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Gene: Sp3 (Sp3 transcription factor) Rattus norvegicus

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Symbol:

Sp3

Name:

Sp3 transcription factor

RGD ID:

1583765

Description:

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of DNA-templated transcription. Located in nucleus. Part of protein-DNA complex and transcription repressor complex. Orthologous to human SP3 (Sp3 transcription factor); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 7,12-dimethyltetraphene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC103691822; Sp3 transcription factor (mapped); Sp3_mapped; trans-acting transcription factor 3; transcription factor Sp3; uncharacterized LOC103691822

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SP3 (Sp3 transcription factor)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Sp3 (trans-acting transcription factor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sp3 (Sp3 transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SP3 (Sp3 transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SP3 (Sp3 transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sp3 (Sp3 transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SP3 (Sp3 transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SP3 (Sp3 transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sp3 (Sp3 transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SP3 (Sp3 transcription factor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sp3 (trans-acting transcription factor 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sp3a (sp3a transcription factor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sp3b (Sp3b transcription factor)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	sptf-3	Alliance	DIOPT (InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spps	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	sp3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	78,219,421 - 78,272,318 (-)	NCBI		GRCr8
mRatBN7.2	3	57,811,855 - 57,857,150 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	57,812,075 - 57,860,342 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	3	59,644,579 - 59,689,011 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	59,646,015 - 59,688,692 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	66,118,151 - 66,163,940 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	3	66,729,636 - 66,739,419 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	55,440,985 - 55,485,768 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	57,350,925 - 57,387,172 (-)	NCBI		Celera
Cytogenetic Map	3	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Sp3	Rat	split hand-foot malformation 5		ISO	RGD:1319818	8554872	ClinVar Annotator: match by term: Split hand-foot malformation 5	ClinVar	PMID:25741868

