Itgav (integrin subunit alpha V) - Rat Genome Database

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Gene: Itgav (integrin subunit alpha V) Rattus norvegicus
Analyze
Symbol: Itgav
Name: integrin subunit alpha V
RGD ID: 1310613
Description: Enables signaling receptor binding activity. Involved in several processes, including blood vessel morphogenesis; positive regulation of cell population proliferation; and positive regulation of cytosolic calcium ion concentration. Predicted to be located in several cellular components, including cell projection membrane; external side of plasma membrane; and focal adhesion. Predicted to be part of alphav-beta3 integrin-HMGB1 complex; alphav-beta3 integrin-IGF-1-IGF1R complex; and integrin complex. Used to study corneal neovascularization; coronary stenosis; and ischemia. Biomarker of hypertension. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Orthologous to human ITGAV (integrin subunit alpha V); PARTICIPATES IN integrin mediated signaling pathway; platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cd51; Dnmt3l-ps1 pseudogene; integrin alpha V ; integrin alpha-V; integrin, alpha V; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8389,245,382 - 89,333,512 (+)NCBIGRCr8
mRatBN7.2368,838,514 - 68,926,653 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl368,838,189 - 68,926,639 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx372,233,903 - 72,315,469 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0380,832,555 - 80,914,128 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0378,567,077 - 78,655,183 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0371,113,269 - 71,205,958 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl371,114,100 - 71,202,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0377,643,270 - 77,731,358 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4366,953,403 - 67,029,774 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1366,848,789 - 66,926,146 (+)NCBI
Celera368,209,136 - 68,297,332 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-adrenaline  (ISO)
(S)-nicotine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-pinene  (ISO)
Arg-Gly-Asp  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dabrafenib  (ISO)
DDE  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenamidone  (ISO)
fenhexamid  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gallic acid  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
irinotecan  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
methyl salicylate  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
nonanoic acid  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phthalaldehyde  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
Ptaquiloside  (ISO)
quercetin  (EXP,ISO)
rebaudioside A  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sucrose  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thyroxine  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tranilast  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IBA,IEP,ISO)
apolipoprotein A-I-mediated signaling pathway  (ISO)
apoptotic cell clearance  (ISO)
blood vessel development  (ISO)
calcium ion transmembrane transport  (ISO)
cell adhesion  (ISO)
cell adhesion mediated by integrin  (IBA,ISO)
cell migration  (IMP,ISO)
cell-cell adhesion  (IBA)
cell-matrix adhesion  (IBA,ISO)
cell-substrate adhesion  (ISO)
endodermal cell differentiation  (ISO)
ERK1 and ERK2 cascade  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
heterotypic cell-cell adhesion  (ISO)
integrin-mediated signaling pathway  (IBA,ISO)
negative chemotaxis  (ISO)
negative regulation of entry of bacterium into host cell  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of lipid storage  (ISO)
negative regulation of lipid transport  (ISO)
negative regulation of lipoprotein metabolic process  (ISO)
negative regulation of low-density lipoprotein receptor activity  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IDA,ISO)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of small GTPase mediated signal transduction  (ISO)
regulation of phagocytosis  (ISO)
response to nitric oxide  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
symbiont entry into host cell  (IEA)
transforming growth factor beta production  (ISO)
vasculogenesis  (IEP)

References

References - curated
# Reference Title Reference Citation
1. Endothelial microparticles and platelet and leukocyte activation in patients with the metabolic syndrome. Arteaga RB, etal., Am J Cardiol. 2006 Jul 1;98(1):70-4. Epub 2006 May 4.
2. The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of alpha(v)beta3 integrins. Baron W, etal., EMBO J. 2002 Apr 15;21(8):1957-66.
3. The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Bonnet S, etal., Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11418-23. Epub 2007 Jun 27.
4. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
5. Connection between integrins and cell activation in rat adrenal glomerulosa cells: a role for Arg-Gly-Asp peptide in the activation of the p42/p44(mapk) pathway and intracellular calcium. Campbell S, etal., Endocrinology. 2003 Apr;144(4):1486-95.
6. Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis. Chang Y and Finnemann SC, J Cell Sci. 2007 Sep 1;120(Pt 17):3053-63. Epub 2007 Aug 7.
7. Acute hyperglycaemia induces changes in the transcription levels of 4 major genes in human endothelial cells: macroarrays-based expression analysis. Chettab K, etal., Thromb Haemost. 2002 Jan;87(1):141-8.
8. Beta3-integrin mediates smooth muscle cell accumulation in neointima after carotid ligation in mice. Choi ET, etal., Circulation. 2004 Mar 30;109(12):1564-9. Epub 2004 Mar 8.
