Itgav (integrin alpha V) - Rat Genome Database

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Gene: Itgav (integrin alpha V) Mus musculus
Analyze
Symbol: Itgav
Name: integrin alpha V
RGD ID: 1617623
MGI Page MGI
Description: Enables integrin binding activity. Contributes to opsonin binding activity and protein kinase C binding activity. Involved in several processes, including ERK1 and ERK2 cascade; extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of osteoblast proliferation. Acts upstream of or within blood vessel development. Located in external side of plasma membrane. Part of integrin alphav-beta5 complex and integrin alphav-beta6 complex. Is expressed in several structures, including early conceptus; embryo mesenchyme; jaw; skeletal muscle; and ventricular layer. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Orthologous to human ITGAV (integrin subunit alpha V).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 1110004F14Rik; 2610028E01Rik; alpha v integrin; alphav-integrin; CD51; D430040G12Rik; integrin alpha-V; vitronectin receptor alpha polypeptide (VNRA); vitronectin receptor subunit alpha
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39283,554,796 - 83,637,261 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl283,554,741 - 83,637,260 (+)EnsemblGRCm39 Ensembl
GRCm38283,722,303 - 83,806,917 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl283,724,397 - 83,806,916 (+)EnsemblGRCm38mm10GRCm38
MGSCv37283,564,554 - 83,647,073 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36283,525,354 - 83,604,646 (+)NCBIMGSCv36mm8
Celera285,367,604 - 85,456,006 (+)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-adrenaline  (ISO)
(S)-nicotine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-dinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-vinylcyclohexene dioxide  (EXP)
5-fluorouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (EXP)
alpha-pinene  (ISO)
Arg-Gly-Asp  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
butane-2,3-dione  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dabrafenib  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
fenamidone  (EXP)
fenhexamid  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
gefitinib  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methyl methanesulfonate  (ISO)
methyl salicylate  (EXP)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (ISO)
niclosamide  (ISO)
nicotine  (EXP)
nitrofen  (ISO)
nonanoic acid  (EXP)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phthalaldehyde  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
Ptaquiloside  (EXP)
quercetin  (ISO)
rebaudioside A  (ISO)
resveratrol  (ISO)
rimonabant  (EXP)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP)
succimer  (EXP)
sucrose  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
tranilast  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IBA,ISO)
apolipoprotein A-I-mediated signaling pathway  (ISO)
apoptotic cell clearance  (IDA,IGI,IMP,ISO)
blood vessel development  (IMP)
calcium ion transmembrane transport  (ISO)
cell adhesion  (ISO)
cell adhesion mediated by integrin  (IBA,IDA,ISO)
cell differentiation  (IEA)
cell migration  (ISO)
cell-cell adhesion  (IBA)
cell-matrix adhesion  (IBA,ISO,NAS,TAS)
cell-substrate adhesion  (ISO)
detection of molecule of bacterial origin  (TAS)
endodermal cell differentiation  (ISO)
endothelial cell migration  (TAS)
ERK1 and ERK2 cascade  (IDA)
extrinsic apoptotic signaling pathway in absence of ligand  (IDA)
fertilization  (NAS)
focal adhesion assembly  (NAS)
gonad morphogenesis  (NAS)
heterotypic cell-cell adhesion  (ISO)
inflammatory response  (TAS)
integrin-mediated signaling pathway  (IBA,ISO)
negative chemotaxis  (ISO)
negative regulation of entry of bacterium into host cell  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of lipid storage  (ISO)
negative regulation of lipid transport  (ISO)
negative regulation of lipoprotein metabolic process  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
obsolete regulation of transforming growth factor beta activation  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of osteoblast proliferation  (IMP)
positive regulation of small GTPase mediated signal transduction  (ISO)
regulation of bone resorption  (TAS)
regulation of phagocytosis  (ISO,NAS)
release of sequestered calcium ion into cytosol  (TAS)
response to nitric oxide  (TAS)
substrate adhesion-dependent cell spreading  (ISO)
symbiont entry into host cell  (ISO)