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Sp3	Rat	(+)-catechin	multiple interactions	ISO	RGD:1319818	6480464	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SP3 mRNA	CTD	PMID:24763279
Sp3	Rat	1,2-dimethylhydrazine	decreases expression	ISO	RGD:1319819	6480464	1,2-Dimethylhydrazine results in decreased expression of SP3 mRNA	CTD	PMID:22206623
Sp3	Rat	1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	increases expression	ISO	RGD:1319819	6480464	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP3 mRNA	CTD	PMID:29071302
Sp3	Rat	17alpha-ethynylestradiol	multiple interactions	ISO	RGD:1319819	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SP3 mRNA	CTD	PMID:17942748
Sp3	Rat	17beta-estradiol	affects expression	EXP		6480464	Estradiol affects the expression of SP3 mRNA	CTD	PMID:32145629
Sp3	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1319819	6480464	Tetrachlorodibenzodioxin affects the expression of SP3 mRNA	CTD	PMID:24058054
Sp3	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of SP3 mRNA	CTD	PMID:32109520
Sp3	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:1319819	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SP3 mRNA	CTD	PMID:17942748
Sp3	Rat	2-methylcholine	affects expression	ISO	RGD:1319818	6480464	beta-methylcholine affects the expression of SP3 mRNA	CTD	PMID:21179406
Sp3	Rat	4,4'-sulfonyldiphenol	decreases expression	ISO	RGD:1319819	6480464	bisphenol S results in decreased expression of SP3 mRNA	CTD	PMID:39298647
Sp3	Rat	4,4'-sulfonyldiphenol	decreases methylation	ISO	RGD:1319818	6480464	bisphenol S results in decreased methylation of SP3 gene	CTD	PMID:31601247
Sp3	Rat	4,4'-sulfonyldiphenol	multiple interactions	ISO	RGD:1319818	6480464	[bisphenol S co-treated with Fulvestrant] results in decreased methylation of SP3 gene	CTD	PMID:31601247
Sp3	Rat	5-aza-2'-deoxycytidine	multiple interactions	ISO	RGD:1319818	6480464	[Decitabine co-treated with trichostatin A] promotes the reaction [SP3 protein binds to CLDN3 promoter]; Decitabine more ...	CTD	PMID:17986852\|PMID:18033804
Sp3	Rat	5-fluorouracil	multiple interactions	ISO	RGD:1319818	6480464	TP53 protein affects the reaction [Fluorouracil results in decreased expression of SP3 mRNA]	CTD	PMID:15016801
Sp3	Rat	7,12-dimethyltetraphene	increases expression	EXP		6480464	9,10-Dimethyl-1,2-benzanthracene results in increased expression of SP3 mRNA	CTD	PMID:36863560
Sp3	Rat	aflatoxin B1	increases expression	ISO	RGD:1319819	6480464	Aflatoxin B1 results in increased expression of SP3 mRNA	CTD	PMID:19770486
Sp3	Rat	aflatoxin B1	decreases methylation	ISO	RGD:1319818	6480464	Aflatoxin B1 results in decreased methylation of SP3 gene	CTD	PMID:27153756
Sp3	Rat	antirheumatic drug	decreases expression	ISO	RGD:1319818	6480464	Antirheumatic Agents results in decreased expression of SP3 mRNA	CTD	PMID:24449571
Sp3	Rat	aristolochic acid A	decreases expression	ISO	RGD:1319818	6480464	aristolochic acid I results in decreased expression of SP3 mRNA; aristolochic acid I results in more ...	CTD	PMID:33212167
Sp3	Rat	arsenous acid	decreases expression	ISO	RGD:1319818	6480464	Arsenic Trioxide results in decreased expression of SP3 mRNA; Arsenic Trioxide results in decreased expression more ...	CTD	PMID:20435036
Sp3	Rat	arsenous acid	decreases expression	ISO	RGD:1319819	6480464	Arsenic Trioxide results in decreased expression of SP3 mRNA	CTD	PMID:35676786
Sp3	Rat	benzene	increases expression	ISO	RGD:1319818	6480464	Benzene results in increased expression of SP3 mRNA	CTD	PMID:21382456
Sp3	Rat	benzo[a]pyrene	decreases methylation	ISO	RGD:1319818	6480464	Benzo(a)pyrene results in decreased methylation of SP3 promoter	CTD	PMID:27901495
Sp3	Rat	benzo[a]pyrene diol epoxide I	decreases expression	ISO	RGD:1319818	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SP3 mRNA	CTD	PMID:19150397
Sp3	Rat	biotin	increases expression	ISO	RGD:1319819	6480464	Biotin results in increased expression of SP3 mRNA	CTD	PMID:34699867
Sp3	Rat	bis(2-ethylhexyl) phthalate	decreases expression	EXP		6480464	Diethylhexyl Phthalate results in decreased expression of SP3 protein	CTD	PMID:25068794
Sp3	Rat	bis(2-ethylhexyl) phthalate	multiple interactions	EXP		6480464	HDAC4 mutant form inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein]	CTD	PMID:25068794
Sp3	Rat	bis(2-ethylhexyl) phthalate	multiple interactions	ISO	RGD:1319818	6480464	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein]; Diethylhexyl more ...	CTD	PMID:25068794
Sp3	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	RGD:1319818	6480464	Diethylhexyl Phthalate results in decreased expression of SP3 protein	CTD	PMID:25068794
Sp3	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of SP3 mRNA	CTD	PMID:30816183\|PMID:32145629
Sp3	Rat	bisphenol A	increases expression	ISO	RGD:1319819	6480464	bisphenol A results in increased expression of SP3 mRNA	CTD	PMID:37894381
Sp3	Rat	bisphenol A	decreases methylation	ISO	RGD:1319818	6480464	bisphenol A results in decreased methylation of SP3 gene	CTD	PMID:31601247
Sp3	Rat	cadmium atom	multiple interactions	ISO	RGD:1319818	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SP3 more ...	CTD	PMID:35301059
Sp3	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1319819	6480464	Cadmium Chloride inhibits the reaction [SP1 protein binds to SP3 protein binds to KLF4 protein more ...	CTD	PMID:25046863
Sp3	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1319818	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SP3 more ...	CTD	PMID:35301059
Sp3	Rat	caffeine	increases phosphorylation	ISO	RGD:1319818	6480464	Caffeine results in increased phosphorylation of SP3 protein	CTD	PMID:35688186
Sp3	Rat	camptothecin	increases activity	ISO	RGD:1319818	6480464	Camptothecin results in increased activity of SP3 protein	CTD	PMID:11261509
Sp3	Rat	camptothecin	multiple interactions	ISO	RGD:1319818	6480464	mithramycin A inhibits the reaction [Camptothecin results in increased activity of SP3 protein]	CTD	PMID:11261509
Sp3	Rat	carbamazepine	affects expression	ISO	RGD:1319818	6480464	Carbamazepine affects the expression of SP3 mRNA	CTD	PMID:25979313
Sp3	Rat	CGP 52608	multiple interactions	ISO	RGD:1319818	6480464	CGP 52608 promotes the reaction [RORA protein binds to SP3 gene]	CTD	PMID:28238834
Sp3	Rat	chlorpyrifos	decreases expression	ISO	RGD:1319819	6480464	Chlorpyrifos results in decreased expression of SP3 mRNA	CTD	PMID:37019170
Sp3	Rat	copper atom	affects expression	ISO	RGD:1319818	6480464	Copper affects the expression of SP3 protein	CTD	PMID:22172574
Sp3	Rat	copper(0)	affects expression	ISO	RGD:1319818	6480464	Copper affects the expression of SP3 protein	CTD	PMID:22172574
Sp3	Rat	copper(II) sulfate	increases expression	ISO	RGD:1319818	6480464	Copper Sulfate results in increased expression of SP3	CTD	PMID:22172574
Sp3	Rat	cordycepin	increases activity	ISO	RGD:1319818	6480464	cordycepin results in increased activity of SP3 protein	CTD	PMID:19051361
Sp3	Rat	coumarin	increases phosphorylation	ISO	RGD:1319818	6480464	coumarin results in increased phosphorylation of SP3 protein	CTD	PMID:35688186
Sp3	Rat	crocidolite asbestos	decreases expression	ISO	RGD:1319819	6480464	Asbestos, Crocidolite results in decreased expression of SP3 mRNA	CTD	PMID:29279043
Sp3	Rat	curcumin	decreases expression	ISO	RGD:1319818	6480464	Curcumin results in decreased expression of SP3 protein	CTD	PMID:18593936
Sp3	Rat	daunorubicin	increases expression	ISO	RGD:1319818	6480464	Daunorubicin results in increased expression of SP3 protein	CTD	PMID:19698806
Sp3	Rat	decabromodiphenyl ether	increases expression	EXP		6480464	decabromobiphenyl ether results in increased expression of SP3 mRNA	CTD	PMID:23914054
Sp3	Rat	diarsenic trioxide	decreases expression	ISO	RGD:1319818	6480464	Arsenic Trioxide results in decreased expression of SP3 mRNA; Arsenic Trioxide results in decreased expression more ...	CTD	PMID:20435036
Sp3	Rat	diarsenic trioxide	decreases expression	ISO	RGD:1319819	6480464	Arsenic Trioxide results in decreased expression of SP3 mRNA	CTD	PMID:35676786
Sp3	Rat	Dibutyl phosphate	affects expression	ISO	RGD:1319818	6480464	di-n-butylphosphoric acid affects the expression of SP3 mRNA	CTD	PMID:37042841
Sp3	Rat	dichloromethane	increases expression	ISO	RGD:1319819	6480464	Methylene Chloride results in increased expression of SP3 mRNA	CTD	PMID:28392392
Sp3	Rat	dicrotophos	decreases expression	ISO	RGD:1319818	6480464	dicrotophos results in decreased expression of SP3 mRNA	CTD	PMID:28302478
Sp3	Rat	dorsomorphin	multiple interactions	ISO	RGD:1319818	6480464	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Sp3	Rat	doxorubicin	decreases expression	ISO	RGD:1319818	6480464	Doxorubicin results in decreased expression of SP3 mRNA	CTD	PMID:29803840
Sp3	Rat	enzyme inhibitor	multiple interactions	ISO	RGD:1319818	6480464	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ...	CTD	PMID:23301498
Sp3	Rat	fenvalerate	increases expression	EXP		6480464	fenvalerate results in increased expression of SP3 mRNA	CTD	PMID:30307764
Sp3	Rat	fluoranthene	multiple interactions	ISO	RGD:1319819	6480464	[1-methylanthracene co-treated with fluoranthene] results in increased expression of SP3 mRNA	CTD	PMID:28329830
Sp3	Rat	folic acid	decreases expression	ISO	RGD:1319819	6480464	Folic Acid results in decreased expression of SP3 mRNA	CTD	PMID:25629700
Sp3	Rat	FR900359	increases phosphorylation	ISO	RGD:1319818	6480464	FR900359 results in increased phosphorylation of SP3 protein	CTD	PMID:37730182
Sp3	Rat	fulvestrant	multiple interactions	ISO	RGD:1319818	6480464	[bisphenol S co-treated with Fulvestrant] results in decreased methylation of SP3 gene; Fulvestrant promotes the more ...	CTD	PMID:20211987\|PMID:31601247
