Slc25a12 (solute carrier family 25 member 12)

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Gene: Slc25a12 (solute carrier family 25 member 12) Rattus norvegicus

Analyze

Symbol:

Slc25a12

Name:

solute carrier family 25 member 12

RGD ID:

1305181

Description:

Predicted to have acidic amino acid transmembrane transporter activity; calcium ion binding activity; and identical protein binding activity. Involved in several processes, including malate-aspartate shuttle; positive regulation of ATP biosynthetic process; and regulation of glucose metabolic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in Asperger syndrome; autistic disorder; and developmental and epileptic encephalopathy 39. Orthologous to human SLC25A12 (solute carrier family 25 member 12); PARTICIPATES IN argininosuccinic aciduria pathway; carbamoyl phosphate synthetase I deficiency pathway; citrullinemia pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

Aralar1; calcium-binding mitochondrial carrier protein Aralar1; LOC362145; LOW QUALITY PROTEIN: calcium-binding mitochondrial carrier protein Aralar1; RGD1561141; solute carrier family 25 (aspartate/glutamate carrier), member 12; solute carrier family 25 (mitochondrial carrier, Aralar), member 12; solute carrier family 25, member 12

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	56,098,080 - 56,192,188 (-)	NCBI
Rnor_6.0 Ensembl	3	57,882,370 - 57,957,346 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	3	57,881,951 - 57,998,214 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	3	64,425,236 - 64,487,369 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	3	64,377,674 - 64,416,725 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	53,620,160 - 53,680,498	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	3	55,645,527 - 55,739,772 (-)	NCBI		Celera
Cytogenetic Map	3	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Asperger syndrome (ISO)

autism spectrum disorder (ISO)

autistic disorder (ISO)

developmental and epileptic encephalopathy 39 (ISO)

epilepsy (ISO)

genetic disease (ISO)

rheumatoid arthritis (ISO)

visual epilepsy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4-hydroxyphenyl retinamide (ISO)

acrylamide (EXP)

aldehydo-D-glucose (EXP)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

Brodifacoum (EXP)

carbamazepine (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

D-glucose (EXP)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

entinostat (ISO)

ethanol (ISO)

folic acid (ISO)

gentamycin (EXP)

glucose (EXP)

hypochlorous acid (ISO)

lamivudine (ISO)

methapyrilene (ISO)

monosodium L-glutamate (ISO)

obeticholic acid (ISO)

panobinostat (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

piroxicam (ISO)

poly(I:C) (EXP)

potassium chromate (ISO)

quercetin (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenite (EXP)

tetrachloromethane (EXP,ISO)

trichostatin A (ISO)

triclosan (ISO)

triptonide (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vitamin E (ISO)

vorinostat (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aspartate transmembrane transport (IBA,ISO)

glutamate biosynthetic process (IMP)

L-aspartate transmembrane transport (IEA)

L-glutamate transmembrane transport (IBA,ISO)

malate-aspartate shuttle (IBA,IMP,ISO)

negative regulation of glucose catabolic process to lactate via pyruvate (IMP)

positive regulation of ATP biosynthetic process (IMP)

positive regulation of glucose metabolic process (IMP)

positive regulation of myelination (IMP)

response to calcium ion (ISO)

Cellular Component

integral component of membrane (IEA)

mitochondrial inner membrane (IEA)

mitochondrion (ISO)

Molecular Function

calcium ion binding (ISO)

identical protein binding (ISO)

L-aspartate transmembrane transporter activity (IBA,ISO)

L-glutamate transmembrane transporter activity (IBA,ISO)

transmembrane transporter activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

argininosuccinic aciduria pathway (ISO)

carbamoyl phosphate synthetase I deficiency pathway (ISO)

citrullinemia pathway (ISO)

hyperargininemia pathway (ISO)

nicotinamide adenine dinucleotide metabolic pathway (ISO)

ornithine carbamoyltransferase deficiency pathway (ISO)

urea cycle pathway (ISO)

