Map3k20 (mitogen-activated protein kinase kinase kinase 20) - Rat Genome Database

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Pathways
Gene: Map3k20 (mitogen-activated protein kinase kinase kinase 20) Rattus norvegicus
Analyze
Symbol: Map3k20
Name: mitogen-activated protein kinase kinase kinase 20
RGD ID: 1561394
Description: Predicted to enable several functions, including ATP binding activity; JUN kinase kinase kinase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including cellular response to radiation; intracellular signal transduction; and regulation of cellular response to stress. Predicted to act upstream of with a positive effect on pyroptotic inflammatory response. Predicted to act upstream of or within cytoskeleton organization; gene expression; and intracellular signal transduction. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Orthologous to human MAP3K20 (mitogen-activated protein kinase kinase kinase 20); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC311743; mitogen-activated protein kinase kinase kinase MLT; MLTK; RGD1561394; similar to MLTK-beta; sterile alpha motif and leucine zipper containing kinase AZK; Zak
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8377,538,146 - 77,697,540 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl377,537,956 - 77,697,538 (+)EnsemblGRCr8
mRatBN7.2357,130,539 - 57,289,943 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl357,130,551 - 57,289,626 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx360,525,000 - 60,684,368 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0369,108,644 - 69,268,008 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0366,873,682 - 67,033,044 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0358,965,025 - 59,120,507 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl358,965,552 - 59,067,369 (+)Ensemblrn6Rnor6.0
Rnor_5.0365,435,276 - 65,598,052 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4354,767,724 - 54,915,022 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera356,670,166 - 56,831,147 (+)NCBICelera
Cytogenetic Map3q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-anisomycin  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
fenamidone  (ISO)
fisetin  (ISO)
fluoranthene  (ISO)
fluorescein 5-isothiocyanate  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
myristicin  (ISO)
nickel atom  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
protein kinase inhibitor  (ISO)
quinoline  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
XMU-MP-1  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7957077   PMID:10924358   PMID:11042189   PMID:11836244   PMID:15342622   PMID:19184368   PMID:22681889   PMID:25869677   PMID:26755636  


