Slc25a12 (solute carrier family 25 member 12) - Rat Genome Database

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Pathways
Gene: Slc25a12 (solute carrier family 25 member 12) Rattus norvegicus
Analyze
Symbol: Slc25a12
Name: solute carrier family 25 member 12
RGD ID: 1305181
Description: Predicted to enable amino acid transmembrane transporter activity; calcium ion binding activity; and identical protein binding activity. Involved in several processes, including malate-aspartate shuttle; positive regulation of ATP biosynthetic process; and regulation of glucose metabolic process. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Asperger syndrome; autistic disorder; and developmental and epileptic encephalopathy 39. Orthologous to human SLC25A12 (solute carrier family 25 member 12); PARTICIPATES IN argininosuccinic aciduria pathway; carbamoyl phosphate synthetase I deficiency pathway; citrullinemia pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Aralar1; calcium-binding mitochondrial carrier protein Aralar1; electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial; LOC362145; RGD1561141; solute carrier family 25 (aspartate/glutamate carrier), member 12; solute carrier family 25 (mitochondrial carrier, Aralar), member 12; solute carrier family 25, member 12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2356,097,166 - 56,191,841 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl356,097,269 - 56,192,100 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx359,494,953 - 59,589,864 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0368,078,560 - 68,173,464 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0365,840,596 - 65,935,265 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0357,881,951 - 57,998,214 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl357,882,370 - 57,957,346 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0364,425,236 - 64,487,369 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0364,377,674 - 64,416,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4353,620,160 - 53,680,498NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera355,645,527 - 55,739,772 (-)NCBICelera
Cytogenetic Map3q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP)
aldehydo-D-glucose  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glucose  (EXP)
hypochlorous acid  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
methapyrilene  (ISO)
monosodium L-glutamate  (ISO)
obeticholic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (EXP)
potassium chromate  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets. Casimir M, etal., Biochem J. 2009 Dec 10;424(3):459-66. doi: 10.1042/BJ20090729.
2. Brief report: High frequency of biochemical markers for mitochondrial dysfunction in autism: no association with the mitochondrial aspartate/glutamate carrier SLC25A12 gene. Correia C, etal., J Autism Dev Disord. 2006 Nov;36(8):1137-40. doi: 10.1007/s10803-006-0138-6.
3. Single nucleotide polymorphism rs6716901 in SLC25A12 gene is associated with Asperger syndrome. Durdiakov√° J, etal., Mol Autism. 2014 Mar 31;5(1):25. doi: 10.1186/2040-2392-5-25.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects. Lepagnol-Bestel AM, etal., Mol Psychiatry. 2008 Apr;13(4):385-97. doi: 10.1038/sj.mp.4002120. Epub 2008 Jan 8.
7. Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools. McKenna MC, etal., Biochem Pharmacol. 2006 Feb 14;71(4):399-407. Epub 2005 Dec 20.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. Ramoz N, etal., Am J Psychiatry 2004 Apr;161(4):662-9.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Slc25a12 disruption alters myelination and neurofilaments: a model for a hypomyelination syndrome and childhood neurodevelopmental disorders. Sakurai T, etal., Biol Psychiatry. 2010 May 1;67(9):887-94. doi: 10.1016/j.biopsych.2009.08.042. Epub 2009 Dec 16.
16. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Ying W Antioxid Redox Signal. 2008 Feb;10(2):179-206.