References

References - curated


1.	Casimir M, etal., Biochem J. 2009 Dec 10;424(3):459-66. doi: 10.1042/BJ20090729.
2.	Correia C, etal., J Autism Dev Disord. 2006 Nov;36(8):1137-40. doi: 10.1007/s10803-006-0138-6.
3.	Durdiaková J, etal., Mol Autism. 2014 Mar 31;5(1):25. doi: 10.1186/2040-2392-5-25.
4.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	GOA data from the GO Consortium
6.	Lepagnol-Bestel AM, etal., Mol Psychiatry. 2008 Apr;13(4):385-97. doi: 10.1038/sj.mp.4002120. Epub 2008 Jan 8.
7.	McKenna MC, etal., Biochem Pharmacol. 2006 Feb 14;71(4):399-407. Epub 2005 Dec 20.
8.	MGD data from the GO Consortium
9.	OMIM Disease Annotation Pipeline
10.	Pipeline to import SMPDB annotations from SMPDB into RGD
11.	Ramoz N, etal., Am J Psychiatry 2004 Apr;161(4):662-9.
12.	RGD automated data pipeline
13.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14.	RGD automated import pipeline for gene-chemical interactions
15.	Sakurai T, etal., Biol Psychiatry. 2010 May 1;67(9):887-94. doi: 10.1016/j.biopsych.2009.08.042. Epub 2009 Dec 16.
16.	Ying W Antioxid Redox Signal. 2008 Feb;10(2):179-206.

Additional References at PubMed

PMID:9722566	PMID:11566871	PMID:12084073	PMID:12865426	PMID:14701727	PMID:15494407	PMID:16269409	PMID:17213189	PMID:17634366	PMID:18614015	PMID:20833797	PMID:25410934

Genomics

Comparative Map Data

Slc25a12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	56,098,080 - 56,192,188 (-)	NCBI
Rnor_6.0 Ensembl	3	57,882,370 - 57,957,346 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	3	57,881,951 - 57,998,214 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	3	64,425,236 - 64,487,369 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	3	64,377,674 - 64,416,725 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	53,620,160 - 53,680,498	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	3	55,645,527 - 55,739,772 (-)	NCBI		Celera
Cytogenetic Map	3	q22	NCBI

SLC25A12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	2	171,783,405 - 171,999,859 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	2	171,783,405 - 171,894,244 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	172,639,915 - 172,750,754 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	172,349,126 - 172,458,979 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	2	172,466,387 - 172,576,240	NCBI
Celera	2	166,256,502 - 166,367,904 (-)	NCBI
Cytogenetic Map	2	q31.1	NCBI
HuRef	2	164,525,268 - 164,635,693 (-)	NCBI		HuRef
CHM1_1	2	172,646,763 - 172,757,956 (-)	NCBI		CHM1_1

Slc25a12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	71,104,614 - 71,198,125 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	2	71,101,407 - 71,198,093 (-)	Ensembl
GRCm38	2	71,274,270 - 71,367,781 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	71,271,063 - 71,367,749 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	71,112,352 - 71,205,611 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	2	71,075,134 - 71,168,393 (-)	NCBI			mm8
Celera	2	72,934,243 - 73,030,549 (-)	NCBI		Celera
Cytogenetic Map	2	C2	NCBI

Slc25a12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955449	3,093,603 - 3,186,737 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955449	3,093,603 - 3,182,513 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC25A12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2B	176,532,940 - 176,755,193 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	176,532,940 - 176,641,894 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2B	59,071,123 - 59,297,327 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

SLC25A12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	16,185,011 - 16,391,080 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	16,185,649 - 16,483,016 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	16,195,022 - 16,399,770 (-)	NCBI
ROS_Cfam_1.0	36	16,305,983 - 16,511,922 (-)	NCBI
UMICH_Zoey_3.1	36	16,393,768 - 16,599,876 (-)	NCBI
UNSW_CanFamBas_1.0	36	16,393,468 - 16,600,256 (-)	NCBI
UU_Cfam_GSD_1.0	36	16,496,286 - 16,703,375 (-)	NCBI

