)

temozolomide (ISO)

thioacetamide (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagic cell death (IDA)

chemical synaptic transmission (NAS)

dephosphorylation (IBA)

lysosome organization (IBA,ISO)

response to organic substance (IDA)

skeletal system development (ISO)

Cellular Component

lysosomal lumen (IEA)

lysosomal membrane (IEA)

lysosome (IBA,IEA,ISO)

membrane (IEA)

synapse (IEA)

Molecular Function

acid phosphatase activity (IBA,IDA,ISO)

phosphoprotein phosphatase activity (IDA)

phosphotyrosine residue binding (IDA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

autophagy pathway (IDA)

riboflavin metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Kinetic studies on rat liver low M(r) phosphotyrosine protein phosphatases. The activation mechanism of the isoenzyme AcP2 by cGMP.	Cirri P, etal., Biochim Biophys Acta 1995 Jan 18;1243(1):129-35.
2.	Combined apoptosis and autophagy, the process that eliminates the oocytes of atretic follicles in immature rats.	Escobar ML, etal., Apoptosis. 2008 Oct;13(10):1253-66.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Isolation and sequencing of a cDNA clone encoding acid phosphatase in rat liver lysosomes.	Himeno M, etal., Biochem Biophys Res Commun 1989 Aug 15;162(3):1044-53.
6.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
7.	Changes in the activity of lysosomal enzymes in rat kidneys in the course of acute pancreatitis.	Lakowska H, etal., Med Sci Monit. 2001 Nov-Dec;7(6):1193-7.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
11.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
12.	GOA pipeline	RGD automated data pipeline
13.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
15.	Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system.	Saftig P, etal., J Biol Chem 1997 Jul 25;272(30):18628-35.
16.	Dephosphorylation of tyrosine phosphorylated synthetic peptides by rat liver phosphotyrosine protein phosphatase isoenzymes.	Stefani M, etal., FEBS Lett. 1993 Jul 12;326(1-3):131-4.
17.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18.	Abundance of low molecular weight phosphotyrosine protein phosphatase in the nerve-ending fraction in the brain.	Tanino H, etal., Biol Pharm Bull 1999 Aug;22(8):794-8.
19.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:1914521	PMID:3160696	PMID:11168643	PMID:11731469	PMID:15503243	PMID:15604265	PMID:19946888	PMID:23376485	PMID:23533145	PMID:25013167

Genomics

Comparative Map Data

Acp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	77,175,022 - 77,185,180 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	77,175,895 - 77,185,680 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	80,654,465 - 80,663,379 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	89,253,472 - 89,262,386 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	87,104,531 - 87,113,457 (+)	NCBI	Rnor_WKY
Rnor_6.0	3	80,020,346 - 80,030,365 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	80,021,440 - 80,030,363 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	86,729,100 - 86,739,118 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	75,559,522 - 75,568,415 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	75,455,893 - 75,464,787 (+)	NCBI
Celera	3	76,384,458 - 76,393,383 (+)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

ACP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	47,239,302 - 47,248,814 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	11	47,239,302 - 47,248,906 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	47,260,853 - 47,270,365 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	47,217,429 - 47,226,939 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	47,217,428 - 47,226,939	NCBI
Celera	11	47,400,080 - 47,409,684 (-)	NCBI		Celera
Cytogenetic Map	11	p11.2	NCBI
HuRef	11	46,959,833 - 46,969,437 (-)	NCBI		HuRef
CHM1_1	11	47,259,545 - 47,269,147 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	47,396,045 - 47,405,572 (-)	NCBI		T2T-CHM13v2.0

Acp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	91,033,157 - 91,044,443 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	91,033,230 - 91,044,443 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	91,202,812 - 91,214,098 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	91,202,885 - 91,214,098 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	91,043,069 - 91,054,255 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	91,003,769 - 91,012,982 (+)	NCBI		MGSCv36	mm8
Celera	2	92,588,418 - 92,599,572 (+)	NCBI		Celera
Cytogenetic Map	2	E1	NCBI
cM Map	2	50.54	NCBI

Acp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	954,089 - 961,522 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	954,108 - 961,522 (+)	NCBI	ChiLan1.0	ChiLan1.0

