Slc1a2 (solute carrier family 1 member 2) - Rat Genome Database

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Gene: Slc1a2 (solute carrier family 1 member 2) Rattus norvegicus
Analyze
Symbol: Slc1a2
Name: solute carrier family 1 member 2
RGD ID: 3697
Description: Enables high-affinity L-glutamate transmembrane transporter activity. Involved in L-glutamate transmembrane transport. Located in several cellular components, including astrocyte projection; dendrite; and presynaptic membrane. Part of membrane protein complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2); PARTICIPATES IN amyotrophic lateral sclerosis pathway; glutamate signaling pathway; INTERACTS WITH (+)-schisandrin B; (4-chloro-2-methylphenoxy)acetic acid; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Eaat2; excitatory amino acid transporter 2; glial glutamate transporter GLT1/V3; glial glutamate transporter GLT1/V4; Glt; GLT-1; GluT; GluT-R; glutamate transporter; glutamate transporter 1; high affinity glucose transporter; sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; solute carrier family 1, member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2389,005,129 - 89,126,498 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl389,005,129 - 89,126,498 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx392,504,212 - 92,634,668 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03101,103,236 - 101,233,691 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0398,927,305 - 99,057,642 (+)NCBIRnor_WKY
Rnor_6.0392,518,679 - 92,665,731 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl392,640,752 - 92,665,644 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0399,168,111 - 99,308,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4387,870,558 - 87,992,401 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1387,766,997 - 87,888,821 (+)NCBI
Celera388,087,285 - 88,206,296 (+)NCBICelera
Cytogenetic Map3q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(4-chloro-2-methylphenoxy)acetic acid  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-chloroethanol  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
ammonium chloride  (EXP)
ampicillin  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylparaben  (EXP)
butyric acid  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
carbon nanotube  (ISO)
ceftriaxone  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
coumarin  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
genistein  (EXP)
haloperidol  (EXP)
hesperidin  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
ivermectin  (ISO)
kainic acid  (EXP,ISO)
ketamine  (EXP)
KT 5720  (EXP)
L-serine  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
LY294002  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mercury dibromide  (ISO)
metacetamol  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
nifedipine  (EXP)
ochratoxin A  (EXP)
oxidopamine  (EXP)
oxybenzone  (EXP)
oxycodone  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (EXP)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
propanal  (ISO)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (ISO)
quinazolines  (EXP)
raloxifene  (EXP)
resveratrol  (EXP)
rifampicin  (ISO)
Riluzole  (EXP)
romidepsin  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
staurosporine  (EXP)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP,ISO)
thiamphenicol  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
Tungsten carbide  (ISO)
tyrphostin AG 1478  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (EXP)
WIN 55212-2  (EXP)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Changes of NMDA receptor subunit (NR1, NR2B) and glutamate transporter (GLT1) mRNA expression in Huntington's disease--an in situ hybridization study. Arzberger T, etal., J Neuropathol Exp Neurol. 1997 Apr;56(4):440-54.
2. Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain. Chen W, etal., J Neurosci 2002 Mar 15;22(6):2142-52.
3. Similar perisynaptic glial localization for the Na+,K+-ATPase alpha 2 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex. Cholet N, etal., Cereb Cortex 2002 May;12(5):515-25.
4. Preconditioning with cortical spreading depression decreases intraischemic cerebral glutamate levels and down-regulates excitatory amino acid transporters EAAT1 and EAAT2 from rat cerebal cortex plasma membranes. Douen AG, etal., J Neurochem. 2000 Aug;75(2):812-8.
5. Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease. Fan MM, etal., J Neurosci. 2007 Apr 4;27(14):3768-79.
6. Glutamate transporter protein subtypes are expressed differentially during rat CNS development. Furuta A, etal., J Neurosci. 1997 Nov 1;17(21):8363-75.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Howland DS, etal., Proc Natl Acad Sci U S A 2002 Feb 5;99(3):1604-1609.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain. Lehre KP and Danbolt NC, J Neurosci. 1998 Nov 1;18(21):8751-7.
12. Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Lin CL, etal., Neuron 1998 Mar;20(3):589-602.
13. The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba. Marie H, etal., Mol Cell Neurosci 2002 Feb;19(2):152-64.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Cloning and expression of a rat brain L-glutamate transporter. Pines G, etal., Nature 1992 Dec 3;360(6403):464-7.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. The rat hepatoma cell line H4-II-E-C3 expresses high activities of the high-affinity glutamate transporter GLT-1A. Pollard M and McGivan J, FEBS Lett 2000 Nov 3;484(2):74-6.
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. A splice variant of glutamate transporter GLT1/EAAT2 expressed in neurons: cloning and localization in rat nervous system. Schmitt A, etal., Neuroscience 2002;109(1):45-61.
Additional References at PubMed
PMID:7521911   PMID:7698742   PMID:7913472   PMID:8099882   PMID:9180080   PMID:9373176   PMID:9539795   PMID:9671661   PMID:11744157   PMID:12420313   PMID:12535941   PMID:12957496  
PMID:14750980   PMID:14766991   PMID:15009636   PMID:15187084   PMID:15265858   PMID:15337309   PMID:15337311   PMID:15390098   PMID:15483603   PMID:15494979   PMID:15739191   PMID:15755674  
PMID:15789431   PMID:15892126   PMID:16024041   PMID:16079146   PMID:16175560   PMID:16197522   PMID:16292503   PMID:16324108   PMID:16474996   PMID:16718509   PMID:16738240   PMID:16868771  
PMID:16950847   PMID:16987241   PMID:17028421   PMID:17122424   PMID:17138558   PMID:17213861   PMID:17254611   PMID:17346885   PMID:17442809   PMID:17680651   PMID:17701165   PMID:17981401  
PMID:18079058   PMID:18248606   PMID:18381652   PMID:18384122   PMID:18428036   PMID:18671901   PMID:18720407   PMID:18720515   PMID:18805448   PMID:18973588   PMID:19200233   PMID:19323820  
PMID:19323997   PMID:19328838   PMID:19428804   PMID:19428805   PMID:19457061   PMID:19551376   PMID:19570219   PMID:19614985   PMID:19625514   PMID:19651762   PMID:19706515   PMID:19728998  
PMID:19747495   PMID:19804828   PMID:19806886   PMID:19998491   PMID:20072121   PMID:20152809   PMID:20193040   PMID:20375134   PMID:20547213   PMID:20685337   PMID:21098017   PMID:21110225  
PMID:21233495   PMID:21258616   PMID:21371514   PMID:21399631   PMID:21426345   PMID:21693777   PMID:21700703   PMID:21730107   PMID:21781120   PMID:21853027   PMID:21853059   PMID:21925558  
PMID:21964391   PMID:22052455   PMID:22069320   PMID:22171032   PMID:22266516   PMID:22266730   PMID:22593010   PMID:22645130   PMID:22710775   PMID:22871113   PMID:22895544   PMID:23020698  
PMID:23392471   PMID:23602887   PMID:23638698   PMID:23665075   PMID:23694703   PMID:23697999   PMID:23936321   PMID:23985782   PMID:24307171   PMID:24442982   PMID:24469401   PMID:24611756  
PMID:24650590   PMID:24687412   PMID:24735535   PMID:24753081   PMID:24836816   PMID:24866234   PMID:24907601   PMID:25059512   PMID:25454285   PMID:25480579   PMID:25716834   PMID:25834045  
PMID:26031379   PMID:26037264   PMID:26301411   PMID:26459476   PMID:26464063   PMID:26690923   PMID:26732590   PMID:26861954   PMID:26920805   PMID:27060486   PMID:27189737   PMID:27226528  
PMID:27247047   PMID:27430327   PMID:27438618   PMID:27769869   PMID:27837432   PMID:28104249   PMID:28461494   PMID:28677303   PMID:28771710   PMID:29045497   PMID:29350434   PMID:29375045  
PMID:29431649   PMID:29476059   PMID:29603414   PMID:30360015   PMID:30558468   PMID:30590449   PMID:30799685   PMID:30915775   PMID:31004734   PMID:31019528   PMID:31872442   PMID:32008166  
PMID:32170887   PMID:32357304   PMID:32433937   PMID:32621862   PMID:32650029   PMID:32847971   PMID:33619583   PMID:33860761   PMID:34197892   PMID:34719508   PMID:35451738  


Genomics

Comparative Map Data
Slc1a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2389,005,129 - 89,126,498 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl389,005,129 - 89,126,498 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx392,504,212 - 92,634,668 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03101,103,236 - 101,233,691 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0398,927,305 - 99,057,642 (+)NCBIRnor_WKY