Sp3	Rat	gentamycin	decreases expression	EXP		6480464	Gentamicins results in decreased expression of SP3 mRNA	CTD	PMID:22061828
Sp3	Rat	glutathione	multiple interactions	ISO	RGD:1319818	6480464	Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP3 protein]	CTD	PMID:20435036
Sp3	Rat	gold atom	decreases expression	ISO	RGD:1319818	6480464	Gold results in decreased expression of SP3 mRNA	CTD	PMID:25523186
Sp3	Rat	gold(0)	decreases expression	ISO	RGD:1319818	6480464	Gold results in decreased expression of SP3 mRNA	CTD	PMID:25523186
Sp3	Rat	homocysteic acid	multiple interactions	ISO	RGD:1319818	6480464	mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP3 protein]	CTD	PMID:11261509
Sp3	Rat	homocysteic acid	increases activity	ISO	RGD:1319818	6480464	homocysteic acid results in increased activity of SP3 protein	CTD	PMID:11261509
Sp3	Rat	hydrogen peroxide	multiple interactions	ISO	RGD:1319818	6480464	Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP3 protein]	CTD	PMID:20435036
Sp3	Rat	hydrogen peroxide	decreases expression	ISO	RGD:1319818	6480464	Hydrogen Peroxide results in decreased expression of SP3 protein	CTD	PMID:20435036
Sp3	Rat	L-ascorbic acid	decreases expression	ISO	RGD:1319818	6480464	Ascorbic Acid results in decreased expression of SP3 protein	CTD	PMID:21919647
Sp3	Rat	lead nitrate	multiple interactions	ISO	RGD:1319819	6480464	lead nitrate affects the reaction [SP3 affects the expression of MT1 mRNA]; lead nitrate affects more ...	CTD	PMID:11891201
Sp3	Rat	lead nitrate	decreases expression	ISO	RGD:1319819	6480464	lead nitrate results in decreased expression of SP3 mRNA	CTD	PMID:11891201
Sp3	Rat	lead(0)	increases expression	ISO	RGD:1319818	6480464	Lead results in increased expression of SP3 protein	CTD	PMID:22272629
Sp3	Rat	leflunomide	increases expression	ISO	RGD:1319818	6480464	leflunomide results in increased expression of SP3 mRNA	CTD	PMID:28988120
Sp3	Rat	MC1568	multiple interactions	ISO	RGD:1319818	6480464	MC1568 inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to NGB promoter]]; more ...	CTD	PMID:25068794
Sp3	Rat	MC1568	increases expression	ISO	RGD:1319818	6480464	MC1568 results in increased expression of SP3 protein	CTD	PMID:25068794
Sp3	Rat	metformin	decreases expression	ISO	RGD:1319818	6480464	Metformin results in decreased expression of SP3 protein	CTD	PMID:26317792
Sp3	Rat	methotrexate	affects expression	ISO	RGD:1319819	6480464	Methotrexate affects the expression of SP3 mRNA	CTD	PMID:18502557
Sp3	Rat	methylmercury chloride	decreases expression	ISO	RGD:1319818	6480464	methylmercuric chloride results in decreased expression of SP3 mRNA	CTD	PMID:28001369
Sp3	Rat	N,N-diethyl-m-toluamide	multiple interactions	EXP		6480464	[Permethrin co-treated with DEET] results in decreased methylation of SP3 gene	CTD	PMID:33148267
Sp3	Rat	N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal	multiple interactions	ISO	RGD:1319818	6480464	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein]	CTD	PMID:25068794
Sp3	Rat	N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal	increases expression	ISO	RGD:1319818	6480464	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SP3 protein	CTD	PMID:25068794
Sp3	Rat	nickel sulfate	increases expression	ISO	RGD:1319818	6480464	nickel sulfate results in increased expression of SP3 mRNA	CTD	PMID:18651567
Sp3	Rat	nitrates	multiple interactions	ISO	RGD:1319819	6480464	[Particulate Matter results in increased abundance of Nitrates] which results in increased expression of SP3 more ...	CTD	PMID:35964746
Sp3	Rat	paraquat	affects expression	ISO	RGD:1319819	6480464	Paraquat affects the expression of SP3 mRNA; Paraquat affects the expression of SP3 protein	CTD	PMID:31368498
Sp3	Rat	perfluorooctane-1-sulfonic acid	decreases expression	ISO	RGD:1319818	6480464	perfluorooctane sulfonic acid results in decreased expression of SP3 mRNA	CTD	PMID:27153767
Sp3	Rat	permethrin	multiple interactions	EXP		6480464	[Permethrin co-treated with DEET] results in decreased methylation of SP3 gene	CTD	PMID:33148267
Sp3	Rat	phenobarbital	increases expression	ISO	RGD:1319819	6480464	Phenobarbital results in increased expression of SP3 mRNA	CTD	PMID:19270015
Sp3	Rat	phenobarbital	affects expression	ISO	RGD:1319819	6480464	Phenobarbital affects the expression of SP3 mRNA	CTD	PMID:23091169
Sp3	Rat	phenytoin	increases expression	ISO	RGD:1319818	6480464	Phenytoin results in increased expression of SP3 mRNA	CTD	PMID:14741686
Sp3	Rat	pirinixic acid	increases expression	ISO	RGD:1319819	6480464	pirinixic acid results in increased expression of SP3 mRNA	CTD	PMID:18301758
Sp3	Rat	potassium dichromate	increases expression	ISO	RGD:1319819	6480464	Potassium Dichromate results in increased expression of SP3 mRNA	CTD	PMID:23608068
Sp3	Rat	promegestone	multiple interactions	ISO	RGD:1319818	6480464	mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter]]; more ...	CTD	PMID:16807381
Sp3	Rat	promegestone	increases expression	ISO	RGD:1319818	6480464	Promegestone results in increased expression of SP3 mRNA; Promegestone results in increased expression of SP3 more ...	CTD	PMID:16807381
Sp3	Rat	quercetin	multiple interactions	ISO	RGD:1319818	6480464	[Quercetin co-treated with hyperoside] results in decreased expression of SP3 mRNA; [Quercetin co-treated with hyperoside] more ...	CTD	PMID:23530649\|PMID:24173369
Sp3	Rat	quercetin 3-O-beta-D-galactopyranoside	multiple interactions	ISO	RGD:1319818	6480464	[Quercetin co-treated with hyperoside] results in decreased expression of SP3 mRNA; [Quercetin co-treated with hyperoside] more ...	CTD	PMID:24173369
Sp3	Rat	resveratrol	multiple interactions	ISO	RGD:1319818	6480464	[resveratrol co-treated with Quercetin] results in decreased expression of SP3 mRNA; [resveratrol co-treated with Quercetin] more ...	CTD	PMID:23530649
Sp3	Rat	S-butyl-DL-homocysteine (S,R)-sulfoximine	multiple interactions	ISO	RGD:1319818	6480464	mithramycin A inhibits the reaction [Buthionine Sulfoximine results in increased activity of SP3 protein]	CTD	PMID:11261509
Sp3	Rat	S-butyl-DL-homocysteine (S,R)-sulfoximine	increases activity	ISO	RGD:1319818	6480464	Buthionine Sulfoximine results in increased activity of SP3 protein	CTD	PMID:11261509
Sp3	Rat	S-nitrosoglutathione	decreases activity	ISO	RGD:1319818	6480464	S-Nitrosoglutathione results in decreased activity of SP3 protein	CTD	PMID:14766015
Sp3	Rat	S-nitrosoglutathione	increases activity	ISO	RGD:1319818	6480464	S-Nitrosoglutathione results in increased activity of SP3 protein	CTD	PMID:14766015
Sp3	Rat	SB 431542	multiple interactions	ISO	RGD:1319818	6480464	[LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in increased expression of SP3 more ...	CTD	PMID:27188386\|PMID:37664457
Sp3	Rat	Se-methyl-L-selenocysteine	multiple interactions	ISO	RGD:1319818	6480464	selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter]	CTD	PMID:25321483
Sp3	Rat	Se-methylselenocysteine	multiple interactions	ISO	RGD:1319818	6480464	selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter]	CTD	PMID:25321483
Sp3	Rat	silver atom	decreases expression	ISO	RGD:1319819	6480464	Silver results in decreased expression of SP3 mRNA	CTD	PMID:27131904
Sp3	Rat	silver(0)	decreases expression	ISO	RGD:1319819	6480464	Silver results in decreased expression of SP3 mRNA	CTD	PMID:27131904
Sp3	Rat	sodium arsenate	increases expression	ISO	RGD:1319819	6480464	sodium arsenate results in increased expression of SP3 mRNA	CTD	PMID:21795629
Sp3	Rat	sodium arsenate	decreases expression	ISO	RGD:1319819	6480464	sodium arsenate results in decreased expression of SP3 mRNA	CTD	PMID:21795629
Sp3	Rat	sodium arsenite	increases expression	ISO	RGD:1319818	6480464	sodium arsenite results in increased expression of SP3 mRNA	CTD	PMID:12016162
Sp3	Rat	tamoxifen	multiple interactions	ISO	RGD:1319818	6480464	Tamoxifen promotes the reaction [SP3 protein binds to ESRRA promoter]	CTD	PMID:20211987
Sp3	Rat	tetrathiomolybdate(2-)	decreases expression	ISO	RGD:1319818	6480464	tetrathiomolybdate results in decreased expression of SP3	CTD	PMID:22172574
Sp3	Rat	titanium dioxide	decreases methylation	ISO	RGD:1319819	6480464	titanium dioxide results in decreased methylation of SP3 gene; titanium dioxide results in decreased methylation more ...	CTD	PMID:35295148
Sp3	Rat	trichostatin A	multiple interactions	ISO	RGD:1319818	6480464	[Decitabine co-treated with trichostatin A] promotes the reaction [SP3 protein binds to CLDN3 promoter]; [NOG more ...	CTD	PMID:17986852\|PMID:27188386
Sp3	Rat	trichostatin A	increases expression	ISO	RGD:1319818	6480464	trichostatin A results in increased expression of SP3 mRNA	CTD	PMID:24935251\|PMID:26272509
Sp3	Rat	triphenyl phosphate	affects expression	ISO	RGD:1319818	6480464	triphenyl phosphate affects the expression of SP3 mRNA	CTD	PMID:37042841
Sp3	Rat	valproic acid	affects expression	ISO	RGD:1319818	6480464	Valproic Acid affects the expression of SP3 mRNA	CTD	PMID:25979313
Sp3	Rat	valproic acid	decreases methylation	ISO	RGD:1319818	6480464	Valproic Acid results in decreased methylation of SP3 gene	CTD	PMID:28853863\|PMID:29154799\|PMID:29201983
Sp3	Rat	valproic acid	decreases expression	ISO	RGD:1319818	6480464	Valproic Acid results in decreased expression of SP3 mRNA	CTD	PMID:23179753\|PMID:25192806\|PMID:27188386
Sp3	Rat	vinclozolin	increases expression	EXP		6480464	vinclozolin results in increased expression of SP3 mRNA	CTD	PMID:23555832
Sp3	Rat	vorinostat	multiple interactions	ISO	RGD:1319818	6480464	SP3 protein promotes the reaction [vorinostat results in increased expression of CDKN1A mRNA]	CTD	PMID:11126357