9. Abdominal aortic aneurysm rupture is associated with increased medial neovascularization and overexpression of proangiogenic cytokines. Choke E, etal., Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2077-82. Epub 2006 Jun 29.
10. Vitronectin is up-regulated after vascular injury and vitronectin blockade prevents neointima formation. Dufourcq P, etal., Cardiovasc Res. 2002 Mar;53(4):952-62.
11. New vessel formation after surgical brain injury in the rat's cerebral cortex I. Formation of the blood vessels proximally to the surgical injury. Frontczak-Baniewicz M and Walski M, Acta Neurobiol Exp (Wars). 2003;63(2):65-75.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. alphaV integrins are necessary for eutrophic inward remodeling of small arteries in hypertension. Heerkens EH, etal., Hypertension. 2006 Feb;47(2):281-7. Epub 2005 Dec 27.
15. Integrins on rat osteoclasts: characterization of two monoclonal antibodies (F4 and F11) to rat beta 3. Helfrich MH, etal., J Bone Miner Res. 1992 Mar;7(3):345-51.
16. Integrins: bidirectional, allosteric signaling machines. Hynes RO Cell 2002 Sep 20;110(6):673-87.
17. Inhibition of corneal neovascularization by alpha(v)-integrin antagonists in the rat. Klotz O, etal., Graefes Arch Clin Exp Ophthalmol. 2000 Jan;238(1):88-93.
18. Radiolabeled RGD uptake and alphav integrin expression is enhanced in ischemic murine hindlimbs. Lee KH, etal., J Nucl Med. 2005 Mar;46(3):472-8.
19. Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression. Leong-Poi H, etal., Circulation. 2005 Jun 21;111(24):3248-54. Epub 2005 Jun 13.
20. In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. Miller PG, etal., Cancer Cell. 2013 Jul 8;24(1):45-58. doi: 10.1016/j.ccr.2013.05.004. Epub 2013 Jun 13.
21. alpha(V)beta (3) Integrin ligands enhance volume-sensitive calcium influx in mechanically stretched osteocytes. Miyauchi A, etal., J Bone Miner Metab. 2006;24(6):498-504.
22. Anti-alphav integrin monoclonal antibody intetumumab enhances the efficacy of radiation therapy and reduces metastasis of human cancer xenografts in nude rats. Ning S, etal., Cancer Res. 2010 Oct 1;70(19):7591-9. doi: 10.1158/0008-5472.CAN-10-1639. Epub 2010 Sep 14.
23. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Losartan prevents stretch-induced electrical remodeling in cultured atrial neonatal myocytes. Saygili E, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2898-905. Epub 2007 Feb 9.
28. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
29. Role of vitronectin receptor-type integrins and osteopontin in ischemia-induced retinal neovascularization. Takagi H, etal., Jpn J Ophthalmol. 2002 May-Jun;46(3):270-8.
30. Calcium-sensing receptor modulates cell adhesion and migration via integrins. Tharmalingam S, etal., J Biol Chem. 2011 Nov 25;286(47):40922-33. doi: 10.1074/jbc.M111.265454. Epub 2011 Oct 3.
31. Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries. Ward MR, etal., Atherosclerosis. 1998 Apr;137(2):267-75. doi: 10.1016/s0021-9150(97)00275-x.
32. SB-267268, a nonpeptidic antagonist of alpha(v)beta3 and alpha(v)beta5 integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity. Wilkinson-Berka JL, etal., Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1600-5.
33. Myocardial ischemic injury after heart transplantation is associated with upregulation of vitronectin receptor (alpha(v)beta3), activation of the matrix metalloproteinase induction system, and subsequent development of coronary vasculopathy. Yamani MH, etal., Circulation. 2002 Apr 23;105(16):1955-61.
34. Systemic activation of integrin alphaVbeta3 in donors with spontaneous intracerebral hemorrhage is associated with subsequent development of vasculopathy in the heart transplant recipient. Yamani MH, etal., J Heart Lung Transplant. 2005 Aug;24(8):1014-8.
35. Inhibition of experimental choroidal neovascularization in rats by an alpha(v)-integrin antagonist. Yasukawa T, etal., Curr Eye Res. 2004 May;28(5):359-66.