T cell activation  (TAS)
transforming growth factor beta production  (IDA)
trophoblast giant cell differentiation  (TAS)
vasculogenesis  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal ascending aorta morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal cell adhesion  (IAGP)
abnormal cellular extravasation  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal dendritic cell differentiation  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal embryonic growth/weight/body size  (IAGP)
abnormal embryonic/fetal subventricular zone morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal gait  (IAGP)
abnormal glial cell morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin level  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal involuntary movement  (IAGP)
abnormal leukocyte morphology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal placenta vasculature  (IAGP)
abnormal posture  (IAGP)
abnormal renal/urinary system physiology  (IAGP)
abnormal secondary palate development  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
ataxia  (IAGP)
axon degeneration  (IAGP)
axonal dystrophy  (IAGP)
cerebellum hemorrhage  (IAGP)
cleft secondary palate  (IAGP)
colitis  (IAGP)
convulsive seizures  (IAGP)
crypts of Lieberkuhn abscesses  (IAGP)
decreased placental labyrinth size  (IAGP)
decreased regulatory T cell number  (IAGP)
demyelination  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enlarged heart  (IAGP)
enlarged mesenteric lymph nodes  (IAGP)
enlarged Peyer's patches  (IAGP)
gliosis  (IAGP)
hemorrhage  (IAGP)
hydrocephaly  (IAGP)
impaired coordination  (IAGP)
impaired limb coordination  (IAGP)
impaired macrophage phagocytosis  (IAGP)
increased autoantibody level  (IAGP)
increased inflammatory response  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased regulatory T cell number  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
intestinal hemorrhage  (IAGP)
intestinal ulcer  (IAGP)
intracerebral hemorrhage  (IAGP)
intracranial hemorrhage  (IAGP)
large intestinal inflammation  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
microcephaly  (IAGP)
muscle hypertonia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
palatal shelves fail to meet at midline  (IAGP)
paraparesis  (IAGP)
patent ductus arteriosus  (IAGP)
pericardial edema  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
retroesophageal right subclavian artery  (IAGP)
seizures  (IAGP)
small pharyngeal arch  (IAGP)
spinal hemorrhage  (IAGP)
thin myocardium  (IAGP)
trabecula carnea hypoplasia  (IAGP)
vascular ring  (IAGP)
ventricular septal defect  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Endothelial microparticles and platelet and leukocyte activation in patients with the metabolic syndrome. Arteaga RB, etal., Am J Cardiol. 2006 Jul 1;98(1):70-4. Epub 2006 May 4.
2. The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Bonnet S, etal., Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11418-23. Epub 2007 Jun 27.
3. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
4. Connection between integrins and cell activation in rat adrenal glomerulosa cells: a role for Arg-Gly-Asp peptide in the activation of the p42/p44(mapk) pathway and intracellular calcium. Campbell S, etal., Endocrinology. 2003 Apr;144(4):1486-95.
5. Acute hyperglycaemia induces changes in the transcription levels of 4 major genes in human endothelial cells: macroarrays-based expression analysis. Chettab K, etal., Thromb Haemost. 2002 Jan;87(1):141-8.
6. alphaV integrins are necessary for eutrophic inward remodeling of small arteries in hypertension. Heerkens EH, etal., Hypertension. 2006 Feb;47(2):281-7. Epub 2005 Dec 27.
7. Radiolabeled RGD uptake and alphav integrin expression is enhanced in ischemic murine hindlimbs. Lee KH, etal., J Nucl Med. 2005 Mar;46(3):472-8.
8. In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. Miller PG, etal., Cancer Cell. 2013 Jul 8;24(1):45-58. doi: 10.1016/j.ccr.2013.05.004. Epub 2013 Jun 13.
9. Anti-alphav integrin monoclonal antibody intetumumab enhances the efficacy of radiation therapy and reduces metastasis of human cancer xenografts in nude rats. Ning S, etal., Cancer Res. 2010 Oct 1;70(19):7591-9. doi: 10.1158/0008-5472.CAN-10-1639. Epub 2010 Sep 14.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
16. Role of vitronectin receptor-type integrins and osteopontin in ischemia-induced retinal neovascularization. Takagi H, etal., Jpn J Ophthalmol. 2002 May-Jun;46(3):270-8.
17. Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries. Ward MR, etal., Atherosclerosis. 1998 Apr;137(2):267-75. doi: 10.1016/s0021-9150(97)00275-x.
18. Inhibition of experimental choroidal neovascularization in rats by an alpha(v)-integrin antagonist. Yasukawa T, etal., Curr Eye Res. 2004 May;28(5):359-66.
Additional References at PubMed
PMID:1431091   PMID:1703206   PMID:7593304   PMID:7593323   PMID:7691492   PMID:7873784   PMID:8557754   PMID:8601592   PMID:8666675   PMID:8834471   PMID:8889548   PMID:8930896  
PMID:9420328   PMID:9473675   PMID:9553049   PMID:9593935   PMID:9686317   PMID:9827803   PMID:9849968   PMID:9916011   PMID:10048576   PMID:10069334   PMID:10090148   PMID:10091056  
PMID:10349636   PMID:10570297   PMID:10700190   PMID:10742111   PMID:10780854   PMID:10965141   PMID:11035110   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11438667   PMID:11856728  
PMID:11970960   PMID:12099514   PMID:12370313   PMID:12466851   PMID:12477932   PMID:12486108   PMID:12603314   PMID:12878490   PMID:12904471   PMID:12927791   PMID:14524530   PMID:14566019  
PMID:14610273   PMID:15007005   PMID:15284116   PMID:15305376   PMID:15370361   PMID:15543338   PMID:15576410   PMID:15591537   PMID:15647754   PMID:15739233   PMID:15760908   PMID:16014375  
PMID:16141072   PMID:16141073   PMID:16150802   PMID:16260650   PMID:16337627   PMID:16338970   PMID:16400188   PMID:16407244   PMID:16479252   PMID:16571912   PMID:16600665   PMID:16622802  
PMID:16679515   PMID:16710477   PMID:16888388   PMID:17028191   PMID:17249615   PMID:17446174   PMID:17530709   PMID:17535848   PMID:17548654   PMID:17694047   PMID:17716972   PMID:17895374  
PMID:17924447   PMID:18084301   PMID:18174291   PMID:18204838   PMID:18221819   PMID:18234903   PMID:18255021   PMID:18276918   PMID:18294287   PMID:18366072   PMID:18378634   PMID:18451854  
PMID:18456735   PMID:18467691   PMID:18538673   PMID:18552165   PMID:18985734   PMID:19017937   PMID:19074851   PMID:19118215   PMID:19118216   PMID:19162043   PMID:19176624   PMID:19228596  
PMID:19255147   PMID:19272161   PMID:19346499   PMID:19454719   PMID:19487690   PMID:19619540   PMID:19695571   PMID:19793892   PMID:19805288   PMID:19808614   PMID:19837659   PMID:20087368  
PMID:20151413   PMID:20155273   PMID:20238010   PMID:20339539   PMID:20404115   PMID:20531304   PMID:20570943   PMID:20675382   PMID:20826760   PMID:20958318   PMID:21048023   PMID:21051860  
PMID:21099114   PMID:21099117   PMID:21181944   PMID:21267068   PMID:21281793   PMID:21307347   PMID:21335239   PMID:21402900   PMID:21406181   PMID:21421844   PMID:21636859   PMID:21646718  
PMID:21677750   PMID:21697282   PMID:21723222   PMID:21745448   PMID:21764795   PMID:21799763   PMID:21855915   PMID:21868707   PMID:21873635   PMID:21945075   PMID:22027834   PMID:22069187  
PMID:22074485   PMID:22183400   PMID:22198947   PMID:22232213   PMID:22279205   PMID:22479590   PMID:22492581   PMID:22494046   PMID:22527796   PMID:22579114   PMID:22615494   PMID:22669616  
PMID:22808199   PMID:22885106   PMID:22975325   PMID:23028753   PMID:23152823   PMID:23264742   PMID:23283986   PMID:23327924   PMID:23362664   PMID:23465490   PMID:23744351   PMID:23776077  
PMID:23789102   PMID:23867618   PMID:23933892   PMID:24023288   PMID:24163432   PMID:24216753   PMID:24294595   PMID:24375788   PMID:24469034   PMID:24495224   PMID:24496617   PMID:24563481  
PMID:24681597   PMID:24726648   PMID:24840544   PMID:24858485   PMID:24952961   PMID:25117682   PMID:25127859   PMID:25263523   PMID:25339175   PMID:25406396   PMID:25428696   PMID:25488971  
PMID:25547154   PMID:25587038   PMID:25670798   PMID:25807551   PMID:25820496   PMID:25822023   PMID:25834823   PMID:25887124   PMID:25972484   PMID:25995225   PMID:26010756   PMID:26212910  
PMID:26238448   PMID:26279426   PMID:26311781   PMID:26371120   PMID:26586223   PMID:26733684   PMID:26901152   PMID:26944089   PMID:26965188   PMID:27233450   PMID:27264390   PMID:27302657  
PMID:27493116   PMID:27596966   PMID:27599164   PMID:27864010   PMID:27905395   PMID:28473400   PMID:28650456   PMID:29061963   PMID:29162887   PMID:29535709   PMID:29702083   PMID:29999501  