Additional References at PubMed
PMID:9722566   PMID:11566871   PMID:12084073   PMID:12865426   PMID:14701727   PMID:15494407   PMID:16269409   PMID:17213189   PMID:17634366   PMID:18614015   PMID:20833797   PMID:25410934  


Genomics

Comparative Map Data
Slc25a12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2356,097,166 - 56,191,841 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl356,097,269 - 56,192,100 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx359,494,953 - 59,589,864 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0368,078,560 - 68,173,464 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0365,840,596 - 65,935,265 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0357,881,951 - 57,998,214 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl357,882,370 - 57,957,346 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0364,425,236 - 64,487,369 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0364,377,674 - 64,416,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4353,620,160 - 53,680,498NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera355,645,527 - 55,739,772 (-)NCBICelera
Cytogenetic Map3q22NCBI
SLC25A12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382171,783,405 - 171,894,244 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2171,783,405 - 171,999,859 (-)EnsemblGRCh38hg38GRCh38
GRCh372172,639,915 - 172,750,754 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362172,349,126 - 172,458,979 (-)NCBINCBI36Build 36hg18NCBI36
Build 342172,466,387 - 172,576,240NCBI
Celera2166,256,502 - 166,367,904 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2164,525,268 - 164,635,693 (-)NCBIHuRef
CHM1_12172,646,763 - 172,757,956 (-)NCBICHM1_1
T2T-CHM13v2.02172,260,855 - 172,372,092 (-)NCBIT2T-CHM13v2.0
Slc25a12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39271,104,614 - 71,198,125 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl271,101,407 - 71,198,093 (-)EnsemblGRCm39 Ensembl
GRCm38271,274,270 - 71,367,781 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl271,271,063 - 71,367,749 (-)EnsemblGRCm38mm10GRCm38
MGSCv37271,112,352 - 71,205,611 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36271,075,134 - 71,168,393 (-)NCBIMGSCv36mm8
Celera272,934,243 - 73,030,549 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map242.38NCBI
Slc25a12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554493,093,603 - 3,186,737 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554493,093,603 - 3,182,513 (+)NCBIChiLan1.0ChiLan1.0
SLC25A12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12B74,475,794 - 74,699,177 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B59,071,123 - 59,297,327 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B176,532,940 - 176,755,193 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B176,532,940 - 176,641,894 (-)Ensemblpanpan1.1panPan2
SLC25A12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13616,185,011 - 16,391,080 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3616,185,649 - 16,483,016 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3616,195,022 - 16,399,770 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03616,305,983 - 16,511,922 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3616,305,986 - 16,511,932 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13616,393,768 - 16,599,876 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03616,393,468 - 16,600,256 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03616,496,286 - 16,703,375 (-)NCBIUU_Cfam_GSD_1.0
Slc25a12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303133,440,179 - 133,608,738 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365091,990,116 - 2,077,938 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365091,994,082 - 2,077,731 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC25A12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1577,895,938 - 78,098,383 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11577,895,935 - 78,021,930 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21587,284,119 - 87,308,544 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC25A12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11057,268,948 - 57,387,958 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1057,265,550 - 57,387,910 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040142,052,296 - 142,277,404 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc25a12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247879,184,514 - 9,320,060 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247879,187,450 - 9,319,684 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc25a12
568 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:56
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000036728
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35318459364655484Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat

Markers in Region
RH135310  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2356,149,389 - 56,149,604 (+)MAPPERmRatBN7.2
Rnor_6.0357,940,302 - 57,940,516NCBIRnor6.0
Rnor_5.0364,428,614 - 64,428,828UniSTSRnor5.0
RGSC_v3.4353,623,508 - 53,623,722UniSTSRGSC3.4
Celera355,696,750 - 55,696,964UniSTS
Cytogenetic Map3q21UniSTS