Additional References at PubMed
PMID:1918072   PMID:7525578   PMID:8557754   PMID:9553049   PMID:10218736   PMID:10570297   PMID:10708943   PMID:11866539   PMID:12370313   PMID:12807887   PMID:14566019   PMID:15044441  
PMID:15203217   PMID:15215180   PMID:15591537   PMID:15647754   PMID:15695822   PMID:16014375   PMID:16135088   PMID:16489109   PMID:17158881   PMID:17442458   PMID:18221819   PMID:18256073  
PMID:18395422   PMID:18441324   PMID:18538673   PMID:19056867   PMID:19122172   PMID:19359426   PMID:19578119   PMID:19581412   PMID:19723805   PMID:19734584   PMID:19739252   PMID:19920116  
PMID:19933311   PMID:20151413   PMID:20458337   PMID:20463011   PMID:20563599   PMID:20580365   PMID:20645409   PMID:20675382   PMID:20682778   PMID:20826760   PMID:21307347   PMID:21310825  
PMID:21423176   PMID:21502139   PMID:21792920   PMID:22262456   PMID:22278742   PMID:22505472   PMID:22885106   PMID:22915765   PMID:23125415   PMID:23154389   PMID:23161541   PMID:23376485  
PMID:23422496   PMID:23533145   PMID:23658023   PMID:23726972   PMID:23747317   PMID:23755149   PMID:24019890   PMID:24556923   PMID:24644077   PMID:24658351   PMID:24681597   PMID:24959065  
PMID:25063885   PMID:25389530   PMID:26010756   PMID:26279426   PMID:27235833   PMID:27535240   PMID:29162887   PMID:29210651   PMID:30541573   PMID:31010681   PMID:31331973  


Genomics

Comparative Map Data
Itgav
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8389,245,382 - 89,333,512 (+)NCBIGRCr8
mRatBN7.2368,838,514 - 68,926,653 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl368,838,189 - 68,926,639 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx372,233,903 - 72,315,469 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0380,832,555 - 80,914,128 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0378,567,077 - 78,655,183 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0371,113,269 - 71,205,958 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl371,114,100 - 71,202,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0377,643,270 - 77,731,358 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4366,953,403 - 67,029,774 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1366,848,789 - 66,926,146 (+)NCBI
Celera368,209,136 - 68,297,332 (+)NCBICelera
Cytogenetic Map3q24NCBI
ITGAV
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382186,590,056 - 186,680,901 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2186,590,010 - 186,680,901 (+)EnsemblGRCh38hg38GRCh38
GRCh372187,454,783 - 187,545,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362187,163,045 - 187,253,873 (+)NCBINCBI36Build 36hg18NCBI36
Build 342187,280,305 - 187,371,133NCBI
Celera2181,050,405 - 181,141,257 (+)NCBICelera
Cytogenetic Map2q32.1NCBI
HuRef2179,314,524 - 179,405,486 (+)NCBIHuRef
CHM1_12187,460,842 - 187,551,625 (+)NCBICHM1_1
T2T-CHM13v2.02187,079,132 - 187,170,024 (+)NCBIT2T-CHM13v2.0
Itgav
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39283,554,796 - 83,637,261 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl283,554,741 - 83,637,260 (+)EnsemblGRCm39 Ensembl
GRCm38283,722,303 - 83,806,917 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl283,724,397 - 83,806,916 (+)EnsemblGRCm38mm10GRCm38
MGSCv37283,564,554 - 83,647,073 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36283,525,354 - 83,604,646 (+)NCBIMGSCv36mm8
Celera285,367,604 - 85,456,006 (+)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.33NCBI
Itgav
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540311,592,339 - 11,659,297 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540311,588,536 - 11,669,809 (-)NCBIChiLan1.0ChiLan1.0
ITGAV
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21389,252,238 - 89,359,439 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B89,280,655 - 89,374,419 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B73,880,962 - 73,972,486 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B191,680,655 - 191,773,028 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B191,680,655 - 191,773,028 (+)Ensemblpanpan1.1panPan2
ITGAV
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13628,815,215 - 28,890,569 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3628,804,013 - 28,887,430 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3628,702,231 - 28,789,503 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03629,028,662 - 29,116,151 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3629,031,003 - 29,116,148 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13629,087,085 - 29,173,016 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03629,020,979 - 29,108,231 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03629,188,373 - 29,276,043 (+)NCBIUU_Cfam_GSD_1.0
Itgav
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303145,999,260 - 146,087,955 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650610,750,101 - 10,839,303 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650610,750,116 - 10,839,018 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGAV
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1591,604,676 - 91,711,851 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11591,604,666 - 91,711,843 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215101,654,958 - 101,717,935 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGAV
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11072,125,710 - 72,216,757 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1072,125,962 - 72,216,809 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040127,289,910 - 127,381,992 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgav
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248993,239,112 - 3,291,586 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248993,235,434 - 3,292,584 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itgav
578 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:43
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000006961
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat

Markers in Region
D3Got143  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2368,881,666 - 68,881,868 (+)MAPPERmRatBN7.2
Rnor_6.0371,156,983 - 71,157,184NCBIRnor6.0
Rnor_5.0377,686,821 - 77,687,022UniSTSRnor5.0
RGSC_v3.4366,985,224 - 66,985,426RGDRGSC3.4
RGSC_v3.4366,985,225 - 66,985,426UniSTSRGSC3.4
RGSC_v3.1366,881,596 - 66,881,798RGD
Celera368,252,850 - 68,253,051UniSTS
RH 2.0 Map31034.3RGD
Cytogenetic Map3q24UniSTS
RH140315  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2368,923,665 - 68,923,861 (+)MAPPERmRatBN7.2
Rnor_6.0371,202,971 - 71,203,166NCBIRnor6.0
Rnor_5.0377,728,371 - 77,728,566UniSTSRnor5.0
RGSC_v3.4367,029,877 - 67,030,072UniSTSRGSC3.4
Celera368,294,341 - 68,294,536UniSTS
Cytogenetic Map3q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000006961   ⟹   ENSRNOP00000006961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl368,838,189 - 68,926,639 (+)Ensembl
Rnor_6.0 Ensembl371,114,100 - 71,202,411 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088549   ⟹   ENSRNOP00000069681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl368,838,599 - 68,926,639 (+)Ensembl
Rnor_6.0 Ensembl371,114,100 - 71,202,411 (+)Ensembl
RefSeq Acc Id: NM_001398692   ⟹   NP_001385621
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,245,382 - 89,333,512 (+)NCBI
mRatBN7.2368,838,514 - 68,926,653 (+)NCBI
RefSeq Acc Id: NM_001398693   ⟹   NP_001385622
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,245,382 - 89,333,512 (+)NCBI
mRatBN7.2368,838,514 - 68,926,653 (+)NCBI
RefSeq Acc Id: XM_039106447   ⟹   XP_038962375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,266,090 - 89,333,512 (+)NCBI
mRatBN7.2368,859,226 - 68,926,653 (+)NCBI
RefSeq Acc Id: XM_063283421   ⟹   XP_063139491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,248,393 - 89,333,512 (+)NCBI
RefSeq Acc Id: XR_010064598
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,245,526 - 89,333,512 (+)NCBI
RefSeq Acc Id: XR_010064599
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,245,504 - 89,333,512 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001385621 (Get FASTA)   NCBI Sequence Viewer  
  NP_001385622 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962375 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139491 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL79295 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006961.8
  ENSRNOP00000069681.2
Ensembl Acc Id: ENSRNOP00000006961   ⟸   ENSRNOT00000006961
Ensembl Acc Id: ENSRNOP00000069681   ⟸   ENSRNOT00000088549
RefSeq Acc Id: XP_038962375   ⟸   XM_039106447
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001385621   ⟸   NM_001398692
- Peptide Label: isoform 1 precursor
RefSeq Acc Id: NP_001385622   ⟸   NM_001398693
- Peptide Label: isoform 2 precursor
- UniProtKB: F1LZX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139491   ⟸   XM_063283421
- Peptide Label: isoform X1
Protein Domains
Integrin alpha first immunoglubulin-like   Integrin alpha second immunoglobulin-like   Integrin alpha third immunoglobulin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVZ6-F1-model_v2 AlphaFold A0A0G2JVZ6 1-1052 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310613 AgrOrtholog
BioCyc Gene G2FUF-49196 BioCyc
Ensembl Genes ENSRNOG00000004912 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006961.8 UniProtKB/TrEMBL
  ENSRNOT00000088549.2 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_3 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom UniProtKB/TrEMBL
NCBI Gene 296456 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/TrEMBL
  INTEGRIN ALPHA-V UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  Integrin_A_Ig_3 UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/TrEMBL
PhenoGen Itgav PhenoGen
PRINTS INTEGRINA UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004912 RatGTEx
SMART Int_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A0G2JVZ6_RAT UniProtKB/TrEMBL
  F1LZX9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itgav  integrin subunit alpha V  Itgav  integrin, alpha V  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Itgav  integrin, alpha V  Itgav  integrin alpha V   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Itgav  integrin alpha V   Itgav_predicted  integrin alpha V (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Itgav_predicted  integrin alpha V (predicted)    integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) (predicted)  Name updated 1299863 APPROVED
2005-01-12 Itgav_predicted  integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) (predicted)      Symbol and Name status set to approved 70820 APPROVED