Slc25a12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	133,440,179 - 133,608,738 (-)	NCBI
SpeTri2.0	NW_004936509	1,994,082 - 2,077,731 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC25A12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	77,895,935 - 78,098,383 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	77,895,935 - 78,021,930 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	87,284,119 - 87,308,544 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC25A12
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	57,268,948 - 57,387,958 (-)	NCBI
ChlSab1.1 Ensembl	10	57,265,550 - 57,387,910 (-)	Ensembl

Slc25a12
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624787	9,187,450 - 9,319,684 (-)	NCBI

Position Markers

RH135310

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	3	57,940,302 - 57,940,516	NCBI	Rnor6.0
Rnor_5.0	3	64,428,614 - 64,428,828	UniSTS	Rnor5.0
RGSC_v3.4	3	53,623,508 - 53,623,722	UniSTS	RGSC3.4
Celera	3	55,696,750 - 55,696,964	UniSTS
Cytogenetic Map	3	q21	UniSTS

RH138988

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	3	57,939,541 - 57,939,666	NCBI	Rnor6.0
Rnor_5.0	3	64,427,853 - 64,427,978	UniSTS	Rnor5.0
RGSC_v3.4	3	53,622,747 - 53,622,872	UniSTS	RGSC3.4
Celera	3	55,695,989 - 55,696,114	UniSTS
RH 3.4 Map	4	402.55	UniSTS
Cytogenetic Map	3	q21	UniSTS

RH139242

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	3	57,942,753 - 57,943,001	NCBI	Rnor6.0
Rnor_5.0	3	64,431,065 - 64,431,313	UniSTS	Rnor5.0
RGSC_v3.4	3	53,625,960 - 53,626,208	UniSTS	RGSC3.4
Celera	3	55,699,201 - 55,699,449	UniSTS
Cytogenetic Map	3	q21	UniSTS

M2SSR54B

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	3	57,935,032 - 57,936,033	NCBI	Rnor6.0
Rnor_6.0	3	57,935,032 - 57,936,043	NCBI	Rnor6.0
Rnor_5.0	3	64,423,344 - 64,424,355	UniSTS	Rnor5.0
Rnor_5.0	3	64,423,344 - 64,424,345	UniSTS	Rnor5.0
RGSC_v3.4	3	53,618,238 - 53,619,239	UniSTS	RGSC3.4
RGSC_v3.4	3	53,618,238 - 53,619,249	UniSTS	RGSC3.4
Celera	3	55,691,478 - 55,692,479	UniSTS
Celera	3	55,691,478 - 55,692,491	UniSTS
Cytogenetic Map	3	q21	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	95176874	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10094081	93415837	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	10119318	79772001	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	10639528	127023997	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	10639528	127023997	Rat
631676	Cm8	Cardiac mass QTL 8	7.03	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	3	18023664	63023664	Rat
10450794	Scl69	Serum cholesterol level QTL 69	6.3	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	21223803	66223803	Rat
10450804	Scl70	Serum cholesterol level QTL 70	4.7	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	21223803	66223803	Rat
631685	Bp118	Blood pressure QTL 118	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	24655225	69655225	Rat
2302055	Pia30	Pristane induced arthritis QTL 30	3.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	3	29321714	74321714	Rat
9590286	Uminl1	Urine mineral level QTL 1	3.5	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	3	29682732	74682732	Rat
9590136	Scort3	Serum corticosterone level QTL 3	23.37	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	29682732	74682732	Rat
8552950	Pigfal12	Plasma insulin-like growth factor 1 level QTL 12	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	29682732	74682732	Rat
8694196	Abfw2	Abdominal fat weight QTL 2	16.58	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	3	29682732	74682732	Rat
8694386	Bw159	Body weight QTL 159	4.52	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	3	29682732	74682732	Rat
1354590	Despr11	Despair related QTL 11		0.000031	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	3	29908255	74908255	Rat
2303593	Gluco46	Glucose level QTL 46	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	29908255	74908255	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	30114912	123700444	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	30846101	172879276	Rat
2301400	Cm68	Cardiac mass QTL 68		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	31103589	72989078	Rat
11565451	Bw177	Body weight QTL 177		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	3	31103589	72989078	Rat
11565452	Kidm57	Kidney mass QTL 57		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	31103589	72989078	Rat
12879866	Cm94	Cardiac mass QTL 94		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	31103589	72989078	Rat
12879867	Cm95	Cardiac mass QTL 95		0.047	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	31103589	72989078	Rat
12879868	Am6	Aortic mass QTL 6		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	31103589	72989078	Rat
61356	Bp37	Blood pressure QTL 37	3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	32130997	77130997	Rat
631647	Bp122	Blood pressure QTL 122	6.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	32130997	77130997	Rat
1300169	Bp177	Blood pressure QTL 177	2.96		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	3	33477354	62922975	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	33477354	81136227	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	33477354	108914061	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	34394121	103141944	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	39248391	140271184	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	40422921	85422921	Rat
2302276	Bw82	Body weight QTL 82	4.32		body mass (VT:0001259)	body weight (CMO:0000012)	3	40523593	64880586	Rat
1331777	Bw24	Body weight QTL 24	3.503		body mass (VT:0001259)	body weight (CMO:0000012)	3	40523593	92654473	Rat
1331795	Rf30	Renal function QTL 30	3.708		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	3	40523593	92654473	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	43295930	108914061	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	43295930	163640485	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	43295930	163640485	Rat
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	45406058	94467785	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	45406058	127023997	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	45406058	177699992	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	48561928	155263151	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	48562146	115249962	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	48562146	115249962	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	51821836	124513579	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	51822008	120917851	Rat
1582249	Bw77	Body weight QTL 77	3.2	0.0025	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	54630948	66711785	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	54630948	119830094	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	54630948	119830094	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	54630948	119830094	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	54631046	93415673	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	55245276	95176874	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	55245276	95176874	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	55245276	95176874	Rat
1358293	Bw38	Body weight QTL 38	6	0.0000031	body mass (VT:0001259)	body weight (CMO:0000012)	3	56735995	101735995	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	60
Count of miRNA genes:	56
Interacting mature miRNAs:	60
Transcripts:	ENSRNOT00000036728
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	48	32	19	32	8	11	74	35	34	11	8
Low			9	9		9					7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008761972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775520	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106368	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106369	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC107446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000036728 ⟹ ENSRNOP00000032909