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Sp3	Rat	B cell differentiation	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:2182438 PMID:12676787	RGD	PMID:12676787
Sp3	Rat	B cell differentiation	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	definitive hemopoiesis	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:98372 PMID:17584888	RGD	PMID:17584888
Sp3	Rat	definitive hemopoiesis	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	embryonic camera-type eye morphogenesis	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:98372 PMID:17584888	RGD	PMID:17584888
Sp3	Rat	embryonic camera-type eye morphogenesis	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	embryonic placenta development	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:98372 PMID:17584888	RGD	PMID:17584888
Sp3	Rat	embryonic placenta development	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	embryonic process involved in female pregnancy	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	embryonic process involved in female pregnancy	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:98372 PMID:17584888	RGD	PMID:17584888
Sp3	Rat	embryonic skeletal system development	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:98372 PMID:17584888	RGD	PMID:17584888
Sp3	Rat	embryonic skeletal system development	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	enucleate erythrocyte differentiation	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:98372 PMID:17584888	RGD	PMID:17584888
Sp3	Rat	enucleate erythrocyte differentiation	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	erythrocyte differentiation	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:2182438 PMID:12676787	RGD	PMID:12676787
Sp3	Rat	erythrocyte differentiation	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	granulocyte differentiation	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:2182438 PMID:12676787	RGD	PMID:12676787
Sp3	Rat	granulocyte differentiation	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	in utero embryonic development	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	in utero embryonic development	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:98372 PMID:17584888	RGD	PMID:17584888
Sp3	Rat	liver development	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	liver development	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:98372 PMID:17584888	RGD	PMID:17584888
Sp3	Rat	lung development	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	lung development	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:98372 PMID:17584888	RGD	PMID:17584888
Sp3	Rat	megakaryocyte differentiation	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:98372 PMID:17584888	RGD	PMID:17584888
Sp3	Rat	megakaryocyte differentiation	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	monocyte differentiation	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	monocyte differentiation	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:2182438 PMID:12676787	RGD	PMID:12676787
Sp3	Rat	myeloid progenitor cell differentiation	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	myeloid progenitor cell differentiation	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:98372 PMID:17584888	RGD	PMID:17584888
Sp3	Rat	natural killer cell differentiation	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:2182438 PMID:12676787	RGD	PMID:12676787
Sp3	Rat	natural killer cell differentiation	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	negative regulation of DNA-templated transcription	involved_in	IDA		8553999	PMID:17130167	UniProt
Sp3	Rat	negative regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	negative regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:Q02447\|ensembl:ENSP00000310301	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	negative regulation of DNA-templated transcription	involved_in	ISO	RGD:1319819	1624291	PMID:17130167	RGD	PMID:17130167
Sp3	Rat	negative regulation of DNA-templated transcription	involved_in	ISO	RGD:1319818	1624291	PMID:20091743	RGD	PMID:20091743
Sp3	Rat	negative regulation of transcription by RNA polymerase II	involved_in	IEA	GO:0001227	1600115	GO_REF:0000108	GOC	GO_REF:0000108
Sp3	Rat	ossification	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:98372 PMID:17584888	RGD	PMID:17584888
Sp3	Rat	ossification	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	positive regulation of DNA-templated transcription	involved_in	ISO	RGD:1319818	1624291	PMID:12771217	RGD	PMID:12771217
Sp3	Rat	positive regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:Q02447\|ensembl:ENSP00000310301	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	positive regulation of transcription by RNA polymerase II	involved_in	ISO	RGD:1319818	1624291	UniProtKB:P08047 PMID:14979875	RGD	PMID:14979875
Sp3	Rat	positive regulation of transcription by RNA polymerase II	involved_in	IEA	UniProtKB:Q02447\|ensembl:ENSP00000310301	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	positive regulation of transcription by RNA polymerase II	involved_in	IC	GO:0000977	10047233	PMID:14979875	UniProt
Sp3	Rat	regulation of DNA-templated transcription	involved_in	ISO	RGD:1319818	1624291	PMID:12560508	RGD	PMID:12560508
Sp3	Rat	regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:Q02447\|ensembl:ENSP00000310301	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	regulation of transcription by RNA polymerase II	involved_in	IBA	CGD:CAL0000177853\|FB:FBgn0000233\|FB:FBgn0043364\|FB:FBgn0261434\|FB:FBgn0263239\|MGI:1306780\|MGI:1333796\|MGI:1333856\|MGI:1338056\|MGI:1342287\|MGI:1342771\|MGI:1342772\|MGI:1342773\|MGI:1354948\|MGI:1927715\|MGI:2153049\|MGI:2153568\|MGI:2181068\|MGI:3577024\|MGI:95295\|MGI:95296\|MGI:98372\|MGI:98968\|PANTHER:PTN004619861\|RGD:2544\|RGD:2546\|RGD:3738\|RGD:3974\|RGD:621445\|RGD:62389\|SGD:S000004972\|UniProtKB:A0A8J1MUN6\|UniProtKB:O14901\|UniProtKB:O43474\|UniProtKB:O75840\|UniProtKB:O95600\|UniProtKB:P08047\|UniProtKB:P11161\|UniProtKB:P18146\|UniProtKB:P19544\|UniProtKB:Q02086\|UniProtKB:Q02446\|UniProtKB:Q02447\|UniProtKB:Q05215\|UniProtKB:Q13118\|UniProtKB:Q13887\|UniProtKB:Q7RTV3\|UniProtKB:Q8TD94\|UniProtKB:Q8TDD2\|UniProtKB:Q99612\|UniProtKB:Q9UIH9\|UniProtKB:Q9Y4X4\|UniProtKB:Q9Y5W3\|WB:WBGene00012735\|WB:WBGene00018990\|ZFIN:ZDB-GENE-021115-9\|ZFIN:ZDB-GENE-980526-55	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Sp3	Rat	T cell differentiation	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:2182438 PMID:12676787	RGD	PMID:12676787
Sp3	Rat	T cell differentiation	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	trophectodermal cell differentiation	acts_upstream_of_or_within	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	trophectodermal cell differentiation	acts_upstream_of_or_within	ISO	RGD:1319819	1624291	MGI:98372 PMID:17584888	RGD	PMID:17584888

