Ambra1 (autophagy and beclin 1 regulator 1) - Rat Genome Database

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Gene: Ambra1 (autophagy and beclin 1 regulator 1) Rattus norvegicus
Analyze
Symbol: Ambra1
Name: autophagy and beclin 1 regulator 1
RGD ID: 621330
Description: Predicted to enable enzyme binding activity and ubiquitin ligase-substrate adaptor activity. Involved in cellular response to starvation; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of autophagy. Predicted to be located in axoneme; cytosol; and phagocytic vesicle. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Predicted to colocalize with mitochondrion. Orthologous to human AMBRA1 (autophagy and beclin 1 regulator 1); PARTICIPATES IN inositol metabolic pathway; mitochondrial autophagy pathway; phosphoinositide metabolic pathway; INTERACTS WITH ammonium chloride; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activating molecule in BECN1-regulated autophagy protein 1; autophagy/beclin 1 regulator 1; ischemia related factor NYW-1; Nyw1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2377,700,936 - 77,890,221 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,700,936 - 77,890,221 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx381,176,110 - 81,365,398 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0389,775,135 - 89,964,426 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0387,626,389 - 87,815,655 (+)NCBIRnor_WKY
Rnor_6.0380,634,470 - 80,830,068 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,634,470 - 80,830,068 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,332,352 - 87,528,736 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4376,109,632 - 76,298,784 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1376,049,420 - 76,098,445 (+)NCBI
Celera376,904,996 - 77,092,869 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mitochondrial autophagy involving renal injury and aging is modulated by caloric intake in aged rat kidneys. Cui J, etal., PLoS One. 2013;8(7):e69720. doi: 10.1371/journal.pone.0069720. Epub 2013 Jul 22.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Mitochondria and mitophagy: the yin and yang of cell death control. Kubli DA and Gustafsson AB, Circ Res. 2012 Oct 12;111(9):1208-21. doi: 10.1161/CIRCRESAHA.112.265819.
4. AMBRA1, a novel α-synuclein-binding protein, is implicated in the pathogenesis of multiple system atrophy. Miki Y, etal., Brain Pathol. 2018 Jan;28(1):28-42. doi: 10.1111/bpa.12461. Epub 2017 Mar 15.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Expression of Ambra1 in mouse brain during physiological and Alzheimer type aging. Sepe S, etal., Neurobiol Aging. 2014 Jan;35(1):96-108. doi: 10.1016/j.neurobiolaging.2013.07.001. Epub 2013 Aug 2.
10. Ambra1 modulates starvation-induced autophagy through AMPK signaling pathway in cardiomyocytes. Shi C, etal., Biochem Biophys Res Commun. 2014 Sep 26;452(3):308-14. doi: 10.1016/j.bbrc.2014.08.017. Epub 2014 Aug 10.
Additional References at PubMed
PMID:12477932   PMID:17589504   PMID:21753002   PMID:22493499   PMID:24089209   PMID:24879156   PMID:25215947   PMID:25891078   PMID:33083461  


Genomics

Comparative Map Data
Ambra1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2377,700,936 - 77,890,221 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,700,936 - 77,890,221 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx381,176,110 - 81,365,398 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0389,775,135 - 89,964,426 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0387,626,389 - 87,815,655 (+)NCBIRnor_WKY
Rnor_6.0380,634,470 - 80,830,068 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,634,470 - 80,830,068 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,332,352 - 87,528,736 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4376,109,632 - 76,298,784 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1376,049,420 - 76,098,445 (+)NCBI
Celera376,904,996 - 77,092,869 (+)NCBICelera
Cytogenetic Map3q24NCBI
AMBRA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381146,396,412 - 46,594,023 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1146,396,414 - 46,594,125 (-)EnsemblGRCh38hg38GRCh38
GRCh371146,417,962 - 46,615,573 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,374,541 - 46,569,490 (-)NCBINCBI36Build 36hg18NCBI36
Celera1146,566,035 - 46,760,894 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1146,124,697 - 46,322,307 (-)NCBIHuRef
CHM1_11146,416,414 - 46,614,031 (-)NCBICHM1_1
T2T-CHM13v2.01146,552,487 - 46,750,082 (-)NCBIT2T-CHM13v2.0
Ambra1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,560,464 - 91,749,194 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl291,560,479 - 91,749,194 (+)EnsemblGRCm39 Ensembl
GRCm38291,730,138 - 91,918,849 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,730,134 - 91,918,849 (+)EnsemblGRCm38mm10GRCm38
MGSCv37291,570,295 - 91,759,006 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36291,531,062 - 91,719,688 (+)NCBIMGSCv36mm8
Celera293,119,370 - 93,309,250 (+)NCBICelera
Cytogenetic Map2E1NCBI
Ambra1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554221,455,380 - 1,644,452 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554221,455,392 - 1,644,368 (+)NCBIChiLan1.0ChiLan1.0
AMBRA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11146,905,454 - 47,103,205 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1146,905,454 - 47,103,205 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01146,355,026 - 46,556,091 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
AMBRA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,903,815 - 43,073,918 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,932,513 - 43,072,827 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1841,632,454 - 41,802,531 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01843,559,883 - 43,730,082 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1843,559,910 - 43,764,738 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11843,045,129 - 43,215,092 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01842,596,905 - 42,766,984 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01843,330,120 - 43,500,181 (+)NCBIUU_Cfam_GSD_1.0
Ambra1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494720,382,209 - 20,565,226 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365622,493,774 - 2,676,912 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365622,493,823 - 2,676,868 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMBRA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,935,375 - 16,119,079 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,935,354 - 16,119,082 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2217,313,942 - 17,465,127 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AMBRA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,777,807 - 18,932,784 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,734,926 - 18,932,785 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038116,020,095 - 116,218,202 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ambra1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,966,898 - 2,160,465 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247671,967,002 - 2,160,102 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ambra1
582 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:155
Count of miRNA genes:102
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000045644
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat

Markers in Region
A001T07  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,890,028 - 77,890,137 (+)MAPPERmRatBN7.2
Rnor_6.0380,829,876 - 80,829,984NCBIRnor6.0
Rnor_5.0387,528,544 - 87,528,652UniSTSRnor5.0
RGSC_v3.4376,298,592 - 76,298,700UniSTSRGSC3.4
Celera377,092,677 - 77,092,785UniSTS
Cytogenetic Map3q24UniSTS
WI-14603  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,890,091 - 77,890,217 (+)MAPPERmRatBN7.2
Rnor_6.0380,829,939 - 80,830,064NCBIRnor6.0
Rnor_5.0387,528,607 - 87,528,732UniSTSRnor5.0
RGSC_v3.4376,298,655 - 76,298,780UniSTSRGSC3.4
Celera377,092,740 - 77,092,865UniSTS
Cytogenetic Map3q24UniSTS
BF397482  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,717,281 - 77,717,407 (+)MAPPERmRatBN7.2
Rnor_6.0380,650,815 - 80,650,940NCBIRnor6.0
Rnor_5.0387,348,697 - 87,348,822UniSTSRnor5.0
RGSC_v3.4376,125,976 - 76,126,101UniSTSRGSC3.4
Celera376,921,359 - 76,921,484UniSTS
RH 3.4 Map3704.9UniSTS
Cytogenetic Map3q24UniSTS
AI176253  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,844,887 - 77,845,006 (+)MAPPERmRatBN7.2
Rnor_6.0380,784,470 - 80,784,588NCBIRnor6.0
Rnor_5.0387,483,343 - 87,483,461UniSTSRnor5.0
RGSC_v3.4376,253,465 - 76,253,583UniSTSRGSC3.4
Celera377,047,569 - 77,047,687UniSTS
Cytogenetic Map3q24UniSTS
AI176683  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,700,842 - 77,701,050 (+)MAPPERmRatBN7.2
Rnor_6.0380,634,377 - 80,634,584NCBIRnor6.0
Rnor_5.0387,332,259 - 87,332,466UniSTSRnor5.0
RGSC_v3.4376,109,539 - 76,109,746UniSTSRGSC3.4
Celera376,904,903 - 76,905,110UniSTS
Cytogenetic Map3q24UniSTS
UniSTS:225336  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,718,970 - 77,719,101 (+)MAPPERmRatBN7.2
Rnor_6.0380,652,504 - 80,652,634NCBIRnor6.0
Rnor_5.0387,350,386 - 87,350,516UniSTSRnor5.0
RGSC_v3.4376,127,665 - 76,127,795UniSTSRGSC3.4
Celera376,923,048 - 76,923,178UniSTS
Cytogenetic Map3q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 21 6 19 6 74 30 41 11
Low 17 36 35 35 8 11 5 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000045644   ⟹   ENSRNOP00000039742
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,700,936 - 77,890,221 (+)Ensembl
Rnor_6.0 Ensembl380,634,470 - 80,830,068 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084809   ⟹   ENSRNOP00000075219
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl380,676,820 - 80,732,084 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085614   ⟹   ENSRNOP00000073365
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,700,936 - 77,890,221 (+)Ensembl
Rnor_6.0 Ensembl380,670,140 - 80,830,058 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093866   ⟹   ENSRNOP00000087603
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,700,936 - 77,890,221 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105609   ⟹   ENSRNOP00000091295
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,700,989 - 77,890,218 (+)Ensembl
RefSeq Acc Id: NM_001134341   ⟹   NP_001127813
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,700,936 - 77,890,221 (+)NCBI
Rnor_6.0380,634,470 - 80,830,068 (+)NCBI
Rnor_5.0387,332,352 - 87,528,736 (+)NCBI
RGSC_v3.4376,109,632 - 76,298,784 (+)RGD
Celera376,904,996 - 77,092,869 (+)RGD
Sequence:
RefSeq Acc Id: XM_008762030   ⟹   XP_008760252
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,701,048 - 77,890,218 (+)NCBI
Rnor_6.0380,634,630 - 80,830,065 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762031   ⟹   XP_008760253
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,701,048 - 77,890,218 (+)NCBI
Rnor_6.0380,634,632 - 80,830,065 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762032   ⟹   XP_008760254
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,701,048 - 77,890,218 (+)NCBI
Rnor_6.0380,634,632 - 80,830,065 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762033   ⟹   XP_008760255
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,701,048 - 77,890,218 (+)NCBI
Rnor_6.0380,634,632 - 80,830,065 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762034   ⟹   XP_008760256
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,701,048 - 77,890,218 (+)NCBI
Rnor_6.0380,634,632 - 80,830,065 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105763   ⟹   XP_038961691
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,701,048 - 77,890,218 (+)NCBI
RefSeq Acc Id: XM_039105764   ⟹   XP_038961692
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,701,048 - 77,890,218 (+)NCBI
RefSeq Acc Id: XM_039105765   ⟹   XP_038961693
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2377,771,393 - 77,890,218 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001127813   ⟸   NM_001134341
- UniProtKB: F1LNQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760252   ⟸   XM_008762030
- Peptide Label: isoform X1
- UniProtKB: F1LNQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760254   ⟸   XM_008762032
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AGV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760253   ⟸   XM_008762031
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008760255   ⟸   XM_008762033
- Peptide Label: isoform X5
- UniProtKB: A0A0G2K5B6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760256   ⟸   XM_008762034
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AF66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075219   ⟸   ENSRNOT00000084809
RefSeq Acc Id: ENSRNOP00000039742   ⟸   ENSRNOT00000045644
RefSeq Acc Id: ENSRNOP00000073365   ⟸   ENSRNOT00000085614
RefSeq Acc Id: XP_038961691   ⟸   XM_039105763
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038961692   ⟸   XM_039105764
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038961693   ⟸   XM_039105765
- Peptide Label: isoform X8
RefSeq Acc Id: ENSRNOP00000091295   ⟸   ENSRNOT00000105609
RefSeq Acc Id: ENSRNOP00000087603   ⟸   ENSRNOT00000093866