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	57,882,370 - 57,957,346 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000090426 ⟹ ENSRNOP00000072270

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	57,882,421 - 57,913,999 (-)	Ensembl

RefSeq Acc Id:

XM_008761972 ⟹ XP_008760194

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	57,881,951 - 57,998,214 (-)	NCBI

Sequence:

show sequence

CGGAATCCAGTGGCCGGAGCTCAGGTGTCCCCCCGCAAGAGGCGCGACAACCCCGCCGGTCCGC
AGATGGACAGACCGAGGCCTCTCGGTGCGCACTGCCGCCGCGCTCTAGTTCATTTGCATATAGA
CGGGCGCGGCGCTGCGACAGGAGGGAGCGCGGGCGCGGCCCCGGGCCGTGGCGCGCGCGCGCCC
TGACAGCTCGGCCCTGCTCGCTCACTCGCTCGTTCCCGGCTTCCGAGCACAGCATGGCGGTCAA
GGTGCACACAACCAAACGAGGTGATCCTCATGAGCTGAGAAACATATTCCTACAGTATGCCAGC
ACCGAGGTGGACGGAGAGCATTACATGACTCCGGAAGACTTCGTTCAACGCTACCTTGGCCTGT
ACAATGATCCGAACAGCAACCCAAAGATCGTGCAGCTCTTGGCAGGAGTAGCTGATCAAACCAA
GGATGGGTTGATCTCCTATCAAGAGTTTTTGGCATTTGAATCTGTTCTATGTGCTCCAGATTCC
ATGTTCATAGTGGCTTTCCAACTGTTTGACAAGAGTGGAAATGGAGAGGTGACATTTGAAAATG
TCAAGGAGATTTTCGGACAGACTATTATCCATCACCACATCCCCTTTAACTGGGACTGCGAGTT
CATCCGGCTGCACTTTGGGCACAACCGCAAGAAGCACCTGAACTATGTGGAATTCACTCAGTTC
CTCCAGGAATTGCAATTGGAGCACGCAAGGCAAGCCTTTGCGCTGAAAGACAAGAGCAAAAGCG
GCATGATCTCAGGCCTGGATTTCAGTGATGTCATGGTCACCATCCGGTCCCACATGCTCACTCC
TTTTGTGGAGGAGAACCTAGTCTCAGCTGCTGGAGGGAGTACCTCACACCAAGTTAGCTTCTCC
TACTTCAACGCGTTTAACTCCCTGCTCAACAATATGGAGCTGGTTCGCAAGATCTACAGCACTC
TGGCCGGCACAAGGAAAGACATTGAAGTTACCAAGGAAAATGTGAATAAGGAGGTGGCCCCTTT
GAATACATCTCTTCAGCTTTTGGGGGAGAAAGGTGTGCTCTACCTGAGGGGTTTGTCAATGTCT
AACAATTCTCTTTGTCACCCTTCTCCCTTAAGGCGCTTGACTCTGGCAGACATCGAGAGAATAG