PMID:30333317   PMID:30354234   PMID:30536905   PMID:30550785   PMID:30629551   PMID:30647151   PMID:30770250   PMID:30770452   PMID:30846482   PMID:31601741   PMID:32049039   PMID:32440878  
PMID:32667911   PMID:32735820   PMID:32882513   PMID:33398028   PMID:33481853   PMID:33483531   PMID:33637617   PMID:33731712   PMID:33795534   PMID:33903257   PMID:33927296   PMID:34233193  
PMID:34321999   PMID:34502434   PMID:34711823   PMID:35062222   PMID:35217866   PMID:35294899   PMID:36808153   PMID:37175535   PMID:37219531   PMID:37403784   PMID:38081108  


Genomics

Comparative Map Data
Itgav
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39283,554,796 - 83,637,261 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl283,554,741 - 83,637,260 (+)EnsemblGRCm39 Ensembl
GRCm38283,722,303 - 83,806,917 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl283,724,397 - 83,806,916 (+)EnsemblGRCm38mm10GRCm38
MGSCv37283,564,554 - 83,647,073 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36283,525,354 - 83,604,646 (+)NCBIMGSCv36mm8
Celera285,367,604 - 85,456,006 (+)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.33NCBI
ITGAV
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382186,590,056 - 186,680,901 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2186,590,010 - 186,680,901 (+)EnsemblGRCh38hg38GRCh38
GRCh372187,454,783 - 187,545,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362187,163,045 - 187,253,873 (+)NCBINCBI36Build 36hg18NCBI36
Build 342187,280,305 - 187,371,133NCBI
Celera2181,050,405 - 181,141,257 (+)NCBICelera
Cytogenetic Map2q32.1NCBI
HuRef2179,314,524 - 179,405,486 (+)NCBIHuRef
CHM1_12187,460,842 - 187,551,625 (+)NCBICHM1_1
T2T-CHM13v2.02187,079,132 - 187,170,024 (+)NCBIT2T-CHM13v2.0
Itgav
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8389,245,382 - 89,333,512 (+)NCBIGRCr8
mRatBN7.2368,838,514 - 68,926,653 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl368,838,189 - 68,926,639 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx372,233,903 - 72,315,469 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0380,832,555 - 80,914,128 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0378,567,077 - 78,655,183 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0371,113,269 - 71,205,958 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl371,114,100 - 71,202,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0377,643,270 - 77,731,358 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4366,953,403 - 67,029,774 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1366,848,789 - 66,926,146 (+)NCBI
Celera368,209,136 - 68,297,332 (+)NCBICelera
Cytogenetic Map3q24NCBI
Itgav
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540311,592,339 - 11,659,297 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540311,588,536 - 11,669,809 (-)NCBIChiLan1.0ChiLan1.0
ITGAV
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21389,252,238 - 89,359,439 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B89,280,655 - 89,374,419 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B73,880,962 - 73,972,486 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B191,680,655 - 191,773,028 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B191,680,655 - 191,773,028 (+)Ensemblpanpan1.1panPan2
ITGAV
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13628,815,215 - 28,890,569 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3628,804,013 - 28,887,430 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3628,702,231 - 28,789,503 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03629,028,662 - 29,116,151 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3629,031,003 - 29,116,148 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13629,087,085 - 29,173,016 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03629,020,979 - 29,108,231 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03629,188,373 - 29,276,043 (+)NCBIUU_Cfam_GSD_1.0
Itgav
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303145,999,260 - 146,087,955 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650610,750,101 - 10,839,303 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650610,750,116 - 10,839,018 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGAV
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1591,604,676 - 91,711,851 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11591,604,666 - 91,711,843 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215101,654,958 - 101,717,935 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGAV
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11072,125,710 - 72,216,757 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1072,125,962 - 72,216,809 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040127,289,910 - 127,381,992 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgav
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248993,239,112 - 3,291,586 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248993,235,434 - 3,292,584 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itgav
2060 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2489
Count of miRNA genes:774
Interacting mature miRNAs:982
Transcripts:ENSMUST00000028499, ENSMUST00000111740, ENSMUST00000125360, ENSMUST00000125402, ENSMUST00000131192, ENSMUST00000141725, ENSMUST00000148256, ENSMUST00000151463, ENSMUST00000155521
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
10755526Lymph1_mlymphocyte differential 1 (mouse)25081931484819314Mouse
1300875Taste1_mtaste-saccharin preference 1 (mouse)Not determined25092317584923278Mouse
1300761Lgth1_mbody length 1 (mouse)Not determined25170327685703425Mouse
13464141Hbbcq3_mhemoglobin concentration QTL 3 (mouse)25244801986448136Mouse
13463471Hctq6_mhematocrit QTL 6 (mouse)25244801986448136Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25752411791524288Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25791999191919991Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26300595497006113Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26300595497006113Mouse
1301405Etohr_methanol response acute (mouse)Not determined26300595497006113Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26300595497006113Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26300595497006113Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26300595497006113Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26357015497570301Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267647887101648142Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267647887101648142Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268724269102724407Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268724269102724407Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74524117114123532Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
1301374Cplaq7_mcircadian period of locomotor activity 7 (mouse)Not determined276421483110421651Mouse
4141657Mohg1_mmodifier of hg 1 (mouse)Not determined276678758103095823Mouse
10043894Bw22_mbody weight QTL 22 (mouse)Not determined280895334114895334Mouse
15092054Egrme5_mearly growth rate, maternal effect 5 (mouse)282190187118004745Mouse

Markers in Region
U14135  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2DUniSTS
cM Map246.0UniSTS
Whitehead/MRC_RH21317.52UniSTS
Itgav  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2DUniSTS
cM Map249.33UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001398691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK003416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK020674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL772301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB632484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC133682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN532926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP296148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000028499   ⟹   ENSMUSP00000028499
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl283,554,741 - 83,637,260 (+)Ensembl
GRCm38.p6 Ensembl283,724,397 - 83,806,916 (+)Ensembl
RefSeq Acc Id: ENSMUST00000111740   ⟹   ENSMUSP00000107369
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl283,554,899 - 83,637,260 (+)Ensembl
GRCm38.p6 Ensembl283,724,555 - 83,806,916 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125360
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl283,554,741 - 83,587,141 (+)Ensembl