ACP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	11	49,460,156 - 49,469,677 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	47,185,611 - 47,195,174 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	47,738,845 - 47,748,450 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	47,738,845 - 47,748,450 (-)	Ensembl	panpan1.1		panPan2

ACP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	42,346,207 - 42,356,447 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	42,345,608 - 42,354,352 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	41,074,892 - 41,082,823 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	43,000,686 - 43,008,615 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	43,000,671 - 43,010,921 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	42,486,567 - 42,494,663 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	42,042,164 - 42,050,092 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	42,771,565 - 42,779,495 (+)	NCBI		UU_Cfam_GSD_1.0

Acp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	19,840,945 - 19,848,685 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936562	1,952,536 - 1,960,327 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936562	1,952,581 - 1,960,327 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	15,334,001 - 15,347,770 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	15,334,015 - 15,342,531 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	16,557,583 - 16,566,096 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	18,061,094 - 18,070,929 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	18,060,994 - 18,072,208 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	115,364,071 - 115,374,315 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Acp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	1,473,205 - 1,485,345 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	1,473,186 - 1,481,395 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Acp2
37 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	380
Count of miRNA genes:	217
Interacting mature miRNAs:	256
Transcripts:	ENSRNOT00000018620
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	30356773	98535386	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	78196190	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	104104347	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	38517803	83517803	Rat
1331777	Bw24	Body weight QTL 24	3.503		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	89115240	Rat
1331795	Rf30	Renal function QTL 30	3.708		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	3	39454637	89115240	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	41874578	104104347	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	43827364	90905114	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	53184692	89878207	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	53781112	91609953	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
631200	Cm25	Cardiac mass QTL 25	4.8	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	3	61134348	89115068	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat

Markers in Region

RH131014

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	77,185,232 - 77,185,417 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	80,030,556 - 80,030,740	NCBI	Rnor6.0
Rnor_5.0	3	86,739,309 - 86,739,493	UniSTS	Rnor5.0
RGSC_v3.4	3	75,568,606 - 75,568,790	UniSTS	RGSC3.4
Celera	3	76,393,574 - 76,393,758	UniSTS
Cytogenetic Map	3	q24	UniSTS

RH139052

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	77,175,085 - 77,175,266 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	80,020,410 - 80,020,590	NCBI	Rnor6.0
Rnor_5.0	3	86,729,163 - 86,729,343	UniSTS	Rnor5.0
RGSC_v3.4	3	75,558,460 - 75,558,640	UniSTS	RGSC3.4
Celera	3	76,383,428 - 76,383,608	UniSTS
Cytogenetic Map	3	q24	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	34	57	41	19	41		1	74	35	41	11
Low		9					8	10					8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001357071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_016988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234500	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC081823	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB720349	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M27893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000018620 ⟹ ENSRNOP00000018620

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	77,175,895 - 77,185,680 (+)	Ensembl
Rnor_6.0 Ensembl	3	80,021,440 - 80,030,363 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000106898 ⟹ ENSRNOP00000081459

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	77,175,895 - 77,185,680 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000109523 ⟹ ENSRNOP00000097452

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	77,176,153 - 77,185,680 (+)	Ensembl

RefSeq Acc Id:

NM_001357071 ⟹ NP_001344000

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	77,176,116 - 77,185,042 (+)	NCBI

RefSeq Acc Id:

NM_016988 ⟹ NP_058684

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	77,176,116 - 77,185,042 (+)	NCBI
Rnor_6.0	3	80,021,440 - 80,030,365 (+)	NCBI
Rnor_5.0	3	86,729,100 - 86,739,118 (+)	NCBI
RGSC_v3.4	3	75,559,522 - 75,568,415 (+)	RGD
Celera	3	76,384,458 - 76,393,383 (+)	NCBI

