Creb3l1 (cAMP responsive element binding protein 3-like 1)

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Gene: Creb3l1 (cAMP responsive element binding protein 3-like 1) Rattus norvegicus

Analyze

Symbol:

Creb3l1

Name:

cAMP responsive element binding protein 3-like 1

RGD ID:

1359613

Description:

Enables transcription cis-regulatory region binding activity. Involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway and positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum; and nucleoplasm. Predicted to be part of chromatin. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 16. Orthologous to human CREB3L1 (cAMP responsive element binding protein 3 like 1); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Huntington's disease pathway; prostate cancer pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cAMP-responsive element-binding protein 3-like protein 1; cyclic AMP-responsive element-binding protein 3-like protein 1; MGC94038; Oasis; old astrocyte specifically-induced substance

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	77,952,589 - 77,993,513 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	77,952,540 - 77,993,456 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	81,427,652 - 81,468,577 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	90,026,683 - 90,067,606 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	87,877,914 - 87,918,770 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	80,892,433 - 80,933,283 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	80,892,435 - 80,933,283 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	87,591,097 - 87,632,703 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	76,361,149 - 76,401,633 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	76,257,522 - 76,298,005 (-)	NCBI
Celera	3	77,155,216 - 77,195,815 (-)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital disorder of glycosylation type IIc (ISO)

Developmental Disabilities (ISO)

genetic disease (ISO)

infantile Refsum disease (ISO)

intellectual disability (ISO)

osteogenesis imperfecta type 16 (ISO)

teratoma (ISO)

Zellweger syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

buta-1,3-diene (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

DDT (EXP)

dichloromethane (ISO)

doxorubicin (EXP,ISO)

endosulfan (EXP)

folic acid (ISO)

gentamycin (EXP)

methamphetamine (EXP)

methylseleninic acid (ISO)

N-methyl-4-phenylpyridinium (ISO)

nickel dichloride (EXP)

obeticholic acid (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

potassium chromate (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

sunitinib (ISO)

T-2 toxin (EXP)

testosterone (ISO)

tetrachloromethane (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

trametinib (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

endoplasmic reticulum unfolded protein response (ISO,ISS)

extracellular matrix constituent secretion (ISO,ISS)

mitotic G2 DNA damage checkpoint signaling (ISO)

negative regulation of DNA-templated transcription (ISO)

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (IMP,ISO)

negative regulation of fibroblast growth factor receptor signaling pathway (IEA,ISO)

negative regulation of gene expression (IEA,ISO)

negative regulation of sprouting angiogenesis (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA)

osteoblast differentiation (ISO,ISS)

positive regulation of collagen biosynthetic process (IEA,ISO,ISS)

positive regulation of transcription by RNA polymerase II (ISO)

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress (IMP,ISO)

regulation of ossification (ISO)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

chromatin (IEA,ISO)

cytosol (IEA,ISO)

endoplasmic reticulum (IEA,ISO,ISS)

endoplasmic reticulum membrane (IEA)

membrane (IEA,ISO,ISS)

nucleoplasm (IEA,ISO)

nucleus (ISO,ISS)

Molecular Function

cAMP response element binding (IBA,ISO,ISS)

chromatin binding (ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO,ISS)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA,ISO)

protein binding (ISO)

sequence-specific double-stranded DNA binding (IEA,ISO)

SMAD binding (IEA,ISO)

transcription cis-regulatory region binding (IDA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

endoplasmic reticulum stress - the unfolded protein response pathway (ISO)

Huntington's disease pathway (IEA)

prostate cancer pathway (IEA)

vasopressin signaling pathway via receptor type 2 (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes.	Kondo S, etal., Nat Cell Biol 2005 Feb;7(2):186-94. Epub 2005 Jan 23.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10.	The impact of the unfolded protein response on human disease.	Wang S and Kaufman RJ, J Cell Biol. 2012 Jun 25;197(7):857-67. doi: 10.1083/jcb.201110131.