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Sp3	Rat	cytosol	located_in	ISO	RGD:1319818\|UniProtKB:Q02447-1\|UniProtKB:Q02447-5	1624291		RGD	GO_REF:0000052
Sp3	Rat	cytosol	located_in	IEA	UniProtKB:Q02447\|ensembl:ENSP00000310301	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	nucleoplasm	located_in	ISO	RGD:1319818\|UniProtKB:Q02447-1\|UniProtKB:Q02447-5	1624291		RGD	GO_REF:0000052
Sp3	Rat	nucleoplasm	located_in	IEA	UniProtKB:Q02447\|ensembl:ENSP00000310301	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	nucleus	located_in	ISO	RGD:1319819	1624291	PMID:15282343, PMID:15817708	RGD	PMID:15282343\|PMID:15817708
Sp3	Rat	nucleus	located_in	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	nucleus	located_in	IDA		10047233	PMID:14979875	UniProt
Sp3	Rat	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Sp3	Rat	protein-DNA complex	part_of	IPI	UniProtKB:A0A0G2QC09,UniProtKB:Q01714	13506263	PMID:10362258	ARUK-UCL
Sp3	Rat	transcription repressor complex	part_of	IDA		8553999	PMID:17130167	UniProt
Sp3	Rat	transcription repressor complex	part_of	ISO	RGD:1319819	1624291	PMID:17130167	RGD	PMID:17130167
Sp3	Rat	transcription repressor complex	part_of	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Sp3	Rat	chromatin binding	enables	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	chromatin binding	enables	ISO	RGD:1319819	1624291	PMID:15522233	RGD	PMID:15522233
Sp3	Rat	cis-regulatory region sequence-specific DNA binding	enables	ISO	RGD:1319819	1624291	PMID:15511642, PMID:19943855	RGD	PMID:15511642\|PMID:19943855
Sp3	Rat	cis-regulatory region sequence-specific DNA binding	enables	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	DNA binding	enables	ISO	RGD:1319819	1624291	PMID:14630713	RGD	PMID:14630713
Sp3	Rat	DNA binding	enables	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	DNA-binding transcription factor activity, RNA polymerase II-specific	enables	IBA	FB:FBgn0000233\|MGI:1277166\|MGI:1306780\|MGI:1333796\|MGI:1333856\|MGI:1338056\|MGI:1342287\|MGI:1342771\|MGI:1354948\|MGI:1927715\|MGI:2153049\|MGI:2153568\|MGI:2181068\|MGI:95295\|MGI:95296\|MGI:98372\|MGI:98968\|PANTHER:PTN004619861\|RGD:1583765\|RGD:2544\|RGD:621445\|SGD:S000004972\|UniProtKB:O14901\|UniProtKB:O43474\|UniProtKB:O75840\|UniProtKB:O95600\|UniProtKB:P08047\|UniProtKB:P11161\|UniProtKB:P18146\|UniProtKB:P19544\|UniProtKB:Q02086\|UniProtKB:Q05215\|UniProtKB:Q13118\|UniProtKB:Q13887\|UniProtKB:Q99612\|UniProtKB:Q9UIH9\|UniProtKB:Q9Y4X4\|UniProtKB:Q9Y5W3\|WB:WBGene00012735\|ZFIN:ZDB-GENE-011116-1\|ZFIN:ZDB-GENE-021115-9\|ZFIN:ZDB-GENE-980526-55	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Sp3	Rat	DNA-binding transcription repressor activity, RNA polymerase II-specific	enables	IDA		8553999	PMID:17130167	UniProt
Sp3	Rat	DNA-binding transcription repressor activity, RNA polymerase II-specific	enables	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	DNA-binding transcription repressor activity, RNA polymerase II-specific	enables	ISO	RGD:1319819	1624291	PMID:17130167	RGD	PMID:17130167
Sp3	Rat	double-stranded DNA binding	enables	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	double-stranded DNA binding	enables	ISO	RGD:1319819	1624291	PMID:15282343	RGD	PMID:15282343
Sp3	Rat	protein binding	enables	ISO	RGD:1319818	1624291	UniProtKB:P03372\|UniProtKB:P14678-2\|UniProtKB:P42858\|UniProtKB:Q13547\|UniProtKB:Q14527\|UniProtKB:Q5MJ10\|UniProtKB:Q6MZP7\|UniProtKB:Q7Z3K3\|UniProtKB:Q92769\|UniProtKB:Q96BD5\|UniProtKB:Q96Q77 PMID:10391891, PMID:10816575, PMID:12176973, PMID:17500595, PMID:31527615, PMID:32296183, PMID:32814053	RGD	PMID:10391891\|PMID:10816575\|PMID:12176973\|PMID:17500595\|PMID:31527615\|PMID:32296183\|PMID:32814053
Sp3	Rat	protein binding	enables	ISO	RGD:1319819	1624291	UniProtKB:Q9Z2D6 PMID:20385708	RGD	PMID:20385708
Sp3	Rat	RNA polymerase II cis-regulatory region sequence-specific DNA binding	enables	IGI	UniProtKB:P01139	13506263	PMID:10362258	ARUK-UCL
Sp3	Rat	RNA polymerase II cis-regulatory region sequence-specific DNA binding	enables	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	RNA polymerase II cis-regulatory region sequence-specific DNA binding	enables	ISO	RGD:1319819	1624291	PMID:15094381, PMID:17670746	RGD	PMID:15094381\|PMID:17670746
Sp3	Rat	RNA polymerase II cis-regulatory region sequence-specific DNA binding	enables	IBA	MGI:1277166\|MGI:1338056\|MGI:1342287\|MGI:1342771\|MGI:1354948\|MGI:2153049\|MGI:2153568\|MGI:2181068\|MGI:95295\|MGI:95296\|MGI:98372\|PANTHER:PTN004619861\|RGD:1583765\|RGD:2544\|RGD:3738\|UniProtKB:O43474\|UniProtKB:O75840\|UniProtKB:O95600\|UniProtKB:P08047\|UniProtKB:P11161\|UniProtKB:P18146\|UniProtKB:P19544\|UniProtKB:Q02086\|UniProtKB:Q13118\|UniProtKB:Q13351\|UniProtKB:Q13887\|UniProtKB:Q99612\|UniProtKB:Q9UIH9\|UniProtKB:Q9Y4X4\|WB:WBGene00018990\|ZFIN:ZDB-GENE-980526-55	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Sp3	Rat	RNA polymerase II transcription regulatory region sequence-specific DNA binding	enables	IMP		10047233	PMID:14979875	UniProt
Sp3	Rat	RNA polymerase II transcription regulatory region sequence-specific DNA binding	enables	IEA	UniProtKB:Q02447\|ensembl:ENSP00000310301	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	RNA polymerase II transcription regulatory region sequence-specific DNA binding	enables	ISO	RGD:1319818	1624291	PMID:14979875	RGD	PMID:14979875
Sp3	Rat	RNA polymerase II-specific DNA-binding transcription factor binding	enables	IPI	UniProtKB:O54963	8553999	PMID:17130167	UniProt
Sp3	Rat	RNA polymerase II-specific DNA-binding transcription factor binding	enables	IEA	UniProtKB:O70494\|ensembl:ENSMUSP00000099750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	RNA polymerase II-specific DNA-binding transcription factor binding	enables	ISO	RGD:1319819	1624291	UniProtKB:Q8VIG1 PMID:17130167	RGD	PMID:17130167
Sp3	Rat	RNA polymerase II-specific DNA-binding transcription factor binding	enables	IEA	UniProtKB:Q02447\|ensembl:ENSP00000310301	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	RNA polymerase II-specific DNA-binding transcription factor binding	enables	ISO	RGD:1319818	1624291	UniProtKB:Q13127 PMID:17130167	RGD	PMID:17130167
Sp3	Rat	sequence-specific double-stranded DNA binding	enables	ISO	RGD:1319818	1624291	PMID:28473536	RGD	PMID:28473536
Sp3	Rat	sequence-specific double-stranded DNA binding	enables	IEA	UniProtKB:Q02447\|ensembl:ENSP00000310301	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Sp3	Rat	zinc ion binding	enables	IEA	UniProtKB-KW:KW-0863	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