Sequence:

show sequence

GGCGTTCCGGGCTCTTGCTGCACAGCCTACAACGGTGATGGCCGGCAGACAGTCTGGTTGGAGC
CAGGCGGCTCTTCTCCAGTTCCTTCTTGGCATGTGCCTAATGGTGATGCCACCCATACAAGCCC
GGAGTCTGCGCTTTGTTACCTTGCTGTATCGACACGGAGATCGGTCACCAGTGAAGGCATATCC
TAAGGACCCCTATCAGGAAGAGAAATGGCCCCAGGGATTTGGTCAGCTAACCAAGGAAGGGATG
CTACAGCATTGGGAGCTGGGCCAGGCCCTGCGGCAACGCTACCATGGCTTTCTGAACGCCTCTT
ACCACAGGCAAGAGGTTTACGTGCGAAGCACAGACTTTGACCGTACTCTCATGAGTGCAGAGGC
CAACCTGGCCGGACTCTTCCCTCCCACTGAAGTTCAGCACTTCAACCCGAACATTTCATGGCAG
CCTATCCCTGTCCACACCGTGCCCATTACTGAAGACAGGTTGCTGAAGTTTCCTTTGGGTCCAT
GTCCCCGTTATGAGCAGTTGCAGAACGAGACTCGGCAGACACCAGAGTATCAGAACATGAGTAT
TCAGAATGCACAATTTCTGGACATGGTGGCCAATGAGACAGGGCTTATGAACTTGACCCTAGAG
ACCATCTGGAATGTGTATGACACACTCTTTTGTGAGCAAACACATGGGCTGCTCCTGCCACCCT
GGGCCTCTCCCCAAACCGTGCAGCGTCTGAGCCAGCTAAAGGACTTCAGCTTCCTCTTCCTCTT
CGGGATCCACGATCAAGTACAGAAGGCCCGGCTTCAGGGGGGAGTTCTGCTGGCTCAAATATTG
AAGAATCTGACCCTAATGGCAACTACCTCTCAATTCCCTAAGCTTCTGGTTTATTCTGCGCATG
ACACTACCCTGGTTGCTCTGCAAATGGCACTGAATGTCTACAATGGTAAACAAGCCCCCTATGC
TTCCTGCCACATATTTGAACTGTACCAGGAAGATAATGGGAATTTCTCAGTCGAGATGTACTTT
CGGAATGACAGTAAGAAGGCACCCTGGCCACTGACCCTGCCTGGCTGTCCTCACCGTTGCCCAC
TGCAGGACTTCCTTCGCCTCACAGAACCTGTCATACCCAAGGACTGGCAGAAGGAGTGCCAGCT
AGCAAGCGATACTGCAGACACAGAGGTGATTGTGGCACTGGCTGTCTGTGGCTCCATCCTCTTC
CTTCTAATAGTGTTGCTCCTCACTGTCCTCTTCCGGATGCAGGCCCAGCCTCCTGGCTACCACC
ATGTTGCAGACAGGGAAGACCATGCTTGACAACCACTCAGTCCCCTTCCCTCTGCCTCCTAGGG
GATGTGGGCTGAGTCCTTGCTCCTGACTATTGCCGATCCCAGCCCAGGGACAGGTTTAGCCTTC
CTGATTACCTACGCCCAAATGAATGAGTGAGGCTGGGCTGGTCGCACGTCACCTGTGACTTACC
ATCCTCATGCCTGATGTTTACCATGTACTGTGTTGGACACTGGCTTTCTCTAAATGGGATTTGC
CTCTTCTATACTCCCTAAGGACTTGAGATACAGACAAGCATTCAGGTTTTACTCAAGACCTGGG
ATTAAAAAAACAAAACAACAACAGAAAAAAAACCCCAAACCCTGAAGAAGCTGGTACTTGATCT
GTCTAGCTCTTCCCCCAAGCCTTGCTCTTTGTCTTCTAGCCCATATCTTTGGCAAATGGCTTGG
AGGACATTGTCCCTTGGTACTTTTGCAGTTCATATAAATGGCTCATTTTATATGGATCACCCAA
CAGCAAAGTTTCCCTCTGACTGAGGCTGCCGTCAGTGTCAACCTCAGGCAGGTTGAAGGACACT
GGTGCTGCACCTGGATGACAGTGGGAGGACACAGGAGTGAAACACATGGAATCATGACGTGACT
CTCCCTCAGCTGGGCTGGACTCTTCAGGGACTTGAAGTAAATGCAGCTGGTGAACTGTACACCT
TGACTGTGGCCCGAAACAGAGCTGAAGTAACTCCGAGGAAATGAAGGTTTTGACTGAGAAAAAA
AAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006234500 ⟹ XP_006234562