RH138988  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2356,148,628 - 56,148,754 (+)MAPPERmRatBN7.2
Rnor_6.0357,939,541 - 57,939,666NCBIRnor6.0
Rnor_5.0364,427,853 - 64,427,978UniSTSRnor5.0
RGSC_v3.4353,622,747 - 53,622,872UniSTSRGSC3.4
Celera355,695,989 - 55,696,114UniSTS
RH 3.4 Map4402.55UniSTS
Cytogenetic Map3q21UniSTS
RH139242  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2356,151,840 - 56,152,089 (+)MAPPERmRatBN7.2
Rnor_6.0357,942,753 - 57,943,001NCBIRnor6.0
Rnor_5.0364,431,065 - 64,431,313UniSTSRnor5.0
RGSC_v3.4353,625,960 - 53,626,208UniSTSRGSC3.4
Celera355,699,201 - 55,699,449UniSTS
Cytogenetic Map3q21UniSTS
M2SSR54B  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2356,144,119 - 56,145,121 (+)MAPPERmRatBN7.2
mRatBN7.2356,144,119 - 56,145,131 (+)MAPPERmRatBN7.2
Rnor_6.0357,935,032 - 57,936,043NCBIRnor6.0
Rnor_6.0357,935,032 - 57,936,033NCBIRnor6.0
Rnor_5.0364,423,344 - 64,424,355UniSTSRnor5.0
Rnor_5.0364,423,344 - 64,424,345UniSTSRnor5.0
RGSC_v3.4353,618,238 - 53,619,249UniSTSRGSC3.4
RGSC_v3.4353,618,238 - 53,619,239UniSTSRGSC3.4
Celera355,691,478 - 55,692,479UniSTS
Celera355,691,478 - 55,692,491UniSTS
Cytogenetic Map3q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 48 32 19 32 8 11 74 35 34 11 8
Low 9 9 9 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000036728   ⟹   ENSRNOP00000032909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl356,097,269 - 56,166,424 (-)Ensembl
Rnor_6.0 Ensembl357,882,370 - 57,957,346 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090426   ⟹   ENSRNOP00000072270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl356,098,786 - 56,130,772 (-)Ensembl
Rnor_6.0 Ensembl357,882,421 - 57,913,999 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118666   ⟹   ENSRNOP00000093623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl356,097,269 - 56,192,100 (-)Ensembl
RefSeq Acc Id: NM_001399269   ⟹   NP_001386198
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2356,097,166 - 56,191,841 (-)NCBI
RefSeq Acc Id: XM_039106369   ⟹   XP_038962297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2356,098,080 - 56,155,402 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386198 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962297 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein F1LX07 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: ENSRNOP00000032909   ⟸   ENSRNOT00000036728
RefSeq Acc Id: ENSRNOP00000072270   ⟸   ENSRNOT00000090426
RefSeq Acc Id: XP_038962297   ⟸   XM_039106369
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AM68 (UniProtKB/TrEMBL),   A0A8W1B2M1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093623   ⟸   ENSRNOT00000118666
RefSeq Acc Id: NP_001386198   ⟸   NM_001399269
- UniProtKB: F1LX07 (UniProtKB/Swiss-Prot)
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LX07-F1-model_v2 AlphaFold F1LX07 1-655 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305181 AgrOrtholog
BioCyc Gene G2FUF-49472 BioCyc
Ensembl Genes ENSRNOG00000022922 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000032909 ENTREZGENE
  ENSRNOP00000032909.7 UniProtKB/TrEMBL
  ENSRNOP00000072270.2 UniProtKB/TrEMBL
  ENSRNOP00000093623 ENTREZGENE
  ENSRNOP00000093623.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036728 ENTREZGENE
  ENSRNOT00000036728.7 UniProtKB/TrEMBL
  ENSRNOT00000090426.2 UniProtKB/TrEMBL
  ENSRNOT00000118666 ENTREZGENE
  ENSRNOT00000118666.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mit_carrier UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mitochondrial_sb/sol_carrier UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mt_carrier_dom UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
NCBI Gene 362145 ENTREZGENE
PANTHER CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Mito_carr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc25a12 PhenoGen
PRINTS MITOCARRIER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLCAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Mitoch_carrier UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K2J7_RAT UniProtKB/TrEMBL
  A0A8I6AM68 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W1B2M1 ENTREZGENE, UniProtKB/TrEMBL
  F1LX07 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc25a12  solute carrier family 25 member 12  Slc25a12  solute carrier family 25 (aspartate/glutamate carrier), member 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc25a12  solute carrier family 25 (aspartate/glutamate carrier), member 12  Slc25a12  solute carrier family 25 (mitochondrial carrier, Aralar), member 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Slc25a12  solute carrier family 25 (mitochondrial carrier, Aralar), member 12  LOC100360985  solute carrier family 25, member 12  Data Merged 1643240 APPROVED
2010-05-05 LOC100360985  solute carrier family 25, member 12      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Slc25a12  solute carrier family 25 (mitochondrial carrier, Aralar), member 12   Slc25a12_predicted  solute carrier family 25 (mitochondrial carrier, Aralar), member 12 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Slc25a12_predicted  solute carrier family 25 (mitochondrial carrier, Aralar), member 12 (predicted)      Symbol and Name status set to approved 70820 APPROVED