Genomics

Comparative Map Data
Map3k20
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8377,538,146 - 77,697,540 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl377,537,956 - 77,697,538 (+)EnsemblGRCr8
mRatBN7.2357,130,539 - 57,289,943 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl357,130,551 - 57,289,626 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx360,525,000 - 60,684,368 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0369,108,644 - 69,268,008 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0366,873,682 - 67,033,044 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0358,965,025 - 59,120,507 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl358,965,552 - 59,067,369 (+)Ensemblrn6Rnor6.0
Rnor_5.0365,435,276 - 65,598,052 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4354,767,724 - 54,915,022 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera356,670,166 - 56,831,147 (+)NCBICelera
Cytogenetic Map3q23NCBI
MAP3K20
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382173,075,517 - 173,268,015 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2173,075,435 - 173,268,015 (+)Ensemblhg38GRCh38
GRCh372173,940,574 - 174,132,743 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362173,648,811 - 173,840,983 (+)NCBIBuild 36Build 36hg18NCBI36
Celera2167,553,959 - 167,746,148 (+)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2165,819,879 - 166,012,160 (+)NCBIHuRef
CHM1_12173,947,661 - 174,139,938 (+)NCBICHM1_1
T2T-CHM13v2.02173,561,966 - 173,754,582 (+)NCBIT2T-CHM13v2.0
Map3k20
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39272,115,970 - 72,272,954 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl272,115,981 - 72,272,954 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38272,285,637 - 72,442,610 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl272,285,637 - 72,442,610 (+)Ensemblmm10GRCm38
MGSCv37272,123,694 - 72,280,667 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36272,086,616 - 72,243,449 (+)NCBIMGSCv36mm8
Celera273,970,184 - 74,127,061 (+)NCBICelera
Cytogenetic Map2C3NCBI
cM Map243.11NCBI
Map3k20
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554491,976,814 - 2,167,530 (-)Ensembl
ChiLan1.0NW_0049554491,976,186 - 2,139,044 (-)NCBIChiLan1.0ChiLan1.0
MAP3K20
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21375,748,878 - 75,942,235 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B75,763,197 - 75,957,208 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B60,362,635 - 60,555,445 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B177,817,875 - 178,010,556 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B177,818,344 - 178,010,556 (+)EnsemblpanPan2panpan1.1
MAP3K20
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13617,353,829 - 17,515,247 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3617,341,300 - 17,514,869 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3617,343,501 - 17,518,950 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03617,466,459 - 17,641,702 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3617,467,503 - 17,641,702 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13617,547,032 - 17,722,456 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03617,545,748 - 17,720,652 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03617,648,987 - 17,824,502 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Map3k20
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303134,476,003 - 134,650,636 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365093,029,979 - 3,202,796 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365093,029,942 - 3,203,319 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K20
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1579,173,033 - 79,380,993 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11579,174,444 - 79,378,520 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21588,495,627 - 88,690,961 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K20
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11058,573,303 - 58,764,759 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040140,811,053 - 140,999,695 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k20
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478710,405,701 - 10,565,943 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478710,392,738 - 10,566,563 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Map3k20
1257 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:507
Count of miRNA genes:257
Interacting mature miRNAs:318
Transcripts:ENSRNOT00000002067, ENSRNOT00000002068
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)37359251285062403Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
RH80553  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2357,248,770 - 57,248,998 (+)MAPPERmRatBN7.2
Rnor_6.0359,071,685 - 59,071,912NCBIRnor6.0
Rnor_5.0365,554,665 - 65,554,892UniSTSRnor5.0
RGSC_v3.4354,873,758 - 54,873,985UniSTSRGSC3.4
Celera356,790,022 - 56,790,249UniSTS
Cytogenetic Map3q22UniSTS
RH134323  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2357,248,547 - 57,248,766 (+)MAPPERmRatBN7.2
Rnor_6.0359,071,462 - 59,071,680NCBIRnor6.0
Rnor_5.0365,554,442 - 65,554,660UniSTSRnor5.0
RGSC_v3.4354,873,535 - 54,873,753UniSTSRGSC3.4
Celera356,789,799 - 56,790,017UniSTS
RH 3.4 Map4402.65UniSTS
Cytogenetic Map3q22UniSTS
BE097452  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2357,287,315 - 57,287,493 (+)MAPPERmRatBN7.2
Rnor_6.0359,117,880 - 59,118,057NCBIRnor6.0
Rnor_5.0365,595,425 - 65,595,602UniSTSRnor5.0
RGSC_v3.4354,912,395 - 54,912,572UniSTSRGSC3.4
Celera356,828,520 - 56,828,697UniSTS
Cytogenetic Map3q22UniSTS
BG374587  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2357,245,781 - 57,245,921 (+)MAPPERmRatBN7.2
Rnor_6.0359,068,696 - 59,068,835NCBIRnor6.0
Rnor_5.0365,551,676 - 65,551,815UniSTSRnor5.0
RGSC_v3.4354,870,769 - 54,870,908UniSTSRGSC3.4
Celera356,787,033 - 56,787,172UniSTS
Cytogenetic Map3q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002068   ⟹   ENSRNOP00000002068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl377,538,097 - 77,697,538 (+)Ensembl
mRatBN7.2 Ensembl357,130,551 - 57,289,626 (+)Ensembl
Rnor_6.0 Ensembl358,965,552 - 59,067,369 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097727   ⟹   ENSRNOP00000087005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl357,130,590 - 57,249,005 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112816   ⟹   ENSRNOP00000077905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl377,537,956 - 77,656,616 (+)Ensembl
mRatBN7.2 Ensembl357,130,590 - 57,249,005 (+)Ensembl
RefSeq Acc Id: NM_001398993   ⟹   NP_001385922
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8377,538,146 - 77,697,540 (+)NCBI
mRatBN7.2357,130,539 - 57,289,943 (+)NCBI
RefSeq Acc Id: NM_001398994   ⟹   NP_001385923
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8377,538,146 - 77,656,619 (+)NCBI
mRatBN7.2357,130,539 - 57,249,019 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001385922 (Get FASTA)   NCBI Sequence Viewer  
  NP_001385923 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002068
  ENSRNOP00000002068.3
  ENSRNOP00000077905
  ENSRNOP00000077905.1
  ENSRNOP00000087005.1
Ensembl Acc Id: ENSRNOP00000002068   ⟸   ENSRNOT00000002068
Ensembl Acc Id: ENSRNOP00000077905   ⟸   ENSRNOT00000112816
Ensembl Acc Id: ENSRNOP00000087005   ⟸   ENSRNOT00000097727
RefSeq Acc Id: NP_001385922   ⟸   NM_001398993
- Peptide Label: isoform 1
- UniProtKB: D4AE17 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385923   ⟸   NM_001398994
- Peptide Label: isoform 2
- UniProtKB: A0A8I5Y262 (UniProtKB/TrEMBL),   A0A8I6A4W9 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AE17-F1-model_v2 AlphaFold D4AE17 1-453 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561394 AgrOrtholog
BioCyc Gene G2FUF-49438 BioCyc
Ensembl Genes ENSRNOG00000001515 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002068 ENTREZGENE
  ENSRNOT00000002068.6 UniProtKB/TrEMBL
  ENSRNOT00000097727.1 UniProtKB/TrEMBL
  ENSRNOT00000112816 ENTREZGENE
  ENSRNOT00000112816.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  Ser/Thr_Kinases-Pseudokinases UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
NCBI Gene 311743 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED UniProtKB/TrEMBL
Pfam Pkinase_Tyr UniProtKB/TrEMBL
  SAM_1 UniProtKB/TrEMBL
PhenoGen Map3k20 PhenoGen
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001515 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF47769 UniProtKB/TrEMBL
UniProt A0A8I5Y262 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4W9 ENTREZGENE, UniProtKB/TrEMBL
  D4AE17 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-28 Map3k20  mitogen-activated protein kinase kinase kinase 20  Zak  sterile alpha motif and leucine zipper containing kinase AZK  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561394  similar to MLTK-beta   RGD1561394_predicted  similar to MLTK-beta (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561394_predicted  similar to MLTK-beta (predicted)  LOC311743  similar to MLTK-beta  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC311743  similar to MLTK-beta      Symbol and Name status set to provisional 70820 PROVISIONAL