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	77,175,022 - 77,185,180 (+)	NCBI
Rnor_6.0	3	80,020,346 - 80,030,365 (+)	NCBI
Rnor_5.0	3	86,729,100 - 86,739,118 (+)	NCBI

Sequence:

show sequence

GGTTCTTTTTTTCAGAGCTTTTTTTTGGAGTTTTTTTTTTTTTTAAATGAACTATTTAGTTTTC
TGCTCTCTCCTCAGTCGTTGTCAAGGTGACTTTGGAAGTAAAGTTTAGGCAGTAAGGCACACAA
TTTTACCTGGAGTTCTGGGACAGTAACAAAAAGTTCTGATCAGATTTGTTTGCAGATAATCTGA
GGTGGGTTTGCTTATAAGTAGACAGATCTGCATTAAAGCATATCAAGGGCCCAAGATGTGACCT
ACAACTGCATGCTATTCTAAGGGTTGGAATTACAACACCCAGAGGCCAGACAGGCTGCCTGTCT
CTAAATCCTAAAGGCTAATGTTTAGAGAAACTCTGATTCTGTGGCAATTCCACAGTTATATGCG
TGCATCAACATTGATGCAGTTATCTGAAATTCCTGCCATTGGAATTCAATGTAATGGGTTTGGG
AAATCTGAACATCTTATACAATCCAACTCCTCTGAAAGGAAAACATTTTGAGTCTAATTTAGAA
ATCGATAAGCACAAGAAAGGGACTGAAAAACTGGTGAGTGAGGTTTGTTCAGGACAGGAATGAC
TGTATCTACCTCAAGGGCACAGGGAGTCCAAAGGGCTGTTTACATGCAGTGCTCTACATCTCAA
ACAAGACCGCTTGGAGGAATAGTGCCTGAGCCAAGGCTAAAACTAAACTACAAACCTAGAAAGT
TAGTCTCTGTACTTCTCCCTTGTCCTAATTTTGCACCAACTGAGGCTCTGGGATCACTCTCAGA
AGCACTGCTCAGAGGAGCCATTCCGTCTCCATTCGGCCCAGACTCCATCCAGGGAAAGCGCCGG
CCGGGTAGACGAAGAGAAAAATGGCGAAGGCTGCACTTCCGGCAAGTGTCCTTACGAATGCATC
CGGGCGGCTGCAGCAGGTACCGCCCAAGGCGTTCCGGGCTCTTGCTGCACAGCCTACAACGGTG
ATGGCCGGCAGACAGTCTGGTTGGAGCCAGGCGGCTCTTCTCCAGTTCCTTCTTGGCATGTGCC
TAATGGTGATGCCACCCATACAAGCCCGGAGTCTGCGCTTTGTTACCTTGCTGTATCGACACGG
AGATCGGTCACCAGTGAAGGCATATCCTAAGGACCCCTATCAGGAAGAGAAATGGCCCCAGGGA
TTTGGTCAGCTAACCAAGGAAGGGATGCTACAGCATTGGGAGCTGGGCCAGGCCCTGCGGCAAC
GCTACCATGGCTTTCTGAACGCCTCTTACCACAGGCAAGAGGTTTACGTGCGAAGCACAGACTT
TGACCGTACTCTCATGAGTGCAGAGGCCAACCTGGCCGGACTCTTCCCTCCCACTGAAGTTCAG
CACTTCAACCCGAACATTTCATGGCAGCCTATCCCTGTCCACACCGTGCCCATTACTGAAGACA
GGTTGCTGAAGTTTCCTTTGGGTCCATGTCCCCGTTATGAGCAGTTGCAGAACGAGACTCGGCA
GACACCAGAGTATCAGAACATGAGTATTCAGAATGCACAATTTCTGGACATGGTGGCCAATGAG
ACAGGGCTTATGAACTTGACCCTAGAGACCATCTGGAATGTGTATGACACACTCTTTTGTGAGC
AAACACATGGGCTGCTCCTGCCACCCTGGGCCTCTCCCCAAACCGTGCAGCGTCTGAGCCAGCT
AAAGGACTTCAGCTTCCTCTTCCTCTTCGGGATCCACGATCAAGTACAGAAGGCCCGGCTTCAG
GGGGGAGTTCTGCTGGCTCAAATATTGAAGAATCTGACCCTAATGGCAACTACCTCTCAATTCC
CTAAGCTTCTGGTTTATTCTGCGCATGACACTACCCTGGTTGCTCTGCAAATGGCACTGAATGT