Additional References at PubMed

PMID:16236796	PMID:19767743	PMID:20668028	PMID:22705851	PMID:24623760	PMID:24716865	PMID:25310401	PMID:25915053	PMID:26503226	PMID:27121396	PMID:32319174	PMID:35051932
PMID:35455992

Genomics

Comparative Map Data

Creb3l1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	77,952,589 - 77,993,513 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	77,952,540 - 77,993,456 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	81,427,652 - 81,468,577 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	90,026,683 - 90,067,606 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	87,877,914 - 87,918,770 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	80,892,433 - 80,933,283 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	80,892,435 - 80,933,283 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	87,591,097 - 87,632,703 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	76,361,149 - 76,401,633 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	76,257,522 - 76,298,005 (-)	NCBI
Celera	3	77,155,216 - 77,195,815 (-)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

CREB3L1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	46,277,662 - 46,321,409 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	46,277,662 - 46,321,409 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	46,299,213 - 46,342,959 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	46,255,804 - 46,299,548 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	46,256,135 - 46,299,546	NCBI
Celera	11	46,447,593 - 46,490,563 (+)	NCBI		Celera
Cytogenetic Map	11	p11.2	NCBI
HuRef	11	46,006,120 - 46,049,912 (+)	NCBI		HuRef
CHM1_1	11	46,297,481 - 46,341,263 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	46,433,747 - 46,477,484 (+)	NCBI		T2T-CHM13v2.0

Creb3l1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	91,812,673 - 91,854,515 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	91,812,673 - 91,854,847 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	91,982,328 - 92,024,170 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	91,982,328 - 92,024,502 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	91,822,485 - 91,864,327 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	91,783,492 - 91,824,970 (-)	NCBI		MGSCv36	mm8
Celera	2	93,372,860 - 93,415,712 (-)	NCBI		Celera
Cytogenetic Map	2	E1	NCBI
cM Map	2	50.63	NCBI

Creb3l1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	1,700,692 - 1,734,773 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	1,702,131 - 1,734,603 (-)	NCBI	ChiLan1.0	ChiLan1.0

CREB3L1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	11	48,497,758 - 48,541,479 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	46,236,384 - 46,280,145 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	46,788,561 - 46,830,246 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	46,788,561 - 46,830,246 (+)	Ensembl	panpan1.1		panPan2

CREB3L1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	43,138,779 - 43,173,535 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	43,139,453 - 43,173,420 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	41,866,950 - 41,901,711 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	43,794,549 - 43,829,336 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	43,795,088 - 43,829,206 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	43,279,443 - 43,314,202 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	42,831,301 - 42,866,047 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	43,564,538 - 43,599,317 (-)	NCBI		UU_Cfam_GSD_1.0

Creb3l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	20,628,266 - 20,660,842 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936562	2,739,905 - 2,772,484 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936562	2,739,908 - 2,772,484 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CREB3L1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	16,186,206 - 16,220,940 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	16,186,206 - 16,220,948 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	17,530,731 - 17,564,910 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CREB3L1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	19,009,169 - 19,054,841 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	19,009,035 - 19,054,804 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	116,294,549 - 116,338,755 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Creb3l1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	2,215,558 - 2,247,509 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	2,215,850 - 2,247,470 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Creb3l1
110 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	85
Count of miRNA genes:	69
Interacting mature miRNAs:	77
Transcripts:	ENSRNOT00000007771
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	30356773	98535386	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	78196190	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	104104347	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	38517803	83517803	Rat
1331777	Bw24	Body weight QTL 24	3.503		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	89115240	Rat
1331795	Rf30	Renal function QTL 30	3.708		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	3	39454637	89115240	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	41874578	104104347	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	43827364	90905114	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	53184692	89878207	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	53781112	91609953	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
631200	Cm25	Cardiac mass QTL 25	4.8	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	3	61134348	89115068	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat

Markers in Region

RH134248

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	77,952,622 - 77,952,807 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	80,892,467 - 80,892,651	NCBI	Rnor6.0
Rnor_5.0	3	87,591,137 - 87,591,321	UniSTS	Rnor5.0
RGSC_v3.4	3	76,361,183 - 76,361,367	UniSTS	RGSC3.4
Celera	3	77,155,250 - 77,155,434	UniSTS
Cytogenetic Map	3	q24	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	20	4	4	1	4		2	3	21	28	2
Low		21	51	35	18	35	6	7	64	14	11	9	6
Below cutoff		2	2	2		2	2	2	7		2		2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001005562	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105430	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC135645	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000007771 ⟹ ENSRNOP00000007771

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	77,952,540 - 77,993,456 (-)	Ensembl
Rnor_6.0 Ensembl	3	80,892,435 - 80,933,283 (-)	Ensembl

RefSeq Acc Id:

NM_001005562 ⟹ NP_001005562

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	77,952,589 - 77,993,456 (-)	NCBI
Rnor_6.0	3	80,892,433 - 80,933,283 (-)	NCBI
Rnor_5.0	3	87,591,097 - 87,632,703 (-)	NCBI
RGSC_v3.4	3	76,361,149 - 76,401,633 (-)	RGD
Celera	3	77,155,216 - 77,195,815 (-)	RGD