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LNQ2-F1-model_v2 AlphaFold F1LNQ2 1-1300 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692219
Promoter ID:EPDNEW_R2743
Type:initiation region
Name:Ambra1_1
Description:autophagy and beclin 1 regulator 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0380,634,523 - 80,634,583EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621330 AgrOrtholog
BioCyc Gene G2FUF-48719 BioCyc
Ensembl Genes ENSRNOG00000017422 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000039742 ENTREZGENE
  ENSRNOP00000039742.6 UniProtKB/TrEMBL
  ENSRNOP00000073365 ENTREZGENE
  ENSRNOP00000073365.2 UniProtKB/TrEMBL
  ENSRNOP00000087603 ENTREZGENE
  ENSRNOP00000087603.1 UniProtKB/TrEMBL
  ENSRNOP00000091295 ENTREZGENE
  ENSRNOP00000091295.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045644 ENTREZGENE
  ENSRNOT00000045644.6 UniProtKB/TrEMBL
  ENSRNOT00000085614 ENTREZGENE
  ENSRNOT00000085614.2 UniProtKB/TrEMBL
  ENSRNOT00000093866 ENTREZGENE
  ENSRNOT00000093866.1 UniProtKB/TrEMBL
  ENSRNOT00000105609 ENTREZGENE
  ENSRNOT00000105609.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7373916 IMAGE-MGC_LOAD
InterPro WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
MGC_CLONE MGC:112805 IMAGE-MGC_LOAD
NCBI Gene 59319 ENTREZGENE
PhenoGen Ambra1 PhenoGen
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP WD40_like UniProtKB/TrEMBL
UniProt A0A0G2K5B6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AF66 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGV8 ENTREZGENE, UniProtKB/TrEMBL
  F1LNQ2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Ambra1  autophagy and beclin 1 regulator 1  Ambra1  autophagy/beclin 1 regulator 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nyw1  ischemia related factor NYW-1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Nyw1  ischemia related factor NYW-1      Symbol and Name status set to provisional 70820 PROVISIONAL