CTACAATGGTAAACAAGCCCCCTATGCTTCCTGCCACATATTTGAACTGTACCAGGAAGATAAT
GGGAATTTCTCAGTCGAGATGTACTTTCGGAATGACAGTAAGAAGGCACCCTGGCCACTGACCC
TGCCTGGCTGTCCTCACCGTTGCCCACTGCAGGACTTCCTTCGCCTCACAGAACCTGTCATACC
CAAGGACTGGCAGAAGGAGTGCCAGCTAGCAAGCGATACTGCAGACACAGAGGTGATTGTGGCA
CTGGCTGTCTGTGGCTCCATCCTCTTCCTTCTAATAGTGTTGCTCCTCACTGTCCTCTTCCGGA
TGCAGGCCCAGCCTCCTGGCTACCACCATGTTGCAGACAGGGAAGACCATGCTTGACAACCACT
CAGTCCCCTTCCCTCTGCCTCCTAGGGGATGTGGGCTGAGTCCTTGCTCCTGACTATTGCCGAT
CCCAGCCCAGGGACAGGTTTAGCCTTCCTGATTACCTACGCCCAAATGAATGAGTGAGGCTGGG
CTGGTCGCACGTCACCTGTGACTTACCATCCTCATGCCTGATGTTTACCATGTACTGTGTTGGA
CACTGGCTTTCTCTAAATGGGATTTGCCTCTTCTATACTCCCTAAGGACTTGAGATACAGACAA
GCATTCAGGTTTTACTCAAGACCTGGGATTAAAAAAACAAAACAACAACAGAAAAAAAACCCCA
AACCCTGAAGAAGCTGGTACTTGATCTGTCTAGCTCTTCCCCCAAGCCTTGCTCTTTGTCTTCT
AGCCCATATCTTTGGCAAATGGCTTGGAGGACATTGTCCCTTGGTACTTTTGCAGTTCATATAA
ATGGCTCATTTTATATGGATCACCCAACAGCAAAGTTTCCCTCTGACTGAGGCTGCCGTCAGTG
TCAACCTCAGGCAGGTTGAAGGACACTGGTGCTGCACCTGGATGACAGTGGGAGGACACAGGAG
TGAAACACATGGAATCATGACGTGACTCTCCCTCAGCTGGGCTGGACTCTTCAGGGACTTGAAG
TAAATGCAGCTGGTGAACTGTACACCTTGACTGTGGCCCGAAACAGAGCTGAAGTAACTCCGAG
GAAATGAAGGTTTTGACTGAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001344000	(Get FASTA)	NCBI Sequence Viewer
	NP_058684	(Get FASTA)	NCBI Sequence Viewer
	XP_006234562	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA40744	(Get FASTA)	NCBI Sequence Viewer
	AAH81823	(Get FASTA)	NCBI Sequence Viewer
	EDL79516	(Get FASTA)	NCBI Sequence Viewer
	EDL79517	(Get FASTA)	NCBI Sequence Viewer
	P20611	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_058684 ⟸ NM_016988
- Peptide Label:	isoform 1 precursor
- UniProtKB:	Q642D2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGRQSGWSQAALLQFLLGMCLMVMPPIQARSLRFVTLLYRHGDRSPVKAYPKDPYQEEKWPQG FGQLTKEGMLQHWELGQALRQRYHGFLNASYHRQEVYVRSTDFDRTLMSAEANLAGLFPPTEVQ HFNPNISWQPIPVHTVPITEDRLLKFPLGPCPRYEQLQNETRQTPEYQNMSIQNAQFLDMVANE TGLMNLTLETIWNVYDTLFCEQTHGLLLPPWASPQTVQRLSQLKDFSFLFLFGIHDQVQKARLQ GGVLLAQILKNLTLMATTSQFPKLLVYSAHDTTLVALQMALNVYNGKQAPYASCHIFELYQEDN GNFSVEMYFRNDSKKAPWPLTLPGCPHRCPLQDFLRLTEPVIPKDWQKECQLASDTADTEVIVA LAVCGSILFLLIVLLLTVLFRMQAQPPGYHHVADREDHA hide sequence