CTCCGCTGGCTGAGGGGGCCTTACCTTACAACCTGGCAGAGCTTCAGAGGCAGCAATCCCCCGG
CTTGGGCAGACCTATCTGGCTCCAGATTGCCGAGTCTGCATACAGGTTCACTCTGGGCTCAGTG
GCAGGAGCTGTGGGGGCCACTGCGGTCTATCCCATAGACCTGGTGAAGACCCGGATGCAAAACC
AGCGCGGCACAGGCTCTGTGGTCGGGGAGCTGATGTATAAAAACAGCTTTGACTGTTTTAAGAA
AGTGTTACGTTATGAGGGTTTCTTTGGACTGTACCGAGGTCTGATCCCACAGCTGATAGGAGTT
GCACCAGAAAAAGCCATTAAGCTAACAGTTAATGATTTTGTCCGGGACAAATTTACCAGAAGAG
ATGGCTCCATCCCACTGCCTGCAGAAATTCTTGCTGGAGGTTGCGCTGGAGGCTCGCAGGTCAT
CTTTACCAATCCTCTGGAGATAGTGAAGATTCGCCTTCAGGTAGCCGGAGAGATCACCACAGGA
CCCAGAGTCAGTGCTCTGAATGTGCTTCAGGACTTGGGACTTTTTGGGCTGTACAAGGGTGCCA
AAGCGTGTTTCCTCCGAGACATTCCCTTCTCCGCGATCTATTTTCCCGTGTATGCTCACTGCAA
ACTCCTCCTGGCGGATGAGAACGGACACGTGGGAGGTATCAATCTCCTAACAGCCGGAGCCATG
GCAGGTGTGCCTGCTGCTTCTCTGGTGACCCCTGCTGATGTTATCAAGACAAGACTGCAAGTGG
CCGCCAGGGCTGGCCAGACAACATACAGCGGGGTCATTGACTGTTTCCGAAAGATTCTCCGGGA
AGAAGGGCCGTCGGCATTCTGGAAAGGGACTGCAGCTCGAGTGTTCCGGTCCTCGCCTCAGTTT
GGTGTCACTCTGGTTACCTACGAGCTTCTGCAGCGGTGGTTTTACATAGATTTTGGAGGCCTGA
AACCTTCTGGCTCAGAACCAACACCAAAGTCACGCATCGCAGACCTCCCTCCTGCCAACCCGGA
CCACATCGGCGGCTACAGACTTGCCACAGCCACTTTCGCTGGCATCGAAAACAAGTTTGGCCTT
TACCTCCCCAAGTTTAAGTCTCCTGGCGTAGCTGCGGCTCAGCCCAAGGTGGCGGCAGCAGCTC
AATGACATAGCAACTACAGACCGAGGCCCGGGAAGATGGGCGGTACCCTGTCCAGTCAGCTGCG
TGTGGTACTGTCTGCGCTGGGGTCAACAACCTTCTACACGACCTCTACATGTATTGTTTATAAA
GTGAGCATAAGCCCAGGGAGAACCACAGTGCAGTTTCGAGCTTTAGTCTTATTTGTTGAAATGT
TTTCTGAGCCTTGGCATGAATTCTGTGTTCTAGACTCCGCTTCGCACAGCTTGTACCTACAGTG
ACTGTACATATGTTGTACATCTTTGTACAGAGACACCTTGGCACCTCCTCCCAACGAATCACGT
TTATAGACATGTAACGCTGTTCCGAGTGGCTTGGACTGTACAGAATGTTTTGAAAGTGTTTTAC
TAAGAATCATATAAGAATAAATGTACTAAAGTTAAATTCA

hide sequence

RefSeq Acc Id:

XM_008775520 ⟹ XP_008773742

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Celera	3	55,645,527 - 55,739,772 (-)	NCBI

Sequence:

show sequence

GTCGGAATCCAGTGGCCGGAGCTCAGGTGTCCCCCCGCAAGAGGCGCGACAACCCCGCCGGTCC
GCAGATGGACAGACCGAGGCCTCTCGGTGCGCACTGCCGCCGCGCTCTAGTTCATTTGCATATA
GACGGGCGCGGCGCTGCGACAGGAGGGAGCGCGGGCGCGGCCCCGGGCCGTGGCGCGCGCGCGC
CCTGACAGCTCGGCCCTGCTCGCTCACTCGCTCGTTCCCGGCTTCCGAGCACAGCATGGCGGTC
AAGGTGCACACAACCAAACGAGGTGATCCTCATGAGCTGAGAAACATATTCCTACAGTATGCCA
GCACCGAGGTGGACGGAGAGCATTACATGACTCCGGAAGACTTCGTTCAACGCTACCTTGGCCT
GTACAATGATCCGAACAGCAACCCAAAGATCGTGCAGCTCTTGGCAGGAGTAGCTGATCAAACC
AAGGATGGGTTGATCTCCTATCAAGAGTTTTTGGCATTTGAATCTGTTCTATGTGCTCCAGATT
CCATGTTCATAGTGGCTTTCCAACTGTTTGACAAGAGTGGAAATGGAGAGGTGACATTTGAAAA
TGTCAAGGAGATTTTCGGACAGACTATTATCCATCACCACATCCCCTTTAACTGGGACTGCGAG
TTCATCCGGCTGCACTTTGGGCACAACCGCAAGAAGCACCTGAACTATGTGGAATTCACTCAGT
TCCTCCAGGAATTGCAATTGGAGCACGCAAGGCAAGCCTTTGCGCTGAAAGACAAGAGCAAAAG
CGGCATGATCTCAGGCCTGGATTTCAGTGATGTCATGGTCACCATCCGGTCCCACATGCTCACT
CCTTTTGTGGAGGAGAACCTAGTCTCAGCTGCTGGAGGGAGTACCTCACACCAAGTTAGCTTCT
CCTACTTCAACGCGTTTAACTCCCTGCTCAACAATATGGAGCTGGTTCGCAAGATCTACAGCAC
TCTGGCCGGCACAAGGAAAGACATTGAAGTTACCAAGGGTAAAAATGTGAATAAGGAGGTGGCC
CCTTTGAATACATCTCTTCAGCTTTTGGGGGAGAAAGGTGTGCTCTACCTGAGGGGTTTGTCAA
TGTCTAACAATTCTCTTTGTCACCCTTCTCCCTTAAGGCGCTTGACTCTGGCAGACATCGAGAG
AATAGCTCCGCTGGCTGAGGGGGCCTTACCTTACAACCTGGCAGAGCTTCAGAGGCAGCAATCC
CCCGGCTTGGGCAGACCTATCTGGCTCCAGATTGCCGAGTCTGCATACAGGTTCACTCTGGGCT
CAGTGGCAGGAGCTGTGGGGGCCACTGCGGTCTATCCCATAGACCTGGTGAAGACCCGGATGCA
AAACCAGCGCGGCACAGGCTCTGTGGTCGGGGAGCTGATGTATAAAAACAGCTTTGACTGTTTT
AAGAAAGTGTTACGTTATGAGGGTTTCTTTGGACTGTACCGAGGTCTGATCCCACAGCTGATAG
GAGTTGCACCAGAAAAAGCCATTAAGCTAACAGTTAATGATTTTGTCCGGGACAAATTTACCAG
AAGAGATGGCTCCATCCCACTGCCTGCAGAAATTCTTGCTGGAGGTTGCGCTGGAGGCTCGCAG
GTCATCTTTACCAATCCTCTGGAGATAGTGAAGATTCGCCTTCAGGTAGCCGGAGAGATCACCA
CAGGACCCAGAGTCAGTGCTCTGAATGTGCTTCAGGACTTGGGACTTTTTGGGCTGTACAAGGG
TGCCAAAGCGTGTTTCCTCCGAGACATTCCCTTCTCCGCGATCTATTTTCCCGTGTATGCTCAC
TGCAAACTCCTCCTGGCGGATGAGAACGGACACGTGGGAGGTATCAATCTCCTAACAGCCGGAG
CCATGGCAGGTGTGCCTGCTGCTTCTCTGGTGACCCCTGCTGATGTTATCAAGACAAGACTGCA
AGTGGCCGCCAGGGCTGGCCAGACAACATACAGCGGGGTCATTGACTGTTTCCGAAAGATTCTC
CGGGAAGAAGGGCCGTCGGCATTCTGGAAAGGGACTGCAGCTCGAGTGTTCCGGTCCTCGCCTC
AGTTTGGTGTCACTCTGGTTACCTACGAGCTTCTGCAGCGGTGGTTTTACATAGATTTTGGAGG
CCTGAAACCTTCTGGCTCAGAACCAACACCAAAGTCACGCATCGCAGACCTCCCTCCTGCCAAC
CCGGACCACATCGGCGGTTACAGACTTGCCACAGCCACTTTCGCTGGCATCGAAAACAAGTTTG
GCCTTTACCTCCCCAAGTTTAAGTCTCCTGGCGTAGCTGCGGCTCAGCCCAAGGTGGCGGCAGC
AGCTCAATGACATAGCAACTACAGACCGAGGCCCGGGAAGATGGGCGGTACCCTGTCCAGTCAG
CTGCGTGTGGTACTGTCTGCGCTGGGGTCAACAACCTTCTACACGACCTCTACATGTATTGTTT
ATAAAGTGAGCATAAGCCCAGGGAGAACCACAGTGCAGTTTCGAGCTTTAGTCTTATTTGTTGA
AATGTTTTCTGAGCCTTGGCATGAATTCTGTGTTCTAGACTCCGCTTCGCACAGCTTGTACCTA
CAGTGACTGTACATATGTTGTACATCTTTGTACAGAGACACCTTGGCACCTCCTCCCAACGAAT
CACGTTTATAGACATGTAACGCTGTTCCGAGTGGCTTGGACTGTACAGAATGTTTTGAAAGTGT
TTTACTAAGAATCATATAAGAATAAATGTACTAAAGTTAAATTCA

