Itgav (integrin subunit alpha V) - Rat Genome Database

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Gene: Itgav (integrin subunit alpha V) Rattus norvegicus
Analyze
Symbol: Itgav
Name: integrin subunit alpha V
RGD ID: 1310613
Description: Enables signaling receptor binding activity. Involved in several processes, including blood vessel morphogenesis; positive regulation of cell population proliferation; and positive regulation of cytosolic calcium ion concentration. Predicted to be located in several cellular components, including cell projection membrane; external side of plasma membrane; and focal adhesion. Predicted to be part of alphav-beta3 integrin-HMGB1 complex; alphav-beta3 integrin-IGF-1-IGF1R complex; and integrin complex. Used to study corneal neovascularization; coronary stenosis; and ischemia. Biomarker of hypertension. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Orthologous to human ITGAV (integrin subunit alpha V); PARTICIPATES IN integrin mediated signaling pathway; platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: MODEL
Also known as: Cd51; Dnmt3l-ps1 pseudogene; integrin alpha V ; integrin alpha-V; integrin, alpha V; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2368,838,524 - 68,926,653 (+)NCBI
Rnor_6.0 Ensembl371,114,100 - 71,202,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0371,113,269 - 71,205,958 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0377,643,270 - 77,731,358 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4366,953,403 - 67,029,774 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1366,848,789 - 66,926,146 (+)NCBI
Celera368,209,136 - 68,297,332 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-adrenaline  (ISO)
(S)-nicotine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-pinene  (ISO)
Arg-Gly-Asp  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dabrafenib  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenamidone  (ISO)
fenhexamid  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
manganese(II) chloride  (ISO)
methyl methanesulfonate  (ISO)
methyl salicylate  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
nonanoic acid  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phthalaldehyde  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
Ptaquiloside  (ISO)
quercetin  (EXP,ISO)
rebaudioside A  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEP,ISO)
apolipoprotein A-I-mediated signaling pathway  (ISO)
apoptotic cell clearance  (ISO)
blood vessel development  (ISO)
calcium ion transmembrane transport  (ISO)
cell adhesion  (ISO)
cell adhesion mediated by integrin  (ISO)
cell migration  (IMP,ISO)
cell-matrix adhesion  (ISO)
cell-substrate adhesion  (ISO)
endodermal cell differentiation  (ISO)
ERK1 and ERK2 cascade  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
heterotypic cell-cell adhesion  (ISO)
integrin-mediated signaling pathway  (ISO)
negative chemotaxis  (ISO)
negative regulation of entry of bacterium into host cell  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of lipid storage  (ISO)
negative regulation of lipid transport  (ISO)
negative regulation of lipoprotein metabolic process  (ISO)
negative regulation of low-density lipoprotein receptor activity  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IDA,ISO)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of small GTPase mediated signal transduction  (ISO)
regulation of phagocytosis  (ISO)
regulation of transforming growth factor beta activation  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
transforming growth factor beta production  (ISO)
vasculogenesis  (IEP)
viral entry into host cell  (ISO)