GRCm38.p6 Ensembl283,724,397 - 83,756,797 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125402   ⟹   ENSMUSP00000118016
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl283,632,193 - 83,634,329 (+)Ensembl
GRCm38.p6 Ensembl283,801,849 - 83,803,985 (+)Ensembl
RefSeq Acc Id: ENSMUST00000131192   ⟹   ENSMUSP00000121295
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl283,633,265 - 83,637,260 (+)Ensembl
GRCm38.p6 Ensembl283,802,921 - 83,806,916 (+)Ensembl
RefSeq Acc Id: ENSMUST00000141725   ⟹   ENSMUSP00000122730
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl283,554,796 - 83,578,288 (+)Ensembl
GRCm38.p6 Ensembl283,724,452 - 83,747,944 (+)Ensembl
RefSeq Acc Id: ENSMUST00000148256
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl283,554,871 - 83,556,133 (+)Ensembl
GRCm38.p6 Ensembl283,724,527 - 83,725,789 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151463
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl283,554,810 - 83,578,716 (+)Ensembl
GRCm38.p6 Ensembl283,724,466 - 83,748,372 (+)Ensembl
RefSeq Acc Id: ENSMUST00000155521
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl283,554,801 - 83,571,082 (+)Ensembl
GRCm38.p6 Ensembl283,724,457 - 83,740,738 (+)Ensembl
RefSeq Acc Id: NM_001398691   ⟹   NP_001385620
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39283,554,796 - 83,637,261 (+)NCBI
RefSeq Acc Id: NM_008402   ⟹   NP_032428
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39283,554,796 - 83,637,261 (+)NCBI
GRCm38283,724,397 - 83,806,917 (+)NCBI
MGSCv37283,564,554 - 83,647,073 (+)RGD
Celera285,367,604 - 85,456,007 (+)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032428   ⟸   NM_008402
- Peptide Label: isoform 1 precursor
- UniProtKB: A2AKI6 (UniProtKB/Swiss-Prot),   P43406 (UniProtKB/Swiss-Prot),   A0A0F7IQ06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000118016   ⟸   ENSMUST00000125402
RefSeq Acc Id: ENSMUSP00000107369   ⟸   ENSMUST00000111740
RefSeq Acc Id: ENSMUSP00000028499   ⟸   ENSMUST00000028499
RefSeq Acc Id: ENSMUSP00000121295   ⟸   ENSMUST00000131192
RefSeq Acc Id: ENSMUSP00000122730   ⟸   ENSMUST00000141725
RefSeq Acc Id: NP_001385620   ⟸   NM_001398691
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A0F7IQ06 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43406-F1-model_v2 AlphaFold P43406 1-1044 view protein structure

Promoters
RGD ID:6831630
Promoter ID:MM_KWN:29949
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_008402,   OTTMUST00000032293,   OTTMUST00000032294,   OTTMUST00000032295,   OTTMUST00000032296,   OTTMUST00000032343,   UC008KIA.1,   UC008KIB.1,   UC008KIC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36283,564,161 - 83,564,727 (+)MPROMDB
RGD ID:6877772
Promoter ID:EPDNEW_M2337
Type:initiation region
Name:Itgav_1
Description:Mus musculus integrin alpha V , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38283,724,493 - 83,724,553EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96608 AgrOrtholog
Ensembl Genes ENSMUSG00000027087 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000028499 ENTREZGENE
  ENSMUST00000028499.11 UniProtKB/Swiss-Prot
  ENSMUST00000111740.9 UniProtKB/TrEMBL
  ENSMUST00000125402.8 UniProtKB/TrEMBL
  ENSMUST00000131192.2 UniProtKB/TrEMBL
  ENSMUST00000141725.3 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16410 UniProtKB/Swiss-Prot
MGD MGI:96608 ENTREZGENE
NCBI Gene 16410 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTEGRIN ALPHA-V UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_A_Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Itgav PhenoGen
PRINTS INTEGRINA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Int_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF69179 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69318 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0F7IQ06 ENTREZGENE, UniProtKB/TrEMBL
  A2AKI5_MOUSE UniProtKB/TrEMBL
  A2AKI6 ENTREZGENE
  B7ZCI9_MOUSE UniProtKB/TrEMBL
  F6RWM8_MOUSE UniProtKB/TrEMBL
  F6W6Q6_MOUSE UniProtKB/TrEMBL
  ITAV_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U4C8_MOUSE UniProtKB/TrEMBL
  Q80Y67_MOUSE UniProtKB/TrEMBL
UniProt Secondary A2AKI6 UniProtKB/Swiss-Prot