hide sequence

RefSeq Acc Id:

XM_039106368 ⟹ XP_038962296

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	56,098,080 - 56,192,188 (-)	NCBI

RefSeq Acc Id:

XM_039106369 ⟹ XP_038962297

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	56,098,080 - 56,155,402 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_038962296	(Get FASTA)	NCBI Sequence Viewer
	XP_038962297	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_008773742 ⟸ XM_008775520

- Peptide Label:

isoform X2

- Sequence:

show sequence

MAVKVHTTKRGDPHELRNIFLQYASTEVDGEHYMTPEDFVQRYLGLYNDPNSNPKIVQLLAGVA
DQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTIIHHHIPFNW
DCEFIRLHFGHNRKKHLNYVEFTQFLQELQLEHARQAFALKDKSKSGMISGLDFSDVMVTIRSH
MLTPFVEENLVSAAGGSTSHQVSFSYFNAFNSLLNNMELVRKIYSTLAGTRKDIEVTKGKNVNK
EVAPLNTSLQLLGEKGVLYLRGLSMSNNSLCHPSPLRRLTLADIERIAPLAEGALPYNLAELQR
QQSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGTGSVVGELMYKNSF
DCFKKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSIPLPAEILAGGCAG
GSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLQDLGLFGLYKGAKACFLRDIPFSAIYFPV
YAHCKLLLADENGHVGGINLLTAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFR
KILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWFYIDFGGLKPSGSEPTPKSRIADLP
PANPDHIGGYRLATATFAGIENKFGLYLPKFKSPGVAAAQPKVAAAAQ

hide sequence

RefSeq Acc Id:

XP_008760194 ⟸ XM_008761972

- Peptide Label:

isoform X1

- Sequence:

show sequence

MAVKVHTTKRGDPHELRNIFLQYASTEVDGEHYMTPEDFVQRYLGLYNDPNSNPKIVQLLAGVA
DQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTIIHHHIPFNW
DCEFIRLHFGHNRKKHLNYVEFTQFLQELQLEHARQAFALKDKSKSGMISGLDFSDVMVTIRSH
MLTPFVEENLVSAAGGSTSHQVSFSYFNAFNSLLNNMELVRKIYSTLAGTRKDIEVTKENVNKE
VAPLNTSLQLLGEKGVLYLRGLSMSNNSLCHPSPLRRLTLADIERIAPLAEGALPYNLAELQRQ
QSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGTGSVVGELMYKNSFD
CFKKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSIPLPAEILAGGCAGG
SQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLQDLGLFGLYKGAKACFLRDIPFSAIYFPVY
AHCKLLLADENGHVGGINLLTAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRK
ILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWFYIDFGGLKPSGSEPTPKSRIADLPP
ANPDHIGGYRLATATFAGIENKFGLYLPKFKSPGVAAAQPKVAAAAQ

hide sequence

RefSeq Acc Id:

ENSRNOP00000032909 ⟸ ENSRNOT00000036728

RefSeq Acc Id:

ENSRNOP00000072270 ⟸ ENSRNOT00000090426

RefSeq Acc Id:	XP_038962296 ⟸ XM_039106368
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038962297 ⟸ XM_039106369
- Peptide Label:	isoform X2

Protein Domains

EF-hand

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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CSV

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

Visual

CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305181	AgrOrtholog
Ensembl Genes	ENSRNOG00000022922	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000032909	UniProtKB/TrEMBL
	ENSRNOP00000072270	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000036728	UniProtKB/TrEMBL
	ENSRNOT00000090426	UniProtKB/TrEMBL
Gene3D-CATH	1.50.40.10	UniProtKB/TrEMBL
InterPro	EF-hand-like_dom	UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	Mit_carrier	UniProtKB/TrEMBL
	Mitochondrial_sb/sol_carrier	UniProtKB/TrEMBL
	Mt_carrier_dom	UniProtKB/TrEMBL
NCBI Gene	362145	ENTREZGENE
Pfam	Mito_carr	UniProtKB/TrEMBL
PhenoGen	Slc25a12	PhenoGen
PRINTS	MITOCARRIER	UniProtKB/TrEMBL
PROSITE	EF_HAND_1	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
	SOLCAR	UniProtKB/TrEMBL
SMART	EFh	UniProtKB/TrEMBL
Superfamily-SCOP	Mitoch_carrier	UniProtKB/TrEMBL
	SSF47473	UniProtKB/TrEMBL
UniProt	A0A0G2K2J7_RAT	UniProtKB/TrEMBL
	F1LX07_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-09	Slc25a12	solute carrier family 25 member 12	Slc25a12	solute carrier family 25 (aspartate/glutamate carrier), member 12	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-02	Slc25a12	solute carrier family 25 (aspartate/glutamate carrier), member 12	Slc25a12	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-05-24	Slc25a12	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	LOC100360985	solute carrier family 25, member 12	Data Merged	1643240	APPROVED
2010-05-05	LOC100360985	solute carrier family 25, member 12			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-04-30	Slc25a12	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	Slc25a12_predicted	solute carrier family 25 (mitochondrial carrier, Aralar), member 12 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Slc25a12_predicted	solute carrier family 25 (mitochondrial carrier, Aralar), member 12 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

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RGD Manual Annotations

Imported Annotations - SMPDB