References

References - curated
1. Arteaga RB, etal., Am J Cardiol. 2006 Jul 1;98(1):70-4. Epub 2006 May 4.
2. Baron W, etal., EMBO J. 2002 Apr 15;21(8):1957-66.
3. Bonnet S, etal., Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11418-23. Epub 2007 Jun 27.
4. Campbell S, etal., Endocrinology. 2003 Apr;144(4):1486-95.
5. Chang Y and Finnemann SC, J Cell Sci. 2007 Sep 1;120(Pt 17):3053-63. Epub 2007 Aug 7.
6. Chettab K, etal., Thromb Haemost. 2002 Jan;87(1):141-8.
7. Choi ET, etal., Circulation. 2004 Mar 30;109(12):1564-9. Epub 2004 Mar 8.
8. Choke E, etal., Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2077-82. Epub 2006 Jun 29.
9. Dufourcq P, etal., Cardiovasc Res. 2002 Mar;53(4):952-62.
10. Frontczak-Baniewicz M and Walski M, Acta Neurobiol Exp (Wars). 2003;63(2):65-75.
11. GOA data from the GO Consortium
12. Heerkens EH, etal., Hypertension. 2006 Feb;47(2):281-7. Epub 2005 Dec 27.
13. Helfrich MH, etal., J Bone Miner Res. 1992 Mar;7(3):345-51.
14. Hynes RO Cell 2002 Sep 20;110(6):673-87.
15. Klotz O, etal., Graefes Arch Clin Exp Ophthalmol. 2000 Jan;238(1):88-93.
16. Lee KH, etal., J Nucl Med. 2005 Mar;46(3):472-8.
17. Leong-Poi H, etal., Circulation. 2005 Jun 21;111(24):3248-54. Epub 2005 Jun 13.
18. Miller PG, etal., Cancer Cell. 2013 Jul 8;24(1):45-58. doi: 10.1016/j.ccr.2013.05.004. Epub 2013 Jun 13.
19. Miyauchi A, etal., J Bone Miner Metab. 2006;24(6):498-504.
20. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. RGD automated data pipeline
22. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. RGD automated import pipeline for gene-chemical interactions
24. Saygili E, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2898-905. Epub 2007 Feb 9.
25. Takada Y, etal., Genome Biol. 2007;8(5):215.
26. Takagi H, etal., Jpn J Ophthalmol. 2002 May-Jun;46(3):270-8.
27. Tharmalingam S, etal., J Biol Chem. 2011 Nov 25;286(47):40922-33. doi: 10.1074/jbc.M111.265454. Epub 2011 Oct 3.
28. Wilkinson-Berka JL, etal., Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1600-5.
29. Yamani MH, etal., Circulation. 2002 Apr 23;105(16):1955-61.
30. Yamani MH, etal., J Heart Lung Transplant. 2005 Aug;24(8):1014-8.
31. Yasukawa T, etal., Curr Eye Res. 2004 May;28(5):359-66.
Additional References at PubMed
PMID:1918072   PMID:7525578   PMID:8557754   PMID:9553049   PMID:10218736   PMID:10570297   PMID:10708943   PMID:11866539   PMID:12370313   PMID:12807887   PMID:14566019   PMID:15044441  
PMID:15203217   PMID:15215180   PMID:15591537   PMID:15647754   PMID:15695822   PMID:16014375   PMID:16135088   PMID:16489109   PMID:17158881   PMID:17442458   PMID:18221819   PMID:18256073  
PMID:18395422   PMID:18441324   PMID:18538673   PMID:19056867   PMID:19122172   PMID:19359426   PMID:19578119   PMID:19581412   PMID:19723805   PMID:19734584   PMID:19739252   PMID:19920116  
PMID:19933311   PMID:20151413   PMID:20458337   PMID:20463011   PMID:20563599   PMID:20580365   PMID:20645409   PMID:20675382   PMID:20682778   PMID:20826760   PMID:21307347   PMID:21310825  
PMID:21423176   PMID:21502139   PMID:21792920   PMID:22262456   PMID:22278742   PMID:22505472   PMID:22885106   PMID:22915765   PMID:23125415   PMID:23154389   PMID:23161541   PMID:23376485  
PMID:23422496   PMID:23533145   PMID:23658023   PMID:23726972   PMID:23747317   PMID:23755149   PMID:24019890   PMID:24556923   PMID:24644077   PMID:24658351   PMID:24681597   PMID:24959065  
PMID:25063885   PMID:25389530   PMID:26010756   PMID:26279426   PMID:27235833   PMID:27535240   PMID:29162887   PMID:29210651   PMID:30541573   PMID:31010681   PMID:31331973  


Genomics

Comparative Map Data
Itgav
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2368,838,524 - 68,926,653 (+)NCBI
Rnor_6.0 Ensembl371,114,100 - 71,202,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0371,113,269 - 71,205,958 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0377,643,270 - 77,731,358 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4366,953,403 - 67,029,774 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1366,848,789 - 66,926,146 (+)NCBI
Celera368,209,136 - 68,297,332 (+)NCBICelera
Cytogenetic Map3q24NCBI
ITGAV
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2186,590,056 - 186,680,901 (+)EnsemblGRCh38hg38GRCh38
GRCh382186,590,056 - 186,680,901 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372187,454,783 - 187,545,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362187,163,045 - 187,253,873 (+)NCBINCBI36hg18NCBI36
Build 342187,280,305 - 187,371,133NCBI
Celera2181,050,405 - 181,141,257 (+)NCBI
Cytogenetic Map2q32.1NCBI
HuRef2179,314,524 - 179,405,486 (+)NCBIHuRef
CHM1_12187,460,842 - 187,551,625 (+)NCBICHM1_1
Itgav
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39283,551,625 - 83,637,261 (+)NCBIGRCm39mm39
GRCm39 Ensembl283,554,741 - 83,637,260 (+)Ensembl
GRCm38283,722,303 - 83,806,917 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl283,724,397 - 83,806,916 (+)EnsemblGRCm38mm10GRCm38
MGSCv37283,564,554 - 83,647,073 (+)NCBIGRCm37mm9NCBIm37
MGSCv36283,525,354 - 83,604,646 (+)NCBImm8
Celera285,367,604 - 85,456,006 (+)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.33NCBI
Itgav
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540311,592,339 - 11,659,297 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540311,588,536 - 11,669,809 (-)NCBIChiLan1.0ChiLan1.0
ITGAV
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B191,680,655 - 191,773,028 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B191,680,655 - 191,773,028 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B73,880,962 - 73,972,486 (+)NCBIMhudiblu_PPA_v0panPan3
ITGAV
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13628,815,215 - 28,890,569 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3628,804,013 - 28,887,430 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3628,702,231 - 28,789,503 (+)NCBI
ROS_Cfam_1.03629,028,662 - 29,116,151 (+)NCBI
UMICH_Zoey_3.13629,087,085 - 29,173,016 (+)NCBI
UNSW_CanFamBas_1.03629,020,979 - 29,108,231 (+)NCBI
UU_Cfam_GSD_1.03629,188,373 - 29,276,043 (+)NCBI
Itgav
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303145,999,260 - 146,087,955 (+)NCBI
SpeTri2.0NW_00493650610,750,116 - 10,839,018 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGAV
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1591,604,676 - 91,711,840 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11591,604,666 - 91,711,843 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215101,654,958 - 101,717,935 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGAV
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11072,125,710 - 72,216,757 (+)NCBI
ChlSab1.1 Ensembl1072,125,962 - 72,216,809 (+)Ensembl
Vero_WHO_p1.0NW_023666040127,289,910 - 127,381,992 (-)NCBI
Itgav
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248993,235,434 - 3,292,584 (-)NCBI