Disease Annotations Click to see Annotation Detail View

split hand-foot malformation 5 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

7,12-dimethyltetraphene (EXP)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

biotin (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

camptothecin (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cordycepin (ISO)

coumarin (ISO)

crocidolite asbestos (ISO)

curcumin (ISO)

daunorubicin (ISO)

decabromodiphenyl ether (EXP)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dichloromethane (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

fenvalerate (EXP)

fluoranthene (ISO)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

gentamycin (EXP)

glutathione (ISO)

gold atom (ISO)

gold(0) (ISO)

homocysteic acid (ISO)

hydrogen peroxide (ISO)

L-ascorbic acid (ISO)

lead nitrate (ISO)

lead(0) (ISO)

leflunomide (ISO)

MC1568 (ISO)

metformin (ISO)

methotrexate (ISO)

methylmercury chloride (ISO)

N,N-diethyl-m-toluamide (EXP)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

nickel sulfate (ISO)

nitrates (ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (EXP)

phenobarbital (ISO)

phenytoin (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

promegestone (ISO)

quercetin (ISO)

quercetin 3-O-beta-D-galactopyranoside (ISO)

resveratrol (ISO)

S-butyl-DL-homocysteine (S,R)-sulfoximine (ISO)

S-nitrosoglutathione (ISO)

SB 431542 (ISO)

Se-methyl-L-selenocysteine (ISO)

Se-methylselenocysteine (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tetrathiomolybdate(2-) (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell differentiation (IEA,ISO)

definitive hemopoiesis (IEA,ISO)

embryonic camera-type eye morphogenesis (IEA,ISO)

embryonic placenta development (IEA,ISO)

embryonic process involved in female pregnancy (IEA,ISO)

embryonic skeletal system development (IEA,ISO)

enucleate erythrocyte differentiation (IEA,ISO)

erythrocyte differentiation (IEA,ISO)

granulocyte differentiation (IEA,ISO)

in utero embryonic development (IEA,ISO)

liver development (IEA,ISO)

lung development (IEA,ISO)

megakaryocyte differentiation (IEA,ISO)

monocyte differentiation (IEA,ISO)

myeloid progenitor cell differentiation (IEA,ISO)

natural killer cell differentiation (IEA,ISO)

negative regulation of DNA-templated transcription (IDA,IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA)

ossification (IEA,ISO)

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IC,IEA,ISO)

regulation of DNA-templated transcription (IEA,ISO)

regulation of transcription by RNA polymerase II (IBA)

T cell differentiation (IEA,ISO)

trophectodermal cell differentiation (IEA,ISO)

Cellular Component

cytosol (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IDA,IEA,ISO)

protein-DNA complex (IPI)

transcription repressor complex (IDA,IEA,ISO)

Molecular Function

chromatin binding (IEA,ISO)

cis-regulatory region sequence-specific DNA binding (IEA,ISO)

DNA binding (IEA,ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IDA,IEA,ISO)

double-stranded DNA binding (IEA,ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA,IGI,ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IEA,IMP,ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA,IPI,ISO)

sequence-specific double-stranded DNA binding (IEA,ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells.	Alfonso-Jaume MA, etal., Biochem J. 2004 Jun 15;380(Pt 3):735-47.
2.	Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation.	Billon N, etal., Oncogene. 1999 May 6;18(18):2872-82. doi: 10.1038/sj.onc.1202712.
3.	Normalization and subtraction: two approaches to facilitate gene discovery.	Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene.	Kim CS, etal., Nucleic Acids Res. 2006;34(22):6392-403. Epub 2006 Nov 27.
6.	Sp1 and Egr1 regulate transcription of the Dmrt1 gene in Sertoli cells.	Lei N and Heckert LL, Biol Reprod 2002 Mar;66(3):675-84.
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12297531	PMID:12560508	PMID:12584202	PMID:12676787	PMID:12700237	PMID:12771217	PMID:14563703	PMID:14630713	PMID:15094381	PMID:15282343	PMID:15511642	PMID:15522233
PMID:15572681	PMID:15721292	PMID:15817708	PMID:16378599	PMID:16403775	PMID:16460348	PMID:17379926	PMID:17584888	PMID:17670746	PMID:18004997	PMID:18275970	PMID:18348986
PMID:19728174	PMID:19943855	PMID:20091743	PMID:20884886	PMID:21289081	PMID:23093703	PMID:25476526	PMID:30110572