Sequence:

show sequence

CAGAAGCTGCGCGGAGGAAGAGACCTAGAGAGATCTCTGCGACTCGGCAGCCACCCATCCTCGG
GGGAGCATTGAGCTCCCCCACCCCCGGCTCCCACCCGGCCCGGGGGGCTCCTCCAGCATCGGCC
CCACCCCCGGGCTCCCCATGGAAGCCAGCTGCGCCCCGGGAGGAGCAGGAGGAGGAGTCGGCTG
AAAGCCCACGGTGCTTTCGGCGCCGCTGCCCTAAGGCCCCCCAGCGCCCCCGACCCGCGCCACC
CCCACCGCTCCTCCCCCCGGGCTCGCCGGGACCTGCCCCCGGGCCGCCTGCCCGCGCCCAGCCG
CAGCCTGGTGCGGGGATCCTCGCCGCCCTGGAGTGAGGGAAGCGCAGCCCGAAGGGGTCCCCTG
GAACCCGGCGCGATGGACGCCGTCTTGGAACCTTTCCCGGCCGACAGGCTGTTCCCGGGATCCA
GCTTCCTGGACTTGGGAGACCTGAATGAGTCGGATTTCCTCAACAATGCGCACTTCCCGGAGCA
CCTGGACCACTTTGTGGAGAACATGGAGGACTTCTCCAATGACCTGTTCAGCAGCTTCTTTGAT
GACCCTGTGCTGGATGAGAAGAGCCCTCTGCTGGACATGGAACTGGATTCCCCTGCTCCAGGCA
TCCAGGCTGAGCACAGCTACTCCCTGAGTGGGGATTCTGCACCCCAGAGCCCCCTTGTGCCTGT
CAAAATGGAGGATACCACCCAAGATATGGAACACGGAGCATGGGCACTGGGAAACAAACTGTGC
TCCATTATGGTGAAGCAGGAGCAGAGCCCGGAGCTTCCGGTTGACCCCCTGGCTGCCTCCTCCG
CCATGGCTGCTGCTACCATGGCCACCCCACCACTGCTGGGCCTCAGCCCCATCTCCAGGCTGCC
CATCCCTCACCAGGCCCCAGGAGAAATGACTCAGCTGCCAGTGATCAAAGCAGAGCCCCCGGAA
ATGAGCCAGTTTCTCAAAGTGACACAAGAGGACCTCGTACAGATGCCTCCAACACCCCCCAGCA
GCCATGGCAGTGACAGTGACGGCTCCCAGAGTCCCCGCTCTCTTCCCCCCTCCAGCCCTGTCCG
GCCCATGGCCCGCTCCTCCACGGCCATTTCCACCTCTCCGCTCCTCACTGCCCCTCACAAACTG
CAGGGGACATCAGGGCCACTGCTCTTGACAGAAGAGGAGAAGCGAACTTTGATCGCCGAGGGTT
ATCCCATCCCCACCAAACTCCCCCTCACCAAGGCTGAGGAGAAGGCCCTGAAGAGAGTGCGCAG
GAAAATTAAGAACAAGATCTCTGCCCAGGAGAGCCGCCGCAAAAAGAAGGAGTATGTGGAGTGT
CTAGAGAAGAAGGTGGAGACATATACATCAGAGAACAATGAACTGTGGAAGAAGGTGGAAACCC
TAGAGACTGCCAACAGGACCCTGCTCCAGCAGCTGCAGAAACTCCAGACTCTGGTCACCAGCAA
GATCTCCAGACCTTACAAGATGGCGGCCACACAGACTGGCACTTGCCTCATGGTGGCAGCCTTG
TGCTTTGTTCTGGTGCTGGGCTCACTTGCGCCCTGCCTTCCTGCATTCTCTTCTGGCTCAAAGA
CTGTGAAAGAAGACCCCGTCGCAGCTGACAGTGTCTACGCAGCCAGTCAGATGCCTTCCCGAAG
CCTGCTGTTTTATGATGATGGGGCAGGCTCCTGGGAAGATGGCCACCGAGGTGCTCTACTGCCT
GTGGAGCCCCCAGAAGGCTGGGAGCTCAAACCCGGGGGACCAGCAGAGCCGAGGCCCCAGGACC
ACCTCCGACATGACCATGCGGACAGCATCCACGAGACAACCAAGTACTTGAGAGAGACCTGGCC
AGAGGATACCGAGGACAATGGCGCCAGCCCCAATTTCTCCCACCCCAAGGAGTGGTTCCACGAC
AGGGATCTGGGCCCCAACACCACCATCAAACTCTCCTAGGCCACTCCGAGACCCAGGACACAGG
ACGGACACCCTGGCACCCAGAAGAGGCGTTCTCTTGCTCACTGACCCAGATCCAGCTCACACCC
CTGCCCTGGGGCCCTCTGCCCCAGGAGAAAGGGTCTTTCTTCTCCCCAGCCCTCCAGCTTCCTG
TAGTGCCTGGGGTCCCTCTATGTCCCCGGACACTTGGACTGCTCCCCTGGGCCGACCACTCTGT
TCCCACTTTTTCCTCCCACAACTATCCGTCCTCCTCCAATCAACCACTCACTGGGCCACCCCTG
TTTCCTTTCCATAGTGACCAACGCAACCACTGTTCCTGGCCCCCTCATATACATACACACAAGC
AGACATGCACACACAAACACACACCCCCACTTCCTACTGTACAGAGACCAAGAACAGAAATCGT
TTGTAAATAATGAACCTTATTTTTTATTATTGCCGACCCCCTAAGATATTGTATTTTACAAATC
TCCCTCCCGTCACCTCTCCCTTATTTTGTATTTTATGAAGTTAGTGCGGGCTTTGCTACCCCTT
GGCCTGGGACAGAGGGACACCCCACCCTCACCAGGCCTCCCCGTGCCGCTGCCCAAGCTGCTGG
GCCTTTTTAACTGCTCCTCCACCAGCTCAGCACACGCTTTAAGAAAGCAAAATTAAAAAAAAAA
AAAAAAGATTCAGCATCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039105430 ⟹ XP_038961358

