Sp3 (Sp3 transcription factor) - Rat Genome Database

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Gene: Sp3 (Sp3 transcription factor) Rattus norvegicus
Analyze
Symbol: Sp3
Name: Sp3 transcription factor
RGD ID: 1583765
Description: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of DNA-templated transcription. Located in nucleus. Part of protein-DNA complex and transcription repressor complex. Orthologous to human SP3 (Sp3 transcription factor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC103691822; Sp3 transcription factor (mapped); Sp3_mapped; trans-acting transcription factor 3; transcription factor Sp3; uncharacterized LOC103691822
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2357,811,855 - 57,857,150 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl357,812,075 - 57,860,342 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0359,644,579 - 59,689,011 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl359,646,015 - 59,688,692 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0366,118,151 - 66,163,940 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0366,729,636 - 66,739,419 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4355,440,985 - 55,485,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera357,350,925 - 57,387,172 (-)NCBICelera
Cytogenetic Map3q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
biotin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
dichloromethane  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glutathione  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
homocysteic acid  (ISO)
hydrogen peroxide  (ISO)
L-ascorbic acid  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
MC1568  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel sulfate  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenytoin  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
promegestone  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tetrathiomolybdate(2-)  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells. Alfonso-Jaume MA, etal., Biochem J. 2004 Jun 15;380(Pt 3):735-47.
2. Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. Billon N, etal., Oncogene. 1999 May 6;18(18):2872-82. doi: 10.1038/sj.onc.1202712.
3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene. Kim CS, etal., Nucleic Acids Res. 2006;34(22):6392-403. Epub 2006 Nov 27.
6. Sp1 and Egr1 regulate transcription of the Dmrt1 gene in Sertoli cells. Lei N and Heckert LL, Biol Reprod 2002 Mar;66(3):675-84.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12297531   PMID:12560508   PMID:12584202   PMID:12676787   PMID:12700237   PMID:12771217   PMID:14563703   PMID:14630713   PMID:15094381   PMID:15282343   PMID:15511642   PMID:15522233  
PMID:15572681   PMID:15721292   PMID:15817708   PMID:16378599   PMID:16403775   PMID:16460348   PMID:17379926   PMID:17584888   PMID:17670746   PMID:18004997   PMID:18275970   PMID:18348986  
PMID:19728174   PMID:19943855   PMID:20091743   PMID:20884886   PMID:21289081   PMID:23093703   PMID:25476526   PMID:30110572  


Genomics

Comparative Map Data
Sp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2357,811,855 - 57,857,150 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl357,812,075 - 57,860,342 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0359,644,579 - 59,689,011 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl359,646,015 - 59,688,692 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0366,118,151 - 66,163,940 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0366,729,636 - 66,739,419 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4355,440,985 - 55,485,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera357,350,925 - 57,387,172 (-)NCBICelera
Cytogenetic Map3q23NCBI
SP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382173,900,775 - 173,965,702 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2173,880,850 - 173,965,373 (-)EnsemblGRCh38hg38GRCh38
GRCh372174,765,503 - 174,830,430 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362174,481,504 - 174,538,309 (-)NCBINCBI36Build 36hg18NCBI36
Celera2168,384,626 - 168,443,931 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2166,650,849 - 166,709,905 (-)NCBIHuRef
CHM1_12174,778,156 - 174,837,417 (-)NCBICHM1_1
T2T-CHM13v2.02174,387,111 - 174,452,024 (-)NCBIT2T-CHM13v2.0
Sp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39272,766,774 - 72,810,790 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl272,766,771 - 72,810,790 (-)EnsemblGRCm39 Ensembl
GRCm38272,936,430 - 72,980,446 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl272,936,427 - 72,980,446 (-)EnsemblGRCm38mm10GRCm38
MGSCv37272,774,487 - 72,818,503 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36272,737,269 - 72,789,548 (-)NCBIMGSCv36mm8
Celera274,621,937 - 74,665,927 (-)NCBICelera
Cytogenetic Map2C3NCBI
Sp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554491,347,781 - 1,404,368 (+)NCBIChiLan1.0ChiLan1.0
SP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B178,639,630 - 178,698,313 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B178,639,677 - 178,692,848 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B61,185,975 - 61,243,155 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13618,023,750 - 18,086,995 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3618,024,627 - 18,077,587 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3618,030,699 - 18,085,623 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03618,154,210 - 18,209,148 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3618,152,355 - 18,209,033 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13618,234,479 - 18,289,351 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03618,232,972 - 18,287,863 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03618,336,948 - 18,391,940 (-)NCBIUU_Cfam_GSD_1.0
Sp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303135,186,490 - 135,238,803 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365093,741,836 - 3,793,136 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365093,740,393 - 3,782,873 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1579,935,994 - 80,025,850 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11579,935,986 - 79,990,139 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21589,252,305 - 89,292,992 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11059,414,739 - 59,471,596 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1059,416,152 - 59,470,456 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040140,106,666 - 140,163,017 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478711,144,581 - 11,193,520 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sp3
178 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:9
Count of miRNA genes:8
Interacting mature miRNAs:8
Transcripts:ENSRNOT00000026148
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35318459364655484Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat

Markers in Region
RH140061  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2357,842,288 - 57,842,475 (+)MAPPERmRatBN7.2
Rnor_6.0359,674,822 - 59,675,008NCBIRnor6.0
Rnor_5.0366,148,466 - 66,148,652UniSTSRnor5.0
RGSC_v3.4355,471,263 - 55,471,449UniSTSRGSC3.4
Celera357,381,143 - 57,381,329UniSTS
Cytogenetic Map3q22UniSTS
PMC169877P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X63,886,820 - 63,887,358 (+)MAPPERmRatBN7.2
mRatBN7.2323,603,189 - 23,603,720 (+)MAPPERmRatBN7.2
Rnor_6.0324,171,597 - 24,172,127NCBIRnor6.0
Rnor_6.0X68,471,397 - 68,471,934NCBIRnor6.0
Rnor_5.0329,388,989 - 29,389,519UniSTSRnor5.0
Rnor_5.0X69,346,132 - 69,346,669UniSTSRnor5.0
RGSC_v3.4X86,814,796 - 86,815,333UniSTSRGSC3.4
RGSC_v3.4319,691,805 - 19,692,335UniSTSRGSC3.4
Celera322,015,742 - 22,016,272UniSTS
CeleraX64,275,723 - 64,276,260UniSTS
Cytogenetic Map3q22UniSTS
Cytogenetic MapXq31UniSTS
RH133751  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2357,816,724 - 57,816,906 (+)MAPPERmRatBN7.2
Rnor_6.0360,252,732 - 60,252,913NCBIRnor6.0
Rnor_6.0359,649,229 - 59,649,410NCBIRnor6.0
Rnor_5.0366,123,021 - 66,123,202UniSTSRnor5.0
Rnor_5.0366,734,506 - 66,734,687UniSTSRnor5.0
RGSC_v3.4355,445,855 - 55,446,036UniSTSRGSC3.4
Celera357,355,575 - 57,355,756UniSTS
Cytogenetic Map3q22UniSTS
PMC305603P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X63,885,649 - 63,885,862 (+)MAPPERmRatBN7.2
mRatBN7.2357,847,231 - 57,847,443 (+)MAPPERmRatBN7.2
Rnor_6.0359,679,764 - 59,679,975NCBIRnor6.0
Rnor_6.0X68,470,226 - 68,470,438NCBIRnor6.0
Rnor_5.0366,153,408 - 66,153,619UniSTSRnor5.0
Rnor_5.0X69,344,961 - 69,345,173UniSTSRnor5.0
RGSC_v3.4X86,813,625 - 86,813,837UniSTSRGSC3.4
RGSC_v3.4355,476,205 - 55,476,416UniSTSRGSC3.4
Celera357,386,085 - 57,386,296UniSTS
CeleraX64,274,552 - 64,274,764UniSTS
Cytogenetic Map3q22UniSTS
Cytogenetic MapXq31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 54 38 19 38 8 8 74 35 38 11 8
Low 3 3 3 3 2 3
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078752   ⟹   ENSRNOP00000073478
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl357,812,075 - 57,848,374 (-)Ensembl
Rnor_6.0 Ensembl359,646,015 - 59,688,692 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103163   ⟹   ENSRNOP00000084927
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl357,812,075 - 57,860,342 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107886   ⟹   ENSRNOP00000090911
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl357,812,075 - 57,860,342 (-)Ensembl
RefSeq Acc Id: XM_039106376   ⟹   XP_038962304
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2357,811,855 - 57,857,150 (-)NCBI
RefSeq Acc Id: XM_039106378   ⟹   XP_038962306
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2357,811,855 - 57,857,150 (-)NCBI
RefSeq Acc Id: XM_039106379   ⟹   XP_038962307
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2357,811,855 - 57,856,460 (-)NCBI
RefSeq Acc Id: XR_005502231
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2357,821,463 - 57,857,150 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038962304 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962306 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962307 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: ENSRNOP00000073478   ⟸   ENSRNOT00000078752
RefSeq Acc Id: XP_038962306   ⟸   XM_039106378
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AEE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962304   ⟸   XM_039106376
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A0B6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962307   ⟸   XM_039106379
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000084927   ⟸   ENSRNOT00000103163
RefSeq Acc Id: ENSRNOP00000090911   ⟸   ENSRNOT00000107886
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K5M1-F1-model_v2 AlphaFold A0A0G2K5M1 1-714 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583765 AgrOrtholog
BioCyc Gene G2FUF-49389 BioCyc
Ensembl Genes ENSRNOG00000060479 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000073478.2 UniProtKB/TrEMBL
  ENSRNOP00000084927 ENTREZGENE
  ENSRNOP00000084927.1 UniProtKB/TrEMBL
  ENSRNOP00000090911 ENTREZGENE
  ENSRNOP00000090911.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078752.2 UniProtKB/TrEMBL
  ENSRNOT00000103163 ENTREZGENE
  ENSRNOT00000103163.1 UniProtKB/TrEMBL
  ENSRNOT00000107886 ENTREZGENE
  ENSRNOT00000107886.1 UniProtKB/TrEMBL
InterPro SP3 UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene 367846 ENTREZGENE
PANTHER PTHR23235:SF3 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Sp3 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A0G2K5M1_RAT UniProtKB/TrEMBL
  A0A8I6A0B6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEE9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Sp3  Sp3 transcription factor  LOC103691822  uncharacterized LOC103691822  Data Merged 737654 PROVISIONAL
2014-08-25 LOC103691822  uncharacterized LOC103691822      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-18 Sp3  Sp3 transcription factor  Sp3  trans-acting transcription factor 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Sp3  trans-acting transcription factor 3  Sp3  Sp3 transcription factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-12 Sp3  Sp3 transcription factor  Sp3_mapped  Sp3 transcription factor (mapped)  Data Merged 737654 APPROVED
2006-11-19 Sp3_mapped  Sp3 transcription factor(mapped)  Sp3  Sp3 transcription factor  Symbol set to symbol_mapped, name set to name (mapped) 1582166 APPROVED
2006-11-19 Sp3  Sp3 transcription factor      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Sp3  Sp3 transcription factor    Trans-acting transcription factor 3  Name updated 629478 APPROVED
2002-06-10 Sp3  Trans-acting transcription factor 3      Symbol and Name status set to approved 70586 APPROVED