RefSeq Acc Id:	XP_006234562 ⟸ XM_006234500
- Peptide Label:	isoform X1
- UniProtKB:	F7F1A3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAKAALPASVLTNASGRLQQVPPKAFRALAAQPTTVMAGRQSGWSQAALLQFLLGMCLMVMPPI QARSLRFVTLLYRHGDRSPVKAYPKDPYQEEKWPQGFGQLTKEGMLQHWELGQALRQRYHGFLN ASYHRQEVYVRSTDFDRTLMSAEANLAGLFPPTEVQHFNPNISWQPIPVHTVPITEDRLLKFPL GPCPRYEQLQNETRQTPEYQNMSIQNAQFLDMVANETGLMNLTLETIWNVYDTLFCEQTHGLLL PPWASPQTVQRLSQLKDFSFLFLFGIHDQVQKARLQGGVLLAQILKNLTLMATTSQFPKLLVYS AHDTTLVALQMALNVYNGKQAPYASCHIFELYQEDNGNFSVEMYFRNDSKKAPWPLTLPGCPHR CPLQDFLRLTEPVIPKDWQKECQLASDTADTEVIVALAVCGSILFLLIVLLLTVLFRMQAQPPG YHHVADREDHA hide sequence

RefSeq Acc Id:

ENSRNOP00000018620 ⟸ ENSRNOT00000018620

RefSeq Acc Id:	NP_001344000 ⟸ NM_001357071
- Peptide Label:	isoform 1x precursor

RefSeq Acc Id:

ENSRNOP00000081459 ⟸ ENSRNOT00000106898

RefSeq Acc Id:

ENSRNOP00000097452 ⟸ ENSRNOT00000109523

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P20611-F1-model_v2	AlphaFold	P20611	1-423	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692211

Promoter ID:

EPDNEW_R2734

Type:

multiple initiation site

Name:

Acp2_1

Description:

acid phosphatase 2, lysosomal

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	80,021,461 - 80,021,521	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2021	AgrOrtholog
BioCyc Gene	G2FUF-48742	BioCyc
Ensembl Genes	ENSRNOG00000013594	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000018620	ENTREZGENE
	ENSRNOP00000018620.3	UniProtKB/TrEMBL
	ENSRNOP00000081459.1	UniProtKB/TrEMBL
	ENSRNOP00000097452.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000018620	ENTREZGENE
	ENSRNOT00000018620.5	UniProtKB/TrEMBL
	ENSRNOT00000106898.1	UniProtKB/TrEMBL
	ENSRNOT00000109523.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1240	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7107570	IMAGE-MGC_LOAD
InterPro	Acid_Pase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	His_Pase_clade-2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	His_PPase_superfam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:93543	IMAGE-MGC_LOAD
NCBI Gene	24162	ENTREZGENE
PANTHER	ACID PHOSPHATASE-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LYSOSOMAL ACID PHOSPHATASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	His_Phos_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	ACP2	RGD
PhenoGen	Acp2	PhenoGen
PROSITE	HIS_ACID_PHOSPHAT_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HIS_ACID_PHOSPHAT_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF53254	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC205149
UniProt	A0A8I5ZST8_RAT	UniProtKB/TrEMBL
	A0A8I6ANF7_RAT	UniProtKB/TrEMBL
	F7F1A3	ENTREZGENE, UniProtKB/TrEMBL
	P20611	ENTREZGENE, UniProtKB/Swiss-Prot
	Q642D2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Acp2	acid phosphatase 2, lysosomal		acid phosphatase 2	Name updated	1299863	APPROVED
2002-06-10	Acp2	acid phosphatase 2			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to nerve endings	631746
gene_expression	expressed in liver	631727
gene_expression	protein detected in brain	631746
gene_function	catalyzes the hydrolysis of p-nitrophenyl phosphate	631727
gene_process	may play a role in synaptic function	631746
gene_regulation	activated strongly by cyclic GMP and guanosine	631727

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)