Rnor_6.0392,518,679 - 92,665,731 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl392,640,752 - 92,665,644 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0399,168,111 - 99,308,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4387,870,558 - 87,992,401 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1387,766,997 - 87,888,821 (+)NCBI
Celera388,087,285 - 88,206,296 (+)NCBICelera
Cytogenetic Map3q32NCBI
SLC1A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381135,251,205 - 35,420,507 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1135,251,205 - 35,420,063 (-)EnsemblGRCh38hg38GRCh38
GRCh371135,272,752 - 35,441,605 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361135,229,328 - 35,397,681 (-)NCBINCBI36Build 36hg18NCBI36
Build 341135,229,328 - 35,397,372NCBI
Celera1135,420,071 - 35,588,420 (-)NCBICelera
Cytogenetic Map11p13NCBI
HuRef1134,972,036 - 35,140,670 (-)NCBIHuRef
CHM1_11135,271,219 - 35,439,999 (-)NCBICHM1_1
T2T-CHM13v2.01135,389,505 - 35,558,889 (-)NCBIT2T-CHM13v2.0
Slc1a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392102,488,584 - 102,621,129 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2102,489,004 - 102,621,129 (+)EnsemblGRCm39 Ensembl
GRCm382102,658,239 - 102,790,784 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2102,658,659 - 102,790,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv372102,498,840 - 102,630,941 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362102,507,277 - 102,578,945 (+)NCBIMGSCv36mm8
Celera2103,898,008 - 104,034,664 (+)NCBICelera
Cytogenetic Map2E2NCBI
cM Map254.13NCBI
Slc1a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542210,930,296 - 11,073,032 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542210,929,987 - 11,082,220 (+)NCBIChiLan1.0ChiLan1.0
SLC1A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11135,098,291 - 35,266,940 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,107,920 - 35,265,878 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01135,223,811 - 35,392,799 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC1A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11832,565,258 - 32,717,052 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1832,565,258 - 32,709,225 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1832,172,140 - 32,315,018 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01833,175,536 - 33,327,487 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1833,175,537 - 33,319,660 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11832,737,141 - 32,880,123 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01832,322,154 - 32,465,264 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01832,967,648 - 33,106,043 (+)NCBIUU_Cfam_GSD_1.0
Slc1a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494729,654,306 - 29,802,620 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365332,779,518 - 2,918,298 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365332,779,650 - 2,918,640 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC1A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl225,604,950 - 25,848,276 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1225,603,892 - 25,771,840 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2227,968,216 - 28,136,634 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC1A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,845,512 - 30,012,261 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,847,043 - 29,989,975 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038126,963,701 - 127,135,271 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc1a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476711,768,951 - 11,911,017 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476711,768,942 - 11,919,315 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc1a2
737 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:518
Count of miRNA genes:243
Interacting mature miRNAs:300
Transcripts:ENSRNOT00000007604
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat

Markers in Region
D3Rat27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2389,115,068 - 89,115,240 (+)MAPPERmRatBN7.2