Genomics

Comparative Map Data

Sp3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	78,219,421 - 78,272,318 (-)	NCBI		GRCr8
mRatBN7.2	3	57,811,855 - 57,857,150 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	57,812,075 - 57,860,342 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	3	59,644,579 - 59,689,011 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	59,646,015 - 59,688,692 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	66,118,151 - 66,163,940 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	3	66,729,636 - 66,739,419 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	55,440,985 - 55,485,768 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	57,350,925 - 57,387,172 (-)	NCBI		Celera
Cytogenetic Map	3	q23	NCBI

SP3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	173,900,775 - 173,965,702 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	173,880,850 - 173,965,373 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	174,765,503 - 174,830,430 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	174,481,504 - 174,538,309 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	168,384,626 - 168,443,931 (-)	NCBI		Celera
Cytogenetic Map	2	q31.1	NCBI
HuRef	2	166,650,849 - 166,709,905 (-)	NCBI		HuRef
CHM1_1	2	174,778,156 - 174,837,417 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	174,387,111 - 174,452,024 (-)	NCBI		T2T-CHM13v2.0

Sp3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	72,766,774 - 72,810,790 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	72,766,771 - 72,810,790 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	72,936,430 - 72,980,446 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	72,936,427 - 72,980,446 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	72,774,487 - 72,818,503 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	72,737,269 - 72,789,548 (-)	NCBI		MGSCv36	mm8
Celera	2	74,621,937 - 74,665,927 (-)	NCBI		Celera
Cytogenetic Map	2	C3	NCBI
cM Map	2	43.35	NCBI

Sp3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955449	1,347,781 - 1,404,368 (+)	NCBI	ChiLan1.0	ChiLan1.0

SP3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	76,573,271 - 76,630,819 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	76,588,245 - 76,645,598 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	61,185,975 - 61,243,155 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	178,639,630 - 178,698,313 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	178,639,677 - 178,692,848 (-)	Ensembl	panpan1.1		panPan2

SP3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	18,023,750 - 18,086,995 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	18,024,627 - 18,077,587 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	18,030,699 - 18,085,623 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	18,154,210 - 18,209,148 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	18,152,355 - 18,209,033 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	18,234,479 - 18,289,351 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	18,232,972 - 18,287,863 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	18,336,948 - 18,391,940 (-)	NCBI		UU_Cfam_GSD_1.0

Sp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	135,186,490 - 135,238,803 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936509	3,741,836 - 3,793,136 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936509	3,740,393 - 3,782,873 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SP3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	79,935,994 - 80,025,850 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	79,935,986 - 79,990,139 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	89,252,305 - 89,292,992 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SP3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	59,414,739 - 59,471,596 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	59,416,152 - 59,470,456 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	140,106,666 - 140,163,017 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sp3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624787	11,144,581 - 11,193,520 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sp3
206 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	9
Count of miRNA genes:	8
Interacting mature miRNAs:	8
Transcripts:	ENSRNOT00000026148
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	15005422	76927699	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
9590286	Uminl1	Urine mineral level QTL 1	3.5	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	3	28249687	73249687	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	53781112	91609953	Rat
61356	Bp37	Blood pressure QTL 37	3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	30684642	75684642	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
8694196	Abfw2	Abdominal fat weight QTL 2	16.58	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	3	28249687	73249687	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
1582249	Bw77	Body weight QTL 77	3.2	0.0025	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	64655484	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
12879868	Am6	Aortic mass QTL 6		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	31426403	70668733	Rat
11565451	Bw177	Body weight QTL 177		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	3	31426403	70668733	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
11565452	Kidm57	Kidney mass QTL 57		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	31426403	70668733	Rat
12879866	Cm94	Cardiac mass QTL 94		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	31426403	70668733	Rat
12879867	Cm95	Cardiac mass QTL 95		0.047	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	31426403	70668733	Rat
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	43827364	90905114	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	53184692	89878207	Rat
2302055	Pia30	Pristane induced arthritis QTL 30	3.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	3	27936919	72936919	Rat
1331795	Rf30	Renal function QTL 30	3.708		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	3	39454637	89115240	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	78196190	Rat
2303593	Gluco46	Glucose level QTL 46	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	28468571	73468571	Rat
1354590	Despr11	Despair related QTL 11		0.000031	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	3	28468571	73468571	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1331777	Bw24	Body weight QTL 24	3.503		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	89115240	Rat
631647	Bp122	Blood pressure QTL 122	6.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	30684642	75684642	Rat
1300169	Bp177	Blood pressure QTL 177	2.96		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	3	33703347	61017857	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2302276	Bw82	Body weight QTL 82	4.32		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	62951183	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	38517803	83517803	Rat
9590136	Scort3	Serum corticosterone level QTL 3	23.37	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	28249687	73249687	Rat
10450804	Scl70	Serum cholesterol level QTL 70	4.7	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	20714090	65714090	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	30356773	98535386	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	41874578	104104347	Rat
8552950	Pigfal12	Plasma insulin-like growth factor 1 level QTL 12	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	28249687	73249687	Rat
631676	Cm8	Cardiac mass QTL 8	7.03	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	3	16954708	61954708	Rat
10450794	Scl69	Serum cholesterol level QTL 69	6.3	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	20714090	65714090	Rat
8694386	Bw159	Body weight QTL 159	4.52	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	3	28249687	73249687	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	104104347	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
2301400	Cm68	Cardiac mass QTL 68		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	31426403	70668733	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat

Markers in Region

RH140061

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	57,842,288 - 57,842,475 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	59,674,822 - 59,675,008	NCBI	Rnor6.0
Rnor_5.0	3	66,148,466 - 66,148,652	UniSTS	Rnor5.0
RGSC_v3.4	3	55,471,263 - 55,471,449	UniSTS	RGSC3.4
Celera	3	57,381,143 - 57,381,329	UniSTS
Cytogenetic Map	3	q22	UniSTS

PMC169877P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	63,886,820 - 63,887,358 (+)	MAPPER	mRatBN7.2
mRatBN7.2	3	23,603,189 - 23,603,720 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	24,171,597 - 24,172,127	NCBI	Rnor6.0
Rnor_6.0	X	68,471,397 - 68,471,934	NCBI	Rnor6.0
Rnor_5.0	3	29,388,989 - 29,389,519	UniSTS	Rnor5.0
Rnor_5.0	X	69,346,132 - 69,346,669	UniSTS	Rnor5.0
RGSC_v3.4	X	86,814,796 - 86,815,333	UniSTS	RGSC3.4
RGSC_v3.4	3	19,691,805 - 19,692,335	UniSTS	RGSC3.4
Celera	3	22,015,742 - 22,016,272	UniSTS
Celera	X	64,275,723 - 64,276,260	UniSTS
Cytogenetic Map	3	q22	UniSTS
Cytogenetic Map	X	q31	UniSTS