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	77,952,589 - 77,993,513 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001005562	(Get FASTA)	NCBI Sequence Viewer
	XP_038961358	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81951	(Get FASTA)	NCBI Sequence Viewer
	EDL79555	(Get FASTA)	NCBI Sequence Viewer
	EDL79556	(Get FASTA)	NCBI Sequence Viewer
	Q66HA2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001005562 ⟸ NM_001005562

- UniProtKB:

Q66HA2 (UniProtKB/Swiss-Prot), A6HNF4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDAVLEPFPADRLFPGSSFLDLGDLNESDFLNNAHFPEHLDHFVENMEDFSNDLFSSFFDDPVL
DEKSPLLDMELDSPAPGIQAEHSYSLSGDSAPQSPLVPVKMEDTTQDMEHGAWALGNKLCSIMV
KQEQSPELPVDPLAASSAMAAATMATPPLLGLSPISRLPIPHQAPGEMTQLPVIKAEPPEMSQF
LKVTQEDLVQMPPTPPSSHGSDSDGSQSPRSLPPSSPVRPMARSSTAISTSPLLTAPHKLQGTS
GPLLLTEEEKRTLIAEGYPIPTKLPLTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEKK
VETYTSENNELWKKVETLETANRTLLQQLQKLQTLVTSKISRPYKMAATQTGTCLMVAALCFVL
VLGSLAPCLPAFSSGSKTVKEDPVAADSVYAASQMPSRSLLFYDDGAGSWEDGHRGALLPVEPP
EGWELKPGGPAEPRPQDHLRHDHADSIHETTKYLRETWPEDTEDNGASPNFSHPKEWFHDRDLG
PNTTIKLS

hide sequence

RefSeq Acc Id:

ENSRNOP00000007771 ⟸ ENSRNOT00000007771

RefSeq Acc Id:	XP_038961358 ⟸ XM_039105430
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2UHZ0 (UniProtKB/TrEMBL)

Protein Domains

bZIP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q66HA2-F1-model_v2	AlphaFold	Q66HA2	1-520	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359613	AgrOrtholog
BioCyc Gene	G2FUF-48714	BioCyc
Ensembl Genes	ENSRNOG00000005413	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000007771	ENTREZGENE
	ENSRNOP00000007771.3	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000007771	ENTREZGENE
	ENSRNOT00000007771.4	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.170	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7122657	IMAGE-MGC_LOAD
InterPro	bZIP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	bZIP_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:362165	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94038	IMAGE-MGC_LOAD
NCBI Gene	362165	ENTREZGENE
PANTHER	CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR46004:SF1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	bZIP_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Creb3l1	PhenoGen
PRINTS	LEUZIPPRCREB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	BZIP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BZIP_BASIC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	BRLZ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF57959	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2UHZ0	ENTREZGENE, UniProtKB/TrEMBL
	A6HNF4	ENTREZGENE, UniProtKB/TrEMBL
	A6HNF5_RAT	UniProtKB/TrEMBL
	CR3L1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Creb3l1	cAMP responsive element binding protein 3-like 1			Symbol and Name status set to approved	1299863	APPROVED
2005-07-29	Creb3l1	cAMP responsive element binding protein 3-like 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)