Rnor_6.0392,654,302 - 92,654,473NCBIRnor6.0
Rnor_5.0399,297,509 - 99,297,680UniSTSRnor5.0
RGSC_v3.4387,981,086 - 87,981,257UniSTSRGSC3.4
RGSC_v3.4387,981,062 - 87,981,257RGDRGSC3.4
RGSC_v3.1387,877,514 - 87,877,685RGD
Celera388,194,883 - 88,195,054UniSTS
RH 3.4 Map3669.6RGD
RH 3.4 Map3669.6UniSTS
RH 2.0 Map3440.8RGD
SHRSP x BN Map347.2698RGD
Cytogenetic Map3q31UniSTS
BF386143  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2389,112,161 - 89,112,321 (+)MAPPERmRatBN7.2
Rnor_6.0392,651,395 - 92,651,554NCBIRnor6.0
Rnor_5.0399,294,602 - 99,294,761UniSTSRnor5.0
RGSC_v3.4387,978,179 - 87,978,338UniSTSRGSC3.4
Celera388,191,976 - 88,192,135UniSTS
RH 3.4 Map3669.7UniSTS
Cytogenetic Map3q31UniSTS
D43796  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2389,126,535 - 89,126,702 (+)MAPPERmRatBN7.2
Rnor_6.0392,665,769 - 92,665,935NCBIRnor6.0
Rnor_5.0399,308,761 - 99,308,927UniSTSRnor5.0
RGSC_v3.4387,992,439 - 87,992,605UniSTSRGSC3.4
Celera388,206,334 - 88,206,500UniSTS
Cytogenetic Map3q31UniSTS
RH138571  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2389,122,654 - 89,122,802 (+)MAPPERmRatBN7.2
Rnor_6.0392,661,888 - 92,662,035NCBIRnor6.0
Rnor_5.0399,304,880 - 99,305,027UniSTSRnor5.0
RGSC_v3.4387,988,558 - 87,988,705UniSTSRGSC3.4
Celera388,202,453 - 88,202,600UniSTS
RH 3.4 Map3670.4UniSTS
Cytogenetic Map3q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 5 5 5 69 7
Low 3 14 31 22 18 22 5 5 4 13 26 11 5
Below cutoff 25 21 14 1 14 3 5 21 8 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001035233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC113891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF297648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF451299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF465909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY044832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY069978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY578981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY643513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY643516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY643517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB760876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ489741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF017228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN132400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP966087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KR006257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U15098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000007604   ⟹   ENSRNOP00000007604
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,081,028 - 89,125,521 (+)Ensembl
Rnor_6.0 Ensembl392,640,752 - 92,665,644 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098273   ⟹   ENSRNOP00000091331
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,005,178 - 89,122,959 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099140   ⟹   ENSRNOP00000097282
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,005,178 - 89,126,498 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106964   ⟹   ENSRNOP00000093236
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,081,028 - 89,122,959 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109994   ⟹   ENSRNOP00000094162
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,005,129 - 89,122,959 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119447   ⟹   ENSRNOP00000097017
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,005,178 - 89,126,434 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119905   ⟹   ENSRNOP00000093496
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,053,004 - 89,122,959 (+)Ensembl
RefSeq Acc Id: NM_001035233   ⟹   NP_001030310
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2389,005,129 - 89,122,961 (+)NCBI
Rnor_6.0392,518,679 - 92,662,194 (+)NCBI
Rnor_5.0399,168,111 - 99,308,723 (+)NCBI
RGSC_v3.4387,870,558 - 87,992,401 (+)RGD
Celera388,087,285 - 88,202,759 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001302089   ⟹   NP_001289018
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2389,081,495 - 89,126,498 (+)NCBI
Rnor_6.0392,640,766 - 92,665,731 (+)NCBI
Celera388,161,302 - 88,206,296 (+)NCBI
Sequence:
RefSeq Acc Id: NM_017215   ⟹   NP_058911
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2389,005,129 - 89,126,498 (+)NCBI
Rnor_6.0392,518,679 - 92,665,731 (+)NCBI
Rnor_5.0399,168,111 - 99,308,723 (+)NCBI
RGSC_v3.4387,870,558 - 87,992,401 (+)RGD
Celera388,087,285 - 88,206,296 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058911   ⟸   NM_017215
- Peptide Label: isoform a
- UniProtKB: P31596 (UniProtKB/Swiss-Prot),   Q8K5B5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001030310   ⟸   NM_001035233
- Peptide Label: isoform b
- UniProtKB: A0A8I6AL04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289018   ⟸   NM_001302089
- Peptide Label: isoform c
- UniProtKB: P31596 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007604   ⟸   ENSRNOT00000007604
RefSeq Acc Id: ENSRNOP00000094162   ⟸   ENSRNOT00000109994
RefSeq Acc Id: ENSRNOP00000091331   ⟸   ENSRNOT00000098273
RefSeq Acc Id: ENSRNOP00000093236   ⟸   ENSRNOT00000106964
RefSeq Acc Id: ENSRNOP00000097282   ⟸   ENSRNOT00000099140
RefSeq Acc Id: ENSRNOP00000097017   ⟸   ENSRNOT00000119447
RefSeq Acc Id: ENSRNOP00000093496   ⟸   ENSRNOT00000119905

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31596-F1-model_v2 AlphaFold P31596 1-573 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3697 AgrOrtholog
BioCyc Gene G2FUF-48594 BioCyc
Ensembl Genes ENSRNOG00000005479 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007604 ENTREZGENE
  ENSRNOP00000007604.7 UniProtKB/TrEMBL
  ENSRNOP00000091331.1 UniProtKB/TrEMBL
  ENSRNOP00000093236.1 UniProtKB/TrEMBL
  ENSRNOP00000093496.1 UniProtKB/TrEMBL
  ENSRNOP00000094162 ENTREZGENE
  ENSRNOP00000094162.1 UniProtKB/TrEMBL
  ENSRNOP00000097017.1 UniProtKB/TrEMBL
  ENSRNOP00000097282 ENTREZGENE
  ENSRNOP00000097282.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007604 ENTREZGENE
  ENSRNOT00000007604.7 UniProtKB/TrEMBL
  ENSRNOT00000098273.1 UniProtKB/TrEMBL
  ENSRNOT00000099140 ENTREZGENE
  ENSRNOT00000099140.1 UniProtKB/TrEMBL
  ENSRNOT00000106964.1 UniProtKB/TrEMBL
  ENSRNOT00000109994 ENTREZGENE
  ENSRNOT00000109994.1 UniProtKB/TrEMBL
  ENSRNOT00000119447.1 UniProtKB/TrEMBL
  ENSRNOT00000119905.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.3860.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Na-dicarboxylate_symporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na-dicarboxylate_symporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na:dicarbo_symporter_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29482 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29482 ENTREZGENE
Pfam SDF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc1a2 PhenoGen
PROSITE NA_DICARBOXYL_SYMP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA_DICARBOXYL_SYMP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF118215 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AJ89_RAT UniProtKB/TrEMBL
  A0A8I6AL04 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AS41_RAT UniProtKB/TrEMBL
  A0A8I6B5J7_RAT UniProtKB/TrEMBL
  A0A8I6GIX2_RAT UniProtKB/TrEMBL
  A0A8I6GKB5_RAT UniProtKB/TrEMBL
  EAA2_RAT UniProtKB/Swiss-Prot
  G3V6R0_RAT UniProtKB/TrEMBL
  P31596 ENTREZGENE
  Q6DUJ4_RAT UniProtKB/TrEMBL
  Q6DUJ5_RAT UniProtKB/TrEMBL
  Q8K5B5 ENTREZGENE, UniProtKB/TrEMBL
  Q8R4I5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc1a2  solute carrier family 1 member 2  Slc1a2  solute carrier family 1 (glial high affinity glutamate transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc1a2  solute carrier family 1 (glial high affinity glutamate transporter), member 2    solute carrier family 1, member 2  Name updated 1299863 APPROVED
2002-06-10 Slc1a2  solute carrier family 1, member 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease significantly decreased in ventral horn of amyotrophic lateral sclerosis patients 70237
gene_disease loss may lead to cell death in amyotrophic lateral sclerosis 70237
gene_expression expressed in astrocytes 70237
gene_function central nervous system glutamate transporter 70237
gene_protein variant forms GLT1a and GLT1b differ at the C terminal region 619547