RH133751

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	57,816,724 - 57,816,906 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	60,252,732 - 60,252,913	NCBI	Rnor6.0
Rnor_6.0	3	59,649,229 - 59,649,410	NCBI	Rnor6.0
Rnor_5.0	3	66,123,021 - 66,123,202	UniSTS	Rnor5.0
Rnor_5.0	3	66,734,506 - 66,734,687	UniSTS	Rnor5.0
RGSC_v3.4	3	55,445,855 - 55,446,036	UniSTS	RGSC3.4
Celera	3	57,355,575 - 57,355,756	UniSTS
Cytogenetic Map	3	q22	UniSTS

PMC305603P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	63,885,649 - 63,885,862 (+)	MAPPER	mRatBN7.2
mRatBN7.2	3	57,847,231 - 57,847,443 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	59,679,764 - 59,679,975	NCBI	Rnor6.0
Rnor_6.0	X	68,470,226 - 68,470,438	NCBI	Rnor6.0
Rnor_5.0	3	66,153,408 - 66,153,619	UniSTS	Rnor5.0
Rnor_5.0	X	69,344,961 - 69,345,173	UniSTS	Rnor5.0
RGSC_v3.4	X	86,813,625 - 86,813,837	UniSTS	RGSC3.4
RGSC_v3.4	3	55,476,205 - 55,476,416	UniSTS	RGSC3.4
Celera	3	57,386,085 - 57,386,296	UniSTS
Celera	X	64,274,552 - 64,274,764	UniSTS
Cytogenetic Map	3	q22	UniSTS
Cytogenetic Map	X	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427405	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775440	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106379	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284297	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005502231	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010064675	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120066	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000078752 ⟹ ENSRNOP00000073478

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	57,812,075 - 57,848,374 (-)	Ensembl
Rnor_6.0 Ensembl	3	59,646,015 - 59,688,692 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103163 ⟹ ENSRNOP00000084927

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	57,812,075 - 57,860,342 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107886 ⟹ ENSRNOP00000090911

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	57,812,075 - 57,860,342 (-)	Ensembl

RefSeq Acc Id:

NM_001427405 ⟹ NP_001414334

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	78,219,421 - 78,264,517 (-)	NCBI

RefSeq Acc Id:

XM_039106378 ⟹ XP_038962306

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	78,219,641 - 78,268,361 (-)	NCBI
mRatBN7.2	3	57,811,855 - 57,857,150 (-)	NCBI

RefSeq Acc Id:

XM_039106379 ⟹ XP_038962307

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	78,219,641 - 78,268,337 (-)	NCBI
mRatBN7.2	3	57,811,855 - 57,856,460 (-)	NCBI

RefSeq Acc Id:

XM_063284295 ⟹ XP_063140365

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	78,219,641 - 78,268,363 (-)	NCBI

RefSeq Acc Id:

XM_063284296 ⟹ XP_063140366

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	78,219,641 - 78,272,318 (-)	NCBI

RefSeq Acc Id:

XM_063284297 ⟹ XP_063140367

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	78,219,641 - 78,268,363 (-)	NCBI

RefSeq Acc Id:

XR_005502231

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	78,229,029 - 78,268,598 (-)	NCBI
mRatBN7.2	3	57,821,463 - 57,857,150 (-)	NCBI

RefSeq Acc Id:

XR_010064675

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	78,223,684 - 78,268,394 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001414334	(Get FASTA)	NCBI Sequence Viewer
	XP_038962306	(Get FASTA)	NCBI Sequence Viewer
	XP_038962307	(Get FASTA)	NCBI Sequence Viewer
	XP_063140365	(Get FASTA)	NCBI Sequence Viewer
	XP_063140366	(Get FASTA)	NCBI Sequence Viewer
	XP_063140367	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000073478
	ENSRNOP00000073478.2
	ENSRNOP00000084927
	ENSRNOP00000084927.1
	ENSRNOP00000090911.1

Ensembl Acc Id:

ENSRNOP00000073478 ⟸ ENSRNOT00000078752

RefSeq Acc Id:	XP_038962306 ⟸ XM_039106378
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6AEE9 (UniProtKB/TrEMBL), A0A0G2K5M1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038962307 ⟸ XM_039106379
- Peptide Label:	isoform X3
- UniProtKB:	A6HM81 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000084927 ⟸ ENSRNOT00000103163

Ensembl Acc Id:

ENSRNOP00000090911 ⟸ ENSRNOT00000107886

RefSeq Acc Id:	NP_001414334 ⟸ NM_001427405
- UniProtKB:	A0A0G2K5M1 (UniProtKB/TrEMBL), A0A8I6A0B6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140366 ⟸ XM_063284296
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K5M1 (UniProtKB/TrEMBL), A0A8I6A0B6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140365 ⟸ XM_063284295
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K5M1 (UniProtKB/TrEMBL), A0A8I6A0B6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140367 ⟸ XM_063284297
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K5M1 (UniProtKB/TrEMBL), A0A8I6A0B6 (UniProtKB/TrEMBL)

Protein Domains

C2H2-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K5M1-F1-model_v2	AlphaFold	A0A0G2K5M1	1-714	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1583765	AgrOrtholog
BioCyc Gene	G2FUF-49389	BioCyc
Ensembl Genes	ENSRNOG00000060479	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000078752	ENTREZGENE
	ENSRNOT00000078752.2	UniProtKB/TrEMBL
	ENSRNOT00000103163	ENTREZGENE
	ENSRNOT00000103163.1	UniProtKB/TrEMBL
	ENSRNOT00000107886.1	UniProtKB/TrEMBL
Gene3D-CATH	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	Znf_C2H2/integrase_DNA-bd	UniProtKB/TrEMBL
	Znf_C2H2_sf	UniProtKB/TrEMBL
NCBI Gene	367846	ENTREZGENE
PANTHER	KRUEPPEL-LIKE TRANSCRIPTION FACTOR	UniProtKB/TrEMBL
	PTHR23235:SF3	UniProtKB/TrEMBL
Pfam	zf-C2H2	UniProtKB/TrEMBL
PhenoGen	Sp3	PhenoGen
PROSITE	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000060479	RatGTEx
SMART	ZnF_C2H2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57667	UniProtKB/TrEMBL
UniProt	A0A0G2K5M1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A0B6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AEE9	ENTREZGENE, UniProtKB/TrEMBL
	A6HM81	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Sp3	Sp3 transcription factor	LOC103691822	uncharacterized LOC103691822	Data merged from RGD:9330173	737654	PROVISIONAL
2014-08-25	LOC103691822	uncharacterized LOC103691822			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-09-18	Sp3	Sp3 transcription factor	Sp3	trans-acting transcription factor 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Sp3	trans-acting transcription factor 3	Sp3	Sp3 transcription factor	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2007-04-12	Sp3	Sp3 transcription factor	Sp3_mapped	Sp3 transcription factor (mapped)	Data merged from RGD:3740	737654	APPROVED
2006-11-19	Sp3	Sp3 transcription factor			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	Sp3_mapped	Sp3 transcription factor(mapped)	Sp3	Sp3 transcription factor	Symbol set to symbol_mapped, name set to name (mapped)	1582166	APPROVED
2003-04-09	Sp3	Sp3 transcription factor		Trans-acting transcription factor 3	Name updated	629478	APPROVED
2002-06-10	Sp3	Trans-acting transcription factor 3			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar