Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Spi1 (Spi-1 proto-oncogene) Rattus norvegicus
Analyze
Symbol: Spi1
Name: Spi-1 proto-oncogene
Description: Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in cellular response to ethanol; negative regulation of transcription, DNA-templated; and positive regulation of transcription, DNA-templated. Localizes to the nucleus. Used to study alcohol use disorder. Biomarker of alcohol use disorder. Orthologous to human SPI1 (Spi-1 proto-oncogene); PARTICIPATES IN DNA modification pathway; interleukin-4 signaling pathway; acute myeloid leukemia pathway; INTERACTS WITH acrylamide; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: hematopoietic transcription factor PU.1; Pu.1; SFFV proviral integration 1; Sfpi1; spleen focus forming virus (SFFV) proviral integration oncogene; spleen focus forming virus (SFFV) proviral integration oncogene spi1; spleen focus forming virus proviral integration oncogene spi1; transcription factor PU.1
Orthologs:
Homo sapiens (human) : SPI1 (Spi-1 proto-oncogene)  HGNC  Alliance
Mus musculus (house mouse) : Spi1 (spleen focus forming virus (SFFV) proviral integration oncogene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spi1 (Spi-1 proto-oncogene)
Pan paniscus (bonobo/pygmy chimpanzee) : SPI1 (Spi-1 proto-oncogene)
Canis lupus familiaris (dog) : SPI1 (Spi-1 proto-oncogene)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spi1 (Spi-1 proto-oncogene)
Sus scrofa (pig) : SPI1 (Spi-1 proto-oncogene)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0379,918,127 - 79,937,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,918,969 - 79,938,301 (+)Ensembl
Rnor_5.0386,627,684 - 86,646,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,456,353 - 75,475,722 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,352,724 - 75,372,093 (+)NCBI
Celera376,282,068 - 76,300,680 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Spi1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1359607
Created: 2005-07-29
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.