Position Markers
D3Got143  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2368,881,666 - 68,881,868 (+)MAPPER
Rnor_6.0371,156,983 - 71,157,184NCBIRnor6.0
Rnor_5.0377,686,821 - 77,687,022UniSTSRnor5.0
RGSC_v3.4366,985,224 - 66,985,426RGDRGSC3.4
RGSC_v3.4366,985,225 - 66,985,426UniSTSRGSC3.4
RGSC_v3.1366,881,596 - 66,881,798RGD
Celera368,252,850 - 68,253,051UniSTS
RH 2.0 Map31034.3RGD
Cytogenetic Map3q24UniSTS
RH140315  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2368,923,665 - 68,923,861 (+)MAPPER
Rnor_6.0371,202,971 - 71,203,166NCBIRnor6.0
Rnor_5.0377,728,371 - 77,728,566UniSTSRnor5.0
RGSC_v3.4367,029,877 - 67,030,072UniSTSRGSC3.4
Celera368,294,341 - 68,294,536UniSTS
Cytogenetic Map3q24UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3195176874Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31009408193415837Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31011931879772001Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32932171474321714Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32968273274682732Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32968273274682732Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32968273274682732Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32968273274682732Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32968273274682732Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32990825574908255Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32990825574908255Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)330114912123700444Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33110358972989078Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33110358972989078Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33110358972989078Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33110358972989078Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33110358972989078Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33110358972989078Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33213099777130997Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33213099777130997Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33347735481136227Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333477354108914061Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)334394121103141944Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)339248391140271184Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)34042292185422921Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)34052359392654473Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)34052359392654473Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)343295930108914061Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)343295930163640485Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)343295930163640485Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34540605894467785Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)345406058127023997Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)348561928155263151Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)348562146115249962Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)348562146115249962Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)351821836124513579Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)351822008120917851Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)354630948119830094Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)354630948119830094Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)354630948119830094Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35463104693415673Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35524527695176874Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35524527695176874Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35524527695176874Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)356735995101735995Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)358204463170534769Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)361241033165369047Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)362922868127023997Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36304905092654302Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)366711607119830094Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)366711607119830094Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:43
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000006961
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 38 33 17 19 17 8 8 70 35 34 11 8
Low 1 5 24 24 24 3 4 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006961   ⟹   ENSRNOP00000006961
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl371,114,100 - 71,202,411 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088549   ⟹   ENSRNOP00000069681
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl371,114,100 - 71,202,411 (+)Ensembl
RefSeq Acc Id: XM_039106445   ⟹   XP_038962373
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2368,838,532 - 68,926,653 (+)NCBI
RefSeq Acc Id: XM_039106446   ⟹   XP_038962374
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2368,838,531 - 68,926,653 (+)NCBI
RefSeq Acc Id: XM_039106447   ⟹   XP_038962375
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2368,859,226 - 68,926,653 (+)NCBI
RefSeq Acc Id: XM_039106448   ⟹   XP_038962376
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2368,838,524 - 68,900,233 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038962373 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962374 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962375 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962376 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL79295 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: ENSRNOP00000006961   ⟸   ENSRNOT00000006961
RefSeq Acc Id: ENSRNOP00000069681   ⟸   ENSRNOT00000088549
RefSeq Acc Id: XP_038962376   ⟸   XM_039106448
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038962374   ⟸   XM_039106446
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038962373   ⟸   XM_039106445
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038962375   ⟸   XM_039106447
- Peptide Label: isoform X3
Protein Domains
Integrin_alpha2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310613 AgrOrtholog
Ensembl Genes ENSRNOG00000004912 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006961 UniProtKB/TrEMBL
  ENSRNOP00000069681 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006961 UniProtKB/TrEMBL
  ENSRNOT00000088549 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom UniProtKB/TrEMBL
NCBI Gene 296456 ENTREZGENE
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/TrEMBL
PhenoGen Itgav PhenoGen
PRINTS INTEGRINA UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
SMART Int_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF69179 UniProtKB/TrEMBL
UniProt A0A0G2JVZ6_RAT UniProtKB/TrEMBL
  F1LZX9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itgav  integrin subunit alpha V  Itgav  integrin, alpha V  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Itgav  integrin, alpha V  Itgav  integrin alpha V   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Itgav  integrin alpha V   Itgav_predicted  integrin alpha V (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Itgav_predicted  integrin alpha V (predicted)    integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) (predicted)  Name updated 1299863 APPROVED
2005-01-12 Itgav_predicted  integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) (predicted)      Symbol and Name status set to approved 70820 APPROVED